David S. Siscovick
YOU?
Author Swipe
View article: Self-reported infertility and longitudinal measures of cardiovascular risk factors: The CARDIA study
Self-reported infertility and longitudinal measures of cardiovascular risk factors: The CARDIA study Open
Introduction Previous reports have noted associations between infertility in women and increased risk of cardiovascular disease (CVD) events in later life. However, reports conflict regarding the associations between infertility and CVD ri…
View article: Circulating Sphingolipids and Incident CKD
Circulating Sphingolipids and Incident CKD Open
Background: Few studies have assessed whether ceramides and sphingomyelin species are associated with kidney health in community-based studies. We investigated associations of 8 ceramide and sphingomyelin species with incident CKD (eGFR 3 …
View article: Advanced Glycation End‐Product Carboxymethyl‐Lysine and Incident Heart Failure and Atrial Fibrillation in Older Adults
Advanced Glycation End‐Product Carboxymethyl‐Lysine and Incident Heart Failure and Atrial Fibrillation in Older Adults Open
Background Advanced glycation end‐products result from chemical modification of proteins under conditions of hyperglycemia or oxidative stress common with advancing age. Advanced glycation end‐product (AGE) formation alters vascular and ca…
View article: Trimethylamine-N-oxide (TMAO) and risk of incident cardiovascular events in the multi ethnic study of Atherosclerosis
Trimethylamine-N-oxide (TMAO) and risk of incident cardiovascular events in the multi ethnic study of Atherosclerosis Open
Trimethylamine- N -oxide (TMAO) is a gut microbiome-derived metabolite of choline, L-carnitine and lecithin, abundant in animal source foods. In experimental models, higher blood TMAO levels enhance atherosclerotic cardiovascular disease (…
View article: Non-Esterified Fatty Acid Profiles and Cause-Specific Mortality: The Cardiovascular Health Study
Non-Esterified Fatty Acid Profiles and Cause-Specific Mortality: The Cardiovascular Health Study Open
Context Total fasting non-esterified fatty acid (NEFA) levels have been associated with mortality. The corresponding associations with NEFA levels following an oral glucose tolerance test (OGTT) and with individual fasting NEFA species are…
View article: Longitudinal Measures of Cardiovascular Risk Factors Are Associated with Subfertility in the Coronary Artery Risk Development in Young Adults (CARDIA) Study
Longitudinal Measures of Cardiovascular Risk Factors Are Associated with Subfertility in the Coronary Artery Risk Development in Young Adults (CARDIA) Study Open
Introduction Previous reports have noted associations between subfertility in women and increased risk of cardiovascular disease (CVD) events in later life. However, reports conflict regarding the associations between subfertility and CVD …
View article: Phenotyping lipid profiles in type 2 diabetes: Risk association and outcomes from the Cardiovascular Health Study
Phenotyping lipid profiles in type 2 diabetes: Risk association and outcomes from the Cardiovascular Health Study Open
Participants with the high triglyceride/low HDL-C phenotype had equivalent or higher CVD risk than those with the high LDL-C phenotype. Further studies are necessary to determine whether lipid phenotyping accounts for the substantial CVD r…
View article: LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes
LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes Open
View article: Circulating Sphingolipids and All‐Cause Mortality: The Strong Heart Family Study
Circulating Sphingolipids and All‐Cause Mortality: The Strong Heart Family Study Open
Background A growing body of research indicates that associations of ceramides and sphingomyelins with mortality depend on the chain length of the fatty acid acylated to the backbone sphingoid base. We examined associations of 8 ceramide a…
View article: LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes
LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes Open
BACKGROUNDPreclinical studies suggest that cholesterol accumulation leads to insulin resistance. We previously reported that alterations in a monocyte cholesterol metabolism transcriptional network (CMTN) - suggestive of cellular cholester…
View article: Accuracy of QT(c) and QTI for detection of autonomic dysfunction
Accuracy of QT(c) and QTI for detection of autonomic dysfunction Open
Background: Correlates of QT interval duration have been described although their effects on its ability to identify autonomic neuropathy have not. Methods: We examined the ability of QT(c) and QTI to detect pharmacologically simulated aut…
View article: The Gut Microbial Metabolite Trimethylamine N-oxide, Incident CKD, and Kidney Function Decline
The Gut Microbial Metabolite Trimethylamine N-oxide, Incident CKD, and Kidney Function Decline Open
Key Points In community-based US adults, higher plasma trimethylamine N -oxide levels associated with higher risk of incident CKD and greater rate of kidney function decline. Findings from our study support future clinical trials to examin…
View article: Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium
Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium Open
View article: Associations of Neurological Biomarkers in Serum With Gait Measures: The Cardiovascular Health Study
Associations of Neurological Biomarkers in Serum With Gait Measures: The Cardiovascular Health Study Open
Background Gait impairment leads to increased mobility decline and may have neurological contributions. This study explores how neurological biomarkers are related to gait in older adults. Methods We studied participants in the Cardiovascu…
View article: Implications of Patient-Reported Outcome Measures among patients with recently diagnosed type 2 diabetes
Implications of Patient-Reported Outcome Measures among patients with recently diagnosed type 2 diabetes Open
Background For the past two decades, the assessment of the quality of diabetes care has mostly relied on clinical quality indicators. These have not included Patient-Reported Outcome Measures (PROMs) which provide information on outcomes d…
View article: Androgenicity in Young Women and Development of Metabolic Syndrome Before Menopause: The CARDIA and CARDIA Women’s Studies
Androgenicity in Young Women and Development of Metabolic Syndrome Before Menopause: The CARDIA and CARDIA Women’s Studies Open
Context There are no reported data from prospective long-term studies on the relation of androgen levels in young women with development of metabolic syndrome (MetS) before menopause. Objective We investigated associations of androgens and…
View article: Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies
Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies Open
BACKGROUND: The effect of marine omega-3 PUFAs on risk of stroke remains unclear. METHODS: We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 int…
View article: Role of Polyunsaturated Fat in Modifying Cardiovascular Risk Associated With Family History of Cardiovascular Disease: Pooled De Novo Results From 15 Observational Studies
Role of Polyunsaturated Fat in Modifying Cardiovascular Risk Associated With Family History of Cardiovascular Disease: Pooled De Novo Results From 15 Observational Studies Open
BACKGROUND: It is unknown whether dietary intake of polyunsaturated fatty acids (PUFA) modifies the cardiovascular disease (CVD) risk associated with a family history of CVD. We assessed interactions between biomarkers of low PUFA intake a…
View article: Plasma Ceramides and Sphingomyelins and Sudden Cardiac Death in the Cardiovascular Health Study
Plasma Ceramides and Sphingomyelins and Sudden Cardiac Death in the Cardiovascular Health Study Open
Importance Sphingolipids, including ceramides and sphingomyelins, may influence the pathophysiology and risk of sudden cardiac death (SCD) through multiple biological activities. Whether the length of the fatty acid acylated to plasma sphi…
View article: The determinants of fasting and post-load non-esterified fatty acids in older adults: The cardiovascular health study
The determinants of fasting and post-load non-esterified fatty acids in older adults: The cardiovascular health study Open
View article: FRI449 Self-reported Diagnosis Of Polycystic Ovary Syndrome In The Coronary Artery Risk Factor Development in Young Adults (CARDIA) Study
FRI449 Self-reported Diagnosis Of Polycystic Ovary Syndrome In The Coronary Artery Risk Factor Development in Young Adults (CARDIA) Study Open
Disclosure: C. Kim: None. P. Schreiner: None. D. Siscovick: None. A. Wang: None. M. Wellons: None. I. Ebong: None. T. Vu: None. D. Appiah: None. J. Catov: None. E. Schisterman: None. Z. Yin: None. C.E. Lewis: None. Background Polycystic ov…
View article: Neighborhood greenspace and neighborhood income associated with white matter grade worsening: Cardiovascular Health Study
Neighborhood greenspace and neighborhood income associated with white matter grade worsening: Cardiovascular Health Study Open
INTRODUCTION We examined whether a combined measure of neighborhood greenspace and neighborhood median income was associated with white matter hyperintensity (WMH) and ventricle size changes. METHODS The sample included 1260 cognitively no…
View article: Evaluation of plasma sphingolipids as mediators of the relationship between kidney disease and cardiovascular events
Evaluation of plasma sphingolipids as mediators of the relationship between kidney disease and cardiovascular events Open
View article: Circulating Omega-3 and Omega-6 Fatty Acids, Cognitive Decline, and Dementia in Older Adults
Circulating Omega-3 and Omega-6 Fatty Acids, Cognitive Decline, and Dementia in Older Adults Open
Background: Comprising nearly 35% of brain lipids, polyunsaturated fatty acids (PUFA) are essential for optimal brain function. However, the role of PUFA on cognitive health outcomes later in life is largely unknown. Objective: We investig…
View article: Genome-wide association studies and fine-mapping identify genomic loci for n-3 and n-6 polyunsaturated fatty acids in Hispanic American and African American cohorts
Genome-wide association studies and fine-mapping identify genomic loci for n-3 and n-6 polyunsaturated fatty acids in Hispanic American and African American cohorts Open
Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) play critical roles in human health. Prior genome-wide association studies (GWAS) of n-3 and n-6 PUFAs in European Americans from the CHARGE Consortium have documented str…
View article: Plasma Trimethylamine‐ <i>N</i> ‐Oxide and Incident Ischemic Stroke: The Cardiovascular Health Study and the Multi‐Ethnic Study of Atherosclerosis
Plasma Trimethylamine‐ <i>N</i> ‐Oxide and Incident Ischemic Stroke: The Cardiovascular Health Study and the Multi‐Ethnic Study of Atherosclerosis Open
Background The association of circulating trimethylamine‐ N ‐oxide (TMAO) with stroke has received limited attention. To address this gap, we examined the associations of serial measures of plasma TMAO with incident ischemic stroke. Method…
View article: Comparing the Safety and Effectiveness of Metformin with Other Medicines for Patients with Type 2 Diabetes and Chronic Kidney Disease
Comparing the Safety and Effectiveness of Metformin with Other Medicines for Patients with Type 2 Diabetes and Chronic Kidney Disease Open
View article: Factors associated with self-report of polycystic ovary syndrome in the Coronary Artery Risk Development in Young Adults study (CARDIA)
Factors associated with self-report of polycystic ovary syndrome in the Coronary Artery Risk Development in Young Adults study (CARDIA) Open
View article: Ambulatory Activity and Risk of Premature Mortality Among Young and Middle-aged American Indian Individuals
Ambulatory Activity and Risk of Premature Mortality Among Young and Middle-aged American Indian Individuals Open
Importance To our knowledge, no published studies have investigated the association of ambulatory activity with risk of death among young and middle-aged American Indian individuals. The burden of chronic disease and risk of premature deat…
View article: Trimethylamine N-oxide is associated with long-term mortality risk: the multi-ethnic study of atherosclerosis
Trimethylamine N-oxide is associated with long-term mortality risk: the multi-ethnic study of atherosclerosis Open
Aims Little is known about associations of trimethylamine N-oxide (TMAO), a novel gut microbiota-generated metabolite of dietary phosphatidylcholine and carnitine, and its changes over time with all-cause and cause-specific mortality in th…