David Tieri
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View article: A mouse model of stereotactic radiosurgery-induced neuroinflammation and blood-brain barrier compromise
A mouse model of stereotactic radiosurgery-induced neuroinflammation and blood-brain barrier compromise Open
View article: Resolving haplotype variation and complex genetic architecture in the human immunoglobulin kappa chain locus in individuals of diverse ancestry
Resolving haplotype variation and complex genetic architecture in the human immunoglobulin kappa chain locus in individuals of diverse ancestry Open
View article: Resolving haplotype variation and complex genetic architecture in the human immunoglobulin kappa chain locus in individuals of diverse ancestry
Resolving haplotype variation and complex genetic architecture in the human immunoglobulin kappa chain locus in individuals of diverse ancestry Open
Immunoglobulins (IGs), critical components of the human immune system, are composed of heavy and light protein chains encoded at three genomic loci. The IG Kappa (IGK) chain locus consists of two large, inverted segmental duplications. The…
View article: Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire
Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire Open
Variation in the antibody response has been linked to differential outcomes in disease, and suboptimal vaccine and therapeutic responsiveness, the determinants of which have not been fully elucidated. Countering models that presume antibod…
View article: FLAIRR-Seq: A Method for Single-Molecule Resolution of Near Full-Length Antibody H Chain Repertoires
FLAIRR-Seq: A Method for Single-Molecule Resolution of Near Full-Length Antibody H Chain Repertoires Open
Current Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) using short-read sequencing strategies resolve expressed Ab transcripts with limited resolution of the C region. In this article, we present the near-full-length AIRR-seq (F…
View article: Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis
Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis Open
View article: FLAIRR-seq: A novel method for single molecule resolution of near full-length immunoglobulin heavy chain repertoires
FLAIRR-seq: A novel method for single molecule resolution of near full-length immunoglobulin heavy chain repertoires Open
Current Adaptive Immune Receptor Repertoire Sequencing (AIRR-seq) strategies resolve expressed antibody (Ab) transcripts with limited resolution of the constant region. Here we present a novel near full-length AIRR-seq (FLAIRR-Seq) method …
View article: Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire
Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire Open
Variation in the antibody response has been linked to differential outcomes in disease, and suboptimal vaccine and therapeutic responsiveness, the determinants of which have not been fully elucidated. Countering models that presume antibod…
View article: Dynamic trafficking patterns of IL-17-producing γδ T cells are linked to the recurrence of skin inflammation in psoriasis-like dermatitis
Dynamic trafficking patterns of IL-17-producing γδ T cells are linked to the recurrence of skin inflammation in psoriasis-like dermatitis Open
View article: The induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression
The induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression Open
Despite the remarkable success of immunotherapy in many types of cancer, pancreatic ductal adenocarcinoma has yet to benefit. Innate immune cells are critical to anti-tumor immunosurveillance and recent studies have revealed that these pop…
View article: Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming Open
View article: Integrin CD11b Negatively Regulates B Cell Receptor Signaling to Shape Humoral Response during Immunization and Autoimmunity
Integrin CD11b Negatively Regulates B Cell Receptor Signaling to Shape Humoral Response during Immunization and Autoimmunity Open
Our previous work has revealed the ability of CD11b to regulate BCR signaling and control autoimmune disease in mice. However, how CD11b regulates the immune response under normal conditions remains unknown. Through the use of a CD11b knoc…
View article: A specific low-density neutrophil population correlates with hypercoagulation and disease severity in hospitalized COVID-19 patients
A specific low-density neutrophil population correlates with hypercoagulation and disease severity in hospitalized COVID-19 patients Open
SARS coronavirus 2 (SARS-CoV-2) is a novel viral pathogen that causes a clinical disease called coronavirus disease 2019 (COVID-19). Although most COVID-19 cases are asymptomatic or involve mild upper respiratory tract symptoms, a signific…
View article: Gut Microbiota Composition Modulates the Magnitude and Quality of Germinal Centers during Plasmodium Infections
Gut Microbiota Composition Modulates the Magnitude and Quality of Germinal Centers during Plasmodium Infections Open
View article: Emergence of Low-density Inflammatory Neutrophils Correlates with Hypercoagulable State and Disease Severity in COVID-19 Patients
Emergence of Low-density Inflammatory Neutrophils Correlates with Hypercoagulable State and Disease Severity in COVID-19 Patients Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel viral pathogen that causes a clinical disease called coronavirus disease 2019 (COVID-19). Approximately 20% of infected patients experience a severe manifestation of t…
View article: Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer
Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer Open
Macrophages have been linked to tumor initiation, progression, metastasis, and treatment resistance. However, the transcriptional regulation of macrophages driving the protumor function remains elusive. Here, we demonstrate that the transc…
View article: Tumor-Derived Exosomes Drive Immunosuppressive Macrophages in a Pre-Metastatic Niche Through NF-Kb Dependent Glycolytic Metabolic Reprogramming
Tumor-Derived Exosomes Drive Immunosuppressive Macrophages in a Pre-Metastatic Niche Through NF-Kb Dependent Glycolytic Metabolic Reprogramming Open
View article: Transcription Factor STAT3 Serves as a Negative Regulator Controlling IgE Class Switching in Mice
Transcription Factor STAT3 Serves as a Negative Regulator Controlling IgE Class Switching in Mice Open
A mutation in STAT3 has been linked to the incidence of autosomal dominant hyper IgE syndrome, a disease characterized by elevated serum IgE Ab. However, how this genetic mutation leads to the phenotype has not been fully understood. We in…
View article: A combined approach with gene-wise normalization improves the analysis of RNA-seq data in human breast cancer subtypes
A combined approach with gene-wise normalization improves the analysis of RNA-seq data in human breast cancer subtypes Open
Breast cancer (BC) is increasing in incidence and resistance to treatment worldwide. The challenges in limited therapeutic options and poor survival outcomes in BC subtypes persist because of its molecular heterogeneity and resistance to s…
View article: Correction to: Proceedings of the 16th Annual UT-KBRIN Bioinformatics Summit 2017: bioinformatics
Correction to: Proceedings of the 16th Annual UT-KBRIN Bioinformatics Summit 2017: bioinformatics Open
After publication of this supplement [1], it was brought to our attention that the wrong year was used in the title of the supplement. The 16th Annual UT-KBRIN Bioinformatics Summit was held in 2017.
View article: Proceedings of the 16th Annual UT-KBRIN Bioinformatics Summit 2016: bioinformatics
Proceedings of the 16th Annual UT-KBRIN Bioinformatics Summit 2016: bioinformatics Open