David Tsao
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View article: Validation of a liquid biopsy assay with increased sensitivity for clinical comprehensive genomic profiling
Validation of a liquid biopsy assay with increased sensitivity for clinical comprehensive genomic profiling Open
View article: Molecular counting enables accurate and precise quantification of methylated ctDNA for tumor-naive cancer therapy response monitoring
Molecular counting enables accurate and precise quantification of methylated ctDNA for tumor-naive cancer therapy response monitoring Open
Personalized cancer treatment can significantly extend survival and improve quality of life for many patients, but accurate and real-time therapy response monitoring remains challenging. To overcome logistical and technical challenges asso…
View article: Absolute quantification of cell-free DNA for prenatal genetics and oncology
Absolute quantification of cell-free DNA for prenatal genetics and oncology Open
View article: Molecular counting enables accurate and precise quantification of methylated ctDNA for tumor-naive cancer therapy response monitoring
Molecular counting enables accurate and precise quantification of methylated ctDNA for tumor-naive cancer therapy response monitoring Open
Personalized cancer treatment can significantly extend survival and improve quality of life for many patients, but accurate and real-time therapy response monitoring remains challenging. To overcome logistical and technical challenges asso…
View article: P398: Effects of Hurricane Maria and the COVID-19 pandemic on genetic testing at a diagnostic reference laboratory in Puerto Rico
P398: Effects of Hurricane Maria and the COVID-19 pandemic on genetic testing at a diagnostic reference laboratory in Puerto Rico Open
View article: Venom protection by broadly neutralizing antibody from a snakebite subject
Venom protection by broadly neutralizing antibody from a snakebite subject Open
Snake envenomation is a neglected tropical disease, causing >100,000 deaths and 300,000 permanent disabilities in humans annually. Could monoclonal antibody technology provide a solution? Here, we recover Centi-3FTX-D09, a potent broadly n…
View article: Validation of single‐gene noninvasive prenatal testing for sickle cell disease
Validation of single‐gene noninvasive prenatal testing for sickle cell disease Open
Screening all pregnancies for sickle cell disease (SCD), as recommended by the American College of Gynecologists,1 is essential to enable informed decisions about diagnostic testing, clinical care, and expand available gene therapy treatme…
View article: Clinical validity of single-gene non-invasive prenatal testing for sickle cell disease and beta thalassemia
Clinical validity of single-gene non-invasive prenatal testing for sickle cell disease and beta thalassemia Open
Background Sickle cell disease (SCD) and beta thalassemia (β-thalassemia) are among the most common and severe genetically inherited disorders in the world. Although the maternal carrier status of these beta hemoglobinopathies is screened …
View article: Membrane and Actin Tethering Transitions Help IQGAP1 Coordinate GTPase and Lipid Messenger Signaling
Membrane and Actin Tethering Transitions Help IQGAP1 Coordinate GTPase and Lipid Messenger Signaling Open
View article: A novel high-throughput molecular counting method with single base-pair resolution enables accurate single-gene NIPT
A novel high-throughput molecular counting method with single base-pair resolution enables accurate single-gene NIPT Open
View article: Demultiplexing overlapping signaling scaffold functions to probe lipid messenger coupling to cytoskeletal dynamics
Demultiplexing overlapping signaling scaffold functions to probe lipid messenger coupling to cytoskeletal dynamics Open
The coordination of lipid messenger signaling with cytoskeletal regulation is central to many organelle-specific signaling and regulatory processes. While central to many aspects of cell physiology, this coupling often depends on the funct…
View article: A novel high-throughput molecular counting method with single base-pair resolution enables accurate single-gene NIPT
A novel high-throughput molecular counting method with single base-pair resolution enables accurate single-gene NIPT Open
Next-generation DNA sequencing is currently limited by an inability to count the number of input DNA molecules. Molecular counting is particularly needed when accurate quantification is required for diagnostic purposes, such as in single-g…
View article: Investigations of macromolecular complex functions in living cells
Investigations of macromolecular complex functions in living cells Open
Characterizing the collective functions of cytoskeletal motors is critical to understanding mechanisms that regulate the internal organization of eukaryotic cells as well as the roles various transport defects play in human diseases. While…
View article: Improving the Positive Predictive Value of Non-Invasive Prenatal Screening (NIPS)
Improving the Positive Predictive Value of Non-Invasive Prenatal Screening (NIPS) Open
We evaluated performance characteristics of a laboratory-developed, non-invasive prenatal screening (NIPS) assay for fetal aneuploidies. This assay employs massively parallel shotgun sequencing with full automation. GC sequencing bias corr…
View article: Coordinating Role of IQGAP1 in the Regulation of Multivesicular Endosomal Compartment Dynamics
Coordinating Role of IQGAP1 in the Regulation of Multivesicular Endosomal Compartment Dynamics Open
View article: The coordinating role of IQGAP1 in the regulation of local, endosome-specific actin networks
The coordinating role of IQGAP1 in the regulation of local, endosome-specific actin networks Open
IQGAP1 is a large, multi-domain scaffold that helps orchestrate cell signaling and cytoskeletal mechanics by controlling interactions among a spectrum of receptors, signaling intermediates, and cytoskeletal proteins. While this coordinatio…