David Tosh
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View article: Ectopic expression of HNF4α in Het1A cells induces an invasive phenotype
Ectopic expression of HNF4α in Het1A cells induces an invasive phenotype Open
Barrett's oesophagus (BO) is a pathological condition in which the squamous epithelium of the distal oesophagus is replaced by an intestinal-like columnar epithelium originating from the gastric cardia. Several somatic mutations contribute…
View article: Ion-driven communication and acclimation strategies in microalgae
Ion-driven communication and acclimation strategies in microalgae Open
Similar to all living organisms since their appearance on Earth, microalgae have continuously been exposed to natural selection and consequently evolved by adapting to different or changing ecological niches and occupying ecosystems worldw…
View article: A Pro-Endocrine Pancreatic Islet Transcriptional Program Established During Development Is Retained in Human Gallbladder Epithelial Cells
A Pro-Endocrine Pancreatic Islet Transcriptional Program Established During Development Is Retained in Human Gallbladder Epithelial Cells Open
In summary, our biochemical, transcriptomic, and functional data in mouse and human gallbladder epithelial cells collectively show the evolutionary and developmental similarities between gallbladder and the pancreas that allow gallbladder …
View article: Electrochemical Impedance Spectroscopy as a Tool for Monitoring Cell Differentiation from Floor Plate Progenitors to Midbrain Neurons in Real Time
Electrochemical Impedance Spectroscopy as a Tool for Monitoring Cell Differentiation from Floor Plate Progenitors to Midbrain Neurons in Real Time Open
Here shows that electrical impedance spectroscopy can be used as a non‐invasive and real time tool to probe cell adhesion and differentiation from midbrain floor plate progenitors into midbrain neurons on Au electrodes coated with human la…
View article: Molecular mechanisms of transcription factor mediated cell reprogramming: conversion of liver to pancreas
Molecular mechanisms of transcription factor mediated cell reprogramming: conversion of liver to pancreas Open
Transdifferentiation is a type of cellular reprogramming involving the conversion of one differentiated cell type to another. This remarkable phenomenon holds enormous promise for the field of regenerative medicine. Over the last 20 years …
View article: A pro-endocrine pancreatic transcriptional program established during development is retained in human gallbladder epithelial cells
A pro-endocrine pancreatic transcriptional program established during development is retained in human gallbladder epithelial cells Open
Objective Pancreatic islet β-cells are factories for insulin production; however ectopic expression of insulin is also well recognized. The gallbladder is a next-door neighbour to the developing pancreas. Here, we wanted to understand if g…
View article: The Canonical Wnt Pathway as a Key Regulator in Liver Development, Differentiation and Homeostatic Renewal
The Canonical Wnt Pathway as a Key Regulator in Liver Development, Differentiation and Homeostatic Renewal Open
The canonical Wnt (Wnt/β-catenin) signalling pathway is highly conserved and plays a critical role in regulating cellular processes both during development and in adult tissue homeostasis. The Wnt/β-catenin signalling pathway is vital for …
View article: Author Correction: Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway
Author Correction: Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Human Breast Cancer Cells Demonstrate Electrical Excitability
Human Breast Cancer Cells Demonstrate Electrical Excitability Open
Breast cancer is one of the most prevalent types of cancers worldwide and yet, its pathophysiology is poorly understood. Single-cell electrophysiological studies have provided evidence that membrane depolarization is implicated in the prol…
View article: Ultrasensitive System for Electrophysiology of Cancer Cell Populations: A Review
Ultrasensitive System for Electrophysiology of Cancer Cell Populations: A Review Open
Bioelectricity is the electrical activity produced by living organisms. Understanding the role of bioelectricity in a disease context is important as it contributes to both disease diagnosis and therapeutic intervention. Electrophysiology …
View article: Correction: Dexamethasone Treatment Induces the Reprogramming of Pancreatic Acinar Cells to Hepatocytes and Ductal Cells
Correction: Dexamethasone Treatment Induces the Reprogramming of Pancreatic Acinar Cells to Hepatocytes and Ductal Cells Open
Correction: Dexamethasone Treatment Induces the Reprogramming of Pancreatic Acinar Cells to Hepatocytes and Ductal Cells
View article: Uncropped Western blots for Tubulin, Albumin, Transferrin, AFP and C/EBPbeta (https://doi.org/10.1371/journal.pone.0013650)
Uncropped Western blots for Tubulin, Albumin, Transferrin, AFP and C/EBPbeta (https://doi.org/10.1371/journal.pone.0013650) Open
Uncropped Western blot for Tubulin.
View article: Luminal basic science
Luminal basic science Open
Aim:The gut microbiota is a contributing factor in overall health throughout the human lifecycle.Probiotics are natural, safe, and beneficial modulators of gut microbiota.However, the relationship between probiotics and gut microbiota in a…
View article: Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity
Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity Open
Compounds 13 and 14 were evaluated against 11 PARP isoforms to reveal that both 13 and 14 were more potent and isoform selective toward inhibiting tankyrases (TNKSs) than the "standard" inhibitor 1 (XAV939)5, i.e., IC50 = 100 pM vs TNKS2 a…