Explanipedia

The Evaluation of Quantitative MRA for Cerebral Amyloid Angiopathy with Vascular Risk Factors Open

Mohamad Hosaam Mosi, Dan Cheng, Mona Kharaji, Gádor Cantón, Charles Watt , et al. · 2025

CAA = Cerebral amyloid angiopathy; TOF-MRA = Time-of-flight MRA; LDL = Low-density lipoprotein; BMI = Body mass index.

Addition of ADAMTS13 Testing to Cryptogenic Stroke Evaluation: Index Case and Single-Center Screening Initial Experience Open

Aaron Boothby, J. López, Livia Hegerova, Dharmini Manogna, Rangaswamy Chintapatla , et al. · 2025

Apixaban Versus Aspirin to Reduce Cognitive Decline After Cryptogenic Stroke and Atrial Cardiopathy: ARCADIA‐Cognition Study Open

Ronald M. Lazar, George Howard, Michael Brewer, Christy Cassarly, Qi Pauls , et al. · 2025

Background ARCADIA (Atrial Cardiopathy and Antithrombotic Drugs in Prevention After Cryptogenic Stroke), a secondary stroke prevention study comparing apixaban versus aspirin for cryptogenic stroke and biomarkers of atrial cardiopathy, end…

MRI findings intracranial hemorrhages in ARCADIA-MRI: an ancillary study to the ARCADIA trial Open

Hui Chen, Maarten G. Lansberg, Guangming Zhu, Christy Cassarly, Qi Paula , et al. · 2025

ARCADIA= atrial cardiopathy and antithrombotic drugs in prevention after cryptogenic stroke; AF= atrial fibrillation; DOAC= direct-acting oral anticoagulants; ICH =intracerebral hemorrhage; NT-proBNP= N-terminal pro-B-type natriuretic pept…

Heart Rhythm Monitoring Practices, Detection of Atrial Fibrillation, and Effect of Anticoagulation in the ARCADIA Trial Open

Hooman Kamel, Mitchell S.V. Elkind, Richard A. Kronmal, Rebeca Aragón García, Pamela Plummer , et al. · 2025

Background The ARCADIA (Atrial Cardiopathy and Antithrombotic Drugs in Prevention After Cryptogenic Stroke) trial found no benefit of anticoagulation for preventing recurrent stroke in patients with atrial cardiopathy. Data on AF monitorin…

Anticoagulation versus antiplatelet therapy in patients with embolic stroke of unknown source: A systematic review and meta-analysis Open

Irum Kotadia, Imran Sunderji, M Elkind, W.T. Longstreth, David Tirschwell , et al. · 2025

Introduction Embolic stroke of undetermined source (ESUS) carries a substantial clinical burden due to high stroke recurrence rate.(1) Recent randomised trials have tested whether anticoagulation is more effective than antiplatelet therapy…

History of Cancer and Atrial Cardiopathy: A Secondary Analysis of the ARCADIA Clinical Trial Open

Babak B. Navi, Mitchell S.V. Elkind, Cenai Zhang, David Tirschwell, Richard A. Kronmal , et al. · 2025

Background Approximately 50% of strokes in patients with cancer are classified as cryptogenic after standard evaluation. Atrial cardiopathy could explain some cancer‐related cryptogenic strokes. However, the relationship between cancer and…

Plasma Proteomic Determinants of Small Vessel Disease of the Brain: the Multi‐Ethnic Study of Atherosclerosis Open

Rizwan Kalani, Alison E. Fohner, Thomas R. Austin, Sheina Emrani, Paul N. Jensen , et al. · 2024

Background The identification of novel blood‐based biomarkers of small vessel disease of the brain (SVD) may improve pathophysiologic understanding and inform the development of new therapeutic strategies for prevention. We evaluated plasm…

Atrial cardiopathy biomarkers and atrial fibrillation in the ARCADIA trial Open

Hooman Kamel, Mitchell S Elkind, Richard A. Kronmal, WT Longstreth, Pamela Plummer , et al. · 2024

Background: ARCADIA compared apixaban to aspirin for secondary stroke prevention in patients with cryptogenic stroke and atrial cardiopathy. One possible explanation for the neutral result is that biomarkers used did not optimally identify…

Apixaban vs Aspirin in Patients With Cancer and Cryptogenic Stroke Open

Babak B. Navi, Cenai Zhang, Benjamin Miller, Mary Cushman, Scott E. Kasner , et al. · 2024

Importance Approximately 10% to 15% of ischemic strokes are associated with cancer; cancer-associated stroke, particularly when cryptogenic, is associated with high rates of recurrent stroke and major bleeding. Limited data exist on the sa…

Genetic Variation and Stroke Recovery: The STRONG Study Open

Steven C. Cramer, Livia Parodi, Zahra Moslemi, Robynne Braun, Chad Aldridge , et al. · 2024

BACKGROUND: Genetic association studies can reveal biology and treatment targets but have received limited attention for stroke recovery. STRONG (Stroke, Stress, Rehabilitation, and Genetics) was a prospective, longitudinal (1-year), genet…

A review of methamphetamine use and stroke in the young Open

Kafi Hemphill, Shannon Tierney, David Tirschwell, Arielle Davis · 2024

Methamphetamine (meth) is a potent and addictive central nervous system stimulant with increasing use. Stroke is one severe possible complication of meth use. Due to high levels of manufacturing in Mexico, the western United States has exp…

Rationale and Design of the Statin Use in Intracerebral Hemorrhage Patients (SATURN) Trial Open

Sarah Marchina, Sharon D. Yeatts, Lydia D. Foster, Scott Janis, Ashkan Shoamanesh , et al. · 2024

Introduction: The benefits and risks of HMG-CoA reductase inhibitor (statin) drugs in survivors of intracerebral hemorrhage (ICH) are unclear. Observational studies suggest an association between statin use and increased risk…

Apixaban to Prevent Recurrence After Cryptogenic Stroke in Patients With Atrial Cardiopathy Open

Hooman Kamel, W. T. Longstreth, David Tirschwell, Richard A. Kronmal, Randolph S. Marshall , et al. · 2024

Importance Atrial cardiopathy is associated with stroke in the absence of clinically apparent atrial fibrillation. It is unknown whether anticoagulation, which has proven benefit in atrial fibrillation, prevents stroke in patients with atr…

Lifetime and Acute Stress Predict Functional Outcomes Following Stroke: Findings From the Longitudinal STRONG Study Open

E. Alison Holman, Steven C. Cramer, Shreyansh Shah, Christoph J. Griessenauer, Nirav Patel , et al. · 2023

BACKGROUND: Stroke is a sudden-onset, uncontrollable event; stroke-related stress may impede rehabilitation and recovery. Lifetime stress may sensitize patients to experiencing greater stroke-related stress and indirectly affect outcomes. …

Associations Between Measures of Disability and Quality of Life at Three Months After Stroke Open

Victoria A. Chang, David Tirschwell, Kyra J. Becker, Glenn Schubert, W.T. Longstreth , et al. · 2023

Background: The modified Rankin Scale (mRS), which measures degree of disability in daily activities, is the most common outcome measure in stroke research. Quality of life (QoL), however, is impacted by factors other than di…

Give us some GRACE, we can't take the HINT: there is still a role for imaging in dizzy patients! Open

Vasisht Srinivasan, David Tirschwell · 2023

Twenty-Year Disparity Trends in United States Stroke Death Rate by Age, Race/Ethnicity, Geography, and Socioeconomic Status Open

Adam de Havenon, Lily Zhou, Karen C. Johnston, Neha Dangayach, John P. Ney , et al. · 2023

Improvements in the stroke death rate in the United States are slowing and even reversing in younger individuals and many US counties. County-level increases in stroke death rate were associated with distinct social determinants of health …

Issue Information Open

Erin E. Longbrake, Sean J. Pittock, Michael Barnett, Jeffrey L. Bennett, Achim Berthele , et al. · 2023

Wiley is a founding member of the UN-backed HINARI, AGORA, and OARE initiatives.They are now collectively known as Research4Life, making online scientific content available free or at nominal cost to researchers in developing countries.

Plasma Proteomic Associations With Incident Ischemic Stroke in Older Adults Open

Rizwan Kalani, Traci M. Bartz, Bruce M. Psaty, Mitchell S.V. Elkind, James S. Floyd , et al. · 2023

In a cohort of older adults, NTproBNP and MMP12 were independently associated with IS risk. We identified plasma proteomic determinants of incident cardioembolic and noncardioembolic IS and found a novel protein associated with IS risk in …

Rehabilitation Therapy Doses Are Low After Stroke and Predicted by Clinical Factors Open

Brittany M. Young, E. Alison Holman, Steven C. Cramer, Shreyansh Shah, Christoph J. Griessenauer , et al. · 2023

Background: Stroke is a leading cause of long-term disability. Greater rehabilitation therapy after stroke is known to improve functional outcomes. This study examined therapy doses during the first year of stroke recovery and identified f…

Blood Pressure and Low‐Density Lipoprotein Cholesterol in Stroke Survivors Versus Controls in the United States From 1999 to 2018 Open

Adam de Havenon, Shyam Prabhakaran, Eric Stulberg, Kaitlin McLean, Karen C. Johnston , et al. · 2022

Hypertension and hyperlipidemia are key modifiable stroke risk factors. 1 Prior analyses have shown stroke survivors have high levels of poorly controlled hypertension and hyperlipidemia, 2,3 but have not explored the temporal trends of sy…

What defines success following reperfusion after mechanical thrombectomy for older patients in the real world? Open

Amber Ruiz, W. T. Longstreth, David Tirschwell, Claire J. Creutzfeldt · 2021

Elevated plasma von Willebrand factor levels are associated with subsequent ischemic stroke in persons with treated HIV infection Open

Susan M. Graham, Robin M. Nance, Junmei Chen, Jennie Le, Dominic W. Chung , et al. · 2021

Background We assessed whether key biomarkers of endothelial activation and hemostasis/thrombosis were elevated in individuals receiving effective antiretroviral therapy (ART) in the year before ischemic stroke. Methods We conducted a case…

Frequency and Patterns of Brain Infarction in Patients With Embolic Stroke of Undetermined Source: NAVIGATE ESUS Trial Open

Mukul Sharma, Eric E. Smith, Lesly A. Pearce, Ashkan Shoamanesh, Kanjana Perera , et al. · 2021

Background and Purpose: The spectrum of brain infarction in patients with embolic stroke of undetermined source (ESUS) has not been well characterized. Our objective was to define the frequency and pattern of brain infarcts detected by mag…

Effect of Adjusting for Baseline Stroke Severity in the National Inpatient Sample Open

Adam de Havenon, Kevin N. Sheth, Karen C. Johnston, Mohammad Anadani, Shadi Yaghi , et al. · 2021

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Medical and Surgical Management of Left Ventricular Assist Device-Associated Intracranial Hemorrhage Open

Chinwe Ibeh, David Tirschwell, Claudius Mahr, Claire J. Creutzfeldt · 2021

Clinical Performance Measures for Stroke Rehabilitation: Performance Measures From the American Heart Association/American Stroke Association Open

Joel Stein, Douglas I. Katz, Randie M. Black Schaffer, Steven C. Cramer, Anne Deutsch , et al. · 2021

The American Heart Association/American Stroke Association released the adult stroke rehabilitation and recovery guidelines in 2016. A working group of stroke rehabilitation experts reviewed these guidelines and identified a subset of reco…

Midlife Blood Pressure Variability and Risk of All-Cause Mortality and Cardiovascular Events During Extended Follow-up Open

Adam de Havenon, Alen Delic, Shadi Yaghi, Ka‐Ho Wong, Jennifer J. Majersik , et al. · 2021

BACKGROUND Studies demonstrate an association between visit-to-visit blood pressure variability (BPV) and cardiovascular events and death. We aimed to determine the long-term cardiovascular and mortality effects of BPV in midlife in partic…

Evaluation of Systolic Blood Pressure, Use of Aspirin and Clopidogrel, and Stroke Recurrence in the Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke Trial Open

Adam de Havenon, S. Claiborne Johnston, J. Donald Easton, Anthony Kim, Kevin N. Sheth , et al. · 2021

In the POINT trial, patients with SBP less than 140 mm Hg at presentation received a greater benefit from 90 days of DAPT than those with higher baseline SBP, particularly for reduction of early ischemic stroke recurrence. Additional resea…

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