David R. Karp
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View article: A Randomized, Placebo‐Controlled Trial of Hydroxychloroquine in Incomplete Lupus
A Randomized, Placebo‐Controlled Trial of Hydroxychloroquine in Incomplete Lupus Open
Objective Patients with features of systemic lupus erythematosus (SLE) who do not fulfill classification criteria can be designated as incomplete lupus erythematosus (ILE). This condition includes individuals with a high risk of progressio…
View article: Dysregulated soluble immune mediators and lupus-associated autoantibody specificities inform the development of immune indexes that characterise classified SLE transition and SLE disease activity
Dysregulated soluble immune mediators and lupus-associated autoantibody specificities inform the development of immune indexes that characterise classified SLE transition and SLE disease activity Open
Objectives Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Significant morbidity and early mortality necessitate early intervention. This study harnessed SLE-associated immune dysregulation to create a Lupus Classificat…
View article: ABS0477 HYDROXYCHLOROQUINE REDUCES AUTOANTIBBODY LEVELS IN PERSONS AT RISK FOR SYSTEMIC LUPUS ERYTHEMATOSUS
ABS0477 HYDROXYCHLOROQUINE REDUCES AUTOANTIBBODY LEVELS IN PERSONS AT RISK FOR SYSTEMIC LUPUS ERYTHEMATOSUS Open
View article: REDEFINING AUTOIMMUNE DISEASES: THE OPPORTUNITY FOR PRECISION AND PREVENTION.
REDEFINING AUTOIMMUNE DISEASES: THE OPPORTUNITY FOR PRECISION AND PREVENTION. Open
In aggregate, autoimmune diseases affect at least 8% of the U.S. population, making them a significant health problem. Multiple lines of evidence accumulated over the last 20+ years have clearly demonstrated that the pathophysiology leadin…
View article: Geographic Socioeconomic Influences on Disease Activity in Rheumatoid Arthritis in an Academic and Safety Net Hospital System
Geographic Socioeconomic Influences on Disease Activity in Rheumatoid Arthritis in an Academic and Safety Net Hospital System Open
Objective The objective of this study was to analyze the impact of the Area Deprivation Index (ADI) on disease activity and cardiovascular comorbidity in rheumatoid arthritis (RA). Methods A retrospective analysis of adult patients with RA…
View article: Register of New Fruit and Nut Cultivars List 52
Register of New Fruit and Nut Cultivars List 52 Open
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View article: High Interleukin-13 level is associated with disease stability in interstitial Lung disease
High Interleukin-13 level is associated with disease stability in interstitial Lung disease Open
IL-13 may be a useful biomarker predicting ILD stability.
View article: 608 Utility 2019 EULAR/ACR SLE criteria to re-classify patients with interstitial pneumonia with autoimmune features as SLE with interstitial lung disease
608 Utility 2019 EULAR/ACR SLE criteria to re-classify patients with interstitial pneumonia with autoimmune features as SLE with interstitial lung disease Open
Background Interstitial pneumonia with autoimmune features (IPAF) is a research classification proposed by the European Respiratory Society and American Thoracic Society Task Force for those patients with forms of interstitial lung disease…
View article: Methamphetamine-Induced Hypoglycemia: A Case Report and Literature Review
Methamphetamine-Induced Hypoglycemia: A Case Report and Literature Review Open
View article: Prevalence of Antiphospholipid Antibodies and Association With Incident Cardiovascular Events
Prevalence of Antiphospholipid Antibodies and Association With Incident Cardiovascular Events Open
Importance The prevalence of antiphospholipid antibodies (aPL) and their association with future atherosclerotic cardiovascular disease (ASCVD) risk has yet to be thoroughly investigated. Objective To determine the association between meas…
View article: Hemophagocytic Lymphohistiocytosis Caused by a Severe Epstein-Barr Virus Infection in a Young Patient Presenting With Hiccups
Hemophagocytic Lymphohistiocytosis Caused by a Severe Epstein-Barr Virus Infection in a Young Patient Presenting With Hiccups Open
View article: Incidental Moyamoya Disease in an Elderly Patient Presenting With Acute Ischemic Pontine Stroke
Incidental Moyamoya Disease in an Elderly Patient Presenting With Acute Ischemic Pontine Stroke Open
Moyamoya disease (MMD) is a rare occlusive cerebrovascular disease that is characterized by progressive stenosis of the terminal portion of the internal carotid artery and its main branches with compensatory development of dilated and frag…
View article: Anti–Neutrophil Extracellular Trap Antibodies in Antiphospholipid Antibody–Positive Patients: Results From the Antiphospholipid Syndrome Alliance for Clinical Trials and <scp>InternatiOnal</scp> Networking Clinical Database and Repository
Anti–Neutrophil Extracellular Trap Antibodies in Antiphospholipid Antibody–Positive Patients: Results From the Antiphospholipid Syndrome Alliance for Clinical Trials and <span>InternatiOnal</span> Networking Clinical Database and Repository Open
Objective This study aimed to elucidate the presence, antigen specificities, and potential clinical associations of anti–neutrophil extracellular trap (anti‐NET) antibodies in a multinational cohort of antiphospholipid (aPL) antibody–posit…
View article: A Rare Case: Acute Liver Injury Uncovering a Diagnosis of B-cell Acute Lymphoblastic Leukemia in a Young Adult
A Rare Case: Acute Liver Injury Uncovering a Diagnosis of B-cell Acute Lymphoblastic Leukemia in a Young Adult Open
Acute liver injury can be seen in a myriad of disease states such as chronic alcoholism, hepatitis, and hepatocellular carcinoma. When considering acute liver injury in a young adult, the list of differential diagnoses is much more narrow.…
View article: 610 The Study of Anti-Malarials in Incomplete Lupus Erythematosus (SMILE): An Interim Report
610 The Study of Anti-Malarials in Incomplete Lupus Erythematosus (SMILE): An Interim Report Open
Background Laboratory and clinical features of systemic lupus erythematosus (SLE) may precede the onset of clinically apparent and classifiable disease. Autoantibodies and cytokines have been shown to be present in the blood years before a…
View article: 1801 Positive ANA testing in an academic medical center: impact on diagnosis
1801 Positive ANA testing in an academic medical center: impact on diagnosis Open
Background Anti-nuclear antibodies (ANA) are common in systemic rheumatic diseases, non-rheumatic autoimmune diseases and the general population. In clinical practice, testing for ANA can inform further clinical diagnoses even in the absen…
View article: 907 ANA associated regulatory polymorphisms in HLA class III region downregulate complement 4 (C4) gene expression
907 ANA associated regulatory polymorphisms in HLA class III region downregulate complement 4 (C4) gene expression Open
Background Loss of self-tolerance and generation of numerous autoantibodies is a hallmark of systemic lupus erythematosus (SLE). Historically, testing for anti-nuclear antibodies (ANA) has been used as a screen for the autoimmunity underly…
View article: Register of New Fruit and Nut Cultivars List 51
Register of New Fruit and Nut Cultivars List 51 Open
Nut: ovate; paper shell; kernel midsize, 1.3 g, slightly wider
View article: Editorial: Understanding the concept of pre-clinical autoimmunity
Editorial: Understanding the concept of pre-clinical autoimmunity Open
EDITORIAL article Front. Immunol., 22 July 2022Sec. Autoimmune and Autoinflammatory Disorders Volume 13 - 2022 | https://doi.org/10.3389/fimmu.2022.983310
View article: Pre-Clinical Autoimmunity in Lupus Relatives: Self-Reported Questionnaires and Immune Dysregulation Distinguish Relatives Who Develop Incomplete or Classified Lupus From Clinically Unaffected Relatives and Unaffected, Unrelated Individuals
Pre-Clinical Autoimmunity in Lupus Relatives: Self-Reported Questionnaires and Immune Dysregulation Distinguish Relatives Who Develop Incomplete or Classified Lupus From Clinically Unaffected Relatives and Unaffected, Unrelated Individuals Open
Systemic lupus erythematosus (SLE) is propelled by pathogenic autoantibody (AutoAb) and immune pathway dysregulation. Identifying populations at risk of reaching classified SLE is essential to curtail inflammatory damage. Lupus blood relat…
View article: Interstitial Pneumonia with Autoimmune Features: What the Rheumatologist Needs to Know
Interstitial Pneumonia with Autoimmune Features: What the Rheumatologist Needs to Know Open
View article: American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS–CoV‐2 and Hyperinflammation in Pediatric COVID‐19: Version 3
American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS–CoV‐2 and Hyperinflammation in Pediatric COVID‐19: Version 3 Open
Objective To provide guidance on the management of Multisystem Inflammatory Syndrome in Children (MIS‐C), a condition characterized by fever, inflammation, and multiorgan dysfunction that manifests late in the course of SARS–CoV‐2 infectio…
View article: Humoral and cellular correlates of a novel immune-related adverse event and its treatment
Humoral and cellular correlates of a novel immune-related adverse event and its treatment Open
Immune-related adverse events (irAE) may affect almost any organ system and occur at any point during treatment with immune checkpoint inhibitors (ICI). We present a patient with advanced lung cancer receiving antiprogrammed death 1 checkp…
View article: 1104 Update on the study of anti-malarials in incomplete lupus erythematosus (SMILE) clinical trial
1104 Update on the study of anti-malarials in incomplete lupus erythematosus (SMILE) clinical trial Open
Background There is clear evidence that clinical and laboratory features of systemic lupus erythematosus (SLE) can be present for many years prior to an individual fulfilling the full disease classification criteria. Most commonly, these f…
View article: Letter from the President, American College of Rheumatology
Letter from the President, American College of Rheumatology Open
Professor Zhanguo Li Professor and Chief, Dept of Rheumatology and Immunology Director, Institute of Rheumatology & Immunology Beijing University Medical School People's Hospital President, Clin Immunology Association of China Honorary-Pre…
View article: Issue Information
Issue Information Open
View article: Issue Information
Issue Information Open
in At-Risk First-Degree Relatives Cover image: The fi gure on the cover (from Yuba et al, pages 769-778) shows immunofl uorescence staining of popliteal lymph node from an arthritic BALB/c mouse after intravenous injection of DyLight 594-l…
View article: Hydroxychloroquine: An Old Drug With New Tricks
Hydroxychloroquine: An Old Drug With New Tricks Open
The aim of the study is to discriminate β-thalassemia from iron defficiency anemia (IDA) using common mathematical indices. A complete blood count (CBC) sample of 100 children (aged 6 months – 18 years) treated for β-thalassemia and IDA i…
View article: Serum IgG Profiling of Toddlers Reveals a Subgroup with Elevated Seropositive Antibodies to Viruses Correlating with Increased Vaccine and Autoantigen Responses
Serum IgG Profiling of Toddlers Reveals a Subgroup with Elevated Seropositive Antibodies to Viruses Correlating with Increased Vaccine and Autoantigen Responses Open
View article: Coupled Effect of Electronic Medical Record Modifications and Lean Six Sigma Methodology on Rheumatoid Arthritis Disease Activity Measurement and Treat‐to‐Target Outcomes
Coupled Effect of Electronic Medical Record Modifications and Lean Six Sigma Methodology on Rheumatoid Arthritis Disease Activity Measurement and Treat‐to‐Target Outcomes Open
Objective Rheumatoid arthritis (RA) disease activity assessment is critical for treatment decisions and treat to target (T2T) outcomes. Utilization of the electronic medical record (EMR) and techniques to improve the routine capture of dis…