David R. Brown
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View article: Development of the Physical Activity Research Opportunities (PARO) framework
Development of the Physical Activity Research Opportunities (PARO) framework Open
Purpose Physical activity is beneficial across the lifespan, but most Americans do not meet physical activity guidelines. Multiple sources exist that identify opportunities to address gaps in physical activity research knowledge and implem…
View article: Interaction Between α-Synuclein and DJ-1 in Parkinson’s Disease
Interaction Between α-Synuclein and DJ-1 in Parkinson’s Disease Open
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders among the elderly. The exact etiology of sporadic PD is still unknown; however, there is general consensus that the accumulation and aggregation of α-synuclein …
View article: Relationship Between Health Care Team Segregation and Receipt of Care by a Cardiologist According to Patient Race in a Midwestern State
Relationship Between Health Care Team Segregation and Receipt of Care by a Cardiologist According to Patient Race in a Midwestern State Open
Background Segregation index (SI) has been associated with worsened health. However, the relationship between SI within health care teams (degree of heterogeneity between teams caring for Black compared with White patients) and cardiovascu…
View article: P-2187. Emergency Department Patients’ Perceptions of the Seriousness of Hepatitis C – Implication on Improvement of HCV Care Continuum
P-2187. Emergency Department Patients’ Perceptions of the Seriousness of Hepatitis C – Implication on Improvement of HCV Care Continuum Open
Background U.S. urban emergency departments (EDs) have identified thousands of individuals infected with hepatitis C virus (HCV) through their testing programs. However, significant challenges remain with linkage to care (LTC) rates from E…
View article: Arthritis Management: Patient-Reported Health Care Provider Screening, Counseling, and Recommendations for Physical Activity
Arthritis Management: Patient-Reported Health Care Provider Screening, Counseling, and Recommendations for Physical Activity Open
HCP counseling about PA among adults with arthritis for arthritis symptom management is lacking in frequency, actionable content, and recommendations to engage in evidence-based PA interventions. Dissemination and implementation of policie…
View article: Meeting the Aerobic and Muscle-Strengthening Physical Activity Guidelines Among Older US Adults, National Health Interview Survey 1998–2018
Meeting the Aerobic and Muscle-Strengthening Physical Activity Guidelines Among Older US Adults, National Health Interview Survey 1998–2018 Open
The Physical Activity Guidelines for Americans, second edition, recommends older adults participate in ≥150 minutes per week of moderate-intensity equivalent aerobic activity and ≥2 days per week of muscle-strengthening activity. We estima…
View article: How Health and Fitness Professionals Can Further Advance the Nation's Health by Working Across the Ecological Model
How Health and Fitness Professionals Can Further Advance the Nation's Health by Working Across the Ecological Model Open
Apply It! From this article, readers should: • Identify how health and fitness professionals can promote health and wellness among their fitness center, health club, or gym members, clients, patients, and communities by working collaborati…
View article: Characteristics of Sepsis or Acute Pyelonephritis Combined with Ureteral Stone in the United States: A Retrospective Analysis of Large National Cohort
Characteristics of Sepsis or Acute Pyelonephritis Combined with Ureteral Stone in the United States: A Retrospective Analysis of Large National Cohort Open
To identify the characteristics of patients with sepsis or acute pyelonephritis (APN) combined with ureteral calculi and to analyze the risk factors in its causation. Methods: We included patients with sepsis or APN caused by ureteral calc…
View article: The AICD fragment of APP initiates a FoxO3a mediated response via FANCD2
The AICD fragment of APP initiates a FoxO3a mediated response via FANCD2 Open
The amyloid precursor protein (APP) is a cell surface protein of uncertain function that is notable for being the parent protein of beta-amyloid. Research around this protein has focussed heavily on the link to Alzheimer's disease and neur…
View article: Senescent Microglia: The Key to the Ageing Brain?
Senescent Microglia: The Key to the Ageing Brain? Open
Ageing represents the single biggest risk factor for development of neurodegenerative disease. Despite being such long-lived cells, microglia have been relatively understudied for their role in the ageing process. Reliably identifying aged…
View article: Cross-sectional association between physical activity level and subjective cognitive decline among US adults aged ≥45 years, 2015
Cross-sectional association between physical activity level and subjective cognitive decline among US adults aged ≥45 years, 2015 Open
View article: Muscle Up: Psychobiological Responses to Social-Evaluative Body Image Threats in University Male Athletes and Non-Athletes
Muscle Up: Psychobiological Responses to Social-Evaluative Body Image Threats in University Male Athletes and Non-Athletes Open
Negative body image often occurs as a result of social evaluation of the physique in men. However, athletes tend to experience fewer body image concerns compared to non-athletes. Social-self preservation theory (SSPT) holds that social-eva…
View article: Exposure assessment of adults living near unconventional oil and natural gas development and reported health symptoms in southwest Pennsylvania, USA
Exposure assessment of adults living near unconventional oil and natural gas development and reported health symptoms in southwest Pennsylvania, USA Open
Recent research has shown relationships between health outcomes and residence proximity to unconventional oil and natural gas development (UOGD). The challenge of connecting health outcomes to environmental stressors requires ongoing resea…
View article: Microglia and the aging brain: are senescent microglia the key to neurodegeneration?
Microglia and the aging brain: are senescent microglia the key to neurodegeneration? Open
The single largest risk factor for etiology of neurodegenerative diseases like Alzheimer’s disease is increased age. Therefore, understanding the changes that occur as a result of aging is central to any possible prevention or cure for suc…
View article: Setback distances for unconventional oil and gas development: Delphi study results
Setback distances for unconventional oil and gas development: Delphi study results Open
Emerging evidence indicates that proximity to unconventional oil and gas development (UOGD) is associated with health outcomes. There is intense debate about "How close is too close?" for maintaining public health and safety. The goal of t…
View article: Model Senescent Microglia Induce Disease Related Changes in α-Synuclein Expression and Activity
Model Senescent Microglia Induce Disease Related Changes in α-Synuclein Expression and Activity Open
Aging is the most prominent risk factor for most neurodegenerative diseases. However, incorporating aging-related changes into models of neurodegeneration rarely occurs. One of the significant changes that occurs in the brain as we age is …
View article: Levels of α‐ and β‐synuclein regulate cellular susceptibility to toxicity from α‐synuclein oligomers
Levels of α‐ and β‐synuclein regulate cellular susceptibility to toxicity from α‐synuclein oligomers Open
α‐Synuclein (α‐syn) is associated with a range of diseases, including Parkinson disease. In disease, α‐syn is known to aggregate and has the potential to be neurotoxic. The association between copper and α‐syn results in the formation of s…
View article: Health symptoms in residents living near shale gas activity: A retrospective record review from the Environmental Health Project
Health symptoms in residents living near shale gas activity: A retrospective record review from the Environmental Health Project Open
Increasing evidence demonstrates an association between health symptoms and exposure to unconventional natural gas development (UNGD). The purpose of this study is to describe the health of adults in communities with intense UNGD who prese…
View article: Prevalence of Modifiable Cancer Risk Factors Among U.S. Adults Aged 18–44 Years
Prevalence of Modifiable Cancer Risk Factors Among U.S. Adults Aged 18–44 Years Open
View article: Alpha-synuclein ferrireductase activity is detectible in vivo, is altered in Parkinson's disease and increases the neurotoxicity of DOPAL
Alpha-synuclein ferrireductase activity is detectible in vivo, is altered in Parkinson's disease and increases the neurotoxicity of DOPAL Open
View article: 1104 MATERNAL DEPRESSION AND SLEEP QUALITY IN EARLY POSTPARTUM: DO MATERNAL SLEEP-RELATED COGNITIONS AND NIGHTTIME BEHAVIOURS MEDIATE THE RELATIONSHIP?
1104 MATERNAL DEPRESSION AND SLEEP QUALITY IN EARLY POSTPARTUM: DO MATERNAL SLEEP-RELATED COGNITIONS AND NIGHTTIME BEHAVIOURS MEDIATE THE RELATIONSHIP? Open
While postpartum depression has been linked to poorer maternal sleep quality, the pathways underlining this relationship are not well known. This study aimed to investigate the links between maternal postpartum depression, cognitions regar…
View article: α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP
α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP Open
α-Synuclein misfolding and aggregation is often accompanied by β-amyloid deposition in some neurodegenerative diseases. We hypothesised that α-synuclein promotes β-amyloid production from APP. β-Amyloid levels and APP amyloidogenic process…
View article: Prion infection in cells is abolished by a mutated manganese transporter but shows no relation to zinc
Prion infection in cells is abolished by a mutated manganese transporter but shows no relation to zinc Open