David Q. Rich
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View article: Ambient air pollution exposure and effects on neutralizing antibody titers following SARS-CoV-2 vaccination in adults
Ambient air pollution exposure and effects on neutralizing antibody titers following SARS-CoV-2 vaccination in adults Open
We examined the association between air pollution and neutralizing antibody responses to COVID-19 vaccination in participants enrolled in a phase 3 clinical trial. Seventy-four adults were vaccinated with two doses of the AstraZeneca ChAdO…
View article: Accountability Assessment of Source-Specific Impacts of Regulations on Emissions and Air Quality Using Positive Matrix Factorization
Accountability Assessment of Source-Specific Impacts of Regulations on Emissions and Air Quality Using Positive Matrix Factorization Open
Emission controls targeting electric generating units (EGUs) and mobile sources have been implemented for decades to mitigate PM2.5 concentrations. Impacts of emission controls on source-apportioned PM2.5 concentrations (diesel/gasoline ve…
View article: Periods of susceptibility for associations between phthalate exposure and preterm birth: Results from a pooled analysis of 16 US cohorts
Periods of susceptibility for associations between phthalate exposure and preterm birth: Results from a pooled analysis of 16 US cohorts Open
The association of preterm birth with gestational biomarkers of DEHP exposure, but not other phthalate metabolites, differed by the timing of exposure. First and second trimester exposures demonstrated the greatest associations. Our study …
View article: Racial and Ethnic Disparities in Phthalate Exposure and Preterm Birth: A Pooled Study of Sixteen U.S. Cohorts
Racial and Ethnic Disparities in Phthalate Exposure and Preterm Birth: A Pooled Study of Sixteen U.S. Cohorts Open
BACKGROUND: Phthalate exposures are ubiquitous during pregnancy and may contribute to racial and ethnic disparities in preterm birth. OBJECTIVES: We investigated race and ethnicity in the relationship between biomarkers of phthalate exposu…
View article: Gestational exposure to PM2.5, NO2, and sex steroid hormones: Identifying critical windows of exposure in the Rochester UPSIDE Cohort
Gestational exposure to PM2.5, NO2, and sex steroid hormones: Identifying critical windows of exposure in the Rochester UPSIDE Cohort Open
Background: Sex steroid hormones are critical for maintaining pregnancy and optimal fetal development. Air pollutants are potential endocrine disruptors that may disturb sex steroidogenesis during pregnancy, potentially leading to adverse …
View article: Benzo[<i>a</i>]pyrene and phenanthrene hemoglobin adducts as biomarkers of longer-term air pollution exposure
Benzo[<i>a</i>]pyrene and phenanthrene hemoglobin adducts as biomarkers of longer-term air pollution exposure Open
PAH-hemoglobin adduct levels were associated with cumulative PM 2.5 exposure over the lifespan of red blood cells, demonstrating their utility as biomarkers for longer-term exposure.
View article: Association of oropharyngeal cancer recurrence with tumor-intrinsic and immune-mediated sequelae of reduced genomic instability
Association of oropharyngeal cancer recurrence with tumor-intrinsic and immune-mediated sequelae of reduced genomic instability Open
Background Limited understanding of the biology predisposing certain human papillomavirus-related (HPV+) oropharyngeal squamous cell carcinomas (OPSCCs) to relapse impedes therapeutic personalization. We aimed to identify molecular traits …
View article: USING CCA-MRI TO PREDICT RESPONSE TO STEREOTACTIC RADIOSURGERY IN PATIENTS WITH BRAIN METASTASES
USING CCA-MRI TO PREDICT RESPONSE TO STEREOTACTIC RADIOSURGERY IN PATIENTS WITH BRAIN METASTASES Open
AIMS Brain metastases (BMs) from different primary cancers may have different radiosensitivity, for example melanoma and renal cell cancers are considered more radioresistant. Radiosensitivity is determined by the intrinsic radiobiological…
View article: Exposure to Low-Level Air Pollution and Hyperglycemia Markers during Pregnancy: A Repeated Measure Analysis
Exposure to Low-Level Air Pollution and Hyperglycemia Markers during Pregnancy: A Repeated Measure Analysis Open
Epidemiologic evidence has emerged showing an association between exposure to air pollution and increased risks of gestational diabetes mellitus (GDM). This study examines the effect of low-level air pollution exposure on a subclinical bio…
View article: Associations of Gestational Exposure to Air Pollution and Polycyclic Aromatic Hydrocarbons with Placental Inflammation
Associations of Gestational Exposure to Air Pollution and Polycyclic Aromatic Hydrocarbons with Placental Inflammation Open
Restricted fetal growth (RFG) is a leading contributor to perinatal mortality and has been associated with gestational exposure to air pollution, such as fine particulate matter (PM2.5), nitrogen dioxide (NO2), and polycyclic aromatic hydr…
View article: Changes in source specific PM2.5 from 2010 to 2019 in New York and New Jersey identified by dispersion normalized PMF
Changes in source specific PM2.5 from 2010 to 2019 in New York and New Jersey identified by dispersion normalized PMF Open
Since the Clean Air Act amendments of 1970, various efforts have been made in the United States to control ambient particulate matter and improve air quality. Although substantial progress had been made by the end of the 1990s, further red…
View article: Long term trends in source apportioned particle number concentrations in Rochester NY
Long term trends in source apportioned particle number concentrations in Rochester NY Open
During the past two decades, efforts have been made to further reduce particulate air pollution across New York State through various Federal and State policy implementations. Air quality has also been affected by economic drivers like the…
View article: Primary Treatment Modification and Treatment Tolerability Among Older Chemotherapy Recipients With Advanced Cancer
Primary Treatment Modification and Treatment Tolerability Among Older Chemotherapy Recipients With Advanced Cancer Open
Importance Older adults with advanced cancer are less likely to tolerate treatment with cytotoxic chemotherapy compared with younger patients due to their aging-related conditions. Hence, oncologists sometimes opt to employ primary treatme…
View article: Change in rate of healthcare encounters for respiratory infection from air pollution exposure after improved vehicle emissions standards in New York State
Change in rate of healthcare encounters for respiratory infection from air pollution exposure after improved vehicle emissions standards in New York State Open
The introduction of Tier 3 light-duty vehicles with reduced emissions began in New York State (NYS) in 2017, with required compliance by 2025. We hypothesized that improved air quality during the early implementation of Tier 3 (2017–2019) …
View article: Impacts of Fuel Prices and Regulations on Electricity Generation Emissions and Urban Air Quality
Impacts of Fuel Prices and Regulations on Electricity Generation Emissions and Urban Air Quality Open
Regulatory actions and fuel price trends have decreased emissions from electricity generating units (EGUs) in the United States. The objective of this study is to separate coincident regulatory and fuel price impacts on EGU emissions and a…
View article: Racial and Ethnic Disparities in Phthalate Exposure and Preterm Birth: A Pooled Study of Sixteen U.S. Cohorts
Racial and Ethnic Disparities in Phthalate Exposure and Preterm Birth: A Pooled Study of Sixteen U.S. Cohorts Open
Phthalate metabolite concentrations differed substantially by race and ethnicity. Our results show hypothetical interventions to reduce population-level racial and ethnic disparities in biomarkers of phthalate exposure could potentially re…
View article: Associations between Prenatal Urinary Biomarkers of Phthalate Exposure and Preterm Birth: A Pooled Study of 16 US Cohorts
Associations between Prenatal Urinary Biomarkers of Phthalate Exposure and Preterm Birth: A Pooled Study of 16 US Cohorts Open
Importance: Phthalate exposure is widespread among pregnant women and may be a risk factor for preterm birth. Objective: To investigate the prospective association between urinary biomarkers of phthalates in pregnancy and preterm birth amo…
View article: Increased HbA1c During Pregnancy is Associated with In-utero Exposure to PM2.5 at Levels below Current Air Quality Guidelines
Increased HbA1c During Pregnancy is Associated with In-utero Exposure to PM2.5 at Levels below Current Air Quality Guidelines Open
BACKGROUND AND AIM: Previous epidemiological studies found increased risk of gestational diabetes associated with fine particle matter (PM2.5) exposure. However, there is a paucity of mechanistic evidence for such an association. We examin…
View article: Air Pollution Exposure During Pregnancy and Placental Inflammation
Air Pollution Exposure During Pregnancy and Placental Inflammation Open
BACKGROUND AND AIM: Regulation of pro and anti-inflammation at various stages of development is imperative to placental growth, function, and an overall healthy pregnancy. Air pollution exposure at critical times during development in the …
View article: Femoral Malrotation Following Intramedullary Nailing of Femoral Shaft Fractures
Femoral Malrotation Following Intramedullary Nailing of Femoral Shaft Fractures Open
Femoral malrotation represents one of the common causes of deformity following intramedullary nailing of femoral shaft fractures that can lead to cosmetic and functional consequences.Femoral malrotation is often underrecognized because fem…
View article: The Radiographic Targeting Attachment-A New Freehand Targeting Device for Distal Locking of Intramedullary Nails
The Radiographic Targeting Attachment-A New Freehand Targeting Device for Distal Locking of Intramedullary Nails Open
The radiographic targeting attachment (RTA) being developed by Eclipse Orthopaedics offers a new way to perform the distal locking portion of intramedullary nailing procedures by combining the modalities of fluoroscopy and drilling into a …