Explanipedia

Referral patterns for post-acute inpatient brain injury rehabilitation in England: Who are the minorities? Open

Rudi Coetzer, Sara da Silva Ramos, Daniel Earnshaw, David Reith · 2025

Belonging to a minority ethnic background affects access to health and social care services. The sparse research available has been one of the factors limiting our understanding of this problem. Within the UK, there appear to be no publish…

Vancomycin dosing in neonates: enhancing outcomes using population pharmacokinetics and simulation Open

Sílvia M. Illamola, Jiraganya Bhongsatiern, Angela K. Birnbaum, Shaun S. Kumar, Joshua Courter , et al. · 2025

Introduction Optimizing vancomycin dosing in neonates is a critical yet complex goal. Traditional trough concentration-based dosing strategies correlate poorly with therapeutic efficacy and often fail to account for the significant renal f…

Treatment Harms in Paediatric Primary Care Open

David Reith, Sharon Leitch, Kyle Eggleton, Katharine Wallis, Steven Lillis , et al. · 2023

The aim of this study was to describe the epidemiology in children of harms detectable from general practice records, and to identify risk factors. The SHARP study examined 9076 patient records from 44 general practices in New Zealand, wit…

Evaluation of the Prescribing Skills Assessment implementation, performance and medical student experience in Australia and New Zealand Open

Paul K. L. Chin, Kellie A. Charles, Bridin Murnion, Treasure McGuire, Sarah N. Hilmer , et al. · 2023

Aims The UK Prescribing Safety Assessment was modified for use in Australia and New Zealand (ANZ) as the Prescribing Skills Assessment (PSA). We investigated the implementation, student performance and acceptability of the ANZ PSA for fina…

Low dose or very low dose phenylephrine and cyclopentolate microdrops for retinopathy of prematurity eye examinations (The Little Eye Drop Study): a randomised controlled non-inferiority trial Open

Lisa Kremer, Natalie J. Medlicott, Mary Jane Sime, Roland Broadbent, Liza Edmonds , et al. · 2023

Objective To determine if very low dose (VLD, 0.5% phenylephrine, 0.1% cyclopentolate) mydriatic microdrop (approximately 7 μL) administration (up to three doses) is non-inferior to low dose (LD, 1% phenylephrine, 0.2% cyclopentolate) mydr…

Data and model bias in artificial intelligence for healthcare applications in New Zealand Open

Vithya Yogarajan, Gillian Dobbie, Sharon Leitch, Te Taka Keegan, Joshua Bensemann , et al. · 2022

Introduction Developments in Artificial Intelligence (AI) are adopted widely in healthcare. However, the introduction and use of AI may come with biases and disparities, resulting in concerns about healthcare access and outcomes for underr…

Epidemiology of healthcare harm in New Zealand general practice: a retrospective records review study Open

Sharon Leitch, Susan Dovey, Wayne Cunningham, Katharine Wallis, Kyle Eggleton , et al. · 2021

Objectives To determine the epidemiology of healthcare harm observable in general practice records. Design Retrospective cohort records review study. Setting 72 general practice clinics were randomly selected from all 988 New Zealand clini…

Medication-related harm in New Zealand general practice: a retrospective records review Open

Sharon Leitch, Susan Dovey, Wayne Cunningham, Alesha Smith, Jiaxu Zeng , et al. · 2021

Background The extent of medication-related harm in general practice is unknown. Aim To identify and describe all medication-related harm in electronic general practice records. The secondary aim was to investigate factors potentially asso…

Monitoring the use of dabigatran etexilate for stroke prevention: compliance with renal function guidelines Open

B. Simpson, David Reith, Natalie J. Medlicott, Alesha Smith · 2020

INTRODUCTION Dabigatran etexilate has become widely used in New Zealand, but information relating to when renal function monitoring is being undertaken is lacking. AIM To investigate if clinically appropriate renal function monitoring is b…

Exposure Response Supports Therapeutic Drug Monitoring for Dabigatran Etexilate in Patients with Atrial Fibrillation Open

B. Simpson, David Reith, Natalie J. Medlicott, Alesha Smith · 2019

Background Dabigatran etexilate has become widely used for the prevention of stroke in patients with nonvalvular atrial fibrillation (NVAF). Currently, there is limited information in real-world patients relating to dabigatran etexilate ex…

In vitro validation of a method for neonatal urine collection and analysis Open

Darren Ritchie, Roland Broadbent, Natalie J. Medlicott, David Reith · 2019

Objective Urine collection and analysis is important for diagnosis, monitoring of clinical progress, and research in neonates. This study aims to validate a novel methodology for neonatal urine collection, which combines the convenience of…

O09 Drug delivery kinetics of intravenous gentamicin in a population of neonates Open

G Salis, Natalie J. Medlicott, David Reith · 2019

Background Gentamicin is commonly used in the NICU setting and is often administered via long lines, which increases variability in the rate of administration. We aimed to model drug delivery pharmacokinetic parameters for intravenous gent…

Systematic review of mydriatics used for screening of retinopathy in premature infants Open

Lisa Kremer, David Reith, Natalie J. Medlicott, Roland Broadbent · 2019

Introduction Routine retinopathy of prematurity eye examinations are an important part of neonatal care, and mydriatic medicines are essential in dilating the pupil for the eye examination. There are concerns about the level of evidence fo…

Deprivation and inequalities lead to worse outcomes with dabigatran etexilate Open

B. Simpson, David Reith, Natalie J. Medlicott, Alesha Smith · 2018

INTRODUCTION Dabigatran etexilate is now prescribed for 51% of the patients receiving oral anticoagulation treatment in New Zealand. Its prescribing trends in relation to patient outcomes are, however, largely unknown for these patients. A…

Choice of Renal Function Estimator Influences Adverse Outcomes with Dabigatran Etexilate in Patients with Atrial Fibrillation Open

B. Simpson, David Reith, Natalie J. Medlicott, Alesha Smith · 2018

Background Clinical significance of dosing dabigatran with different estimates of renal function for treatment of atrial fibrillation (AF) is unknown. Renal function is routinely estimated by the chronic kidney disease epidemiology initiat…

The influence of patient variables on insulin total daily dose in paediatric inpatients with new onset type 1 diabetes mellitus Open

Marion Müller, Benjamin J. Wheeler, Miranda Blackwell, Mathilde Colas, David Reith , et al. · 2018

Comment on van Rongen et al., “Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults” Open

David Reith, Hesham Al‐Sallami · 2018

Characteristics of a stratified random sample of New Zealand general practices Open

Sharon Leitch, Susan Dovey, Ari Samaranayaka, David Reith, Katharine Wallis , et al. · 2018

INTRODUCTION Practice size and location may affect the quality and safety of health care. Little is known about contemporary New Zealand general practice characteristics in terms of staffing, ownership and services. AIM To describe and com…

Antiepileptic drug exposure in pregnancy and pregnancy outcome from national drug usage data Open

Noni Richards, David Reith, Michael L. Stitely, Alesha Smith · 2018

Medication-related Harms to Paediatric Patients in Primary Care Open

David Reith, Susan Dovey, Sharon Leitch, Katharine Wallis, Kyle Eggleton , et al. · 2018

Background: Safety incidents in a primary care setting occur in approximately 2.2% of patient contacts, and 1 in 4 of these incidents have effects on patients, with hospital admission in approximately 3% of incidents (1).Available data ind…

Pharmacovigilance Study of Antipsychotics in New Zealand using Three Outcomes Databases Open

David Reith, Andy Tomlin, John Fountain, Alesha Smith, Murray Tilyard · 2018

Background: Antipsychotics are widely used and have major benefits in the treatment of psychiatric disorders. However, there are also well-documented risks including serious metabolic, cardiac, haematological, hepatic and pancreatic advers…

Are doses of lamotrigine or levetiracetam adjusted during pregnancy? Open

Noni Richards, David Reith, Michael L. Stitely, Alesha Smith · 2017

Summary Subtherapeutic levels of lamotrigine and levetiracetam are more likely to occur during pregnancy owing to the effect of pregnancy on their pharmacokinetics. This can lead to suboptimal control of epilepsy, and guidelines recommend …

Hyperglycaemic preterm neonates exhibit insulin resistance and low insulin production Open

Emma R Salis, David Reith, Benjamin J. Wheeler, Roland Broadbent, Natalie J. Medlicott · 2017

This study demonstrates that preterm neonates exhibit insulin resistance, hyperglycaemic neonates have lower insulin production than euglycaemic neonates and treatment with exogenous insulin did not appear to suppress insulin production in…

Antiepileptic drug exposure in pregnancy and pregnancy outcome from national drug usage data Open

Noni Richards, Alesha Smith Smith, David Reith, M. Stitely · 2017

Introduction: Antiepileptic drugs (AEDs) taken during pregnancy are known to increase the risk of fetal malformations and potentially affect the neurodevelopment in children exposed. This study aimed to determine the overall use of AEDs an…

Choice of Renal Function Estimator May Affect Adverse Outcomes with Dabigatran Open

B. Simpson, David Reith, Natalie J. Medlicott, Alesha Smith · 2017

Epidemiology of Patient Harms in New Zealand: Protocol of a General Practice Records Review Study Open

Susan Dovey, Sharon Leitch, Katharine Wallis, Kyle Eggleton, Wayne Cunningham , et al. · 2017

Background: Knowing where and why harm occurs in general practice will assist patients, doctors, and others in making informed decisions about the risks and benefits of treatment options. Research to date has been unable to verify the safe…

Using an Electronic Decision Support Tool to Reduce Inappropriate Polypharmacy and Optimize Medicines: Rationale and Methods Open

Amber Young, June Tordoff, Susan Dovey, David Reith, Hywel Lloyd , et al. · 2016

This study will establish whether the MORE decision support tool stands up to real world conditions and promotes changes in prescribing practice.

Challenges Associated with Route of Administration in Neonatal Drug Delivery Open

Matthew W. Linakis, Jessica K. Roberts, Anita Lala, Michael G. Spigarelli, Natalie J. Medlicott , et al. · 2015

Perinatal influences on the uptake of newborn Vitamin K prophylaxis – a retrospective cohort study Open

M S Burke, H Bernhardt, David Reith, David Barker, Roland Broadbent , et al. · 2015

Acebutolol and Immediate Release Melatonin in Treatment of Smith-Magenis Syndrome Open

Benjamin J. Wheeler, Barry Taylor, Kirsten Simonsen, David Reith · 2015

Sleep disturbance occurs in Smith-Magenis syndrome (SMS) as part of the phenotype. It appears that this disturbance lies primarily in an inversion of the circadian rhythm of melatonin. We assessed whether the use of melatonin and acebutolo…

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