David T. Asuzu
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View article: Phosphoproteomic dysregulation drives tumor proliferation in Cushing’s disease
Phosphoproteomic dysregulation drives tumor proliferation in Cushing’s disease Open
Pituitary adenomas constitute up to 20% of primary brain tumors, yet somatic mutations are only found in 15% of pituitary adenomas. Epigenomic dysregulation has been proposed as a tumorigenic mechanism in pituitary adenomas causing Cushing…
View article: Multidisciplinary management of cervical disc herniation in pregnancy: illustrative case
Multidisciplinary management of cervical disc herniation in pregnancy: illustrative case Open
BACKGROUND Cervical disc herniation during pregnancy is a rare but clinically significant condition. While conservative management is generally preferred, progressive neurological symptoms may necessitate surgical intervention. When conser…
View article: Intracavitary Coil for High Resolution MRI During Pituitary Surgery
Intracavitary Coil for High Resolution MRI During Pituitary Surgery Open
View article: Supplementary Methods and Key Resources Table 1 from Proteostasis modulation in germline missense von Hippel Lindau disease
Supplementary Methods and Key Resources Table 1 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
Supplementary Methods and Key Resources Table
View article: Figure S1 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S1 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
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View article: Figure S4 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S4 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
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View article: Figure S6 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S6 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
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View article: Supplementary Tables 1 from Proteostasis modulation in germline missense von Hippel Lindau disease
Supplementary Tables 1 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
Supplementary tables in tabs.
View article: Figure S5 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S5 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
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View article: Supplementary Tables 1 from Proteostasis modulation in germline missense von Hippel Lindau disease
Supplementary Tables 1 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
Supplementary tables in tabs.
View article: Figure S4 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S4 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
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View article: Supplementary Methods and Key Resources Table 1 from Proteostasis modulation in germline missense von Hippel Lindau disease
Supplementary Methods and Key Resources Table 1 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
Supplementary Methods and Key Resources Table
View article: Figure S3 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S3 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
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View article: Figure S6 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S6 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
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View article: Figure S5 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S5 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
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View article: Figure S3 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S3 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
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View article: Data from Proteostasis modulation in germline missense von Hippel Lindau disease
Data from Proteostasis modulation in germline missense von Hippel Lindau disease Open
Purpose: Missense mutated von Hippel Lindau (VHL) protein (pVHL) maintains intrinsic function but undergoes proteasomal degradation and tumor initiation/progression in VHL disease. Vorinostat can rescue missense mutated pVHL and arrest tum…
View article: Figure S2 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S2 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
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View article: Figure S2 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S2 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
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View article: Figure S1 from Proteostasis modulation in germline missense von Hippel Lindau disease
Figure S1 from Proteostasis modulation in germline missense von Hippel Lindau disease Open
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View article: CSIG-28. R17 INDUCES A PRO-ONCOGENIC PROTEIN HYPERPHOSPHORYLATION PROGRAM IN CUSHING’S DISEASE
CSIG-28. R17 INDUCES A PRO-ONCOGENIC PROTEIN HYPERPHOSPHORYLATION PROGRAM IN CUSHING’S DISEASE Open
OBJECTIVES to investigate molecular drivers of CD. METHODS We performed single-nucleus assays for transposase-accessible chromatin (snATACseq) and single-nucleus RNAseq (snRNAseq) in 4 CD adenomas including two adenoma-normal pairs. To ass…
View article: EXTH-03. A VEGF+ SUBPOPULATION OF SCHWANN CELLS DRIVES VESTIBULAR SCHWANNOMA TUMORIGENESIS
EXTH-03. A VEGF+ SUBPOPULATION OF SCHWANN CELLS DRIVES VESTIBULAR SCHWANNOMA TUMORIGENESIS Open
INTRODUCTION Up to 95% of vestibular schwannomas (VS) are sporadic, however their molecular underpinnings remain obscure. OBJECTIVE To perform transcriptomic profiling of VS and investigate novel tumorigenic mechanisms. METHODS We analyzed…
View article: THU478 Unchecked Kinase Activation Underlies Pituitary Adenomas Causing Cushing’s Disease
THU478 Unchecked Kinase Activation Underlies Pituitary Adenomas Causing Cushing’s Disease Open
Disclosure: D. Asuzu: None. D. Mullaney: None. Y. Li: None. D. Mandal: None. C. Tatsi: None. L.K. Nieman: None. P. Chittiboina: None. Introduction: Common mechanisms underlying canonically mutated (USP8, USP48 and BRAF) and ‘wildtype’ pitu…
View article: OR01-02 Epigenomic Dysregulation Of PPP1R17 Drives The Cell Cycle In Adenomas Causing Cushing’s Disease
OR01-02 Epigenomic Dysregulation Of PPP1R17 Drives The Cell Cycle In Adenomas Causing Cushing’s Disease Open
Disclosure: D. Asuzu: None. D. Mullaney: None. S. Stoica: None. D. Mandal: None. D. Maric: None. A. Elkahloun: None. B. Sisay: None. C. Tatsi: None. L.K. Nieman: None. P. Chittiboina: None. Introduction: Pituitary adenomas causing Cushing’…
View article: OR2803 Corticotroph Fate Weighted Cell Differentiation Paradigm For Human Induced Pluripotent Stem Cells
OR2803 Corticotroph Fate Weighted Cell Differentiation Paradigm For Human Induced Pluripotent Stem Cells Open
Disclosure: M.E. Moore: None. K.G. Chen: None. K. Park: None. D. Asuzu: None. N. Ramavenkat: None. S. Walbridge: None. D. Mullaney: None. M. Arhin: None. D. Maric: None. D. Mandal: None. P. Chittiboina: None. Introduction: The vertebrate a…
View article: Supplementary Tables 1 from Proteostasis Modulation in Germline Missense von Hippel Lindau Disease
Supplementary Tables 1 from Proteostasis Modulation in Germline Missense von Hippel Lindau Disease Open
Supplementary tables in tabs.
View article: Figure S4 from Proteostasis Modulation in Germline Missense von Hippel Lindau Disease
Figure S4 from Proteostasis Modulation in Germline Missense von Hippel Lindau Disease Open
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View article: Figure S2 from Proteostasis Modulation in Germline Missense von Hippel Lindau Disease
Figure S2 from Proteostasis Modulation in Germline Missense von Hippel Lindau Disease Open
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View article: Supplementary Methods and Key Resources Table 1 from Proteostasis Modulation in Germline Missense von Hippel Lindau Disease
Supplementary Methods and Key Resources Table 1 from Proteostasis Modulation in Germline Missense von Hippel Lindau Disease Open
Supplementary Methods and Key Resources Table
View article: Supplementary Tables 1 from Proteostasis Modulation in Germline Missense von Hippel Lindau Disease
Supplementary Tables 1 from Proteostasis Modulation in Germline Missense von Hippel Lindau Disease Open
Supplementary tables in tabs.