David Hung-Tsang Yen
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View article: Willingness-to-pay per quality-adjusted life year of patients with psoriasis: A study in Vietnam
Willingness-to-pay per quality-adjusted life year of patients with psoriasis: A study in Vietnam Open
Background: The chronic nature and frequent recurrence of psoriasis reduce patients' quality of life and increase treatment costs. This study aimed to estimate the willingness-to-pay (WTP) per quality-adjusted life-year (QALY) of psoriasis…
View article: Health-related quality of life of patients with psoriasis: A pilot study in Vietnam
Health-related quality of life of patients with psoriasis: A pilot study in Vietnam Open
Background: Psoriasis is a chronic proliferative skin inflammation associated with an immune-allergic mechanism. Long-term treatment regimen and abnormal recurrences may negatively affect the patients' health-related quality of life (HR-Qo…
View article: Outcomes of Older Patients with Malnutrition and Malnutrition–Sarcopenia in the Emergency Department: A 3-Month Prospective Observational Study
Outcomes of Older Patients with Malnutrition and Malnutrition–Sarcopenia in the Emergency Department: A 3-Month Prospective Observational Study Open
Objectives Malnutrition and sarcopenia are both associated with increased risks of adverse outcomes in older people. The emergency department (ED) is a unique and crucial part of geriatric care. Clinical evaluation of malnutrition-sarcopen…
View article: Percutaneous catheter drainage versus percutaneous needle aspiration for liver abscess: a systematic review, meta-analysis and trial sequential analysis
Percutaneous catheter drainage versus percutaneous needle aspiration for liver abscess: a systematic review, meta-analysis and trial sequential analysis Open
Objective To compare the effectiveness and safety of percutaneous catheter drainage (PCD) against percutaneous needle aspiration (PNA) for liver abscess. Design Systematic review, meta-analysis and trial sequential analysis. Data sources P…
View article: EVALUATION OF A METAGENOMIC NEXT-GENERATION SEQUENCING ASSAY WITH A NOVEL HOST DEPLETION METHOD FOR PATHOGEN IDENTIFICATION IN SEPTIC PATIENTS
EVALUATION OF A METAGENOMIC NEXT-GENERATION SEQUENCING ASSAY WITH A NOVEL HOST DEPLETION METHOD FOR PATHOGEN IDENTIFICATION IN SEPTIC PATIENTS Open
Background The traditional diagnosis of sepsis has always been based on microbial blood culture (BC). However, BC suffers from (1) long culture cycle, leading to delay in results, and (2) low diagnostic yields. Metagenomic next-generation …
View article: Comprehensive Geriatric Assessment in the Emergency Department for Identifying Elderly Individuals at Risk of Hip Fracture.
Comprehensive Geriatric Assessment in the Emergency Department for Identifying Elderly Individuals at Risk of Hip Fracture. Open
By performing CGAs in the ED, we found that female sex and decreased handgrip strength were associated with HF risk. Therefore, we propose that targeted assessment of handgrip strength in female patients aged > 75 years in the ED may ident…
View article: The impact of COVID-19 epidemic on emergency department visits of older patients in Taiwan
The impact of COVID-19 epidemic on emergency department visits of older patients in Taiwan Open
Background The number of emergency department (ED) visits has significantly declined since the COVID-19 pandemic. In Taiwan, an aging society, it is unknown whether older adults are accessing emergency care during the COVID-19 epidemic. Th…
View article: Gastric Mobility and Gastrointestinal Hormones in Older Patients with Sarcopenia
Gastric Mobility and Gastrointestinal Hormones in Older Patients with Sarcopenia Open
Sarcopenia has serious clinical consequences and poses a major threat to older people. Gastrointestinal environmental factors are believed to be the main cause. The aim of this study was to describe the relationship between sarcopenia and …
View article: Esophageal Cancer Stem-like Cells Resist Ferroptosis-Induced Cell Death by Active Hsp27-GPX4 Pathway
Esophageal Cancer Stem-like Cells Resist Ferroptosis-Induced Cell Death by Active Hsp27-GPX4 Pathway Open
Cancer stem cells (CSCs), a subpopulation of cancer cells responsible for tumor initiation and treatment failure, are more susceptible to ferroptosis-inducing agents than bulk cancer cells. However, regulatory pathways controlling ferropto…
View article: Differences in Characteristics, Hospital Care, and Outcomes between Acute Critically Ill Emergency Department Patients Receiving Palliative Care and Usual Care
Differences in Characteristics, Hospital Care, and Outcomes between Acute Critically Ill Emergency Department Patients Receiving Palliative Care and Usual Care Open
Background: The early integration of palliative care in the emergency department (ED-PC) provides several benefits, including improved quality of life with optimal comfort measures, and symptom control. Whether palliative care could affect…
View article: Emergency Department Referral for Hospice and Palliative Care Differs among Patients with Different End-of-Life Trajectories: A Retrospective Cohort Study
Emergency Department Referral for Hospice and Palliative Care Differs among Patients with Different End-of-Life Trajectories: A Retrospective Cohort Study Open
Emergency units have been gradually recognized as important settings for palliative care initiation, but require precise palliative care assessments. Patients with different illness trajectories are found to differ in palliative care refer…
View article: Differences in end-of-life care and outcomes in palliative consultation-eligible patients with and without do-not-resuscitate orders: A propensity score-matched study
Differences in end-of-life care and outcomes in palliative consultation-eligible patients with and without do-not-resuscitate orders: A propensity score-matched study Open
Background: The primary objective of palliative care, not synonymous with end-of-life (EOL) care, is to align care plans with patient goals, regardless of whether these goals include the pursuit of invasive, life-sustaining procedures, or …
View article: Experience of resources management on coronavirus disease 2019 epidemic at a tertiary medical center in Northern Taiwan
Experience of resources management on coronavirus disease 2019 epidemic at a tertiary medical center in Northern Taiwan Open
Background: Coronavirus disease 2019 (COVID-19) is a respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes infectious symptoms including fever, cough, respiratory and gastrointestinal symp…
View article: The Potential Risk Factors for Mortality in Patients After In-Hospital Cardiac Arrest: A Multicenter Study
The Potential Risk Factors for Mortality in Patients After In-Hospital Cardiac Arrest: A Multicenter Study Open
Background and Purpose: In-hospital cardiac arrest (IHCA) has high mortality rate, which needs more research. This multi-center study aims to evaluate potential risk factors for mortality in patients after IHCA. Methods: Data for this stud…
View article: Comparisons of Colistin-Induced Nephrotoxicity Between Two Different Formulations of Colistin in Critically Ill Patients: A Retrospective Cohort Study
Comparisons of Colistin-Induced Nephrotoxicity Between Two Different Formulations of Colistin in Critically Ill Patients: A Retrospective Cohort Study Open
BackgroundColistin is widely used for the treatment of nosocomial infections caused by carbapenem-resistant gram-negative bacilli (CR-GNB). Colistin-induced nephrotoxicity is one of the major adverse reactions during colistin treatment. Co…
View article: Comprehensive Geriatric Assessment in the Emergency Department for Identifying Elderly Individuals at Risk of Hip Fracture
Comprehensive Geriatric Assessment in the Emergency Department for Identifying Elderly Individuals at Risk of Hip Fracture Open
Background Hip fracture (HF) is a major challenge for healthcare systems in terms of increased costs and lengths of stay, and it has been estimated that by 2050, half of the projected 6.26 million global HFs will occur in Asia. Owing to th…
View article: Differences in Characteristics, Hospital Care and Outcomes between Acute Critically Ill Emergency Department Patients with Early and Late Do-Not-Resuscitate Orders
Differences in Characteristics, Hospital Care and Outcomes between Acute Critically Ill Emergency Department Patients with Early and Late Do-Not-Resuscitate Orders Open
Background: A do-not-resuscitate (DNR) order is associated with an increased risk of death among emergency department (ED) patients. Little is known about patient characteristics, hospital care, and outcomes associated with the timing of t…
View article: Effects of Sodium Silicate Complex against Hemorrhagic Activities Induced by Protobothrops mucrosquamatus Venom
Effects of Sodium Silicate Complex against Hemorrhagic Activities Induced by Protobothrops mucrosquamatus Venom Open
Protobothrops mucrosquamatus poses a serious medical threat to humans in Southern and Southeastern Asia. Hemorrhage is one of the conspicuous toxicities related to the pathology of P. mucrosquamatus envenoming. Previous in vitro and in viv…
View article: Emergency department response to coronavirus disease 2019 outbreak with a fever screening station and “graded approach” for isolation and testing
Emergency department response to coronavirus disease 2019 outbreak with a fever screening station and “graded approach” for isolation and testing Open
Background: Ever since coronavirus disease 2019 (COVID-19) emerged in Wuhan, China, in December 2019, it has had a devastating effect on the world through exponential case growth and death tolls in at least 146 countries. Rapid response an…
View article: Comparison of in-hospital and out-of-hospital cardiac arrest patients receiving targeted temperature management: A matched case-control study
Comparison of in-hospital and out-of-hospital cardiac arrest patients receiving targeted temperature management: A matched case-control study Open
Background: Evidences that support the use of targeted temperature management (TTM) for in-hospital cardiac arrest (IHCA) are lacking. We aimed to investigate the hypothesis that TTM benefits for patients with IHCA are similar to those wit…
View article: Initiating palliative care consultation for acute critically ill patients in the emergency department intensive care unit
Initiating palliative care consultation for acute critically ill patients in the emergency department intensive care unit Open
Background: Little is known about the characteristics of patients needing palliative care consultation in the emergency department (ED). This study aimed to investigate the impacts of initiating screening in acute critically ill patients n…
View article: Impact of a routine neurosurgical dispatch on emergency air medical transport and outcome of patients with intracranial hemorrhage
Impact of a routine neurosurgical dispatch on emergency air medical transport and outcome of patients with intracranial hemorrhage Open
Incorporating RNSD with EAMT is a plausible alternative to EAMT with a significant decrease in EAMT and decreased 90-day mortality in patients with ICH compared with non-neurosurgical care with EAMT. Despite a 34% decrease in 90-day mortal…
View article: Clinical Predictors for Intensive Care Unit Admission in Patients With Benzodiazepines Poisoning in the Emergency Department.
Clinical Predictors for Intensive Care Unit Admission in Patients With Benzodiazepines Poisoning in the Emergency Department. Open
The incidence of mortality in patients with BZD overdose is low, but all-cause mortality remains high in those admitted to ICU (15%). Emergency physicians are suggested to pay more attentions on BZD overdose patients with suicidal attempt …
View article: Diabetes Shared Care Program (DSCP) and risk of infection mortality: a nationwide cohort study using administrative claims data in Taiwan
Diabetes Shared Care Program (DSCP) and risk of infection mortality: a nationwide cohort study using administrative claims data in Taiwan Open
Objective The Diabetes Shared Care Program (DSCP) is an integrated care model in Taiwan that has been proven to improve the care quality of patients with diabetes. We aimed to evaluate the efficacy of DSCP in decreasing the hospital mortal…
View article: Protobothrops mucrosquamatus Bites to the Head: Clinical Spectrum from Case Series
Protobothrops mucrosquamatus Bites to the Head: Clinical Spectrum from Case Series Open
Protobothrops mucrosquamatus ( Trimeresurus mucrosquamatus ) is a medically important species of pit viper with a wide geographic distribution in Southeast Asia. Bites by P. mucrosquamatus mostly involve the extremities. Little is known ab…
View article: Transcriptional evaluation of the developmental accuracy, reproducibility and robustness of kidney organoids derived from human pluripotent stem cells
Transcriptional evaluation of the developmental accuracy, reproducibility and robustness of kidney organoids derived from human pluripotent stem cells Open
We have previously reported a protocol for the directed differentiation of human induced pluripotent stem cells to kidney organoids comprised of nephrons, proximal and distal epithelium, vasculature and surrounding interstitial elements. T…