David Sammut
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View article: Effects of Obesity on Response to Asthma Biologic Treatment: Longitudinal Data From the United Kingdom Severe Asthma Registry
Effects of Obesity on Response to Asthma Biologic Treatment: Longitudinal Data From the United Kingdom Severe Asthma Registry Open
Asthma biologic agents appear to have important clinical benefits across the spectrum of BMI. However, because patients with obesity start at a worse baseline with respect to symptoms and exacerbations, they are still more likely to remain…
View article: Pre-biologic assessment of adherence in severe asthma and association with biologic continuation: a UK Severe Asthma Registry Study
Pre-biologic assessment of adherence in severe asthma and association with biologic continuation: a UK Severe Asthma Registry Study Open
Background Biologic therapies are approved for uncontrolled severe asthma despite good adherence to inhaled corticosteroids (ICS) and additional controllers. We examined the adherence assessments used across UK Severe Asthma Centres (SACs)…
View article: Neutrophils fuel effective immune responses through gluconeogenesis and glycogenesis
Neutrophils fuel effective immune responses through gluconeogenesis and glycogenesis Open
sponsorship: Academy of Medical Sciences (AMS)|AMS-SGCL11-Thompson, British Heart Foundation|FS/18/13/33281, Medical Research Council|MR/N02995X/1, Medical Research Council|MC_PC_U127574433, MRC|MR/N02995X/1
View article: Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis
Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis Open
Neutrophils can function and survive in injured and infected tissues, where oxygen and metabolic substrates are limited. Using radioactive flux assays and LC-MS tracing with U-13C glucose, glutamine, and pyruvate, we observe that neutrophi…
View article: Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation
Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation Open
Neutrophilic inflammation with prolonged neutrophil survival is common to many inflammatory conditions, including chronic obstructive pulmonary disease (COPD). There are few specific therapies that reverse neutrophilic inflammation, but un…
View article: Author response: Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation
Author response: Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Neutrophilic inflammation wit…
View article: Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation
Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation Open
Neutrophilic inflammation with prolonged neutrophil survival is common to many inflammatory conditions, including chronic obstructive pulmonary disease (COPD). There are few specific therapies that reverse neutrophilic inflammation, but un…
View article: Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses
Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses Open
Fully activated innate immune cells are required for effective responses to infection, but their prompt deactivation and removal are essential for limiting tissue damage. Here, we have identified a critical role for the prolyl hydroxylase …
View article: Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression
Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression Open
sponsorship: Medical Research Council|MR/K023845/1, Medical Research Council|G0802255, Medical Research Council|MR/K023845/2, Wellcome Trust|098516, MRC|MR/K023845/2, MRC|MR/K023845/1, MRC|G0802255