David E. Reichert
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View article: Development and Use of Human Recombinant <sup>64</sup>Cu-rHCF as a Kidney Glomerulus-Targeted Contrast Agent for Positron Emission Tomography
Development and Use of Human Recombinant <sup>64</sup>Cu-rHCF as a Kidney Glomerulus-Targeted Contrast Agent for Positron Emission Tomography Open
In this work, we develop recombinant human cationic ferritin (rHCF) as a contrast agent to detect glomeruli in the kidney using positron emission tomography (PET). We first expressed recombinant human ferritin (rHF) in E. coli and t…
View article: Microreactor and method for preparing a radiolabeled complex or a biomolecule conjugate
Microreactor and method for preparing a radiolabeled complex or a biomolecule conjugate Open
A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for i…
View article: Validation of Trifluoromethylphenyl Diazirine Cholesterol Analogues As Cholesterol Mimetics and Photolabeling Reagents
Validation of Trifluoromethylphenyl Diazirine Cholesterol Analogues As Cholesterol Mimetics and Photolabeling Reagents Open
Aliphatic diazirine analogues of cholesterol have been used previously to elaborate the cholesterol proteome and identify cholesterol binding sites on proteins. Cholesterol analogues containing the trifluoromethylphenyl diazirine (TPD) gro…
View article: Intrasubunit and Intersubunit Steroid Binding Sites Independently and Additively Mediate α1β2γ2L GABAA Receptor Potentiation by the Endogenous Neurosteroid Allopregnanolone
Intrasubunit and Intersubunit Steroid Binding Sites Independently and Additively Mediate α1β2γ2L GABAA Receptor Potentiation by the Endogenous Neurosteroid Allopregnanolone Open
View article: 47149 Imaging Tools for Early Detection of Kidney Disease.
47149 Imaging Tools for Early Detection of Kidney Disease. Open
IMPACT: Chronic kidney disease (CKD) affects ˜15% of the US population and the majority of patients are diagnosed too late to benefit from early intervention. We are developing a new diagnostic imaging tool (RadioCF-PET) for the kidney to …
View article: Mapping nephron mass in vivo using positron emission tomography
Mapping nephron mass in vivo using positron emission tomography Open
Nephron number varies widely in humans. A low nephron endowment at birth or a loss of functioning nephrons is strongly linked to increased susceptibility to chronic kidney disease. In this work, we developed a contrast agent, radiolabeled …
View article: Site-specific effects of neurosteroids on GABAA receptor activation and desensitization
Site-specific effects of neurosteroids on GABAA receptor activation and desensitization Open
This study examines how site-specific binding to three identified neurosteroid-binding sites in the α 1 β 3 GABA A receptor (GABA A R) contributes to neurosteroid allosteric modulation. We found that the potentiating neurosteroid, allopreg…
View article: Author response: Site-specific effects of neurosteroids on GABAA receptor activation and desensitization
Author response: Site-specific effects of neurosteroids on GABAA receptor activation and desensitization Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract This study examines how site-specific bind…
View article: Analysis of Modulation of the ρ1 GABAA Receptor by Combinations of Inhibitory and Potentiating Neurosteroids Reveals Shared and Distinct Binding Sites
Analysis of Modulation of the ρ1 GABAA Receptor by Combinations of Inhibitory and Potentiating Neurosteroids Reveals Shared and Distinct Binding Sites Open
View article: Site-specific effects of neurosteroids on GABA<sub>A</sub>receptor activation and desensitization
Site-specific effects of neurosteroids on GABA<sub>A</sub>receptor activation and desensitization Open
This study examines how site-specific binding to the three identified neurosteroid binding sites in the α 1 β 3 GABA A receptor (GABA A R) contributes to neurosteroid allosteric modulation. We found that the potentiating neurosteroid, allo…
View article: The molecular determinants of neurosteroid binding in the GABA(A) receptor
The molecular determinants of neurosteroid binding in the GABA(A) receptor Open
View article: Assessment of Copper Nanoclusters for Accurate in Vivo Tumor Imaging and Potential for Translation
Assessment of Copper Nanoclusters for Accurate in Vivo Tumor Imaging and Potential for Translation Open
Nanoparticles have been widely used for preclinical cancer imaging. However, their successful clinical translation is largely hampered by potential toxicity, unsatisfactory detection of malignancy at early stages, inaccurate diagnosis of t…
View article: Multiple functional neurosteroid binding sites on GABAA receptors
Multiple functional neurosteroid binding sites on GABAA receptors Open
Neurosteroids are endogenous modulators of neuronal excitability and nervous system development and are being developed as anesthetic agents and treatments for psychiatric diseases. While gamma amino-butyric acid Type A (GABAA) receptors a…
View article: Multiple Functional Neurosteroid Binding Sites on GABA<sub>A</sub>Receptors
Multiple Functional Neurosteroid Binding Sites on GABA<sub>A</sub>Receptors Open
Neurosteroids are endogenous modulators of neuronal excitability and nervous system development and are being developed as anesthetic agents and treatments for psychiatric diseases. While GABA A receptors are the primary molecular targets …
View article: A Clickable Analogue of Ketamine Retains NMDA Receptor Activity, Psychoactivity, and Accumulates in Neurons
A Clickable Analogue of Ketamine Retains NMDA Receptor Activity, Psychoactivity, and Accumulates in Neurons Open
View article: Microfluidic Preparation of a <sup>89</sup>Zr-Labeled Trastuzumab Single-Patient Dose
Microfluidic Preparation of a <sup>89</sup>Zr-Labeled Trastuzumab Single-Patient Dose Open
(89)Zr-labeled trastuzumab for use in a clinical setting was synthesized in a microfluidic reactor in under an hour while reducing the amount of handling required by a technician. Use of this compact platform not only could enable the use …