David S. Sharlin
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View article: 8490 The mRNA for the Nonsyndromic Deafness Gene Atp2b2 Is Reduced Following Developmental Hypothyroidism
8490 The mRNA for the Nonsyndromic Deafness Gene Atp2b2 Is Reduced Following Developmental Hypothyroidism Open
Disclosure: E.A. Gregersen: None. R.P. Peeters: None. D. Forrest: None. D.S. Sharlin: None. Thyroid hormone (TH) is essential for auditory system development. In rodent models, low levels of TH during the early postnatal period delay cochl…
View article: SAT-448 Limited Adaptive Response by Deiodinase Enzymes in the Perinatal Hypothyroid Cochlea
SAT-448 Limited Adaptive Response by Deiodinase Enzymes in the Perinatal Hypothyroid Cochlea Open
Thyroid hormone (TH) is essential for cochlear development and normal auditory function. Considering the importance of TH in mediating cochlear development, understanding the degree to which developing tissues can adapt to perturbations in…
View article: SAT-562 Thyroid Hormone Transporter Mct8 is Specially Expressed in the Adrenal Gland Inner Cortex and Partially Mediates the Thyroid Hormone Action in the Adrenal Cortex.
SAT-562 Thyroid Hormone Transporter Mct8 is Specially Expressed in the Adrenal Gland Inner Cortex and Partially Mediates the Thyroid Hormone Action in the Adrenal Cortex. Open
It is well known that thyroid hormone plays a key role in amphibian metamorphosis and mammalian tissue remodeling. We and others have reported that treatment with thyroid hormone will prevent or postpone the regression of the adrenal inner…
View article: Deafness and loss of cochlear hair cells in the absence of thyroid hormone transporters Slc16a2 (Mct8) and Slc16a10 (Mct10)
Deafness and loss of cochlear hair cells in the absence of thyroid hormone transporters Slc16a2 (Mct8) and Slc16a10 (Mct10) Open
View article: Disruption of Auditory Function by Thyroid Hormone Receptor Mutations
Disruption of Auditory Function by Thyroid Hormone Receptor Mutations Open
More than a century ago, associations between deaf-mutism, cretinism, and goiter were reported. Since then, our understanding for the role of T3 and its receptors in auditory system development has greatly advanced. Much of current underst…