David van Klaveren
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View article: Accuracy of Predicting Residual Disease and Disease Progression During Active Surveillance for Esophageal Cancer
Accuracy of Predicting Residual Disease and Disease Progression During Active Surveillance for Esophageal Cancer Open
Background To date, active surveillance has been non-inferior to standard surgery for patients with esophageal cancer, achieving a clinical complete response (CCR) after neoadjuvant chemoradiotherapy (nCRT). However, two thirds of patients…
View article: Development and Validation of a Prognostic Model for Persistent Hypoparathyroidism After Total or Completion Thyroidectomy
Development and Validation of a Prognostic Model for Persistent Hypoparathyroidism After Total or Completion Thyroidectomy Open
Background The aim of this study was to develop and validate a clinical prediction model to predict the occurrence of persistent hypoparathyroidism after total or completion thyroidectomy. Methods This multicentre retrospective cohort stud…
View article: Early‐life prediction of school‐age asthma among recurrent Wheezers in preschoolers: The WHEEP study
Early‐life prediction of school‐age asthma among recurrent Wheezers in preschoolers: The WHEEP study Open
Background Early identification of childhood asthma is critical to prevent over‐ and undertreatment. Previous asthma prediction models often rely on subjective outcomes, limiting generalizability. This study aimed to develop an asthma pred…
View article: <scp>A</scp> Comprehensive Assessment of Plasma <scp>CXCL9</scp> and <scp>CXCL10</scp> in Improving Clinical Prediction Models for Kidney Allograft Rejection
<span>A</span> Comprehensive Assessment of Plasma <span>CXCL9</span> and <span>CXCL10</span> in Improving Clinical Prediction Models for Kidney Allograft Rejection Open
Chemokine levels may predict kidney graft rejection. This study evaluated whether adding early plasma chemokines C‐X‐C motif ligand 9 (CXCL9) or chemokines C‐X‐C motif ligand 10 (CXCL10) measurements to a standard‐of‐care model improves th…
View article: Estimating the benefits of personalised glycaemic control
Estimating the benefits of personalised glycaemic control Open
View article: Validation of the prognostic model “oncologiq palliative” for head and neck cancer patients
Validation of the prognostic model “oncologiq palliative” for head and neck cancer patients Open
Purpose Patients diagnosed with incurable head and neck squamous cell carcinoma (HNSCC) have a poor prognosis, with a median survival of approximately five months. Physicians often struggle to predict prognosis accurately and tend to overe…
View article: Development and validation of a clinical prediction model for hospitalization after emergency department admission in patients with cancer
Development and validation of a clinical prediction model for hospitalization after emergency department admission in patients with cancer Open
View article: 8 Patient perspectives on the implementation of patient-reported outcome measures in the lung cancer consultation room
8 Patient perspectives on the implementation of patient-reported outcome measures in the lung cancer consultation room Open
View article: External validation of a model to predict recurrence-free and melanoma-specific survival for patients with melanoma after sentinel node biopsy
External validation of a model to predict recurrence-free and melanoma-specific survival for patients with melanoma after sentinel node biopsy Open
Background Recently, a model to predict 5-year recurrence-free survival (RFS) and melanoma-specific survival (MSS) after sentinel lymph node biopsy (SLNB) was published. The aim of this study was to validate that model in a large independe…
View article: Instability of the AUROC of Clinical Prediction Models
Instability of the AUROC of Clinical Prediction Models Open
Background External validations are essential to assess the performance of a clinical prediction model (CPM) before deployment. Apart from model misspecification, also differences in patient population, the standard of care, predictor defi…
View article: Carbohydrate antigen 19-9 (CA19-9) response after induction FOLFIRINOX for locally advanced pancreatic cancer identifies patients who may benefit from surgical exploration: multicentre, observational cohort study
Carbohydrate antigen 19-9 (CA19-9) response after induction FOLFIRINOX for locally advanced pancreatic cancer identifies patients who may benefit from surgical exploration: multicentre, observational cohort study Open
Background Which patients with locally advanced pancreatic cancer may benefit from surgical exploration after induction treatment remains debated. The aim of this retrospective cohort study was to identify independent factors for overall s…
View article: The association between hospital volume and overall survival in adult AML patients treated with intensive chemotherapy
The association between hospital volume and overall survival in adult AML patients treated with intensive chemotherapy Open
View article: Prevalence, incidence, and mortality of inflammatory bowel disease in the Netherlands: development and external validation of machine learning models
Prevalence, incidence, and mortality of inflammatory bowel disease in the Netherlands: development and external validation of machine learning models Open
Background and aims Large registries are promising tools to study the epidemiology of inflammatory bowel disease (IBD). We aimed to develop and validate machine learning models to identify IBD cases in administrative data, aiming to determ…
View article: Prognostic prediction models for rare skin cancer outcomes: a practical guide to handling nested-case control and case-cohort data (with care)
Prognostic prediction models for rare skin cancer outcomes: a practical guide to handling nested-case control and case-cohort data (with care) Open
View article: Prognostic models for depression and post-traumatic stress disorder symptoms following traumatic brain injury: a CENTER-TBI study
Prognostic models for depression and post-traumatic stress disorder symptoms following traumatic brain injury: a CENTER-TBI study Open
Background Traumatic brain injury (TBI) is associated with an increased risk of major depressive disorder (MDD) and post-traumatic stress disorder (PTSD). We aimed to identify predictors and develop models for the prediction of depression …
View article: High-impact complications after breast cancer surgery in the Dutch national quality registry: evaluating case-mix adjustment for hospital comparisons
High-impact complications after breast cancer surgery in the Dutch national quality registry: evaluating case-mix adjustment for hospital comparisons Open
Background Comparison of quality indicators can improve quality of care. However, case-mix adjustment is deemed essential. The aim of this study was to develop and validate case-mix adjustment models and to evaluate the effect of case-mix …
View article: Quantifying absolute treatment effect heterogeneity for time-to-event outcomes across different risk strata: divergence of conclusions with risk difference and restricted mean survival difference
Quantifying absolute treatment effect heterogeneity for time-to-event outcomes across different risk strata: divergence of conclusions with risk difference and restricted mean survival difference Open
Background Risk-based analyses are increasingly popular for understanding heterogeneous treatment effects (HTE) in clinical trials. For time-to-event analyses, the assumption that high-risk patients benefit most on the clinically important…
View article: Ten-year survival benefit and appropriateness of surgical versus percutaneous revascularization in synergy between percutaneous coronary intervention with Taxus and cardiac surgery randomized trial
Ten-year survival benefit and appropriateness of surgical versus percutaneous revascularization in synergy between percutaneous coronary intervention with Taxus and cardiac surgery randomized trial Open
OBJECTIVES Average treatment effects from randomized trials do not reflect the heterogeneity of an individual’s response to treatment. This study evaluates the appropriate proportions of patients for coronary artery bypass grafting, or per…
View article: Guidance for unbiased predictive information for healthcare decision-making and equity (GUIDE): considerations when race may be a prognostic factor
Guidance for unbiased predictive information for healthcare decision-making and equity (GUIDE): considerations when race may be a prognostic factor Open
View article: Comparative effectiveness of 6x R-CHOP21 versus 6x R-CHOP21 + 2 R for patients with advanced-stage diffuse large B-cell lymphoma
Comparative effectiveness of 6x R-CHOP21 versus 6x R-CHOP21 + 2 R for patients with advanced-stage diffuse large B-cell lymphoma Open
View article: Experienced financial toxicity among long-term cancer survivors: results from a national cross-sectional survey
Experienced financial toxicity among long-term cancer survivors: results from a national cross-sectional survey Open
Purpose Financial toxicity, the subjective distress caused by objective financial burden, significantly impacts cancer survivors. Yet, enduring effects on survivors remain unclear. Therefore, we investigated the experienced objective finan…
View article: 796. P02.05 NEOADJUVANT CHEMORADIOTHERAPY FOLLOWED BY ACTIVE SURVEILLANCE VERSUS STANDARD SURGERY FOR OESOPHAGEAL CANCER (SANO-TRIAL): A MULTICENTRE STEPPED-WEDGE CLUSTER-RANDOMISED NONINFERIORITY TRIAL
796. P02.05 NEOADJUVANT CHEMORADIOTHERAPY FOLLOWED BY ACTIVE SURVEILLANCE VERSUS STANDARD SURGERY FOR OESOPHAGEAL CANCER (SANO-TRIAL): A MULTICENTRE STEPPED-WEDGE CLUSTER-RANDOMISED NONINFERIORITY TRIAL Open
Background One of the standard treatments for patients with locally advanced oesophageal cancer is neoadjuvant chemoradiotherapy followed by oesophagectomy. Of these patients, 29% have a pathologically complete response. Active surveillanc…
View article: Disease extent according to baseline [18F]fluorodeoxyglucose PET/CT and molecular subtype: prediction of axillary treatment response after neoadjuvant systemic therapy for breast cancer
Disease extent according to baseline [18F]fluorodeoxyglucose PET/CT and molecular subtype: prediction of axillary treatment response after neoadjuvant systemic therapy for breast cancer Open
Background Axillary disease extent according to baseline [18F]fluorodeoxyglucose PET/CT combined with pathological axillary treatment response has been proposed to guide de-escalation of axillary treatment for clinically node-positive brea…
View article: Pitfalls of single-study external validation illustrated with a model predicting functional outcome after aneurysmal subarachnoid hemorrhage
Pitfalls of single-study external validation illustrated with a model predicting functional outcome after aneurysmal subarachnoid hemorrhage Open
View article: Regional disparities in the use of intensive chemotherapy for AML in the Netherlands: does it influence survival?
Regional disparities in the use of intensive chemotherapy for AML in the Netherlands: does it influence survival? Open
Objective Acute myeloid leukaemia (AML) prognosis is enhanced with intensive remission induction chemotherapy (ICT) in eligible patients. However, ICT eligibility perceptions may differ among healthcare professionals. This nationwide, popu…
View article: Empirical Evidence That There Is No Such Thing As A Validated Prediction Model
Empirical Evidence That There Is No Such Thing As A Validated Prediction Model Open
Background: External validations are essential to assess clinical prediction models (CPMs) before deployment. Apart from model misspecification, differences in patient population and other factors influence a model's AUC (c-statistic). We …
View article: Weighted metrics are required when evaluating the performance of prediction models in nested case–control studies
Weighted metrics are required when evaluating the performance of prediction models in nested case–control studies Open
Background Nested case–control (NCC) designs are efficient for developing and validating prediction models that use expensive or difficult-to-obtain predictors, especially when the outcome is rare. Previous research has focused on how to d…
View article: Development and External Validation of a Prediction Model for Patients with Varicose Veins Suitable for Isolated Ambulatory Phlebectomy
Development and External Validation of a Prediction Model for Patients with Varicose Veins Suitable for Isolated Ambulatory Phlebectomy Open
View article: PREVENTION OF INCISIONAL HERNIA WITH PROPHYLACTIC ONLAY AND SUBLAY MESH REINFORCEMENT VERSUS PRIMARY SUTURE ONLY IN MIDLINE LAPAROTOMIES (PRIMA): LONG-TERM OUTCOMES OF A MULTICENTRE, DOUBLE-BLIND, RANDOMISED CONTROLLED TRIAL
PREVENTION OF INCISIONAL HERNIA WITH PROPHYLACTIC ONLAY AND SUBLAY MESH REINFORCEMENT VERSUS PRIMARY SUTURE ONLY IN MIDLINE LAPAROTOMIES (PRIMA): LONG-TERM OUTCOMES OF A MULTICENTRE, DOUBLE-BLIND, RANDOMISED CONTROLLED TRIAL Open
Background Incisional hernia occurs approximately in 40% of high-risk patients after midline laparotomy. Prophylactic mesh placement has shown promising results, but long-term outcomes are needed. The present study aimed to assess long-ter…
View article: Personalized decision-making for aneurysm treatment of aneurysmal subarachnoid hemorrhage: development and validation of a clinical prediction tool
Personalized decision-making for aneurysm treatment of aneurysmal subarachnoid hemorrhage: development and validation of a clinical prediction tool Open