David B. Sacks
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View article: KSR1 is a scaffold for the Hippo signaling pathway
KSR1 is a scaffold for the Hippo signaling pathway Open
The evolutionarily conserved Hippo signaling pathway regulates organ size and tissue homeostasis. Yes-associated protein (YAP) functions as a transcriptional co-activator and is a critical downstream effector of the Hippo signaling pathway…
View article: AcetyLeish: acetylation-driven control of stage differentiation and virulence in Leishmania mexicana
AcetyLeish: acetylation-driven control of stage differentiation and virulence in Leishmania mexicana Open
Protein acetylation regulates essential processes across eukaryotes. In trypanosomatids, stage-specific acetylation suggests roles in parasite differentiation. Here, we functionally characterized zinc-dependent lysine deacetylases (DAC1, D…
Continuous glucose monitoring in gestational diabetes mellitus: hope or hype? Open
The screening, diagnosis and management of gestational diabetes mellitus (GDM) have evolved over time. Similarly, continuous glucose monitoring (CGM) has advanced in parallel: from intermittent to real-time monitoring, shorter to longer we…
Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma Open
In this study, we explored the intricate relationship between Pannexin 1 (PANX1) and the Hippo signaling pathway effector, Yes‐associated protein (YAP). Analysis of The Cancer Genome Atlas (TCGA) data revealed a significant positive correl…
View article: <i>Leishmania mexicana</i> N‐Acetyltransferease 10 Is Important for Polysome Formation and Cell Cycle Progression
<i>Leishmania mexicana</i> N‐Acetyltransferease 10 Is Important for Polysome Formation and Cell Cycle Progression Open
Leishmania presents a complex life cycle that involves both invertebrate and vertebrate hosts. By regulating gene expression, protein synthesis, and metabolism, the parasite can adapt to various environmental conditions. This regulation oc…
View article: The Diabetes Technology Society Error Grid and Trend Accuracy Matrix for Glucose Monitors.
The Diabetes Technology Society Error Grid and Trend Accuracy Matrix for Glucose Monitors. Open
INTRODUCTION: An error grid compares measured versus reference glucose concentrations to assign clinical risk values to observed errors. Widely used error grids for blood glucose monitors (BGMs) have limited value because they do not also …
View article: Functional plasticity shapes neutrophil response to Leishmania major infection in susceptible and resistant strains of mice
Functional plasticity shapes neutrophil response to Leishmania major infection in susceptible and resistant strains of mice Open
Neutrophils rapidly infiltrate sites of infection and possess several microbicidal strategies, such as neutrophil extracellular traps release and phagocytosis. Enhanced neutrophil infiltration is associated with higher susceptibility to Le…
View article: The Diabetes Technology Society Error Grid and Trend Accuracy Matrix for Glucose Monitors
The Diabetes Technology Society Error Grid and Trend Accuracy Matrix for Glucose Monitors Open
Introduction: An error grid compares measured versus reference glucose concentrations to assign clinical risk values to observed errors. Widely used error grids for blood glucose monitors (BGMs) have limited value because they do not also …
Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma Open
In this study, we explored the intricate relationship between Pannexin 1 (PANX1) and the Hippo signaling pathway effector, Yes-associated protein (YAP). Analysis of The Cancer Genome Atlas (TCGA) data revealed a significant positive correl…
Plasma Glycated Albumin in Early Pregnancy and Gestational Diabetes Mellitus: a prospective and longitudinal study Open
ObjectiveInvestigate associations of plasma glycated albumin (GA) concentrations in early and mid-pregnancy with GDM risk.Research Design and MethodsWe measured GA concentrations using blood samples collected at 10-14 and 15-26 weeks’ gest…
Plasma Glycated Albumin in Early Pregnancy and Gestational Diabetes Mellitus: a prospective and longitudinal study Open
ObjectiveInvestigate associations of plasma glycated albumin (GA) concentrations in early and mid-pregnancy with GDM risk.Research Design and MethodsWe measured GA concentrations using blood samples collected at 10-14 and 15-26 weeks’ gest…
Multiplexing the Identification of Microorganisms via Tandem Mass Tag Labeling Augmented by Interference Removal through a Novel Modification of the Expectation Maximization Algorithm Open
Having fast, accurate, and broad spectrum methods for the identification of microorganisms is of paramount importance to public health, research, and safety. Bottom-up mass spectrometer-based proteomics has emerged as an effective tool for…
Disruption of Ca<sup>2+</sup>/calmodulin:<span>KSR1</span> interaction lowers <span>ERK</span> activation Open
KSR1, a key scaffold protein for the MAPK pathway, facilitates ERK activation upon growth factor stimulation. We recently demonstrated that KSR1 binds the Ca 2+ ‐binding protein calmodulin (CaM), thereby providing an intersection between K…
Advanced Glycation Endproducts: A Marker of Long-term Exposure to Glycemia Open
This article examines the importance of advanced glycation endproducts (AGEs) and summarizes the structure of AGEs, pathological changes associated with AGEs, the contribution of AGEs to metabolic memory, and the value of AGEs as a predict…
Emerging Biomarkers in the Laboratory and in Practice: A Novel Approach to Diagnosing Heart Failure in Diabetes Open
The Biomarkers for the Diagnosis of Heart Failure in Diabetes webinar was hosted by Diabetes Technology Society on September 20, 2023, with the objective to review current evidence and management practices of biomarker screening for heart …
Dynamic Elevation of Aromatic Amino Acids in Hepatitis C Virus-Induced Cirrhosis After a Standard Meal Open
INTRODUCTION: Perturbations in aromatic (AAAs) and branched-chain amino acids (BCAAs) are seen in decompensated liver disease. The aim of this study was to evaluate the dynamic, postprandial relationship between hepatitis C virus-induced l…
A Longitudinal Study of Plasma Glycated Albumin across Pregnancy and Associations with Maternal Characteristics and Cardiometabolic Biomarkers Open
Background Glycated albumin (GA) has recently been proposed as a screening marker for diabetes among non-pregnant individuals. However, data on GA during pregnancy are sparse and lacking among women of diverse race/ethnicity. We investigat…
Fructosamine is Not a Reliable Test for the Detection of Hyperglycemia: Insight from the Africans in America Study Open
As HbA1c and GA provided similar diagnostic results on different days and FA did not, HbA1C and GA are superior to FA in both clinical care settings and epidemiologic studies.
View article: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus Open
BACKGROUND Numerous laboratory tests are used in the diagnosis and management of diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. APPROACH An expert committee compiled evide…
View article: Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus Open
Background Numerous laboratory tests are used in the diagnosis and management of patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. An expert committee compiled …
View article: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus Open
BACKGROUND Numerous laboratory tests are used in the diagnosis and management of diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. APPROACH An expert committee compiled evide…
View article: Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus Open
BACKGROUND Numerous laboratory tests are used in the diagnosis and management of patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. An expert committee compiled …
View article: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus Open
BACKGROUND Numerous laboratory tests are used in the diagnosis and management of diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. APPROACH An expert committee compiled evide…
View article: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus Open
Background Numerous laboratory tests are used in the diagnosis and management of diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. Approach An expert committee compiled evide…
Biomarkers for the Diagnosis of Heart Failure in People with Diabetes: A Consensus Report from Diabetes Technology Society Open
Diabetes Technology Society assembled a panel of clinician experts in diabetology, cardiology, clinical chemistry, nephrology, and primary care to review the current evidence on biomarker screening of people with diabetes (PWD) for heart f…
The IQGAP scaffolds: Critical nodes bridging receptor activation to cellular signaling Open
The scaffold protein IQGAP1 assembles multiprotein signaling complexes to influence biological functions. Cell surface receptors, particularly receptor tyrosine kinases and G-protein coupled receptors, are common IQGAP1 binding partners. I…