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View article: The SDSS-V Local Volume Mapper Telescope System
The SDSS-V Local Volume Mapper Telescope System Open
This paper presents the Local Volume Mapper (LVM) telescope system. LVM is one of three surveys that form the fifth generation of the Sloan Digital Sky Survey (SDSS-V), and it employs a coordinated network of four, 16 cm diameter telescope…
View article: Fibroscanning Recommended by NICE in Drug and Addiction Services: An Audit
Fibroscanning Recommended by NICE in Drug and Addiction Services: An Audit Open
Aims The prevalence and subsequent physical health burden of alcohol use disorder is on the increase in almost all age groups in the UK and nearly 1 in 5 of the population will drink at hazardous levels. Those who drink heavily often have …
View article: Therapy-induced normal tissue damage promotes breast cancer metastasis
Therapy-induced normal tissue damage promotes breast cancer metastasis Open
View article: Application of specific ELISAs for BMP15 and GDF9 to cumulus cell extracts from infertile women
Application of specific ELISAs for BMP15 and GDF9 to cumulus cell extracts from infertile women Open
Bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) are oocyte-specific paracrine factors which regulate ovarian cumulus cell (CC) functions. This study aimed to investigate if BMP15 and GDF9 bound to CCs can b…
View article: Data from GDNF–RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors
Data from GDNF–RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors Open
Most breast cancers at diagnosis are estrogen receptor-positive (ER+) and depend on estrogen for growth and survival. Blocking estrogen biosynthesis by aromatase inhibitors has therefore become a first-line endocrine therapy for…
View article: Supplementary Table 1 from GDNF–RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors
Supplementary Table 1 from GDNF–RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors Open
XLSX file - 1167K, Gene Set Expression Analysis (GSEA) performed using default values for all the parameters. Also includes GDNF-RGS gene list and GO Analysis.
View article: Supplementary Figures 1 - 8 from GDNF–RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors
Supplementary Figures 1 - 8 from GDNF–RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors Open
PDF file - 4112K, Characterization of long-term E2 deprived (LTED) breast cancer cell line (S1); Characterization of the MCF7-2A model (S2); Treatment of MCF7 cells with ICI 182,780 blocks ERdependent GDNF signaling (S3); Generation of the…
View article: Data from The Collagen Receptor Endo180 (CD280) Is Expressed on Basal-like Breast Tumor Cells and Promotes Tumor Growth <i>In vivo</i>
Data from The Collagen Receptor Endo180 (CD280) Is Expressed on Basal-like Breast Tumor Cells and Promotes Tumor Growth <i>In vivo</i> Open
Tumor cell invasion into the surrounding stroma requires increased cell motility and extensive remodeling of the extracellular matrix. Endo180 (CD280, MRC2, urokinase-type plasminogen activator receptor-associated protein) is a recycling e…
View article: Supplementary Figures 1 - 8 from GDNF–RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors
Supplementary Figures 1 - 8 from GDNF–RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors Open
PDF file - 4112K, Characterization of long-term E2 deprived (LTED) breast cancer cell line (S1); Characterization of the MCF7-2A model (S2); Treatment of MCF7 cells with ICI 182,780 blocks ERdependent GDNF signaling (S3); Generation of the…
View article: Supplementary Table 1, Figures 1-5 from The Collagen Receptor Endo180 (CD280) Is Expressed on Basal-like Breast Tumor Cells and Promotes Tumor Growth <i>In vivo</i>
Supplementary Table 1, Figures 1-5 from The Collagen Receptor Endo180 (CD280) Is Expressed on Basal-like Breast Tumor Cells and Promotes Tumor Growth <i>In vivo</i> Open
Supplementary Table 1, Figures 1-5 from The Collagen Receptor Endo180 (CD280) Is Expressed on Basal-like Breast Tumor Cells and Promotes Tumor Growth In vivo
View article: Supplementary Table 1 from GDNF–RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors
Supplementary Table 1 from GDNF–RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors Open
XLSX file - 1167K, Gene Set Expression Analysis (GSEA) performed using default values for all the parameters. Also includes GDNF-RGS gene list and GO Analysis.
View article: Data from GDNF–RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors
Data from GDNF–RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors Open
Most breast cancers at diagnosis are estrogen receptor-positive (ER+) and depend on estrogen for growth and survival. Blocking estrogen biosynthesis by aromatase inhibitors has therefore become a first-line endocrine therapy for…
View article: Data from The Collagen Receptor Endo180 (CD280) Is Expressed on Basal-like Breast Tumor Cells and Promotes Tumor Growth <i>In vivo</i>
Data from The Collagen Receptor Endo180 (CD280) Is Expressed on Basal-like Breast Tumor Cells and Promotes Tumor Growth <i>In vivo</i> Open
Tumor cell invasion into the surrounding stroma requires increased cell motility and extensive remodeling of the extracellular matrix. Endo180 (CD280, MRC2, urokinase-type plasminogen activator receptor-associated protein) is a recycling e…
View article: Supplementary Table 1, Figures 1-5 from The Collagen Receptor Endo180 (CD280) Is Expressed on Basal-like Breast Tumor Cells and Promotes Tumor Growth <i>In vivo</i>
Supplementary Table 1, Figures 1-5 from The Collagen Receptor Endo180 (CD280) Is Expressed on Basal-like Breast Tumor Cells and Promotes Tumor Growth <i>In vivo</i> Open
Supplementary Table 1, Figures 1-5 from The Collagen Receptor Endo180 (CD280) Is Expressed on Basal-like Breast Tumor Cells and Promotes Tumor Growth In vivo
View article: Oocyte-Secreted Serum Biomarkers GDF9 and BMP15 in Women with Endometriosis
Oocyte-Secreted Serum Biomarkers GDF9 and BMP15 in Women with Endometriosis Open
Oocyte-secreted growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are critical paracrine regulators of female fertility. Recent studies demonstrated that serum concentrations are associated with the number of…
View article: Serum GDF9 and BMP15 as potential markers of ovarian function in women with and without polycystic ovary syndrome
Serum GDF9 and BMP15 as potential markers of ovarian function in women with and without polycystic ovary syndrome Open
Objective Growth differentiation factor‐9 (GDF9) and bone morphogenetic protein‐15 (BMP15) are critical paracrine regulators of female fertility and are predominantly expressed by oocytes. However, it is unknown if serum concentrations ref…
View article: Serum GDF9 and BMP15 as Markers of Ovarian Function in Healthy Women and Women with Polycystic Ovary Syndrome
Serum GDF9 and BMP15 as Markers of Ovarian Function in Healthy Women and Women with Polycystic Ovary Syndrome Open
Background: The oocyte-secreted factors growth differentiation factor-9 (GDF9) and bone morphogenetic protein-15 (BMP15) are key regulators of female fertility and are predominantly expressed by oocytes. Recently, methods to quantitate the…
View article: Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic
Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic Open
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View article: ARHGEF9 regulates melanoma morphogenesis in environments with diverse geometry and elasticity by promoting filopodial-driven adhesion
ARHGEF9 regulates melanoma morphogenesis in environments with diverse geometry and elasticity by promoting filopodial-driven adhesion Open
View article: Roasted Malt for Distilling: Impact on Malt Whisky New Make Spirit Production and Aroma Volatile Development
Roasted Malt for Distilling: Impact on Malt Whisky New Make Spirit Production and Aroma Volatile Development Open
Scotch malt whisky is typically produced using lightly kilned malted barley that imparts a relatively subtle aroma to the final product. Recently, there has been increased interest in exploring the feasibility of using roasted malts during…
View article: Challenges in Measuring AMH in the Clinical Setting
Challenges in Measuring AMH in the Clinical Setting Open
Serum anti-Mullerian hormone (AMH) is a widely used marker of functional ovarian reserve in the assessment and treatment of infertility. It is used to determine dosing of gonadotropins used for superovulation prior to in vitro fertilizatio…
View article: Serum Concentrations of GDF9 and BMP15 Across the Menstrual Cycle
Serum Concentrations of GDF9 and BMP15 Across the Menstrual Cycle Open
Growth differentiation factor-9 (GDF9) and bone morphogenetic protein-15 (BMP15) are TGF-β proteins that regulate key processes throughout folliculogenesis and are determinants of mammalian fecundity (1). They are uniquely produced predomi…
View article: Therapy-induced normal tissue damage promotes breast cancer metastasis
Therapy-induced normal tissue damage promotes breast cancer metastasis Open
Disseminated tumour cells frequently exhibit a period of dormancy that renders them insensitive to targeting by chemotherapeutic agents, conversely the systemic delivery of chemotherapies can result in normal tissue damage. Using multiple …
View article: Interactions between serum FSH, inhibin B and antral follicle count in the decline of serum AMH during the menstrual cycle in late reproductive age
Interactions between serum FSH, inhibin B and antral follicle count in the decline of serum AMH during the menstrual cycle in late reproductive age Open
Objective To investigate the hormonal interrelationships during the menstrual cycle in women of late reproductive age with suppressed serum AMH and antral follicle count (AFC). Methods Serum hormones (AMH, FSH, LH, estradiol, progesterone,…
View article: Cross-Border Medical Research Using Multi-Layered and Distributed Knowledge
Cross-Border Medical Research Using Multi-Layered and Distributed Knowledge Open
As medical research becomes ever finer-grained, experiments require healthcare data in quantities that single countries cannot provide. Cross-jurisdictional data collection remains, however, extremely challenging due to the diverging legal…
View article: Serum Concentrations of Oocyte-Secreted Factors BMP15 and GDF9 During IVF and in Women With Reproductive Pathologies
Serum Concentrations of Oocyte-Secreted Factors BMP15 and GDF9 During IVF and in Women With Reproductive Pathologies Open
Oocyte-secreted factors bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) are critical for folliculogenesis and fertility. This study developed ELISAs for the measurement of BMP15 and GDF9 in serum and invest…
View article: SAT-195 Oocyte-Secreted Factors GDF9 and BMP15 Measured in Serum Correlate with Reproductive Potential in Women
SAT-195 Oocyte-Secreted Factors GDF9 and BMP15 Measured in Serum Correlate with Reproductive Potential in Women Open
Bone morphogenetic protein-15 (BMP15) and growth differentiation factor-9 (GDF9) are oocyte-secreted factors critical for folliculogenesis, oocyte developmental competence and fertility. BMP15 and GDF9 are produced only by gametes and desp…
View article: Cumulin and FSH Cooperate to Regulate Inhibin B and Activin B Production by Human Granulosa-Lutein Cells In Vitro
Cumulin and FSH Cooperate to Regulate Inhibin B and Activin B Production by Human Granulosa-Lutein Cells In Vitro Open
The oocyte-secreted factors bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) interact functionally, and it is hypothesized that this interaction may be mediated by formation of a GDF9:BMP15 heterodimer terme…
View article: SAM volume 13 issue 1 Cover and Back matter
SAM volume 13 issue 1 Cover and Back matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation
RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation Open
Receptor-interacting protein kinase (RIPK) 1 functions as a key mediator of tissue homeostasis via formation of Caspase-8 activating ripoptosome complexes, positively and negatively regulating apoptosis, necroptosis, and inflammation. Here…