David Šaman
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View article: Cytotoxicity and Nanoassembly Characteristics of Aromatic Amides of Oleanolic Acid and Ursolic Acid
Cytotoxicity and Nanoassembly Characteristics of Aromatic Amides of Oleanolic Acid and Ursolic Acid Open
A series of more than 20 new amides of oleanolic acid and ursolic acid with selected aromatic amines were synthesized, and the structures of all compounds were analyzed and elucidated. Moreover, the compounds were subjected to the cytotoxi…
View article: Amides of moronic acid and morolic acid with the tripeptides MAG and GAM targeting antimicrobial, antiviral and cytotoxic effects
Amides of moronic acid and morolic acid with the tripeptides MAG and GAM targeting antimicrobial, antiviral and cytotoxic effects Open
The most successful structures showing their antimicrobial, antiviral or cytotoxic effects. Selectivity of their effects has been observed.
View article: Oxime derivatives of betulonic acid and platanic acid as novel cytotoxic or antiviral agents
Oxime derivatives of betulonic acid and platanic acid as novel cytotoxic or antiviral agents Open
Less frequently studied plant triterpenoids betulonic acid and platanic acid were selected to design, synthesize and investigate their oxime derivatives as novel and potentially effective cytotoxic and/or antiviral agents.
View article: Chemie na Přírodovědecké fakultě Německé univerzity v Praze 1920–1945
Chemie na Přírodovědecké fakultě Německé univerzity v Praze 1920–1945 Open
Chemistry at the Faculty of Sciences of the German University in Prague in 1920–1945 Chemistry was established at the University of Prague – mainly in connection with medicine - already in the 19th century. In the interwar period, the Germ…
View article: Novel Oleanolic Acid-Tryptamine and -Fluorotryptamine Amides: From Adaptogens to Agents Targeting In Vitro Cell Apoptosis
Novel Oleanolic Acid-Tryptamine and -Fluorotryptamine Amides: From Adaptogens to Agents Targeting In Vitro Cell Apoptosis Open
Background: Oleanolic acid is a natural plant adaptogen, and tryptamine is a natural psychoactive drug. To compare their effects of with the effect of their derivatives, tryptamine and fluorotryptamine amides of oleanolic acid were designe…
View article: Triterpenoid–PEG Ribbons Targeting Selectivity in Pharmacological Effects
Triterpenoid–PEG Ribbons Targeting Selectivity in Pharmacological Effects Open
(1) Background: To compare the effect of selected triterpenoids with their structurally resembling derivatives, designing of the molecular ribbons was targeted to develop compounds with selectivity in their pharmacological effects. (2) Met…
View article: Rapid Self-Healing and Thixotropic Organogelation of Amphiphilic Oleanolic Acid–Spermine Conjugates
Rapid Self-Healing and Thixotropic Organogelation of Amphiphilic Oleanolic Acid–Spermine Conjugates Open
Natural and abundant plant triterpenoids are attractive starting materials for the synthesis of conformationally rigid and chiral building blocks for functional soft materials. Here, we report the rational design of three oleanolic acid-tr…
View article: Helquats as Promoters of the Povarov Reaction: Synthesis of 1,2,3,4‐Tetrahydroquinoline Scaffolds Catalyzed by Helicene‐Viologen Hybrids
Helquats as Promoters of the Povarov Reaction: Synthesis of 1,2,3,4‐Tetrahydroquinoline Scaffolds Catalyzed by Helicene‐Viologen Hybrids Open
Invited for this month's cover are the synthetic and physical chemistry groups of Paul E. Reyes‐Gutiérrez and Lubomír Pospíšil from the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, J. Heyrovský Institut…
View article: Front Cover: Helquats as Promoters of the Povarov Reaction: Synthesis of 1,2,3,4‐Tetrahydroquinoline Scaffolds Catalyzed by Helicene‐Viologen Hybrids (ChemPlusChem 10/2020)
Front Cover: Helquats as Promoters of the Povarov Reaction: Synthesis of 1,2,3,4‐Tetrahydroquinoline Scaffolds Catalyzed by Helicene‐Viologen Hybrids (ChemPlusChem 10/2020) Open
The Front Cover shows how helquat molecules (shown as solar panels) can be used as organocatalysts in the Povarov reaction. The background combines historical monuments of Prague and the new research centre of the Institute of Organic Chem…
View article: Synthesis and Pharmacological Effects of Diosgenin–Betulinic Acid Conjugates
Synthesis and Pharmacological Effects of Diosgenin–Betulinic Acid Conjugates Open
The target diosgenin–betulinic acid conjugates are reported to investigate their ability to enhance and modify the pharmacological effects of their components. The detailed synthetic procedure that includes copper(I)-catalyzed Huisgen 1,3-…
View article: Spermine amides of selected triterpenoid acids: dynamic supramolecular system formation influences the cytotoxicity of the drugs
Spermine amides of selected triterpenoid acids: dynamic supramolecular system formation influences the cytotoxicity of the drugs Open
Cytotoxicity data: 8a: IC50 [μM]: 18.8/31.8/32.6/17.2 (25.1 ± 8.2), due to the dynamic self-assembly found, low-contrast networks (TEM); 8b: IC50 [μM]: 7.5 ± 1.6, dynamic self-assembly not detected, partly helical structures (TEM).
View article: Synthesis and anti-human immunodeficiency virus activity of substituted (<i>o,o</i>-difluorophenyl)-linked-pyrimidines as potent non‐nucleoside reverse transcriptase inhibitors
Synthesis and anti-human immunodeficiency virus activity of substituted (<i>o,o</i>-difluorophenyl)-linked-pyrimidines as potent non‐nucleoside reverse transcriptase inhibitors Open
With the worldwide number of human immunodeficiency virus positive patients stagnant and the increasing emergence of viral strains resistant to current treatment, the development of novel anti-human immunodeficiency virus drug candidates i…
View article: Cover Image, Volume 30, Issue 3
Cover Image, Volume 30, Issue 3 Open
The cover image, by Lukáš Severa et al., is based on the Short Communication Dutch Resolution of a configurationally stable [5]helquat, DOI: 10.1002/chir.22789. Background Image Credit: Dr. Paul E. Reyes-Gutiérrez.
View article: CCDC 1447598: Experimental Crystal Structure Determination
CCDC 1447598: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1447596: Experimental Crystal Structure Determination
CCDC 1447596: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1469245: Experimental Crystal Structure Determination
CCDC 1469245: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1447599: Experimental Crystal Structure Determination
CCDC 1447599: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1532597: Experimental Crystal Structure Determination
CCDC 1532597: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1447600: Experimental Crystal Structure Determination
CCDC 1447600: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1447597: Experimental Crystal Structure Determination
CCDC 1447597: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1455875: Experimental Crystal Structure Determination
CCDC 1455875: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1447601: Experimental Crystal Structure Determination
CCDC 1447601: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Tunable Chiral Second-Order Nonlinear Optical Chromophores Based on Helquat Dications
Tunable Chiral Second-Order Nonlinear Optical Chromophores Based on Helquat Dications Open
Fourteen new dipolar cations have been synthesized, containing methoxy or tertiary amino electron donor groups attached to helquat (Hq) acceptors. These Hq derivatives have been characterized as their TfO- salts by using various techniques…
View article: Correction: Corrigendum: Structural revisions of small molecules reported to cross-link G-quadruplex DNA in vivo reveal a repetitive assignment error in the literature
Correction: Corrigendum: Structural revisions of small molecules reported to cross-link G-quadruplex DNA in vivo reveal a repetitive assignment error in the literature Open
Scientific Reports 6: Article number: 23499; published online: 23 March 2016; updated: 09 February 2017 This article contains inaccuracies in its description of the work presented in reference 1. In the Introduction, “the authors reported …