Explanipedia

Supplementary Table 1 from Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia Open

Giorgia Giordano, Girish Venkataraman, Tiffaney L. Vincent, Adam DuVall, Yi Chen , et al. · 2025

Supplementary Table

Supplementary figures 1-9 from Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia Open

Giorgia Giordano, Bartholomew J. Eisfelder, Girish Venkataraman, Vijayalakshmi Ananthanarayanan, Tiffaney L. Vincent , et al. · 2025

Supplementary Figures 1-9

Remodeling of the immune microenvironment is linked to adverse outcome in pediatric T cell acute lymphoblastic leukemia Open

Caroline R.M. Wiggers, Merve Özdemir, Gbolahan Bamgbose, Frederike Warlitz, I. Pop , et al. · 2025

Changes in the immune microenvironment are frequent in cancers occurring in adult patients, yet our understanding of the pediatric cancer immune microenvironment and its clinical relevance is limited. We investigate the immune microenviron…

A non-canonical lymphoblast in refractory childhood T-cell leukaemia Open

Holly J. Whitfield, Mi K. Trinh, Gianna Bloye, Nathaniel D. Anderson, Angus Hodder , et al. · 2025

Refractory cancers may arise either through the acquisition of resistance mechanisms or represent distinct disease states. The origin of childhood T-cell acute lymphoblastic leukaemia (T-ALL) that does not respond to initial treatment, i.e…

The hematopoietic stem cell MYB enhancer is essential and recurrently amplified during T-cell leukemogenesis Open

Carea Mullin, Karena Lin, Elizabeth Choe, Cher Sha, Zeel Shukla , et al. · 2025

There is an urgent need to find targeted agents for T-cell acute lymphoblastic leukemia (T-ALL). NOTCH1 is the most frequently mutated oncogene in T-ALL, but clinical trials showed that pan-Notch inhibitors caused dose-limiting toxicities.…

Table S1 from Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia Open

Haley Newman, Shawn H.R. Lee, Petri Pölönen, Rawan Shraim, Yimei Li , et al. · 2025

T-cell Acute Lymphoblastic Leukemia Genomic Subtype Description.

Table S5 from Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia Open

Haley Newman, Shawn H.R. Lee, Petri Pölönen, Rawan Shraim, Yimei Li , et al. · 2025

Association of Genetic Ancestries (25% Interval) as Continuous Variables with Pathway Alteration using Logistic Regression Models for Each Pathway.

Table S2 from Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia Open

Haley Newman, Shawn H.R. Lee, Petri Pölönen, Rawan Shraim, Yimei Li , et al. · 2025

T-cell Acute Lymphoblastic Leukemia subtype by Categorical Genetic Ancestry

Table S10 from Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia Open

Haley Newman, Shawn H.R. Lee, Petri Pölönen, Rawan Shraim, Yimei Li , et al. · 2025

Detailed clinical data

Table S6 from Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia Open

Haley Newman, Shawn H.R. Lee, Petri Pölönen, Rawan Shraim, Yimei Li , et al. · 2025

Association of Genetic Ancestry (25% interval) as Continuous Variables with Survival Outcomes.

Table S9 from Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia Open

Haley Newman, Shawn H.R. Lee, Petri Pölönen, Rawan Shraim, Yimei Li , et al. · 2025

Association of NOTCH pathway alteration with Survival Outcomes stratified by categorical genetic ancestry.

Table S3 from Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia Open

Haley Newman, Shawn H.R. Lee, Petri Pölönen, Rawan Shraim, Yimei Li , et al. · 2025

Association of Genetic Ancestries (25% Interval) as Continuous Variables with Biologic Subtype (TAL1 DP-like as reference subtype) Using Multinomial Regression Model.

Table S7 from Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia Open

Haley Newman, Shawn H.R. Lee, Petri Pölönen, Rawan Shraim, Yimei Li , et al. · 2025

Types of Reported Events by Genetic Ancestry.

Table S4 from Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia Open

Haley Newman, Shawn H.R. Lee, Petri Pölönen, Rawan Shraim, Yimei Li , et al. · 2025

T-cell Acute Lymphoblastic Leukemia Pathway Alterations by Categorical Genetic Ancestry

Supplementary Figures S1-S11 from Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia Open

Haley Newman, Shawn H.R. Lee, Petri Pölönen, Rawan Shraim, Yimei Li , et al. · 2025

Supplementary Figure S1. T-ALL subtype classifying driver genes among individuals of European, Admixed American, and African ancestry. Supplementary Figure S2. T-ALL subtype classifying driver genes among patients with Early T-cell Precurs…

Table S8 from Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia Open

Haley Newman, Shawn H.R. Lee, Petri Pölönen, Rawan Shraim, Yimei Li , et al. · 2025

Frequency of Genetic Alterations of Genes in the NOTCH Pathway by Ancestry.

Erratum to <[Transplant Cell Ther. 2023 Jul;29(7):438.e1-438.e16. Epub 2023 Mar 9]> Open

Melissa Hines, Tristan Knight, Kevin O. McNerney, Mark B. Leick, Tania Jain , et al. · 2025

Harnessing the CD2 axis to broaden and enhance the efficacy of CAR T cell therapies Open

Alberto Carturan, Mathew G. Angelos, Puneeth Guruprasad, Ruchi P. Patel, Raymone Pajarillo , et al. · 2025

Patients with T-cell lymphomas and leukemias have overall poor outcomes due to the lack of targeted and effective treatments, particularly in the relapsed and refractory settings. Development of chimeric antigen receptor (CAR) T-cells agai…

Age-Based Pegaspargase Dosing is Safe and Achieves Therapeutic Levels in Infants with ALL: Report from COG AALL15P1 Open

Kelly E. Faulk, John A. Kairalla, Emily Hibbitts, Janel Long-Boyle, Meenakshi Devidas , et al. · 2025