David van Dellen
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View article: The Variation in Practice of the Living Donor Kidney Transplant Pathway in the UK: Results of a National Survey
The Variation in Practice of the Living Donor Kidney Transplant Pathway in the UK: Results of a National Survey Open
Living donor kidney transplantation (LDKT) accounts for 35% of kidney transplants in the UK. The Organ Donation and Transplantation 2030 initiative underscores the necessity to enhance LDKT rates to meet growing demand. There is limited da…
View article: Description of the Protocol Investigating Whether Remote Care Can Reduce Clinic Attendance in Lung Transplantation
Description of the Protocol Investigating Whether Remote Care Can Reduce Clinic Attendance in Lung Transplantation Open
View article: Negative Pressure Wound Therapy: Significant Improvement in Definitive Fascial Closure With Reduced Theatre Episodes and Complications in Patients With Encapsulating Peritoneal Sclerosis
Negative Pressure Wound Therapy: Significant Improvement in Definitive Fascial Closure With Reduced Theatre Episodes and Complications in Patients With Encapsulating Peritoneal Sclerosis Open
View article: 559 Beta-Cell Replacement After Pancreas Transplant Failure: A Systematic Review
559 Beta-Cell Replacement After Pancreas Transplant Failure: A Systematic Review Open
Aim This systematic review assesses the evidence on treatment options available for glycaemic control after pancreas transplantation (PT) failure (further PT (PAP), islet transplantation (IAP) or best medical therapy (BMTAP)). Method A sys…
View article: 168 Pancreas transplant outcomes after allocation though the NHSBT pancreas fast-track scheme (FTS)
168 Pancreas transplant outcomes after allocation though the NHSBT pancreas fast-track scheme (FTS) Open
Background The fast-track pancreas scheme (FTS) was brought in to improve pancreas utilisation. It created a scheme for the allocation of pancreas grafts not yet allocated at the time retrieval commenced. There are no previous reports of p…
View article: The impact of pancreas transplantation on diabetic complications: A systematic review
The impact of pancreas transplantation on diabetic complications: A systematic review Open
SPK and PTA have beneficial effects in ameliorating or stabilising diabetes complications. Future work should seek to reduce heterogeneity of outcome metrics assessing T1DM complication profile to facilitate robust comparison of beta-cell …
View article: Renal hyperparathyroidism- a risk factor in the development of encapsulating peritoneal sclerosis
Renal hyperparathyroidism- a risk factor in the development of encapsulating peritoneal sclerosis Open
Background Encapsulating peritoneal sclerosis (EPS) is a rare complication of prolonged peritoneal dialysis (PD) exposure, characterised by peritoneal thickening, calcification, and fibrosis ultimately presenting with life-threatening bowe…
View article: The impact of time to death in donors after circulatory death on recipient outcome in simultaneous pancreas-kidney transplantation
The impact of time to death in donors after circulatory death on recipient outcome in simultaneous pancreas-kidney transplantation Open
View article: British Transplantation Society guidelines on abdominal organ transplantation from deceased donors after circulatory death
British Transplantation Society guidelines on abdominal organ transplantation from deceased donors after circulatory death Open
The British Transplantation Society (BTS) 'Guideline on transplantation from deceased donors after circulatory death' has recently been updated and this manuscript summarises the relevant recommendations in abdominal organ transplantation …
View article: Beta‐cell death and dysfunction drives hyperglycaemia in organ donors
Beta‐cell death and dysfunction drives hyperglycaemia in organ donors Open
Background Donor hyperglycaemia following brain death has been attributed to reversible insulin resistance. However, our islet and pancreas transplant data suggest that other mechanisms may be predominant. We aimed to determine the relatio…
View article: 1058 Jejunal or Ileal Exocrine Drainage in Pancreas Transplantation?
1058 Jejunal or Ileal Exocrine Drainage in Pancreas Transplantation? Open
Aim Pancreas transplantation (PT) is performed for restoration of endocrine function in type 1 diabetes mellitus with amelioration of diabetic complications. However, PT can have serious complications requiring salvage pancreatectomy and s…
View article: Unlocking the post-transplant microenvironment for successful islet function and survival
Unlocking the post-transplant microenvironment for successful islet function and survival Open
Islet transplantation (IT) offers the potential to restore euglycemia for patients with type 1 diabetes mellitus (T1DM). Despite improvements in islet isolation techniques and immunosuppressive regimes, outcomes remain suboptimal with UK f…
View article: WTP2.11 Ipsilateral allograft placement in simultaneous pancreas and kidney transplantation provides equivalent outcomes to standard techniques
WTP2.11 Ipsilateral allograft placement in simultaneous pancreas and kidney transplantation provides equivalent outcomes to standard techniques Open
Aims In simultaneous pancreas kidney transplantation (SPK) grafts are conventionally implanted controlaterally (cSPK), with the pancreas allograft (PG) on right iliac fossa and kidney allograft (KG) on the left. Ipsilateral implant (iSPK) …
View article: Kidney Transplantation From Donors With Acute Kidney Injury: Are the Concerns Justified? A Systematic Review and Meta-Analysis
Kidney Transplantation From Donors With Acute Kidney Injury: Are the Concerns Justified? A Systematic Review and Meta-Analysis Open
Renal transplantation improves quality of life and prolongs survival in patients with end-stage kidney disease, although challenges exist due to the paucity of suitable donor organs. This has been addressed by expanding the donor pool to i…
View article: Donor noradrenaline use is associated with better allograft survival in recipients of pancreas transplantation
Donor noradrenaline use is associated with better allograft survival in recipients of pancreas transplantation Open
Noradrenaline use was associated with better graft survival in models adjusted for donor and recipient variables - this may be related to inhibition of pancreatic insulin secretion initiating pancreatic beta-cell 'rest'. Further research i…
View article: Using Laser Speckle Contrast Imaging to Quantify Perfusion Quality in Kidney and Pancreas Grafts on Vascular Reperfusion: A Proof-of-Principle Study
Using Laser Speckle Contrast Imaging to Quantify Perfusion Quality in Kidney and Pancreas Grafts on Vascular Reperfusion: A Proof-of-Principle Study Open
Introduction. The accuracy of intraoperative graft perfusion assessment still remains subjective, with doppler examination being the only objective adjunct. Laser speckle contrast imaging (LSCI) has been used to assess intraoperative blood…
View article: ClinCirc identifies alterations of the circadian peripheral oscillator in critical care patients
ClinCirc identifies alterations of the circadian peripheral oscillator in critical care patients Open
BackgroundAssessing circadian rhythmicity from infrequently sampled data is challenging; however, these types of data are often encountered when measuring circadian transcripts in hospitalized patients.MethodsWe present ClinCirc. This meth…
View article: P-043 A RETROSPECTIVE OUTCOME REVIEW OF THE USE OF EGIS ACELLULAR DERMAL MATRIX DURING ABDOMINAL WALL RECONSTRUCTION
P-043 A RETROSPECTIVE OUTCOME REVIEW OF THE USE OF EGIS ACELLULAR DERMAL MATRIX DURING ABDOMINAL WALL RECONSTRUCTION Open
Aim We aimed to demonstrate the relative safety profile of an established non-crosslinked porcine acellular dermal matrix (ADM) during abdominal wall reconstruction. Material & Methods Individual real-world safety data on specific mesh pro…
View article: OC-059 TEMPORARY ABDOMINAL CLOSURE NEGATIVE THERAPY IMPROVES DEFINITIVE FASCIAL CLOSURE RATES IN PATIENTS WITH OPEN ABDOMEN MANAGEMENT
OC-059 TEMPORARY ABDOMINAL CLOSURE NEGATIVE THERAPY IMPROVES DEFINITIVE FASCIAL CLOSURE RATES IN PATIENTS WITH OPEN ABDOMEN MANAGEMENT Open
Aims Encapsulating peritoneal sclerosis (EPS) is a rare phenomenon characterised by encasement of the bowel by a thickened peritoneum due to prolonged peritoneal dialysis exposure. We are an international referral centre, typically managin…
View article: DD-06 SPIN (SURGICAL PRACTICES IN INCISIONAL HERNIA REPAIR). A NATIONAL TRAINEE-LED COLLABORATIVE MULTICENTRE PROSPECTIVE OBSERVATIONAL STUDY
DD-06 SPIN (SURGICAL PRACTICES IN INCISIONAL HERNIA REPAIR). A NATIONAL TRAINEE-LED COLLABORATIVE MULTICENTRE PROSPECTIVE OBSERVATIONAL STUDY Open
Aim There is currently no established UK database establishing reliable outcome data for surgical repair of incisional herniae (IH). Their heterogeneity (variability in size, patient comorbidity, and multiple repair techniques) has resulte…
View article: Kidney and combined kidney and pancreas transplantation may be under-utilized in cystic fibrosis
Kidney and combined kidney and pancreas transplantation may be under-utilized in cystic fibrosis Open
Cystic fibrosis (CF) is a multisystem disorder and represents the most common inherited condition leading to death in Western countries. Previous reports of chronic kidney disease (CKD) in CF focus on cases post lung, or other solid organ,…
View article: Kidney Transplantation From Deceased Donors With Vaccine-induced Immune Thrombocytopenia and Thrombosis: An Updated Analysis of the UK Experience
Kidney Transplantation From Deceased Donors With Vaccine-induced Immune Thrombocytopenia and Thrombosis: An Updated Analysis of the UK Experience Open
Background. The emergence and attendant mortality of vaccine-induced immune thrombocytopenia and thrombosis (VITT) as a consequence of vaccination against severe acute respiratory syndrome coronavirus 2 have resulted in some patients with …
View article: Kidney Transplantation From Hepatitis-C Viraemic Donors:Considerations for Practice in the United Kingdom
Kidney Transplantation From Hepatitis-C Viraemic Donors:Considerations for Practice in the United Kingdom Open
Background: Donor hepatitis-C (HCV) infection has historically represented a barrier to kidney transplantation (KT). However, direct-acting antiviral (DAA) medications have revolutionised treatment of chronic HCV infection. Recent American…
View article: Donor Autonomy and Self-Sacrifice in Living Organ Donation: An Ethical Legal and Psychological Aspects of Transplantation (ELPAT) View
Donor Autonomy and Self-Sacrifice in Living Organ Donation: An Ethical Legal and Psychological Aspects of Transplantation (ELPAT) View Open
Clinical teams understandably wish to minimise risks to living kidney donors undergoing surgery, but are often faced with uncertainty about the extent of risk, or donors who wish to proceed despite those risks. Here we explore how these di…
View article: Laterality in laparoscopic hand assisted donor nephrectomy - Does it matter anymore? Outcomes of a large retrospective series
Laterality in laparoscopic hand assisted donor nephrectomy - Does it matter anymore? Outcomes of a large retrospective series Open
View article: SP5.2.6 Adrenal Incidentalomas in Living Kidney Donors: A Dilemma?
SP5.2.6 Adrenal Incidentalomas in Living Kidney Donors: A Dilemma? Open
Aims During donor multi-detector CT angiogram (MDCTA), incidental findings occur, commonly adrenal incidentalomas (AIs). These are usually benign and non-functional with an estimated incidence of 4%.1 These potentially limit organ donation…
View article: EP.WE.962Pre-emptive arterial stenting with covered vascular stents to prevent mycotic haemorrhage in infected fields following failed kidney and pancreas transplants prior to graft explant
EP.WE.962Pre-emptive arterial stenting with covered vascular stents to prevent mycotic haemorrhage in infected fields following failed kidney and pancreas transplants prior to graft explant Open
Aims Allograft nephrectomy and pancreatectomy present a significant surgical challenge in contaminated surgical fields, with risks of post-operative pseudoaneurysms and mycotic bleeds. We report on our experience of prophylactic endovascul…
View article: SP5.2.3 Comparison of Open Abdomen Management Techniques in a cohort of patients with Encapsulating Peritoneal Sclerosis – A large single centre retrospective review
SP5.2.3 Comparison of Open Abdomen Management Techniques in a cohort of patients with Encapsulating Peritoneal Sclerosis – A large single centre retrospective review Open
Aims Encapsulating peritoneal sclerosis (EPS) is a rare phenomenon characterised by encasement and obstruction of the bowel by thickened peritoneum. In our centre, EPS laparotomies are typically managed with open abdomen (OA) and planned r…
View article: EP.TH.108A Descriptive Case Series of Incisional Hernia Repair Using Dual Mesh Technique
EP.TH.108A Descriptive Case Series of Incisional Hernia Repair Using Dual Mesh Technique Open
Aims Incisional hernias are a common complication after surgery that cause significant patient morbidity. Symptomatic patients are offered repair but many surgical techniques exist, with abdominal wall reconstruction becoming preferable fo…
View article: Perioperative optimization in complex abdominal wall hernias: Delphi consensus statement
Perioperative optimization in complex abdominal wall hernias: Delphi consensus statement Open
Background The incidence of incisional hernia after major abdominal surgery via a midline laparotomy is 20–41 per cent with short-term follow-up, and over 50 per cent in those surviving an abdominal catastrophe. Abdominal wall reconstructi…