David Pubill
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View article: The psychedelic phenethylamine 25C-NBF, a selective 5-HT2A agonist, shows psychoplastogenic properties and rapid antidepressant effects in male rodents
The psychedelic phenethylamine 25C-NBF, a selective 5-HT2A agonist, shows psychoplastogenic properties and rapid antidepressant effects in male rodents Open
Psychedelics have garnered significant interest for their therapeutic potential in mental health conditions such as depression, anxiety, and post-traumatic stress disorder. While research has primarily focused on well-studied psychedelics,…
View article: Neuropharmacology of halogenated DMT analogs: psychoplastogenic and antidepressant properties of 5-Br-DMT, a psychedelic derivative with low hallucinogenic potential
Neuropharmacology of halogenated DMT analogs: psychoplastogenic and antidepressant properties of 5-Br-DMT, a psychedelic derivative with low hallucinogenic potential Open
Current first-line antidepressants, such as selective serotonin reuptake inhibitors (SSRI), often present a delayed onset of action and fail to effectively treat a large proportion of patients, leaving a gap in the treatment of mood disord…
View article: Psychedelics for the Treatment of Substance Use Disorder
Psychedelics for the Treatment of Substance Use Disorder Open
Substance Use Disorder (SUD) is a chronic, relapsing mental health condition characterized by compulsive substance use despite harmful consequences. According to the World Health Organization, in 2021, approximately 39.5 million individual…
View article: Unveiling the potential abuse liability of α-D2PV: A novel α-carbon phenyl-substituted synthetic cathinone
Unveiling the potential abuse liability of α-D2PV: A novel α-carbon phenyl-substituted synthetic cathinone Open
Synthetic cathinones are emerging psychoactive substances designed to mimic the effects of classical psychostimulants. Among them, α-D2PV, a novel pyrrolidine-containing cathinone characterized by a phenyl group on the α-carbon atom, has g…
View article: Acute Paraoxon-Induced Neurotoxicity in a Mouse Survival Model: Oxidative Stress, Dopaminergic System Alterations and Memory Deficits
Acute Paraoxon-Induced Neurotoxicity in a Mouse Survival Model: Oxidative Stress, Dopaminergic System Alterations and Memory Deficits Open
The secondary neurotoxicity induced by severe organophosphorus (OP) poisoning, including paraoxon (POX), is associated with cognitive impairments in survivors, who, despite receiving appropriate emergency treatments, may still experience l…
View article: Structure–Activity Relationship of Synthetic Cathinones: An Updated Review
Structure–Activity Relationship of Synthetic Cathinones: An Updated Review Open
The escalating prevalence of new psychoactive substances (NPSs) poses a significant public health challenge, evidenced by the vast chemical diversity, with over 500 substances reported annually to the United Nations Office on Drugs and Cri…
View article: Sex differences in the effects of <i>N</i>‐ethylpentylone in young CD1 mice: Insights on behaviour, thermoregulation and early gene expression
Sex differences in the effects of <i>N</i>‐ethylpentylone in young CD1 mice: Insights on behaviour, thermoregulation and early gene expression Open
Background and Purpose New psychoactive substances such as N ‐ethylpentylone (NEP) are continuously emerging in the illicit drug market, and knowledge of their effects and risks, which may vary between sexes, is scarce. Our present study c…
View article: Structure-activity relationships of serotonergic 5-MeO-DMT derivatives: insights into psychoactive and thermoregulatory properties
Structure-activity relationships of serotonergic 5-MeO-DMT derivatives: insights into psychoactive and thermoregulatory properties Open
View article: 5-halo-substituted DMT derivatives. Hallucinogenic response and early gene expression in mice
5-halo-substituted DMT derivatives. Hallucinogenic response and early gene expression in mice Open
View article: First-Generation Synthetic Cathinones Produce Arrhythmia in Zebrafish Eleutheroembryos: A New Approach Methodology for New Psychoactive Substances Cardiotoxicity Evaluation
First-Generation Synthetic Cathinones Produce Arrhythmia in Zebrafish Eleutheroembryos: A New Approach Methodology for New Psychoactive Substances Cardiotoxicity Evaluation Open
The increasing number of new psychoactive substances (NPS) entering the illicit drug market, especially synthetic cathinones, as well as the risk of cardiovascular complications, is intensifying the need to quickly assess their cardiotoxic…
View article: OP0134 REAL WORLD “POLY-REFRACTORY RA”: A RARE BUT UNMET CLINICAL CHALLENGE
OP0134 REAL WORLD “POLY-REFRACTORY RA”: A RARE BUT UNMET CLINICAL CHALLENGE Open
Background In an age of dose optimization and drug tapering due to excellent conventional (c), biological (b) or targeted synthetic (ts) disease-modifying anti-rheumatic drugs (DMARDs), the fact remains that many patients still have active…
View article: Structure–Activity Relationship of <i>N</i>-Ethyl-Hexedrone Analogues: Role of the α-Carbon Side-Chain Length in the Mechanism of Action, Cytotoxicity, and Behavioral Effects in Mice
Structure–Activity Relationship of <i>N</i>-Ethyl-Hexedrone Analogues: Role of the α-Carbon Side-Chain Length in the Mechanism of Action, Cytotoxicity, and Behavioral Effects in Mice Open
Synthetic cathinones are β-keto amphetamine derivatives whose appearance has increased dramatically in the past decades. N-Ethyl substituted cathinones have been proven to potently inhibit dopamine (DA) uptake and induce psychostimu…
View article: 5-MeO-MET, 5-MeO-DET and 5-MeO-pyr-T strongly bind to 5-HT1A and 5-HT2A receptors and act as partial SERT substrates
5-MeO-MET, 5-MeO-DET and 5-MeO-pyr-T strongly bind to 5-HT1A and 5-HT2A receptors and act as partial SERT substrates Open
View article: Oxidative stress and memory impairments in a mouse survival model of acute paraoxon poisoning
Oxidative stress and memory impairments in a mouse survival model of acute paraoxon poisoning Open
View article: In vitro structure-activity relationship of 5-halo-DMT derivatives as novel psychedelics
In vitro structure-activity relationship of 5-halo-DMT derivatives as novel psychedelics Open
View article: Sex differences in the rewarding and reinforcing effects of N-ethylpentylone in mice
Sex differences in the rewarding and reinforcing effects of N-ethylpentylone in mice Open
View article: Role of the 5-HT2A and 5-HT1A receptors in the hallucinogenic effects and thermoregulation after acute administration of 5-methoxy-tryptamines in mice
Role of the 5-HT2A and 5-HT1A receptors in the hallucinogenic effects and thermoregulation after acute administration of 5-methoxy-tryptamines in mice Open
View article: 3,4-Methylenedioxy methamphetamine, synthetic cathinones and psychedelics: From recreational to novel psychotherapeutic drugs
3,4-Methylenedioxy methamphetamine, synthetic cathinones and psychedelics: From recreational to novel psychotherapeutic drugs Open
The utility of classical drugs used to treat psychiatric disorders (e.g., antidepressants, anxiolytics) is often limited by issues of lack of efficacy, delayed onset of action or side effects. Psychoactive substances have a long history of…
View article: Repeated administration of N-ethyl-pentedrone induces increased aggression and impairs social exploration after withdrawal in mice
Repeated administration of N-ethyl-pentedrone induces increased aggression and impairs social exploration after withdrawal in mice Open
N-ethyl-pentedrone (NEPD, 2-(ethylamino)-1-phenyl-1-pentanone) is one of the latest synthetic cathinone derivatives that emerged into the illicit drug market. This drug has psychostimulant properties and has been related with several intox…
View article: Neuropsychopharmacology of Emerging Drugs of Abuse: meta- and para-Halogen-Ring-Substituted α-PVP (“flakka”) Derivatives
Neuropsychopharmacology of Emerging Drugs of Abuse: meta- and para-Halogen-Ring-Substituted α-PVP (“flakka”) Derivatives Open
Changes in the molecular structure of synthetic cathinones has led to an increase in the number of novel emerging drugs in the illicit drug market at an unprecedented rate. Unfortunately, little is known about the neuropsychopharmacology o…
View article: Behavioural and neurochemical effects after repeated administration of N‐ethylpentylone (ephylone) in mice
Behavioural and neurochemical effects after repeated administration of N‐ethylpentylone (ephylone) in mice Open
N‐ethyl‐pentylone (NEP), also known as ‘ephylone’ and N‐ethylnorpentylone, has been identified as one of the most recent novel psychostimulants to emerge into the illicit drug market and it has been associated with some intoxications and e…
View article: Structure–Activity Relationship of Novel Second-Generation Synthetic Cathinones: Mechanism of Action, Locomotion, Reward, and Immediate-Early Genes
Structure–Activity Relationship of Novel Second-Generation Synthetic Cathinones: Mechanism of Action, Locomotion, Reward, and Immediate-Early Genes Open
Several new synthetic cathinones, which mimic the effect of classical psychostimulants such as cocaine or MDMA, have appeared in the global illicit drug market in the last decades. In fact, the illicit drug market is continually evolving b…
View article: Role of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones
Role of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones Open
View article: Effects of High-Fat Diet and Maternal Binge-Like Alcohol Consumption and Their Influence on Cocaine Response in Female Mice Offspring
Effects of High-Fat Diet and Maternal Binge-Like Alcohol Consumption and Their Influence on Cocaine Response in Female Mice Offspring Open
Background Prenatal alcohol exposure is a leading cause of neurobehavioral and neurocognitive deficits collectively known as fetal alcohol spectrum disorders, including eating disorders and increased risk for substance abuse as very common…
View article: Role of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones
Role of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones Open
Background and Purpose: The emergence of new synthetic cathinones continues to be a matter of public health concern. In fact, they are quickly replaced by new structurally related alternatives. The main goal of the present study was to cha…
View article: Enantioselective Synthesis of the Ethyl Analog of the Marine Alkaloid Haliclorensin C
Enantioselective Synthesis of the Ethyl Analog of the Marine Alkaloid Haliclorensin C Open
The enantioselective synthesis (3.7% overall yield in nine steps from 2) and biological screening of the ethyl analog of the macrocyclic marine alkaloid haliclorensin C (compound 5) are reported. Amino alcohol 3, generated by a LiNH2BH3-pr…
View article: 7,8-Dihydroxyflavone blocks the development of behavioral sensitization to MDPV, but not to cocaine: Differential role of the BDNF-TrkB pathway
7,8-Dihydroxyflavone blocks the development of behavioral sensitization to MDPV, but not to cocaine: Differential role of the BDNF-TrkB pathway Open
View article: MDPV induces a rapid up-regulation of striatal dopamine transporter function. A comparative study with cocaine
MDPV induces a rapid up-regulation of striatal dopamine transporter function. A comparative study with cocaine Open
Background: New psychoactive substances, such as synthetic cathinones, have been recently identified, representing an important public health challenge. 3,4-Methylenedioxypyrovalerone (MDPV) is considered as one of the most abused syntheti…
View article: Ethanol enhances the psychostimulant effect and the monoamine release induced by mephedrone in rats
Ethanol enhances the psychostimulant effect and the monoamine release induced by mephedrone in rats Open
Background: Mephedrone (4-methylmethcathinone) is an increasingly consumed synthetic cathinone with powerful psychostimulant effects. Previous studies in rodents have also shown that ethanol (EtOH), a drug which is the most combined with m…
View article: The BDNF-TrkB signaling pathway is involved differently in the development of locomotor sensitization and place conditioning by MDPV and cocaine
The BDNF-TrkB signaling pathway is involved differently in the development of locomotor sensitization and place conditioning by MDPV and cocaine Open
3,4-Methylenedioxypyrovalerone (MDPV) is a cathinone that acts as a dopamine transporter blocker and proved to increase vulnerability to cocaine abuse. Accordingly, we determined if there is also a cross-sensitization between both drugs. I…