David Venzon
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View article: Preclinical Evaluation of a Novel Series of Polyfluorinated Thalidomide Analogs in Drug-Resistant Multiple Myeloma
Preclinical Evaluation of a Novel Series of Polyfluorinated Thalidomide Analogs in Drug-Resistant Multiple Myeloma Open
Immunomodulatory imide drugs (IMiDs) play a crucial role in the treatment landscape across various stages of multiple myeloma. Despite their evident efficacy, some patients may exhibit primary resistance to IMiD therapy, and acquired resis…
View article: In Vivo Treatment with Insulin-like Growth Factor 1 Reduces CCR5 Expression on Vaccine-Induced Activated CD4+ T-Cells
In Vivo Treatment with Insulin-like Growth Factor 1 Reduces CCR5 Expression on Vaccine-Induced Activated CD4+ T-Cells Open
At the heart of the DNA/ALVAC/gp120/alum vaccine’s efficacy in the absence of neutralizing antibodies is a delicate balance of pro- and anti-inflammatory immune responses that effectively decreases the risk of SIVmac251 acquisition in maca…
View article: <i>GNRH2</i>Polymorphism in Men With Prostate Cancer Treated With Androgen Deprivation Therapy
<i>GNRH2</i>Polymorphism in Men With Prostate Cancer Treated With Androgen Deprivation Therapy Open
GNRH2 is expressed in normal, hyperplastic, and neoplastic prostate tissues; the A16V variant is not related to treatment outcome or survival.
View article: Long-term safety and efficacy of selumetinib in children with neurofibromatosis type 1 on a phase 1/2 trial for inoperable plexiform neurofibromas
Long-term safety and efficacy of selumetinib in children with neurofibromatosis type 1 on a phase 1/2 trial for inoperable plexiform neurofibromas Open
Background Selumetinib shrank inoperable symptomatic plexiform neurofibromas (PN) in children with neurofibromatosis type 1 (NF1) and provided clinical benefit for many in our previously published phase 1/2 clinical trials (SPRINT, NCT0136…
View article: Vaccine plus microbicide effective in preventing vaginal SIV transmission in macaques
Vaccine plus microbicide effective in preventing vaginal SIV transmission in macaques Open
The human immunodeficiency virus epidemic continues in sub-Saharan Africa, and particularly affects adolescent girls and women who have limited access to antiretroviral therapy. Here we report that the risk of vaginal simian immunodeficien…
View article: Figure S2 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Figure S2 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
S2. Ten hypoxia response elements were identified by sequence alignment of the RefSeq SLCO1B3 gene (NG_032071.1).
View article: Supplementary Figures 1 - 4 from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy
Supplementary Figures 1 - 4 from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy Open
PDF file - 470K, Figure S1. UN1 mAb did not affect the proliferation rate, cell cycle, viability and apoptosis of HPB-ALL cells. Figure S2. The 2/165 phage clone and synthetic peptides do not inhibit the binding of mAb W6/32 to HPB-ALL cel…
View article: Figure S4 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Figure S4 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
S4. Both (A) lt-SLCO1B3 and (B) ct-SLCO1B3 were plotted as a function of t-SLCO1B3 in 384 tissue and tumor samples.
View article: Table S1 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Table S1 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
Supplemental Table 1
View article: Supplementary Methods from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy
Supplementary Methods from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy Open
PDF file - 37K
View article: Table S1 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Table S1 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
Supplemental Table 1
View article: Data from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy
Data from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy Open
CD43 is a sialoglycosylated membrane protein that is involved in cell proliferation and differentiation. CD43 glycoforms that are recognized by the UN1 monoclonal antibody (mAb) were expressed in lymphoblastoid T-cell lines and solid tumor…
View article: Figure S3 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Figure S3 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
S3. t-SLCO1B3 expression was optimized using various concentrations of chetomin at different timepoints in (A) LNCaP and (B) 22Rv1 cell lines.
View article: Figure S2 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Figure S2 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
S2. Ten hypoxia response elements were identified by sequence alignment of the RefSeq SLCO1B3 gene (NG_032071.1).
View article: Supplemental Figure Legends from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Supplemental Figure Legends from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
Supplemental Figure Legends 1-4
View article: Figure S4 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Figure S4 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
S4. Both (A) lt-SLCO1B3 and (B) ct-SLCO1B3 were plotted as a function of t-SLCO1B3 in 384 tissue and tumor samples.
View article: Data from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Data from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
Castration-resistant prostate cancer (CRPC) has greater intratumoral testosterone concentrations than similar tumors from eugonadal men; simple diffusion does not account for this observation. This study was undertaken to ascertain the and…
View article: Figure S1 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Figure S1 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
S1. Expression of (A) doxycycline-inducible GFP-linked OATP1B3 was confirmed in the membrane and not cytosolic fractions of PC3 cells using a GFP-specific antibody Abcam goat antibody (#ab6673).
View article: Supplemental Figure Legends from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Supplemental Figure Legends from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
Supplemental Figure Legends 1-4
View article: Figure S1 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Figure S1 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
S1. Expression of (A) doxycycline-inducible GFP-linked OATP1B3 was confirmed in the membrane and not cytosolic fractions of PC3 cells using a GFP-specific antibody Abcam goat antibody (#ab6673).
View article: Figure S3 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Figure S3 from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
S3. t-SLCO1B3 expression was optimized using various concentrations of chetomin at different timepoints in (A) LNCaP and (B) 22Rv1 cell lines.
View article: Supplementary Methods from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy
Supplementary Methods from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy Open
PDF file - 37K
View article: Data from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy
Data from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy Open
CD43 is a sialoglycosylated membrane protein that is involved in cell proliferation and differentiation. CD43 glycoforms that are recognized by the UN1 monoclonal antibody (mAb) were expressed in lymphoblastoid T-cell lines and solid tumor…
View article: Data from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx
Data from Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx Open
Castration-resistant prostate cancer (CRPC) has greater intratumoral testosterone concentrations than similar tumors from eugonadal men; simple diffusion does not account for this observation. This study was undertaken to ascertain the and…
View article: Supplementary Figures 1 - 4 from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy
Supplementary Figures 1 - 4 from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy Open
PDF file - 470K, Figure S1. UN1 mAb did not affect the proliferation rate, cell cycle, viability and apoptosis of HPB-ALL cells. Figure S2. The 2/165 phage clone and synthetic peptides do not inhibit the binding of mAb W6/32 to HPB-ALL cel…
View article: Data from <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography in the Management of Patients with Thymic Epithelial Tumors
Data from <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography in the Management of Patients with Thymic Epithelial Tumors Open
Purpose: There are limited data regarding the role of 18F-fluorodeoxyglucose positron emission tomography ([18F]-FDG PET) imaging in management of patients with thymic epithelial tumors (TET). The primary objective of this study was to ass…
View article: Supplementary Tables from Phase I Trial of a New Schedule of Romidepsin in Patients with Advanced Cancers
Supplementary Tables from Phase I Trial of a New Schedule of Romidepsin in Patients with Advanced Cancers Open
Supplementary Tables - PDF file 33K, Supplementary Table 1. Dose levels, dose administered on each treatment day, days 1,3, and 5 of a 21-day cycle, and number of patients treated on each dose level. Supplementary Table 2. Romidepsin toxic…
View article: Data from Sorafenib Is an Inhibitor of UGT1A1 but Is Metabolized by UGT1A9: Implications of Genetic Variants on Pharmacokinetics and Hyperbilirubinemia
Data from Sorafenib Is an Inhibitor of UGT1A1 but Is Metabolized by UGT1A9: Implications of Genetic Variants on Pharmacokinetics and Hyperbilirubinemia Open
Purpose: Several case reports suggest sorafenib exposure and sorafenib-induced hyperbilirubinemia may be related to a (TA)5/6/7 repeat polymorphism in UGT1A1*28 (UGT, uridine glucuronosyl transferase). We hypothesized that sorafenib inhibi…
View article: Supplementary Figure 3 from Electrocardiographic Studies of Romidepsin Demonstrate Its Safety and Identify a Potential Role for K<sub>ATP</sub> Channel
Supplementary Figure 3 from Electrocardiographic Studies of Romidepsin Demonstrate Its Safety and Identify a Potential Role for K<sub>ATP</sub> Channel Open
Supplementary Figure 3 - PDF file 62K, Changes in mean heart rate during cycles 1 when patients taking betablockers were excluded