David W. Hutton
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View article: Physician Preferences for Universal Routine Depression Screening for Adolescents in Primary Care
Physician Preferences for Universal Routine Depression Screening for Adolescents in Primary Care Open
Importance Universal adolescent depression screening is recommended as routine primary care, but it is unclear how best to implement it. Systematic evaluation of physician preferences can support optimal screening implementation. Objective…
View article: Investing in Interventions to Prevent Opioid Use Disorder in Adolescents and Young Adults: Start-up Costs from NIDA’s HEAL Prevention Initiative
Investing in Interventions to Prevent Opioid Use Disorder in Adolescents and Young Adults: Start-up Costs from NIDA’s HEAL Prevention Initiative Open
View article: Use of Clesrovimab for Prevention of Severe Respiratory Syncytial Virus–Associated Lower Respiratory Tract Infections in Infants: Recommendations of the Advisory Committee on Immunization Practices — United States, 2025
Use of Clesrovimab for Prevention of Severe Respiratory Syncytial Virus–Associated Lower Respiratory Tract Infections in Infants: Recommendations of the Advisory Committee on Immunization Practices — United States, 2025 Open
Before the introduction of universal respiratory syncytial virus (RSV) immunization recommendations for infants, RSV was the leading cause of hospitalization among infants in the United States. Since 2023, CDC's Advisory Committee on Immun…
View article: Cost-Effectiveness of 2023-2024 COVID-19 Vaccination in US Adults
Cost-Effectiveness of 2023-2024 COVID-19 Vaccination in US Adults Open
Importance Evidence is needed on the economic favorability of a 2023-2024 COVID-19 vaccination program to support policy decisions on recommendations for COVID-19 vaccination. Objective To measure the cost-effectiveness of vaccination with…
View article: Understanding risk and protective factors associated with opioid misuse among at-risk adolescents and young adults in the emergency department
Understanding risk and protective factors associated with opioid misuse among at-risk adolescents and young adults in the emergency department Open
View article: Cost effectiveness of mosunetuzumab and CAR-T cell therapy in relapsed/refractory follicular lymphoma
Cost effectiveness of mosunetuzumab and CAR-T cell therapy in relapsed/refractory follicular lymphoma Open
T cell redirecting therapies, including mosunetuzumab (mosun), axicabtagene ciloleucel (axi-cel), and tisagenlecleucel (tisa-cel), are FDA-approved for relapsed refractory follicular lymphoma (FL) in the 3rd line and beyond. There's no hea…
View article: Cost-Effectiveness of Universal Routine Depression Screening for Adolescents in Primary Care
Cost-Effectiveness of Universal Routine Depression Screening for Adolescents in Primary Care Open
Importance Approximately one-fifth of adolescents in the US experience a major depressive episode each year. Universal depression screening for adolescents is recommended as part of routine pediatric primary care, but its cost-effectivenes…
View article: Cost-Effectiveness of One-time Universal Testing for Hepatitis D Among Adults With Chronic Hepatitis B in the United States
Cost-Effectiveness of One-time Universal Testing for Hepatitis D Among Adults With Chronic Hepatitis B in the United States Open
Background Chronic hepatitis D virus (HDV) infection increases the risk of liver-related deaths in adults with chronic hepatitis B (CHB). In the United States (US), only an estimated 12.9% of adults with CHB have received an HDV antibody t…
View article: Correction: Best-worst scaling preferences among patients with well-controlled epilepsy: Pilot results
Correction: Best-worst scaling preferences among patients with well-controlled epilepsy: Pilot results Open
[This corrects the article DOI: 10.1371/journal.pone.0282658.].
View article: Cost-effectiveness of novel diagnostic tools for idiopathic pulmonary fibrosis in the United States
Cost-effectiveness of novel diagnostic tools for idiopathic pulmonary fibrosis in the United States Open
View article: The Cancer Tracking System (CATSystem): Study protocol of a randomized control trial to evaluate a systems level intervention for cervical cancer screening, treatment, referral and follow up in Kenya
The Cancer Tracking System (CATSystem): Study protocol of a randomized control trial to evaluate a systems level intervention for cervical cancer screening, treatment, referral and follow up in Kenya Open
Background Cervical cancer (CC) is preventable, yet remains a significant public health threat, particularly in Sub-Saharan Africa. Despite considerable awareness, screening rates for CC in Kenya are low and loss to follow-up following tre…
View article: Cost-effectiveness of monitoring and liver cancer surveillance among patients with inactive chronic hepatitis B
Cost-effectiveness of monitoring and liver cancer surveillance among patients with inactive chronic hepatitis B Open
Patients with chronic hepatitis B infection (CHB) have an increased risk for death from liver cirrhosis and hepatocellular carcinoma (HCC). In the United States, only an estimated 37% of adults with chronic hepatitis B diagnosis without ci…
View article: Cost-effectiveness of vaccinating adults aged 60 years and older against respiratory syncytial virus
Cost-effectiveness of vaccinating adults aged 60 years and older against respiratory syncytial virus Open
View article: Correction: The Effect of an mHealth Self-Monitoring Intervention (MI-BP) on Blood Pressure Among Black Individuals With Uncontrolled Hypertension: Randomized Controlled Trial
Correction: The Effect of an mHealth Self-Monitoring Intervention (MI-BP) on Blood Pressure Among Black Individuals With Uncontrolled Hypertension: Randomized Controlled Trial Open
[This corrects the article DOI: 10.2196/57863.].
View article: Use of Respiratory Syncytial Virus Vaccines in Adults Aged ≥60 Years: Updated Recommendations of the Advisory Committee on Immunization Practices — United States, 2024
Use of Respiratory Syncytial Virus Vaccines in Adults Aged ≥60 Years: Updated Recommendations of the Advisory Committee on Immunization Practices — United States, 2024 Open
Respiratory syncytial virus (RSV) is a major cause of respiratory illness and hospitalization in older adults during fall and winter in the United States. The 2023-2024 RSV season was the first during which RSV vaccination was recommended …
View article: Modelling the potential impact of global hepatitis B vaccination on the burden of chronic hepatitis B in the United States
Modelling the potential impact of global hepatitis B vaccination on the burden of chronic hepatitis B in the United States Open
About 80% of persons with chronic hepatitis B virus (HBV) infection in the United States are non‐US‐born. Despite improvements in infant hepatitis B vaccination globally since 2000, work remains to attain the World Health Organization's (W…
View article: The Effect of an mHealth Self-Monitoring Intervention (MI-BP) on Blood Pressure Among Black Individuals With Uncontrolled Hypertension: Randomized Controlled Trial
The Effect of an mHealth Self-Monitoring Intervention (MI-BP) on Blood Pressure Among Black Individuals With Uncontrolled Hypertension: Randomized Controlled Trial Open
Background Hypertension is one of the most important cardiovascular disease risk factors and affects >100 million American adults. Hypertension-related health inequities are abundant in Black communities as Black individuals are more likel…
View article: The Effect of an mHealth Self-Monitoring Intervention (MI-BP) on Blood Pressure Among Black Individuals With Uncontrolled Hypertension: Randomized Controlled Trial (Preprint)
The Effect of an mHealth Self-Monitoring Intervention (MI-BP) on Blood Pressure Among Black Individuals With Uncontrolled Hypertension: Randomized Controlled Trial (Preprint) Open
BACKGROUND Hypertension is one of the most important cardiovascular disease risk factors and affects >100 million American adults. Hypertension-related health inequities are abundant in Black communities as Black individuals are more l…
View article: Working under short timescales to deliver a national trial: a case study of the ComFluCOV trial from a statistician’s perspective
Working under short timescales to deliver a national trial: a case study of the ComFluCOV trial from a statistician’s perspective Open
Background In early 2021, the Department of Health and Social Care in the UK called for research on the safety and immunogenicity of concomitant administration of COVID-19 and influenza vaccines. Co-administration of these vaccines would f…
View article: Delivering COVID-19 vaccine trials at speed: the implementation of a phase IV UK multi-centre randomised controlled trial to determine safety and immunogenicity of COVID-19 vaccines co-administered with seasonal influenza vaccines (ComFluCOV)
Delivering COVID-19 vaccine trials at speed: the implementation of a phase IV UK multi-centre randomised controlled trial to determine safety and immunogenicity of COVID-19 vaccines co-administered with seasonal influenza vaccines (ComFluCOV) Open
Background In February 2021, the UK Department of Health and Social Care sought evidence on the safety and immunogenicity of COVID-19 and influenza vaccine co-administration to inform the 2021/2022 influenza vaccine policy. Co-administrati…
View article: Cost-Effectiveness of Vaccinating Adults Aged 60 Years and Older Against Respiratory Syncytial Virus
Cost-Effectiveness of Vaccinating Adults Aged 60 Years and Older Against Respiratory Syncytial Virus Open
View article: A mixed methods partner-focused cost and budget impact analysis to deploy implementation strategies for school-based prevention
A mixed methods partner-focused cost and budget impact analysis to deploy implementation strategies for school-based prevention Open
Background Obtaining information on implementation strategy costs and local budget impacts from multiple perspectives is essential to data-driven decision-making about resource allocation for successful evidence-based intervention delivery…
View article: Preferences and experiences of pediatricians on implementing national guidelines on universal routine screening of adolescents for major depressive disorder: A qualitative study
Preferences and experiences of pediatricians on implementing national guidelines on universal routine screening of adolescents for major depressive disorder: A qualitative study Open
To promote the uptake of universal routine screening of adolescent major depression, pediatricians expressed it was important to address key implementation factors regarding the screening modality, screening validity, time constraints, and…
View article: Cost-effectiveness of surgical treatment of thumb carpometacarpal joint arthritis: a value of information study
Cost-effectiveness of surgical treatment of thumb carpometacarpal joint arthritis: a value of information study Open
Background Thumb carpometacarpal (CMC) joint arthritis is one of the most prevalent arthritic conditions commonly treated with trapeziectomy alone or trapeziectomy with ligament reconstruction and tendon interposition (LRTI). We evaluate t…
View article: Gaps in Prenatal Hepatitis B Screening and Management of HBsAg Positive Pregnant Persons in the U.S., 2015–2020
Gaps in Prenatal Hepatitis B Screening and Management of HBsAg Positive Pregnant Persons in the U.S., 2015–2020 Open
View article: Best-worst scaling preferences among patients with well-controlled epilepsy: Pilot results
Best-worst scaling preferences among patients with well-controlled epilepsy: Pilot results Open
Epilepsy is a common, serious condition. Fortunately, seizure risk decreases with increasing seizure-free time on antiseizure medications (ASMs). Eventually, patients may consider whether to stop ASMs, which requires weighing treatment ben…
View article: The burden of Chronic Pelvic Pain (CPP): Costs and quality of life of women and men with CPP treated in outpatient referral centers
The burden of Chronic Pelvic Pain (CPP): Costs and quality of life of women and men with CPP treated in outpatient referral centers Open
Introduction Chronic Pelvic Pain (CPP) is a complex, multifaceted condition that affects both women and men. There is limited literature on the cost utilization the healthcare system and CPP patients incur. The purpose of this analysis is …
View article: Gaps and Disparities in Chronic Hepatitis B Monitoring and Treatment in the United States, 2016-2019
Gaps and Disparities in Chronic Hepatitis B Monitoring and Treatment in the United States, 2016-2019 Open
Background: Chronic hepatitis B (CHB) carries an increased risk of death from cirrhosis and hepatocellular carcinoma (HCC). The American Association for the Study of Liver Diseases recommends patients with CHB receive monitoring of disease…
View article: Cost-effectiveness of Aflibercept Monotherapy vs Bevacizumab First Followed by Aflibercept If Needed for Diabetic Macular Edema
Cost-effectiveness of Aflibercept Monotherapy vs Bevacizumab First Followed by Aflibercept If Needed for Diabetic Macular Edema Open
Importance The DRCR Retina Network Protocol AC showed no significant difference in visual acuity outcomes over 2 years between treatment with aflibercept monotherapy and bevacizumab first with switching to aflibercept for suboptimal respon…
View article: Impact of the national hepatitis B immunization program in China: a modeling study
Impact of the national hepatitis B immunization program in China: a modeling study Open