David W. Cadotte
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View article: Early Surgery Improves Neurological, Functional, and Quality of Life Outcomes in Acute Traumatic Spinal Cord Injury: A Global Endpoint Analysis of 470 Patients from the Spine Trauma Study Group (STSG) Prospective Cohort
Early Surgery Improves Neurological, Functional, and Quality of Life Outcomes in Acute Traumatic Spinal Cord Injury: A Global Endpoint Analysis of 470 Patients from the Spine Trauma Study Group (STSG) Prospective Cohort Open
View article: Spinal cord demyelination predicts neurological deterioration in patients with mild degenerative cervical myelopathy
Spinal cord demyelination predicts neurological deterioration in patients with mild degenerative cervical myelopathy Open
Background Degenerative cervical myelopathy (DCM) is the most common form of atraumatic spinal cord injury globally. Clinical guidelines regarding surgery for patients with mild DCM and minimal symptoms remain uncertain. This study aims to…
View article: E.4 Machine learning based patient classification to predict neurological deterioration in mild Degenerative Cervical Myelopathy
E.4 Machine learning based patient classification to predict neurological deterioration in mild Degenerative Cervical Myelopathy Open
Background: Degenerative Cervical Myelopathy (DCM) is the functional derangement of the spinal cord because of compression from degenerate tissues. Typical neurological symptoms of DCM include gait imbalance and upper extremity paresthesia…
View article: P.109 Machine learning based approach to improving the prediction of neurological deterioration in mild Degenerative Cervical Myelopathy
P.109 Machine learning based approach to improving the prediction of neurological deterioration in mild Degenerative Cervical Myelopathy Open
Background: Degenerative cervical myelopathy (DCM) is the most common form of atraumatic spinal cord injury globally, yet clinical guidelines remain unclear on surgical recommendations for patients with mild forms of DCM. This is in part d…
View article: Focal compression of the cervical spinal cord alone does not indicate high risk of neurological deterioration in patients with a diagnosis of mild degenerative cervical myelopathy
Focal compression of the cervical spinal cord alone does not indicate high risk of neurological deterioration in patients with a diagnosis of mild degenerative cervical myelopathy Open
Degenerative Cervical Myelopathy (DCM) is the functional derangement of the spinal cord resulting from vertebral column spondylotic degeneration. Typical neurological symptoms of DCM include gait imbalance, hand/arm numbness, and upper ext…
View article: Preoperative expectations of patients with degenerative cervical myelopathy: an observational study from the Canadian Spine Outcomes and Research Network
Preoperative expectations of patients with degenerative cervical myelopathy: an observational study from the Canadian Spine Outcomes and Research Network Open
View article: Does Ending a Posterior Construct Proximally at C2 Versus C3 Impact Patient Reported Outcomes in Degenerative Cervical Myelopathy Patients up to 24 months After the Surgery?
Does Ending a Posterior Construct Proximally at C2 Versus C3 Impact Patient Reported Outcomes in Degenerative Cervical Myelopathy Patients up to 24 months After the Surgery? Open
Study Design Retrospective cohort study. Objective The primary objective was to evaluate the impact of the upper instrumented level (UIV) being at C2 vs C3 in posterior cervical construct on patient reported outcomes (PROs) up to 24 months…
View article: Advanced MRI scan acquisition metrics improve baseline disease severity predictions compared to traditional community MRI scan metrics
Advanced MRI scan acquisition metrics improve baseline disease severity predictions compared to traditional community MRI scan metrics Open
Degenerative Cervical Myelopathy (DCM) is the functional derangement of the spinal cord and acts as one of the most common atraumatic spinal cord injuries. Magnetic resonance imaging (MRI) are key in confirming the diagnosis of DCM in pati…
View article: Spinal Cord Signal Change on Magnetic Resonance Imaging May Predict Worse Clinical In- and Outpatient Outcomes in Patients with Spinal Cord Injury: A Prospective Multicenter Study in 459 Patients
Spinal Cord Signal Change on Magnetic Resonance Imaging May Predict Worse Clinical In- and Outpatient Outcomes in Patients with Spinal Cord Injury: A Prospective Multicenter Study in 459 Patients Open
Prognostic factors for clinical outcome after spinal cord (SC) injury (SCI) are limited but important in patient management and education. There is a lack of evidence regarding magnetic resonance imaging (MRI) and clinical outcomes in SCI …
View article: Delivering Precision Medicine to Patients with Spinal Cord Disorders; Insights into Applications of Bioinformatics and Machine Learning from Studies of Degenerative Cervical Myelopathy
Delivering Precision Medicine to Patients with Spinal Cord Disorders; Insights into Applications of Bioinformatics and Machine Learning from Studies of Degenerative Cervical Myelopathy Open
With the common adoption of electronic health records and new technologies capable of producing an unprecedented scale of data, a shift must occur in how we practice medicine in order to utilize these resources. We are entering an era in w…
View article: Machine Learning - Algorithms, Models and Applications
Machine Learning - Algorithms, Models and Applications Open
Recent times are witnessing rapid development in machine learning algorithm\nsystems, especially in reinforcement learning, natural language processing,\ncomputer and robot vision, image processing, speech, and emotional processing\nand un…
View article: Spinal Cord Morphology in Degenerative Cervical Myelopathy Patients; Assessing Key Morphological Characteristics Using Machine Vision Tools
Spinal Cord Morphology in Degenerative Cervical Myelopathy Patients; Assessing Key Morphological Characteristics Using Machine Vision Tools Open
Despite Degenerative Cervical Myelopathy (DCM) being the most common form of spinal cord injury, effective methods to evaluate patients for its presence and severity are only starting to appear. Evaluation of patient images, while fast, is…
View article: Factors Associated With Return to Work After Surgery for Degenerative Cervical Spondylotic Myelopathy: Cohort Analysis From the Canadian Spine Outcomes and Research Network
Factors Associated With Return to Work After Surgery for Degenerative Cervical Spondylotic Myelopathy: Cohort Analysis From the Canadian Spine Outcomes and Research Network Open
Study design: Retrosepctive analysis of prospectively collected data from the multicentre Canadian Surgical Spine Registry (CSORN). Objective: Degenerative cervical myelopathy (DCM) is the most common cause of spinal cord dysfunction in No…
View article: Clinical predictors of achieving the minimal clinically important difference after surgery for cervical spondylotic myelopathy: an external validation study from the Canadian Spine Outcomes and Research Network
Clinical predictors of achieving the minimal clinically important difference after surgery for cervical spondylotic myelopathy: an external validation study from the Canadian Spine Outcomes and Research Network Open
OBJECTIVE Recently identified prognostic variables among patients undergoing surgery for cervical spondylotic myelopathy (CSM) are limited to two large international data sets. To optimally inform shared clinical decision-making, the autho…
View article: A Comparison of Patient and Surgeon Expectations of Spine Surgical Outcomes
A Comparison of Patient and Surgeon Expectations of Spine Surgical Outcomes Open
Study Design: Ambispective cohort study. Objective: Limited data exists comparing surgeon and patient expectations of outcome following spine surgery. The objective of this study was to elicit whether any differences exist between patient …
View article: CJN volume 46 issue 4 Cover and Front matter
CJN volume 46 issue 4 Cover and Front matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: Consultation and Surgical Wait Times in Cervical Spondylotic Myelopathy
Consultation and Surgical Wait Times in Cervical Spondylotic Myelopathy Open
Background: Cervical spondylotic myelopathy (CSM) is the leading cause of spinal cord impairment. In a public healthcare system, wait times to see spine specialists and eventually access surgical treatment for CSM can be substantial. The g…
View article: High Speed, High Density Intraoperative 3D Optical Topographical Imaging with Efficient Registration to MRI and CT for Craniospinal Surgical Navigation
High Speed, High Density Intraoperative 3D Optical Topographical Imaging with Efficient Registration to MRI and CT for Craniospinal Surgical Navigation Open
View article: Correction: Monitoring for myelopathic progression with multiparametric quantitative MRI
Correction: Monitoring for myelopathic progression with multiparametric quantitative MRI Open
[This corrects the article DOI: 10.1371/journal.pone.0195733.].
View article: Monitoring for myelopathic progression with multiparametric quantitative MRI
Monitoring for myelopathic progression with multiparametric quantitative MRI Open
Quantitative MRI shows high sensitivity to detect myelopathic progression. Our results suggest that neuroplasticity and behavioural adaptation may mask progressive SC tissue injury. qMRI appears to be a useful method to confirm subtle myel…
View article: Can microstructural MRI detect subclinical tissue injury in subjects with asymptomatic cervical spinal cord compression? A prospective cohort study
Can microstructural MRI detect subclinical tissue injury in subjects with asymptomatic cervical spinal cord compression? A prospective cohort study Open
Objectives Degenerative cervical myelopathy (DCM) involves extrinsic spinal cord compression causing tissue injury and neurological dysfunction. Asymptomatic spinal cord compression (ASCC) is more common, but its significance is poorly def…
View article: Corrigendum to “Generating level-dependent models of cervical and thoracic spinal cord injury: Exploring the interplay of neuroanatomy, physiology, and function” Neurobiology of Disease 105 (2017) 194–212
Corrigendum to “Generating level-dependent models of cervical and thoracic spinal cord injury: Exploring the interplay of neuroanatomy, physiology, and function” Neurobiology of Disease 105 (2017) 194–212 Open
View article: Generating level-dependent models of cervical and thoracic spinal cord injury: Exploring the interplay of neuroanatomy, physiology, and function
Generating level-dependent models of cervical and thoracic spinal cord injury: Exploring the interplay of neuroanatomy, physiology, and function Open
View article: Clinically Feasible Microstructural MRI to Quantify Cervical Spinal Cord Tissue Injury Using DTI, MT, and T2*-Weighted Imaging: Assessment of Normative Data and Reliability
Clinically Feasible Microstructural MRI to Quantify Cervical Spinal Cord Tissue Injury Using DTI, MT, and T2*-Weighted Imaging: Assessment of Normative Data and Reliability Open
Reliable multiparametric assessment of spinal cord microstructure is possible by using clinically suitable methods. These results establish normalization procedures and pave the way for clinical studies, with the potential for improving di…
View article: A Novel MRI Biomarker of Spinal Cord White Matter Injury: T2*-Weighted White Matter to Gray Matter Signal Intensity Ratio
A Novel MRI Biomarker of Spinal Cord White Matter Injury: T2*-Weighted White Matter to Gray Matter Signal Intensity Ratio Open
T2*WI WM/GM shows promise as a novel biomarker of WM injury. It detects damage in compressed and uncompressed regions and contributes substantially to multivariate models for diagnosis and correlation with impairment. Our multiparametric a…
View article: Building surgical capacity through the implementation of an online neurosurgical curriculum in Preah-Kossamak Hospital in Cambodia
Building surgical capacity through the implementation of an online neurosurgical curriculum in Preah-Kossamak Hospital in Cambodia Open
Welcome to Annals of Global Health,Annals of Global Health is a peer-reviewed, fully open access, online journal dedicated to publishing high quality articles dedicated to all aspects of global health. The journal's mission is to advance g…
View article: Translating state-of-the-art spinal cord MRI techniques to clinical use: A systematic review of clinical studies utilizing DTI, MT, MWF, MRS, and fMRI
Translating state-of-the-art spinal cord MRI techniques to clinical use: A systematic review of clinical studies utilizing DTI, MT, MWF, MRS, and fMRI Open
State-of-the-art spinal cord MRI techniques are emerging with great potential to improve the diagnosis and management of various spinal pathologies, but the current body of evidence has only showed limited clinical utility to date. Among t…
View article: Longitudinal and hierarchical organization of the FAIRNESS framework.
Longitudinal and hierarchical organization of the FAIRNESS framework. Open
The FAIRNESS framework encompasses indicators that are increasingly acquired through rigorous data collection as well as with longer follow-up intervals.
View article: Spinal Cord Segmentation by One Dimensional Normalized Template Matching: A Novel, Quantitative Technique to Analyze Advanced Magnetic Resonance Imaging Data
Spinal Cord Segmentation by One Dimensional Normalized Template Matching: A Novel, Quantitative Technique to Analyze Advanced Magnetic Resonance Imaging Data Open
Spinal cord segmentation is a developing area of research intended to aid the processing and interpretation of advanced magnetic resonance imaging (MRI). For example, high resolution three-dimensional volumes can be segmented to provide a …
View article: Complications from the use of intrawound vancomycin in lumbar spinal surgery: a systematic review
Complications from the use of intrawound vancomycin in lumbar spinal surgery: a systematic review Open
OBJECT The use of intrawound vancomycin is rapidly being adopted for the prevention of surgical site infection (SSI) in spinal surgery. At operative closure, the placement of vancomycin powder in the wound bed—in addition to standard infec…