David R. Harder
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View article: Astrocytic responses to high glucose impair barrier formation in cerebral microvessel endothelial cells
Astrocytic responses to high glucose impair barrier formation in cerebral microvessel endothelial cells Open
Hyperglycemic conditions are prodromal to blood-brain barrier (BBB) impairment. The BBB comprises cerebral microvessel endothelial cells (CMECs) that are surrounded by astrocytic foot processes. Astrocytes express high levels of gap juncti…
View article: Electromagnetic energy (670 nm) stimulates vasodilation through activation of the large conductance potassium channel (BKCa)
Electromagnetic energy (670 nm) stimulates vasodilation through activation of the large conductance potassium channel (BKCa) Open
Introduction Peripheral artery disease (PAD) is a highly morbid condition in which impaired blood flow to the limbs leads to pain and tissue loss. Previously we identified 670 nm electromagnetic energy (R/NIR) to increase nitric oxide leve…
View article: A New Magnetic Measurement System for the Future Low Emittance NSLS-II Storage Ring
A New Magnetic Measurement System for the Future Low Emittance NSLS-II Storage Ring Open
A new magnetic measurement system is under construc-tion at BNL for accurate field harmonic measurements and fiducialization of magnets for a future upgrade of the NSLS- II storage ring. The entire storage ring is envi-sioned to be replace…
View article: Interaction of tumor cells and astrocytes promotes breast cancer brain metastases through TGF-β2/ANGPTL4 axes
Interaction of tumor cells and astrocytes promotes breast cancer brain metastases through TGF-β2/ANGPTL4 axes Open
Metastatic outcomes depend on the interactions of metastatic cells with a specific organ microenvironment. Our previous studies have shown that triple-negative breast cancer (TNBC) MDA-MB-231 cells passaged in astrocyte-conditioned medium …
View article: High glucose conditioned neonatal astrocytes results in impaired mitogenic activity in cerebral microvessel endothelial cells in co-culture
High glucose conditioned neonatal astrocytes results in impaired mitogenic activity in cerebral microvessel endothelial cells in co-culture Open
Angiogenesis is a highly complex and coordinated process in the brain. Under normal conditions, it is a vital process in growth and development, but under adverse conditions such as diabetes mellitus, it can lead to severe pathology. Astro…
View article: The Role of Astrocytes in Tumor Growth and Progression
The Role of Astrocytes in Tumor Growth and Progression Open
Current research is continually implicating the importance of astrocytes as active participants in neurological injury, disease, and tumor progression. This chapter will discuss some of these emerging concepts, especially as they relate to…
View article: Detection of TRPV4 channel current-like activity in Fawn Hooded hypertensive (FHH) rat cerebral arterial muscle cells
Detection of TRPV4 channel current-like activity in Fawn Hooded hypertensive (FHH) rat cerebral arterial muscle cells Open
The transient receptor potential vallinoid type 4 (TRPV4) is a calcium entry channel known to modulate vascular function by mediating endothelium-dependent vasodilation. The present study investigated if isolated cerebral arterial myocytes…
View article: Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen‐glucose deprivation
Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen‐glucose deprivation Open
Epoxyeicosatrienoic acids (EETs) are synthesized in astrocytes, and inhibitors of soluble epoxide hydrolase (sEH), which hydrolyzes EETs, reduce infarct volume in ischemic stroke. Astrocytes can release protective neurotrophic factors, suc…