David T. Jones
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View article: Unsupervised machine learning identifies clinically relevant patterns of CSF dynamic dysfunction in normal pressure hydrocephalus
Unsupervised machine learning identifies clinically relevant patterns of CSF dynamic dysfunction in normal pressure hydrocephalus Open
NMF-generated patterns of CSF distribution showed high accuracy in discerning individuals with iNPH from controls. The patterns most relying on DESH features showed highest potential for independently predicting NPH diagnosis. The algorith…
View article: Who Makes It Through the Funnel? Sociodemographic Drivers of Recruitment Completion into an AI-Ready Digital Speech Bank (Preprint)
Who Makes It Through the Funnel? Sociodemographic Drivers of Recruitment Completion into an AI-Ready Digital Speech Bank (Preprint) Open
BACKGROUND Digital recruitment methods offer promising opportunities to address persistent challenges in clinical research participation, particularly in specialized fields like neurology. However, the impact of digital approaches across …
View article: Who Makes It Through the Funnel? Sociodemographic Drivers of Recruitment Completion into an AI-Ready Digital Speech Bank
Who Makes It Through the Funnel? Sociodemographic Drivers of Recruitment Completion into an AI-Ready Digital Speech Bank Open
Background Digital recruitment methods offer promising opportunities to address persistent challenges in clinical research participation, particularly in specialized fields like neurology. However, the impact of digital approaches across d…
View article: Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia
Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia Open
We explore neurodevelopmental heterogeneity in Autism Spectrum Disorder (ASD) through normative modeling of cross-cultural cohorts. By leveraging large-scale datasets from Autism Brain Imaging Data Exchange (ABIDE) and China Autism Brain I…
View article: Author Correction: Cortical microstructural abnormalities in dementia with Lewy bodies and their associations with Alzheimer’s disease copathologies
Author Correction: Cortical microstructural abnormalities in dementia with Lewy bodies and their associations with Alzheimer’s disease copathologies Open
View article: Population-based spectral characteristics of normal interictal scalp EEG inform diagnosis and treatment planning in focal epilepsy
Population-based spectral characteristics of normal interictal scalp EEG inform diagnosis and treatment planning in focal epilepsy Open
View article: Discrepancies between CSF biomarker and PET determinations of elevated brain amyloid and their prognostic significance
Discrepancies between CSF biomarker and PET determinations of elevated brain amyloid and their prognostic significance Open
INTRODUCTION When cerebrospinal fluid (CSF) and positron emission tomography (PET) measurements for amyloid‐beta‐peptide (Aβ) related pathology are discordant, therapeutic decision‐making becomes uncertain. METHODS Using data from patients…
View article: Brain-derived extracellular vesicle microRNAs in Lewy body and Alzheimer’s disease
Brain-derived extracellular vesicle microRNAs in Lewy body and Alzheimer’s disease Open
INTRODUCTION Robust plasma-based biomarkers to distinguish Lewy body disease (LBD) and Alzheimer’s disease (AD) are currently lacking. We applied track-etch magnetic nanopore (TENPO) sorting for enrichment of brain-derived extracellular ve…
View article: Cortical microstructural abnormalities in dementia with Lewy bodies and their associations with Alzheimer’s disease copathologies
Cortical microstructural abnormalities in dementia with Lewy bodies and their associations with Alzheimer’s disease copathologies Open
Dementia with Lewy bodies (DLB) frequently coexists with Alzheimer's disease pathology, yet the pattern of cortical microstructural injury and its relationship with amyloid, tau, and cerebrovascular pathologies remains unclear. We applied …
View article: Genes that cause severe liver disease in children also influence risk and severity of common liver conditions in adults
Genes that cause severe liver disease in children also influence risk and severity of common liver conditions in adults Open
Background and aims Rare, pathogenic variants in multiple genes can cause severe liver disease, requiring transplantation in childhood, but it is unclear whether common variants in the same genes confer risk of liver disease in adults. Her…
View article: Spatially convergent fMRI signatures of diabetes and male sex identify genetic vulnerabilities to accelerated brain aging
Spatially convergent fMRI signatures of diabetes and male sex identify genetic vulnerabilities to accelerated brain aging Open
Age-related cognitive decline results from complex interactions between neuroendocrine and neurometabolic processes that undergo lifelong degredation, yet the mechanisms underlying these interactions remain poorly understood. This study ex…
View article: Longitudinal Evolution of Posterior Cortical Atrophy
Longitudinal Evolution of Posterior Cortical Atrophy Open
This study highlights the protracted time from symptom onset and frequent misdiagnoses/misattribution of symptoms in PCA. Ophthalmologic evaluations often preceded neurologic assessments. Psychiatric diagnoses were more frequent among youn…
View article: High resolution autoradiography of [18F]MK-6240 and [18F]Flortaucipir shows similar neurofibrillary tangle binding patterns preferentially recognizing middling neurofibrillary tangle maturity
High resolution autoradiography of [18F]MK-6240 and [18F]Flortaucipir shows similar neurofibrillary tangle binding patterns preferentially recognizing middling neurofibrillary tangle maturity Open
View article: Accelerating Biomedical Discoveries in Aging and Neurodegeneration Through Transformative Neuropathology
Accelerating Biomedical Discoveries in Aging and Neurodegeneration Through Transformative Neuropathology Open
Transformative neuropathology is redefining human brain research by integrating foundational descriptive pathology with advanced methodologies to drive discoveries that inform diagnostics, therapeutics, and disease prevention. These approa…
View article: Brain aging shows nonlinear transitions, suggesting a midlife “critical window” for metabolic intervention
Brain aging shows nonlinear transitions, suggesting a midlife “critical window” for metabolic intervention Open
Understanding the key drivers of brain aging is essential for effective prevention and treatment of neurodegenerative diseases. Here, we integrate human brain and physiological data to investigate underlying mechanisms. Functional MRI anal…
View article: Multiple Neuropathologies Underly Hippocampal Subfield Atrophy in a Case With a Slowly Progressive Amnestic Syndrome: Challenging the Notion of Pure <scp>LATE</scp>‐<scp>NC</scp>
Multiple Neuropathologies Underly Hippocampal Subfield Atrophy in a Case With a Slowly Progressive Amnestic Syndrome: Challenging the Notion of Pure <span>LATE</span>‐<span>NC</span> Open
Alzheimer's disease (AD) is the leading cause of dementia in the elderly, marked by abnormal protein buildup (beta‐amyloid and tau) resulting in neuronal loss, especially in the medial temporal lobe and other limbic regions. The presence o…
View article: Characterizing and validating 12-month reliable cognitive change in Early-Onset Alzheimer's Disease for use in clinical trials
Characterizing and validating 12-month reliable cognitive change in Early-Onset Alzheimer's Disease for use in clinical trials Open
View article: Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer’s disease: a neuropsychological data-driven approach
Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer’s disease: a neuropsychological data-driven approach Open
A neuropsychological data-driven method to phenotype EOAD individuals uncovered a more detailed understanding of the presenting heterogeneity in this atypical AD sample compared to clinical judgment alone. Clinicians and patients may over-…
View article: Dissociable spatial topography of cortical atrophy in early‐onset and late‐onset Alzheimer's disease: A head‐to‐head comparison of the LEADS and ADNI cohorts
Dissociable spatial topography of cortical atrophy in early‐onset and late‐onset Alzheimer's disease: A head‐to‐head comparison of the LEADS and ADNI cohorts Open
INTRODUCTION Early‐onset and late‐onset Alzheimer's disease (EOAD and LOAD, respectively) have distinct clinical manifestations, with prior work based on small samples suggesting unique patterns of neurodegeneration. The current study perf…
View article: Artificial intelligence models using F-wave responses predict amyotrophic lateral sclerosis
Artificial intelligence models using F-wave responses predict amyotrophic lateral sclerosis Open
Nerve conduction F-wave studies contain crucial information about subclinical motor dysfunction that can be used to diagnose patients with amyotrophic lateral sclerosis (ALS). However, F-wave responses are highly variable in morphology, ma…
View article: The Value of Normal Interictal EEGs in Epilepsy Diagnosis and Treatment Planning: A Retrospective Cohort Study using Population-level Spectral Power and Connectivity Patterns
The Value of Normal Interictal EEGs in Epilepsy Diagnosis and Treatment Planning: A Retrospective Cohort Study using Population-level Spectral Power and Connectivity Patterns Open
Introduction Scalp electroencephalography (EEG) is a cornerstone in the diagnosis and treatment of epilepsy, but routine EEG is often interpreted as normal without identification of epileptiform activity during expert visual review. The ab…
View article: Clinical criteria for limbic‐predominant age‐related TDP‐43 encephalopathy
Clinical criteria for limbic‐predominant age‐related TDP‐43 encephalopathy Open
Limbic predominant age‐related TDP‐43 encephalopathy neuropathologic change (LATE‐NC) is highly prevalent in late life and a common co‐pathology with Alzheimer's disease neuropathologic change (ADNC). LATE‐NC is a slowly progressive, amnes…
View article: Real‐Time 2D Phase‐Contrast MRI to Assess Cardiac‐ and Respiratory‐Driven CSF Movement in Normal Pressure Hydrocephalus
Real‐Time 2D Phase‐Contrast MRI to Assess Cardiac‐ and Respiratory‐Driven CSF Movement in Normal Pressure Hydrocephalus Open
Background and Purpose In idiopathic normal pressure hydrocephalus (iNPH) patients, cerebrospinal fluid (CSF) flow is typically evaluated with a cardiac‐gated two‐dimensional (2D) phase‐contrast (PC) MRI through the cerebral aqueduct. This…
View article: Differences in baseline cognitive performance between participants with early‐onset and late‐onset Alzheimer's disease: Comparison of LEADS and ADNI
Differences in baseline cognitive performance between participants with early‐onset and late‐onset Alzheimer's disease: Comparison of LEADS and ADNI Open
INTRODUCTION Early‐onset Alzheimer's disease (EOAD) and late‐onset Alzheimer's disease (LOAD) share similar amyloid etiology, but evidence from smaller‐scale studies suggests that they manifest differently clinically. Current analyses soug…
View article: Longitudinal cognitive performance of participants with sporadic early onset Alzheimer's disease from LEADS
Longitudinal cognitive performance of participants with sporadic early onset Alzheimer's disease from LEADS Open
INTRODUCTION Early‐onset Alzheimer's disease (EOAD) manifests prior to the age of 65, and affects 4%–8% of patients with Alzheimer's disease (AD). The current analyses sought to examine longitudinal cognitive trajectories of participants w…
View article: Clinical performance of plasma P‐tau217 for the identification of primary Alzheimer’s disease pathology or co‐pathology in sporadic frontotemporal dementia
Clinical performance of plasma P‐tau217 for the identification of primary Alzheimer’s disease pathology or co‐pathology in sporadic frontotemporal dementia Open
Background As new anti‐amyloid immunotherapies emerge for Alzheimer’s disease (AD), it is clear that early diagnosis of AD pathology is crucial for treatment success. This can be challenging in atypical presentations of AD and, together wi…
View article: Amyloid Biomarker Discordance in Patients Evaluated for Anti‐Amyloid Therapy
Amyloid Biomarker Discordance in Patients Evaluated for Anti‐Amyloid Therapy Open
Background Evidence for abnormal amyloid‐β (Aβ) plaque accumulation is necessary prior to initiating anti‐amyloid therapy in early symptomatic Alzheimer’s disease (AD). While the clinical trials for lecanemab and related drugs utilized pos…
View article: Substantia nigra iron deposition in Lewy body disease: an MRI quantitative susceptibility mapping and neuropathology study
Substantia nigra iron deposition in Lewy body disease: an MRI quantitative susceptibility mapping and neuropathology study Open
Background Parkinson’s disease and dementia with Lewy bodies are characterized by abnormal iron deposition in the substantia nigra, which can be measured with quantitative susceptibility mapping (QSM) on MRI. However, neuropathologic valid…
View article: Clinical criteria for a limbic‐predominant amnestic neurodegenerative syndrome highly associated with TDP‐43 and slow clinical progression
Clinical criteria for a limbic‐predominant amnestic neurodegenerative syndrome highly associated with TDP‐43 and slow clinical progression Open
Background Limbic‐predominant age‐related TDP‐43 encephalopathy (LATE) is a neuropathologically‐defined disease, and it is frequently comorbid with Alzheimer’s disease neuropathological change (ADNC). However, the neurological syndrome ass…
View article: Tau deposition is associated with neurite abnormalities in white matter tracts and cortical grey matter regions in dementia with Lewy bodies
Tau deposition is associated with neurite abnormalities in white matter tracts and cortical grey matter regions in dementia with Lewy bodies Open
Background Dementia with Lewy bodies (DLB) frequently co‐occurs with Alzheimer’s disease (AD) pathologies, exacerbating disease progression. Biophysical models of diffusion imaging data, such as Neurite Orientation Dispersion and Density I…