David S. Goldberg
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View article: Investigating Disparities Related to Insurance Status and Access to Locoregional Therapies for Patients with Hepatocellular Carcinoma Awaiting Liver Transplantation
Investigating Disparities Related to Insurance Status and Access to Locoregional Therapies for Patients with Hepatocellular Carcinoma Awaiting Liver Transplantation Open
Purpose Patients with hepatocellular carcinoma (HCC) and Medicaid insurance on the liver transplantation (LT) waitlist face higher risks of waitlist dropout, though mechanisms behind this disparity remain unclear. We aimed to assess differ…
View article: State-Level Variability in Location of Death of Patients with End-Stage Liver Disease
State-Level Variability in Location of Death of Patients with End-Stage Liver Disease Open
Purpose Although deaths from end-stage liver disease (ESLD) and hepatocellular carcinoma (HCC) in the United States increasingly occur at home or in hospice, inpatient medical facility deaths remain high. Despite the decrease in in-hospita…
View article: Safe and effective acne treatment across skin types with a 1726 nm sebum-selective laser: One year data from a prospective multicenter study
Safe and effective acne treatment across skin types with a 1726 nm sebum-selective laser: One year data from a prospective multicenter study Open
The seboselective 1726-nm laser is an effective and well-tolerated therapy for reducing moderate-to-severe facial acne for at least 1 year.
View article: Low prevalence of glomerulonephritis in transplanted kidneys from deceased donors with active hepatitis C virus infection
Low prevalence of glomerulonephritis in transplanted kidneys from deceased donors with active hepatitis C virus infection Open
View article: Risk of Cytomegalovirus Viremia Following Transplantation of Hepatitis C‐Viremic Donor Kidneys Into Uninfected Recipients: A Multi‐Center Retrospective Cohort Study
Risk of Cytomegalovirus Viremia Following Transplantation of Hepatitis C‐Viremic Donor Kidneys Into Uninfected Recipients: A Multi‐Center Retrospective Cohort Study Open
Background Several studies have suggested an increased risk of cytomegalovirus (CMV) viremia among Hepatitis C virus (HCV)‐uninfected recipients of kidney transplants from HCV‐RNA+ deceased donors (HCV D+/R−), but these studies featured sm…
View article: Pancreas Procurement from Deceased Donors for Islet Cells: Updated Data and Gaps in Reporting
Pancreas Procurement from Deceased Donors for Islet Cells: Updated Data and Gaps in Reporting Open
Background In 2020, CMS updated the ‘Final Rule’ for organ procurement organizations (OPO), the non-profit organizations tasked with managing organ donation. The final rule included new metrics of performance with a carveout whereby pancre…
View article: Risk of colorectal cancer after weight loss in the obese: a pooled cohort study
Risk of colorectal cancer after weight loss in the obese: a pooled cohort study Open
Weight loss after obesity is associated with a lower CRC risk in diverse populations. In persons with obesity, 15-20% weight loss appears to be optimal.
View article: Predicting long-term survival among patients with HCC
Predicting long-term survival among patients with HCC Open
Background: Prognosticating survival among patients with HCC and cirrhosis must account for both the tumor burden/stage, as well as the severity of the underlying liver disease. Although there are many staging systems used to guide therapy…
View article: Immunosuppression regimen and latitude impact keratinocyte carcinoma risk in U.S. liver transplant recipients
Immunosuppression regimen and latitude impact keratinocyte carcinoma risk in U.S. liver transplant recipients Open
Immunosuppression after solid organ transplantation is associated with an increased risk of keratinocyte carcinoma (KC). Despite its established morbidity, KC risk in liver transplant (LT) recipients is understudied, including the contribu…
View article: Investigating the Obesity Paradox in Colorectal Cancer: An Analysis of Prospectively Collected Data in a Diverse Cohort
Investigating the Obesity Paradox in Colorectal Cancer: An Analysis of Prospectively Collected Data in a Diverse Cohort Open
Background: Prior studies are inconclusive regarding the effect of obesity on mortality in persons with colorectal cancer (CRC). We sought to determine the association of pre-diagnosis body mass index (BMI) trajectories on mortality after …
View article: Liver Transplant Costs and Activity After United Network for Organ Sharing Allocation Policy Changes
Liver Transplant Costs and Activity After United Network for Organ Sharing Allocation Policy Changes Open
Importance A new liver allocation policy was implemented by United Network for Organ Sharing (UNOS) in February 2020 with the stated intent of improving access to liver transplant (LT). There are growing concerns nationally regarding the i…
View article: Pragmatic strategies to address health disparities along the continuum of care in chronic liver disease
Pragmatic strategies to address health disparities along the continuum of care in chronic liver disease Open
Racial, ethnic, and socioeconomic disparities exist in the prevalence and natural history of chronic liver disease, access to care, and clinical outcomes. Solutions to improve health equity range widely, from digital health tools to policy…
View article: Upper helical reconstruction during aesthetic facelift procedure: a case report
Upper helical reconstruction during aesthetic facelift procedure: a case report Open
We present a case of a two-stage reconstruction of a traumatic right upper helix deformity using a random pattern layover skin flap in conjunction with an aesthetic facelift procedure. This serves to encourage reconstructive surgeons to be…
View article: African American race does not confer an increased risk of clinical events in patients with primary sclerosing cholangitis
African American race does not confer an increased risk of clinical events in patients with primary sclerosing cholangitis Open
Background: The natural history of primary sclerosing cholangitis (PSC) among African Americans (AA) is not well understood. Methods: Transplant-free survival and hepatic decompensation–free survival were assessed using a retrospective res…
View article: Food-Related Quality of Life Is Impaired in Latinx and Non-Latinx Patients With Inflammatory Bowel Disease
Food-Related Quality of Life Is Impaired in Latinx and Non-Latinx Patients With Inflammatory Bowel Disease Open
This is the largest study to date to examine FRQoL in American IBD patients, and the first to include Latinx patients. Disease-related factors had a greater impact on FRQoL than ethnicity. Clinical and endoscopic disease activity had a mor…
View article: A randomized trial of mailed outreach with behavioral economic interventions to improve liver cancer surveillance
A randomized trial of mailed outreach with behavioral economic interventions to improve liver cancer surveillance Open
Background: Surveillance rates for HCC remain limited in patients with cirrhosis. We evaluated whether opt-out mailed outreach increased uptake with or without a $20 unconditional incentive. Methods: This was a pragmatic randomized control…
View article: Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2022 Clinical Practice Guideline
Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2022 Clinical Practice Guideline Open
The 2022 updated guideline includes 43 graded recommendations and 20 ungraded recommendations, 7 of which are new or modified on the basis of the most recent evidence and consensus among the WG members. The updated guidelines recommend exp…
View article: Association between country of birth and gastric intestinal metaplasia: a retrospective cohort study
Association between country of birth and gastric intestinal metaplasia: a retrospective cohort study Open
View article: Regional Social Vulnerability is Associated With Geographic Disparity in Waitlist Outcomes for Patients With Non–Hepatocellular Carcinoma Model for End-stage Liver Disease Exceptions in the United States
Regional Social Vulnerability is Associated With Geographic Disparity in Waitlist Outcomes for Patients With Non–Hepatocellular Carcinoma Model for End-stage Liver Disease Exceptions in the United States Open
Objective: This study was undertaken to evaluate the role of regional social vulnerability in geographic disparity for patients listed for liver transplantation with non–hepatocellular carcinoma (HCC) model for end-stage liver disease (MEL…
View article: Procurement of Pancreatic Tissue for Research From Deceased Donors Before vs After the CMS Final Rule in 2020
Procurement of Pancreatic Tissue for Research From Deceased Donors Before vs After the CMS Final Rule in 2020 Open
This cohort study examines changes in research pancreas procurement from deceased donors before and after the Centers for Medicare & Medicaid Services (CMS) updated its Final Rule in November 2020.
View article: Patient randomised controlled trial of technology enabled strategies to promote treatment adherence in liver transplantation: rationale and design of the TEST trial
Patient randomised controlled trial of technology enabled strategies to promote treatment adherence in liver transplantation: rationale and design of the TEST trial Open
Background and aims Liver transplantation is a life-saving procedure for end-stage liver disease. However, post-transplant medication regimens are complex and non-adherence is common. Post-transplant medication non-adherence is associated …
View article: The SHELTER Trial of Transplanting Hepatitis C Virus–Infected Lungs Into Uninfected Recipients
The SHELTER Trial of Transplanting Hepatitis C Virus–Infected Lungs Into Uninfected Recipients Open
Background. SHELTER is a trial of transplanting lungs from deceased donors with hepatitis C virus (HCV) infection into HCV-negative candidates (sponsor: Merck; NCT03724149). Few trials have reported outcomes using thoracic organs from HCV-…
View article: Urgent need to mitigate disparities in federal funding for cancer research
Urgent need to mitigate disparities in federal funding for cancer research Open
We evaluate National Cancer Institute (NCI) funding distribution to the most common cancers, considering their respective public health burdens, and explore associations between funding and racial and ethnic burden of disease. The NCI’s Su…
View article: Prediction of long-term survival among patients with cirrhosis using time-varying models
Prediction of long-term survival among patients with cirrhosis using time-varying models Open
Background: Risk prediction among patients with cirrhosis has historically focused on short-term (ie, 90 days) mortality among patients waitlisted for a transplant. Although several models have been developed to predict intermediate and lo…
View article: Should patients with acute-on-chronic liver failure grade 3 receive higher priority for liver transplantation?
Should patients with acute-on-chronic liver failure grade 3 receive higher priority for liver transplantation? Open
View article: Longer-Term Clinical Outcomes From the THINKER and EXPANDER Trials of Transplantation of HCV-RNA+ Donor Kidneys Into Hepatitis C Virus-Negative Recipients
Longer-Term Clinical Outcomes From the THINKER and EXPANDER Trials of Transplantation of HCV-RNA+ Donor Kidneys Into Hepatitis C Virus-Negative Recipients Open
Long waiting times for kidney transplantation and the major health burdens of dialysis have generated interest in transplanting kidneys from donors with blood-borne viral infections. Until 2015, most kidneys from deceased donors with hepat…
View article: Data from Validation of a Coding Algorithm to Identify Bladder Cancer and Distinguish Stage in an Electronic Medical Records Database
Data from Validation of a Coding Algorithm to Identify Bladder Cancer and Distinguish Stage in an Electronic Medical Records Database Open
Studies on outcomes in bladder cancer rely on accurate methods to identify patients with bladder cancer and differentiate bladder cancer stage. Medical record and administrative databases are increasingly used to study cancer incidence, bu…
View article: Data from Validation of a Coding Algorithm to Identify Bladder Cancer and Distinguish Stage in an Electronic Medical Records Database
Data from Validation of a Coding Algorithm to Identify Bladder Cancer and Distinguish Stage in an Electronic Medical Records Database Open
Studies on outcomes in bladder cancer rely on accurate methods to identify patients with bladder cancer and differentiate bladder cancer stage. Medical record and administrative databases are increasingly used to study cancer incidence, bu…
View article: Implementing pragmatic clinical trials in hepatology
Implementing pragmatic clinical trials in hepatology Open
Patients with chronic liver disease would benefit from pragmatic trial designs. A pragmatic trial seeks to inform clinical decision-making by providing evidence for the adoption of an intervention into real-world clinical practice. A trial…
View article: Variability in Organ Procurement Organization Performance by Individual Hospital in the United States
Variability in Organ Procurement Organization Performance by Individual Hospital in the United States Open
Importance Availability of organs inadequately addresses the need of patients waiting for a transplant. Objective To estimate the true number of donor patients in the United States and identify inefficiencies in the donation process as a w…