David R. Jacobs
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View article: Implementation of Wellness Days for Pharmacy Students during Advanced Pharmacy Practice Experiences (APPEs)
Implementation of Wellness Days for Pharmacy Students during Advanced Pharmacy Practice Experiences (APPEs) Open
View article: Predicting Breath Hold Task Compliance From Head Motion
Predicting Breath Hold Task Compliance From Head Motion Open
Background Cerebrovascular reactivity reflects changes in cerebral blood flow in response to an acute stimulus and is reflective of the brain's ability to match blood flow to demand. Functional MRI with a breath‐hold task can be used to el…
View article: Cardiometabolic Health and Bariatric Surgery: A 25-Year Longitudinal Cohort Study in CARDIA Participants
Cardiometabolic Health and Bariatric Surgery: A 25-Year Longitudinal Cohort Study in CARDIA Participants Open
Objective: Compare longitudinal cardiometabolic health outcomes among individuals who underwent bariatric surgery (BarS) with nonsurgical controls. Background: BarS is well-established for inducing profound weight loss and improving cardio…
View article: Prediabetes transitions to normoglycaemia or type 2 diabetes and associated risk factors in the Obesity, Diabetes and Cardiovascular Disease Collaboration: an individual-level pooled analysis of 19 prospective cohort studies
Prediabetes transitions to normoglycaemia or type 2 diabetes and associated risk factors in the Obesity, Diabetes and Cardiovascular Disease Collaboration: an individual-level pooled analysis of 19 prospective cohort studies Open
Deakin University Postgraduate Research Scholarship.
View article: No Evidence of Metabolomic Disruptions From Real‐World Intakes of Aspartame or Saccharin: The Coronary Artery Risk Development in Young Adults Study
No Evidence of Metabolomic Disruptions From Real‐World Intakes of Aspartame or Saccharin: The Coronary Artery Risk Development in Young Adults Study Open
Background Artificial sweeteners have become ubiquitous additives in the food supply, and yet the safety of their regular consumption remains controversial. The present study examined whether intakes of aspartame or saccharin are related t…
View article: Risk of adverse pregnancy outcomes and impact of statin use in pregnant women with familial hypercholesterolemia
Risk of adverse pregnancy outcomes and impact of statin use in pregnant women with familial hypercholesterolemia Open
Women with FH had lower risk of gestational diabetes and intrapartum hemorrhage, but a higher risk of preeclampsia compared to controls. No adverse birth outcomes were observed for offspring of mothers with FH, but the association between …
View article: Arterial Stiffness in Heart‐Healthy Indigenous Tsimane Forager‐Horticulturalists
Arterial Stiffness in Heart‐Healthy Indigenous Tsimane Forager‐Horticulturalists Open
Background Little is known about arterial stiffness in rural subsistence populations that experience few cardiovascular risk factors. We conducted a cross‐sectional study comparing 3 arterial stiffness metrics among Tsimane forager‐horticu…
View article: Thirty-Year Glycemic Trajectories From Young Adulthood Through Middle Age
Thirty-Year Glycemic Trajectories From Young Adulthood Through Middle Age Open
Importance Type 2 diabetes prevalence is increasing, and currently 24% of young adults have prediabetes. Little is known regarding timing and progression from normoglycemia to diabetes starting in young adulthood. Objective To examine glyc…
View article: Quantifying the impact of early-life growth adversity on later-life health
Quantifying the impact of early-life growth adversity on later-life health Open
Background Early-life growth adversity is important to later-life health, but precision assessment in adulthood is challenging. We evaluated whether the difference between attained and genotype-predicted adult height (“height-GaP”) would a…
View article: Impaired lung function is associated with elevated blood biomarkers of AD/ADRD: Unraveling the interplay with risk of dementia
Impaired lung function is associated with elevated blood biomarkers of AD/ADRD: Unraveling the interplay with risk of dementia Open
Rationale We hypothesize that impaired lung function contributes to dementia risk via biological mechanisms reflected in AD/ADRD-related protein biomarkers, and aim to evaluate their role in mediating this relationship. Methods Serum p-Tau…
View article: Dietary carbohydrate quality, fibre-rich food intake, and left ventricular structure and function: the CARDIA study
Dietary carbohydrate quality, fibre-rich food intake, and left ventricular structure and function: the CARDIA study Open
Background and Aims Identifying lifestyle risk factors related to abnormal cardiac phenotypes, including structure and function, will be essential to prevent or slow down the progression to heart failure. Little is known about intakes of m…
View article: Association of Race With Risk of Incident Cardiovascular Disease, Coronary Heart Disease, Heart Failure, and Stroke
Association of Race With Risk of Incident Cardiovascular Disease, Coronary Heart Disease, Heart Failure, and Stroke Open
View article: Association Between Artificial Sweetener Consumption and Risk of Incident Diabetes: The CARDIA study
Association Between Artificial Sweetener Consumption and Risk of Incident Diabetes: The CARDIA study Open
View article: The Social Determinants of Health Index Is Associated With Diet Quality: A Cross-Sectional Study
The Social Determinants of Health Index Is Associated With Diet Quality: A Cross-Sectional Study Open
View article: Urban imperviousness and carotid intima-medial thickness: Evidence from the Coronary Artery Risk Development in Young Adults (CARDIA) study
Urban imperviousness and carotid intima-medial thickness: Evidence from the Coronary Artery Risk Development in Young Adults (CARDIA) study Open
View article: Genome-wide association study and multi-ancestry meta-analysis identify common variants associated with carotid artery intima-media thickness
Genome-wide association study and multi-ancestry meta-analysis identify common variants associated with carotid artery intima-media thickness Open
Carotid artery intima-media thickness (cIMT) is a measurement of subclinical atherosclerosis that predicts future cardiovascular events, including stroke and myocardial infarction. Genome-wide association studies (GWAS) have identified onl…
View article: Validation of a Time-to-Exhaustion-Derived VO2max Prediction Equation and Secondary Criteria Agreement: The CARDIA Study
Validation of a Time-to-Exhaustion-Derived VO2max Prediction Equation and Secondary Criteria Agreement: The CARDIA Study Open
Introduction Measuring maximal oxygen consumption (V˙O 2max ) during a graded exercise test (GXT) poses challenges in population-based studies. We examined the relationship between GXT duration (GXTd) and V˙O 2max to create a prediction eq…
View article: 182 Micro-credentials and translational workforce development: Motivation and benefits
182 Micro-credentials and translational workforce development: Motivation and benefits Open
Objectives/Goals: Micro-credentials (MCs) or digital badges are short programs designed to allow learners to gain knowledge and skills at their own pace to tailor their professional development. This study aims to examine the characteristi…
View article: The association of childhood HDL cholesterol with atherosclerotic cardiovascular disease events in adults: findings from the International Childhood Cardiovascular Cohort Consortium
The association of childhood HDL cholesterol with atherosclerotic cardiovascular disease events in adults: findings from the International Childhood Cardiovascular Cohort Consortium Open
Aims The role of adult HDL-C in atherosclerotic cardiovascular disease (ASCVD) faces challenges from Mendelian randomizations and drug trials. However, the association between childhood HDL-C and its changes and adult ASCVD remains undefin…
View article: Chronic Inflammatory-Related Disease and Cardiovascular Disease in MESA
Chronic Inflammatory-Related Disease and Cardiovascular Disease in MESA Open
View article: Financial Strain Across 25 years and Men’s Lower Urinary Tract Symptoms: A Life Course Perspective
Financial Strain Across 25 years and Men’s Lower Urinary Tract Symptoms: A Life Course Perspective Open
This research utilizes Coronary Artery Risk Development in Young Adults (CARDIA) cohort study data to examine whether financial strain is associated with subsequent lower urinary tract symptoms among men and whether healthcare barriers, he…
View article: Associations of metabolic syndrome with lung function decline and clinical respiratory outcomes: the NHLBI Pooled Cohort Study
Associations of metabolic syndrome with lung function decline and clinical respiratory outcomes: the NHLBI Pooled Cohort Study Open
Background Whether metabolic syndrome (MetS) increases the risk of chronic lung diseases remains uncertain. We aimed to test whether MetS was associated with lung function and clinical respiratory outcomes. Methods Data were harmonised fro…
View article: Associations of long-term exposure to temperature with coronary artery calcification risk among middle-aged adults: The Coronary Artery Risk Development in Young Adults (CARDIA) study
Associations of long-term exposure to temperature with coronary artery calcification risk among middle-aged adults: The Coronary Artery Risk Development in Young Adults (CARDIA) study Open
View article: Dietary Carbohydrate Quality Is Associated with Epigenetic Age Acceleration: a Cross-Sectional Study of the CARDIA Cohort
Dietary Carbohydrate Quality Is Associated with Epigenetic Age Acceleration: a Cross-Sectional Study of the CARDIA Cohort Open
View article: The association between depressive symptoms and lower urinary tract symptoms and impact among women: Investigating behavioural, cognitive and physiological pathways
The association between depressive symptoms and lower urinary tract symptoms and impact among women: Investigating behavioural, cognitive and physiological pathways Open
Objective Mechanistic studies are needed to understand why depressive symptoms are associated with poorer physical health. The objective of this study was to examine whether behavioural, cognitive and physiological factors mediated an asso…
View article: Spatial and signal features of white matter integrity and associations with clinical factors: A CARDIA brain MRI study
Spatial and signal features of white matter integrity and associations with clinical factors: A CARDIA brain MRI study Open
White matter hyperintensities (WMH) may be indicative of age-related cerebrovascular diseases and contribute to cognitive and functional decline. Normal appearing WM (NAWM) adjacent to WMH, termed "penumbra," is known to be vulnerable to f…
View article: United States Pooled Cohort Cardiovascular Disease Risk Scores in Adults With Diabetes Mellitus
United States Pooled Cohort Cardiovascular Disease Risk Scores in Adults With Diabetes Mellitus Open
Our U.S. pooled cohort DMRS for predicting CVD events demonstrated good predictive performance for assessing CVD risk in adults with DM.
View article: Inflammation biomarkers and neurobehavioral performance in rural adolescents
Inflammation biomarkers and neurobehavioral performance in rural adolescents Open
Higher levels of inflammation were associated with lower neurobehavioral performance in adolescents, especially with social perception. In addition, using a robust analytic method to examine an association between a composite inflammatory …
View article: Associations of exposure to PM2.5 and its compounds with carotid intima-media thickness among middle-aged adults
Associations of exposure to PM2.5 and its compounds with carotid intima-media thickness among middle-aged adults Open
View article: Advance Layoff Notice Provision and the WARN Act
Advance Layoff Notice Provision and the WARN Act Open
We find that the incidence of advance layoff notice more than doubled in the years following the passage of the federal Worker Adjustment and Retraining Notification (WARN) Act. Geographic variation confirms that the act was likely respons…