David Schlütermann
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View article: Small-molecule inhibitor of C-terminal HSP90 dimerization modulates autophagy and functions synergistically with mTOR inhibition to kill cisplatin-resistant cancer cells
Small-molecule inhibitor of C-terminal HSP90 dimerization modulates autophagy and functions synergistically with mTOR inhibition to kill cisplatin-resistant cancer cells Open
Background A major obstacle for the successful treatment of cancer is the primary presence or development of resistance mechanisms toward therapeutic intervention. In urothelial cancer, cisplatin-based regimens are still routinely employed…
View article: The Golgi stacking protein GRASP55 is targeted by the natural compound prodigiosin
The Golgi stacking protein GRASP55 is targeted by the natural compound prodigiosin Open
Background The bacterial secondary metabolite prodigiosin has been shown to exert anticancer, antimalarial, antibacterial and immunomodulatory properties. With regard to cancer, it has been reported to affect cancer cells but not non-malig…
View article: Metamorphic proteins at the basis of human autophagy initiation and lipid transfer
Metamorphic proteins at the basis of human autophagy initiation and lipid transfer Open
Autophagy is a conserved intracellular degradation pathway that generates de novo double-membrane autophagosomes to target a wide range of material for lysosomal degradation. In multicellular organisms, autophagy initiation requires the ti…
View article: Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells
Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells Open
View article: FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates
FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates Open
View article: High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol
High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol Open
View article: An essential role of the autophagy activating kinase ULK1 in snRNP biogenesis
An essential role of the autophagy activating kinase ULK1 in snRNP biogenesis Open
The biogenesis of small uridine-rich nuclear ribonucleoproteins (UsnRNPs) depends on the methylation of Sm proteins catalyzed by the methylosome and the subsequent action of the SMN complex, which assembles the heptameric Sm protein ring o…
View article: TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy
TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy Open
Macroautophagy/autophagy and necroptosis represent two opposing cellular s tress responses. Whereas autophagy primarily fulfills a cyto-protective function, necroptosis is a form of regulated cell death induced via death receptors. Here, w…
View article: Prodigiosin Sensitizes Sensitive and Resistant Urothelial Carcinoma Cells to Cisplatin Treatment
Prodigiosin Sensitizes Sensitive and Resistant Urothelial Carcinoma Cells to Cisplatin Treatment Open
Cisplatin-based treatment is the standard of care therapy for urothelial carcinomas. However, complex cisplatin resistance mechanisms limit the success of this approach. Both apoptosis and autophagy have been shown to contribute to this re…
View article: MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes
MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes Open
Homologous apolipoproteins of MICOS complex, MIC26 and MIC27, show an antagonistic regulation of their protein levels, making it difficult to deduce their individual functions using a single gene deletion. We obtained single and double kno…
View article: The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death
The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death Open
View article: EBV Negative Lymphoma and Autoimmune Lymphoproliferative Syndrome Like Phenotype Extend the Clinical Spectrum of Primary Immunodeficiency Caused by STK4 Deficiency
EBV Negative Lymphoma and Autoimmune Lymphoproliferative Syndrome Like Phenotype Extend the Clinical Spectrum of Primary Immunodeficiency Caused by STK4 Deficiency Open
Serine/threonine kinase 4 (STK4) deficiency is an autosomal recessive genetic condition that leads to primary immunodeficiency (PID) typically characterized by lymphopenia, recurrent infections and Epstein Barr Virus (EBV) induced l…
View article: The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane
The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane Open
Mitochondria are cellular organelles with crucial functions in the generation and distribution of ATP, the buffering of cytosolic Ca 2+ and the initiation of apoptosis. Compounds that interfere with these functions are termed mitochondrial…
View article: Targeting urothelial carcinoma cells by combining cisplatin with a specific inhibitor of the autophagy-inducing class III PtdIns3K complex
Targeting urothelial carcinoma cells by combining cisplatin with a specific inhibitor of the autophagy-inducing class III PtdIns3K complex Open
Cisplatin-based regimens are routinely employed for the treatment of urothelial carcinoma. However, therapeutic success is hampered by the primary presence of or the development of cisplatin resistance. This chemoresistance is executed by …
View article: Systematic analysis of ATG13 domain requirements for autophagy induction
Systematic analysis of ATG13 domain requirements for autophagy induction Open
Macroautophagy/autophagy is an evolutionarily conserved cellular process whose induction is regulated by the ULK1 protein kinase complex. The subunit ATG13 functions as an adaptor protein by recruiting ULK1, RB1CC1 and ATG101 to a core ULK…