David W. Raible
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View article: Multiple mechanisms of aminoglycoside ototoxicity are distinguished by subcellular localization of action
Multiple mechanisms of aminoglycoside ototoxicity are distinguished by subcellular localization of action Open
Mechanosensory hair cells of the inner ears and lateral line of vertebrates display heightened vulnerability to environmental insult, with damage resulting in hearing and balance disorders. An important example is hair cell loss due to exp…
View article: eLife assessment: Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish
eLife assessment: Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish Open
View article: Transdifferentiation is temporally uncoupled from progenitor pool expansion during hair cell regeneration in the zebrafish inner ear
Transdifferentiation is temporally uncoupled from progenitor pool expansion during hair cell regeneration in the zebrafish inner ear Open
Death of mechanosensory hair cells in the inner ear is a common cause of auditory and vestibular impairment in mammals, which have a limited ability to regrow these cells after damage. In contrast, non-mammalian vertebrates, including zebr…
View article: Multiple mechanisms of aminoglycoside ototoxicity are distinguished by subcellular localization of action
Multiple mechanisms of aminoglycoside ototoxicity are distinguished by subcellular localization of action Open
Mechanosensory hair cells of the inner ears and lateral line of vertebrates display heightened vulnerability to environmental insult, with damage resulting in hearing and balance disorders. An important example is hair cell loss due to exp…
View article: eLife Assessment: Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish
eLife Assessment: Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish Open
In a developing nervous system, axonal arbors often undergo complex rearrangements before neural circuits attain their final innervation topology. In the lateral line sensory system of the zebrafish, developing sensory axons reorganize the…
View article: Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain
Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain Open
Neurons on the left and right sides of the nervous system often show asymmetric properties, but how such differences arise is poorly understood. Genetic screening in zebrafish revealed that loss of function of the transmembrane protein Cac…
View article: Decision letter: Atoh1 is required for the formation of lateral line electroreceptors and hair cells, whereas FoxG1 represses an electrosensory fate
Decision letter: Atoh1 is required for the formation of lateral line electroreceptors and hair cells, whereas FoxG1 represses an electrosensory fate Open
View article: Transdifferentiation is uncoupled from progenitor pool expansion during hair cell regeneration in the zebrafish inner ear
Transdifferentiation is uncoupled from progenitor pool expansion during hair cell regeneration in the zebrafish inner ear Open
Death of mechanosensory hair cells in the inner ear is a common cause of auditory and vestibular impairment in mammals, which have a limited ability to regrow these cells after damage. In contrast, non-mammalian vertebrates including zebra…
View article: eLife Assessment: Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish
eLife Assessment: Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish Open
In a developing nervous system, axonal arbors often undergo complex rearrangements before neural circuits attain their final innervation topology. In the lateral line sensory system of the zebrafish, developing sensory axons reorganize the…
View article: In vivo screening for toxicity-modulating drug interactions identifies antagonism that protects against ototoxicity in zebrafish
In vivo screening for toxicity-modulating drug interactions identifies antagonism that protects against ototoxicity in zebrafish Open
Introduction: Ototoxicity is a debilitating side effect of over 150 medications with diverse mechanisms of action, many of which could be taken concurrently to treat multiple conditions. Approaches for preclinical evaluation of drug-drug i…
View article: Correction: Spherical harmonics analysis reveals cell shape-fate relationships in zebrafish lateral line neuromasts
Correction: Spherical harmonics analysis reveals cell shape-fate relationships in zebrafish lateral line neuromasts Open
There was an error in Development (2024) 151, dev202251 (doi:10.1242/dev.202251).Tor H. Linbo was not included in the author list. The correct author list appears above.The Author contributions list has also been corrected.Corrected:Concep…
View article: Spherical harmonics analysis reveals cell shape-fate relationships in zebrafish lateral line neuromasts
Spherical harmonics analysis reveals cell shape-fate relationships in zebrafish lateral line neuromasts Open
Cell shape is a powerful readout of cell state, fate and function. We describe a custom workflow to perform semi-automated, 3D cell and nucleus segmentation, and spherical harmonics and principal components analysis to distill cell and nuc…
View article: Embryo-scale reverse genetics at single-cell resolution
Embryo-scale reverse genetics at single-cell resolution Open
The maturation of single-cell transcriptomic technologies has facilitated the generation of comprehensive cellular atlases from whole embryos 1–4 . A majority of these data, however, has been collected from wild-type embryos without an app…
View article: Differential expression of mechanotransduction complex genes in auditory/vestibular hair cells in zebrafish
Differential expression of mechanotransduction complex genes in auditory/vestibular hair cells in zebrafish Open
Ciliated sensory cells such as photo- and olfactory receptors employ multiple types of opsins or hundreds of unique olfactory G-protein coupled receptors to respond to various wavelengths of light or odorants. With respect to hearing and b…
View article: <i>In vivo</i>screening for toxicity-modulating drug interactions identifies antagonism that protects against ototoxicity in zebrafish
<i>In vivo</i>screening for toxicity-modulating drug interactions identifies antagonism that protects against ototoxicity in zebrafish Open
Ototoxicity is a debilitating side effect of over 150 medications with diverse mechanisms of action, many of which could be taken concurrently to treat multiple conditions. Approaches for preclinical evaluation of drug interactions that mi…
View article: Proteostasis governs differential temperature sensitivity across embryonic cell types
Proteostasis governs differential temperature sensitivity across embryonic cell types Open
View article: eLife assessment: Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish
eLife assessment: Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish Open
In a developing nervous system, axonal arbors often undergo complex rearrangements before neural circuits attain their final innervation topology. In the lateral line sensory system of the zebrafish, developing sensory axons reorganize the…
View article: Data-Driven 3D Shape Analysis Reveals Cell Shape-Fate Relationships in Zebrafish Lateral Line Neuromasts
Data-Driven 3D Shape Analysis Reveals Cell Shape-Fate Relationships in Zebrafish Lateral Line Neuromasts Open
Cell shape is a powerful readout of cell state, fate, and function. With the advent of sophisticated microscopes, image segmentation algorithms, and numerical shape representations, it is becoming more feasible to study cell shape in devel…
View article: Vestibular physiology and function in zebrafish
Vestibular physiology and function in zebrafish Open
The vestibular system of the inner ear provides information about head motion and spatial orientation relative to gravity to ensure gaze stability, balance, and postural control. Zebrafish, like humans, have five sensory patches per ear th…
View article: Activity regulates a cell type-specific mitochondrial phenotype in zebrafish lateral line hair cells
Activity regulates a cell type-specific mitochondrial phenotype in zebrafish lateral line hair cells Open
Hair cells of the inner ear are particularly sensitive to changes in mitochondria, the subcellular organelles necessary for energy production in all eukaryotic cells. There are over 30 mitochondrial deafness genes, and mitochondria are imp…
View article: Author response: Activity regulates a cell type-specific mitochondrial phenotype in zebrafish lateral line hair cells
Author response: Activity regulates a cell type-specific mitochondrial phenotype in zebrafish lateral line hair cells Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Hair cell…
View article: Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells
Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells Open
Touch system function requires precise interactions between specialized skin cells and somatosensory axons, as exemplified by the vertebrate mechanosensory Merkel cell-neurite complex. Development and patterning of Merkel cells and associa…
View article: Author response: Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells
Author response: Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells Open
View article: Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes
Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes Open
A major cause of human deafness and vestibular dysfunction is permanent loss of the mechanosensory hair cells of the inner ear. In non-mammalian vertebrates such as zebrafish, regeneration of missing hair cells can occur throughout life. W…
View article: Author response: Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes
Author response: Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes Open
View article: Single-Cell Transcriptomic Profiling of the Zebrafish Inner Ear Reveals Molecularly Distinct Hair Cell and Supporting Cell Subtypes
Single-Cell Transcriptomic Profiling of the Zebrafish Inner Ear Reveals Molecularly Distinct Hair Cell and Supporting Cell Subtypes Open
A major cause of human deafness and vestibular dysfunction is permanent loss of the mechanosensory hair cells of the inner ear. In non-mammalian vertebrates such as zebrafish, regeneration of missing hair cells can occur throughout life. W…
View article: Decision letter: Kiaa1024L/Minar2 is essential for hearing by regulating cholesterol distribution in hair bundles
Decision letter: Kiaa1024L/Minar2 is essential for hearing by regulating cholesterol distribution in hair bundles Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstrac…
View article: Dermal appendage-dependent patterning of zebrafish <i>atoh1a+</i> Merkel cells
Dermal appendage-dependent patterning of zebrafish <i>atoh1a+</i> Merkel cells Open
Touch system function requires precise interactions between specialized skin cells and somatosensory axons, as exemplified by the vertebrate mechanosensory Merkel cell-neurite complex. Development and patterning of Merkel cells and associa…
View article: Deep molecular, cellular and temporal phenotyping of developmental perturbations at whole organism scale
Deep molecular, cellular and temporal phenotyping of developmental perturbations at whole organism scale Open
The maturation of single cell transcriptomic technologies has facilitated the generation of comprehensive cellular atlases from whole embryos. A majority of this data, however, has been collected from wild type embryos without an appreciat…
View article: Proteostasis governs differential temperature sensitivity across embryonic cell types
Proteostasis governs differential temperature sensitivity across embryonic cell types Open
The genetic program of embryonic development is remarkably robust, but temperature stress can degrade its ability to generate animals with invariant anatomy. While the stereotyped, consistent phenotypes associated with environmental stress…