David Schnell
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View article: Posttraumatic Growth in Intensive Care Unit Health Care Professionals After COVID-19
Posttraumatic Growth in Intensive Care Unit Health Care Professionals After COVID-19 Open
Importance Posttraumatic growth (PTG) refers to positive psychological changes following adversity, including deeper relationships and a greater appreciation for life. Objective To assess PTG among intensive care unit (ICU) health care pro…
View article: Life-Supporting Treatment Limitations in Patients Who Die Within 48 Hours After ICU Admission: A French, Multicenter, Observational, Exploratory Study
Life-Supporting Treatment Limitations in Patients Who Die Within 48 Hours After ICU Admission: A French, Multicenter, Observational, Exploratory Study Open
IMPORTANCE: The occurrence of death shortly after ICU admission raises concerns about the appropriateness of providing intensive care to frail patients—many of whom are subsequently subject to decisions to limit life-supporting treatment l…
View article: Supplemental Figure S1 from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells
Supplemental Figure S1 from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells Open
The effect of PEG-CAT on radiosensitization of AA in PC3 cells was determined by MTT assay.
View article: Supplemental Table S1 from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells
Supplemental Table S1 from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells Open
Mutually exclusive CIs for the AA-IR combined treatment for PC3 cells and PZ cells at indicated doses.
View article: Data from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells
Data from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells Open
Cancer cells typically experience higher oxidative stress than normal cells, such that elevating pro-oxidant levels can trigger cancer cell death. Although pre-exposure to mild oxidative agents will sensitize cancer cells to radiation, thi…
View article: Supplemental Figure S2 from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells
Supplemental Figure S2 from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells Open
After treatment with AA, the expression of RelB, Bcl-xL, and Bax in PC3 and PZ cells was quantified by western blots by RT-PCR.
View article: Data from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells
Data from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells Open
Cancer cells typically experience higher oxidative stress than normal cells, such that elevating pro-oxidant levels can trigger cancer cell death. Although pre-exposure to mild oxidative agents will sensitize cancer cells to radiation, thi…
View article: Supplemental Figure S2 from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells
Supplemental Figure S2 from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells Open
After treatment with AA, the expression of RelB, Bcl-xL, and Bax in PC3 and PZ cells was quantified by western blots by RT-PCR.
View article: Supplementary Table S1 from Phase I Study to Assess the Combination of Afatinib with Trastuzumab in Patients with Advanced or Metastatic HER2-Positive Breast Cancer
Supplementary Table S1 from Phase I Study to Assess the Combination of Afatinib with Trastuzumab in Patients with Advanced or Metastatic HER2-Positive Breast Cancer Open
Supplementary Table S1. Best overall response (RECIST version 1.1)
View article: Supplementary Table S1 from Phase I Study to Assess the Combination of Afatinib with Trastuzumab in Patients with Advanced or Metastatic HER2-Positive Breast Cancer
Supplementary Table S1 from Phase I Study to Assess the Combination of Afatinib with Trastuzumab in Patients with Advanced or Metastatic HER2-Positive Breast Cancer Open
Supplementary Table S1. Best overall response (RECIST version 1.1)
View article: Supplemental Figure S1 from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells
Supplemental Figure S1 from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells Open
The effect of PEG-CAT on radiosensitization of AA in PC3 cells was determined by MTT assay.
View article: Data from Phase I Study to Assess the Combination of Afatinib with Trastuzumab in Patients with Advanced or Metastatic HER2-Positive Breast Cancer
Data from Phase I Study to Assess the Combination of Afatinib with Trastuzumab in Patients with Advanced or Metastatic HER2-Positive Breast Cancer Open
Purpose: The HER2 mAb, trastuzumab, is a standard therapy for patients with HER2-positive breast cancer before acquired resistance. Afatinib, an irreversible, oral, small-molecule ErbB family blocker, shows clinical activity in trastuzumab…
View article: Supplemental Figure S3 from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells
Supplemental Figure S3 from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells Open
The subgroups of the animal experiment were analyzed using Kaplan-Meier survival curves with the log-rank test.
View article: Supplemental Figure S3 from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells
Supplemental Figure S3 from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells Open
The subgroups of the animal experiment were analyzed using Kaplan-Meier survival curves with the log-rank test.
View article: Supplemental Table and Figure Legend from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells
Supplemental Table and Figure Legend from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells Open
Legends for Supplemental Table S1 and Supplemental Figures S1-S3.
View article: Data from Phase I Study to Assess the Combination of Afatinib with Trastuzumab in Patients with Advanced or Metastatic HER2-Positive Breast Cancer
Data from Phase I Study to Assess the Combination of Afatinib with Trastuzumab in Patients with Advanced or Metastatic HER2-Positive Breast Cancer Open
Purpose: The HER2 mAb, trastuzumab, is a standard therapy for patients with HER2-positive breast cancer before acquired resistance. Afatinib, an irreversible, oral, small-molecule ErbB family blocker, shows clinical activity in trastuzumab…
View article: Supplemental Table S1 from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells
Supplemental Table S1 from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells Open
Mutually exclusive CIs for the AA-IR combined treatment for PC3 cells and PZ cells at indicated doses.
View article: Supplemental Table and Figure Legend from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells
Supplemental Table and Figure Legend from RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells Open
Legends for Supplemental Table S1 and Supplemental Figures S1-S3.
View article: Influence of socioeconomic status on functional recovery after ARDS caused by SARS-CoV-2: a multicentre, observational study
Influence of socioeconomic status on functional recovery after ARDS caused by SARS-CoV-2: a multicentre, observational study Open
Introduction Prognosis of patients with COVID-19 depends on the severity of the pulmonary affection. The most severe cases may progress to acute respiratory distress syndrome (ARDS), which is associated with a risk of long-term repercussio…
View article: Impact of targeted hypothermia in expanded-criteria organ donors on recipient kidney-graft function: study protocol for a multicentre randomised controlled trial (HYPOREME)
Impact of targeted hypothermia in expanded-criteria organ donors on recipient kidney-graft function: study protocol for a multicentre randomised controlled trial (HYPOREME) Open
Introduction Expanded-criteria donors (ECDs) are used to reduce the shortage of kidneys for transplantation. However, kidneys from ECDs are associated with an increased risk of delayed graft function (DGF), a risk factor for allograft loss…
View article: Multicentre observational status-epilepticus registry: protocol for ICTAL
Multicentre observational status-epilepticus registry: protocol for ICTAL Open
Introduction Status epilepticus (SE) is a common life-threatening neurological emergency that can cause long-term impairments. Overall outcomes remain poor. Major efforts are required to clarify the epidemiology of SE and the determinants …