David Stroebel
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Roles of the zona pellucida in gamete fusion and of the perivitelline space in blocking polyspermy in mice Open
The mechanisms regulating gamete fusion and preventing polyspermy in mammalian fertilization remain incompletely understood. This study combines real-time imaging, confocal microscopy and statistical analysis to investigate fertilization a…
The Buds of <i>Oscarella lobularis</i> (Porifera, Homoscleromorpha): A New Convenient Model for Sponge Cell and Evolutionary Developmental Biology Open
The comparative study of the four non‐bilaterian phyla (Cnidaria, Placozoa, Ctenophora, and Porifera) provides insights into the origin of bilaterian traits. To complete our knowledge of the cell biology and development of these animals, a…
Key roles of the zona pellucida and perivitelline space in promoting gamete fusion and fast block to polyspermy inferred from the choreography of spermatozoa in mice oocytes Open
Mammalian fertilization is still lacking a comprehensive understanding of gamete fusion and block to polyspermy mechanisms. One reason is that they are highly dynamic processes involving transient events that can only be revealed and chara…
View article: Evolution is not Uniform Along Coding Sequences
Evolution is not Uniform Along Coding Sequences Open
Amino acids evolve at different speeds within protein sequences, because their functional and structural roles are different. Notably, amino acids located at the surface of proteins are known to evolve more rapidly than those in the core. …
Evolution is not uniform along protein sequences Open
Amino acids evolve at different speeds within protein sequences, because their functional and structural roles are different. However, the position of an amino-acid within the sequence is not known to influence this evolutionary speed. Her…
Evolution is not uniform along protein sequence length Open
This repository contains all the raw data (coding sequences) and scripts required to generate the figures presented in the manuscript entitled "Evolution is not uniform along protein sequence length" by R. Bricout, D. Weil, D. Stroebel, A.…
Evolution is not uniform along protein sequence length Open
This repository contains all the raw data (coding sequences) and scripts required to generate the figures presented in the manuscript entitled "Evolution is not uniform along protein sequence length" by R. Bricout, D. Weil, D. Stroebel, A.…
GluN2A and GluN2B NMDA receptors use distinct allosteric routes Open
Allostery represents a fundamental mechanism of biological regulation that involves long-range communication between distant protein sites. It also provides a powerful framework for novel therapeutics. NMDA receptors (NMDARs), glutamate-ga…
Architecture and function of NMDA receptors: an evolutionary perspective Open
Ionotropic glutamate receptors (iGluRs) are a major class of ligand‐gated ion channels that are widespread in the living kingdom. Their critical role in excitatory neurotransmission and brain function of arthropods and vertebrates has made…
Dimer interaction in the Hv1 proton channel Open
Significance The Hv1 proton channel is an unusual voltage-gated ion channel with atypical architecture and stoichiometry. While functional as a monomer, Hv1 is usually expressed as a dimer of two voltage-sensing domains (VSDs). How the two…
Arabidopsis S2Lb links AtCOMPASS-like and SDG2 activity in histone H3 Lys-4 trimethylation independently from histone H2B monoubiquitination Open
The functional determinants of histone H3 Lys-4 trimethylation (H3K4me3), their potential dependency on histone H2B monoubiquitination (H2Bub) and their contribution to defining transcriptional regimes are poorly defined in plant systems. …
DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis Open
DE-ETIOLATED 1 (DET1) is an evolutionarily conserved component of the ubiquitination machinery that mediates the destabilization of key regulators of cell differentiation and proliferation in multicellular organisms. In this study, we prov…
DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis Open
Summary DE-ETIOLATED 1 (DET1) is an evolutionarily conserved component of the ubiquitination machinery that mediates the destabilization of key regulators of cell differentiation and proliferation in multicellular organisms. In this study,…
Oxidation of F-actin controls the terminal steps of cytokinesis Open
Cytokinetic abscission, the terminal step of cell division, crucially depends on the local constriction of ESCRT-III helices after cytoskeleton disassembly. While the microtubules of the intercellular bridge are cut by the ESCRT-associated…