David W. Victor
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View article: Developing a Fully Automated Imaging Biomarker for HCC Risk Assessment via MRI-Based Tumor Segmentation and EPM
Developing a Fully Automated Imaging Biomarker for HCC Risk Assessment via MRI-Based Tumor Segmentation and EPM Open
This study investigates the feasibility of using automated tumor segmentation as the region of interest for early detection of hepatocellular carcinoma (HCC) using magnetic resonance imaging (MRI). Enhancement Pattern Mapping (EPM) is used…
View article: Terlipressin for Hepatorenal Syndrome in Patients With Early‐Stage Acute‐on‐Chronic Liver Failure
Terlipressin for Hepatorenal Syndrome in Patients With Early‐Stage Acute‐on‐Chronic Liver Failure Open
Background & Aims Hepatorenal syndrome‐acute kidney injury (HRS‐AKI) is a life‐threatening complication of decompensated cirrhosis. The US Food and Drug Administration approved terlipressin use for HRS‐AKI based on the CONFIRM study, which…
View article: Tumor-informed circulating tumor DNA assay for surveillance post-liver transplantation in patients with hepatocellular and cholangiocarcinoma
Tumor-informed circulating tumor DNA assay for surveillance post-liver transplantation in patients with hepatocellular and cholangiocarcinoma Open
This study corroborates the feasibility of ctDNA assays for recurrence surveillance in LT recipients. The results imply that ctDNA assays show promise in confirming recurrence and minimizing the need for invasive biopsy. However, additiona…
View article: Cefepime-zidebactam therapy for extensively drug-resistant <i>Pseudomonas aeruginosa</i> and <i>Klebsiella pneumoniae</i> infection as a bridge to liver transplantation
Cefepime-zidebactam therapy for extensively drug-resistant <i>Pseudomonas aeruginosa</i> and <i>Klebsiella pneumoniae</i> infection as a bridge to liver transplantation Open
Background Infections due to antimicrobial-resistant Gram-negative organisms present increasingly difficult therapeutic challenges, especially in the presence of metallo-β-lactamases. We present the case of a patient with cholangitis due t…
View article: Long-term outcomes of light chain amyloidosis patients receiving heart transplant: A single-center experience
Long-term outcomes of light chain amyloidosis patients receiving heart transplant: A single-center experience Open
View article: Blood bacterial DNA signatures in a prospective cohort of patients with MASLD cirrhosis
Blood bacterial DNA signatures in a prospective cohort of patients with MASLD cirrhosis Open
Background: Predictive biomarkers are needed to identify individuals with metabolic dysfunction–associated steatotic liver disease (MASLD), at high risk for HCC. Our study aimed to determine whether the detection of circulating bacterial D…
View article: Disparities in liver transplantation for metabolic dysfunction-associated steatohepatitis-associated hepatocellular carcinoma
Disparities in liver transplantation for metabolic dysfunction-associated steatohepatitis-associated hepatocellular carcinoma Open
BACKGROUND Metabolic dysfunction-associated steatohepatitis (MASH) is increasingly common, as is hepatocellular carcinoma (HCC) in the background of MASH. Liver transplantation (LT) provides superior long-term survival for patients with un…
View article: Longitudinal Relationship Between Elevated Liver Biochemical Tests and Negative Clinical Outcomes in Primary Biliary Cholangitis: A Population‐Based Study
Longitudinal Relationship Between Elevated Liver Biochemical Tests and Negative Clinical Outcomes in Primary Biliary Cholangitis: A Population‐Based Study Open
Background Elevated liver biochemistries are associated with increased risk of negative outcomes in patients with primary biliary cholangitis (PBC). Aims To evaluate whether longitudinal monitoring of liver biochemistries and fibrosis scor…
View article: Outcomes for Early Liver Transplantation for Alcohol-associated Liver Disease in High-acuity Liver Transplant Recipients With Alcohol Use Disorder
Outcomes for Early Liver Transplantation for Alcohol-associated Liver Disease in High-acuity Liver Transplant Recipients With Alcohol Use Disorder Open
Background. Alcohol use disorder (AUD) incidence is increasing, and alcohol-associated liver disease is the leading indication for liver transplantation (LT) in the United States. Many centers have adopted “early LT” (ELT) for patients wit…
View article: Neoadjuvant Multiagent Systemic Therapy Approach to Liver Transplantation for Perihilar Cholangiocarcinoma
Neoadjuvant Multiagent Systemic Therapy Approach to Liver Transplantation for Perihilar Cholangiocarcinoma Open
Background. Perihilar cholangiocarcinoma (phCCA) has excellent outcomes following liver transplantation (LT). Neoadjuvant radiation-based locoregional therapy is standard-of-care. Gemcitabine and cisplatin (gem/cis) combination systemic th…
View article: Sorafenib as Adjuvant Therapy Post–Liver Transplant: A Single-center Experience
Sorafenib as Adjuvant Therapy Post–Liver Transplant: A Single-center Experience Open
Background. Hepatocellular carcinoma (HCC) has a rising incidence and mortality in North America. Liver transplantation (LT) with adjunctive therapies offers excellent outcomes. However, HCC recurrences are associated with high mortality. …
View article: Prevalence and Factors Influencing the Transmission of Pulmonary Tuberculosis in Patients Followed at the National Tuberculosis Control Program in N’Djamena, Chad
Prevalence and Factors Influencing the Transmission of Pulmonary Tuberculosis in Patients Followed at the National Tuberculosis Control Program in N’Djamena, Chad Open
Prevalence and factors influencing the transmission of pulmonary tuberculosis in patients followed at the National Tuberculosis Control Program (PNT) in N’Djamena at Chad. Tuberculosis is an infectious disease caused by a bacillus called M…
View article: Dimensionality Reduction and Nearest Neighbors for Improving Out-of-Distribution Detection in Medical Image Segmentation
Dimensionality Reduction and Nearest Neighbors for Improving Out-of-Distribution Detection in Medical Image Segmentation Open
Clinically deployed deep learning-based segmentation models are known to fail on data outside of their training distributions. While clinicians review the segmentations, these models tend to perform well in most instances, which could exac…
View article: Training robust T1-weighted magnetic resonance imaging liver segmentation models using ensembles of datasets with different contrast protocols and liver disease etiologies
Training robust T1-weighted magnetic resonance imaging liver segmentation models using ensembles of datasets with different contrast protocols and liver disease etiologies Open
View article: A Case of Hepatic Tuberculosis in a Patient on Adalimumab for Ankylosing Spondylitis
A Case of Hepatic Tuberculosis in a Patient on Adalimumab for Ankylosing Spondylitis Open
Hepatic tuberculosis (TB) is an uncommon extrapulmonary manifestation of tuberculosis. Hepatic TB is more common in immunocompromised patients, such as those on immunosuppressive medications or those with a human immunodeficiency virus (HI…
View article: Utilization of Immunotherapy as a Neoadjuvant Therapy for Liver Transplant Recipients with Hepatocellular Carcinoma
Utilization of Immunotherapy as a Neoadjuvant Therapy for Liver Transplant Recipients with Hepatocellular Carcinoma Open
Background: Hepatocellular carcinoma (HCC) is widely recognized as the predominant type of primary liver malignancy. Orthotopic liver transplantation (OLT) has emerged as a highly effective treatment option for unresectable HCC. Immunother…
View article: Metabolomics biomarkers of hepatocellular carcinoma in a prospective cohort of patients with cirrhosis
Metabolomics biomarkers of hepatocellular carcinoma in a prospective cohort of patients with cirrhosis Open
View article: Training Robust T1-Weighted Magnetic Resonance Imaging Liver Segmentation Models Using Ensembles of Datasets with Different Contrast Protocols and Liver Disease Etiologies
Training Robust T1-Weighted Magnetic Resonance Imaging Liver Segmentation Models Using Ensembles of Datasets with Different Contrast Protocols and Liver Disease Etiologies Open
Image segmentation of the liver is an important step in several treatments for liver cancer. However, manual segmentation at a large scale is not practical, leading to increasing reliance on deep learning models to automatically segment th…
View article: Single-center Outcomes After Liver Transplantation With SARS-CoV-2–Positive Donors: An Argument for Increased Utilization
Single-center Outcomes After Liver Transplantation With SARS-CoV-2–Positive Donors: An Argument for Increased Utilization Open
Background. The COVID-19 pandemic has led to an increase in SARS-CoV-2–test positive potential organ donors. The benefits of life-saving liver transplantation (LT) must be balanced against the potential risk of donor-derived viral transmis…
View article: Bloodstream infections after solid organ transplantation: clinical epidemiology and antimicrobial resistance (2016–21)
Bloodstream infections after solid organ transplantation: clinical epidemiology and antimicrobial resistance (2016–21) Open
Background Solid organ transplant (SOT) recipients are at risk of bloodstream infections (BSIs) with MDR organisms (MDROs). Objectives To describe the epidemiology of BSI in the year after several types of SOT, as well as the prevalence of…
View article: Transplant Oncology: An Emerging Discipline of Cancer Treatment
Transplant Oncology: An Emerging Discipline of Cancer Treatment Open
Transplant oncology is an emerging concept of cancer treatment with a promising prospective outcome. The applications of oncology, transplant medicine, and surgery are the core of transplant oncology to improve patients’ survival and quali…
View article: Polyarteritis Nodosa Associated With Hepatitis C Virus Infection
Polyarteritis Nodosa Associated With Hepatitis C Virus Infection Open
View article: Combined Hepatocellular Neuroendocrine Carcinoma: A Rare Tumor
Combined Hepatocellular Neuroendocrine Carcinoma: A Rare Tumor Open
Neuroendocrine tumors originate from neuroendocrine cells primarily located in the gastrointestinal tract. These tumors often metastasize to the liver. Primary hepatic neuroendocrine carcinomas are uncommon, and combined hepatocellular neu…
View article: Women’s health issues in solid organ transplantation: Breast and gynecologic cancers in the post-transplant population
Women’s health issues in solid organ transplantation: Breast and gynecologic cancers in the post-transplant population Open
The success of solid organ transplant has steadily improved which has led to a unique set of post-transplant issues. The rates of de novo cancer in the solid organ transplant recipient population are higher than those in the general…
View article: Hepatocellular Carcinoma Recurrence as Isolated Adrenal Metastasis
Hepatocellular Carcinoma Recurrence as Isolated Adrenal Metastasis Open
Hepatocellular carcinoma is the sixth most common cancer in the Western world. The most frequent sites of metastasis are lungs, lymph nodes, and bones. Risk factors for extrahepatic metastasis are advanced intrahepatic lesions, vascular in…
View article: #6389 EARLY WEIGHT LOSS AFTER BARIATRIC SURGERY IN PATIENTS WITH ORGAN FAILURE OR TRANSPLANTATION
#6389 EARLY WEIGHT LOSS AFTER BARIATRIC SURGERY IN PATIENTS WITH ORGAN FAILURE OR TRANSPLANTATION Open
Background and Aims Obesity is an epidemic that complicates global health and economies. Surgery for obesity (OS) is one effective treatment that results in significant weight loss. Patients with chronic organ failure who are obese undergo…
View article: Factors affecting survival after liver retransplantation: a systematic review and meta-analysis
Factors affecting survival after liver retransplantation: a systematic review and meta-analysis Open
Background Liver retransplantation (reLT) has historically had inferior survival relative to primary liver transplant (LT). To improve outcomes after reLT, researchers have identified factors predicting overall (OS) and/or graft survival (…
View article: Trial in Progress: Neoadjuvant Combination Therapy of Lenvatinib Plus Transcatheter Arterial Chemoembolization (TACE) for Transplant-eligible Patients with Large HCC
Trial in Progress: Neoadjuvant Combination Therapy of Lenvatinib Plus Transcatheter Arterial Chemoembolization (TACE) for Transplant-eligible Patients with Large HCC Open
View article: Early Liver Transplantation for Severe Alcohol-Associated Hepatitis and a History of Prior Liver Decompensation
Early Liver Transplantation for Severe Alcohol-Associated Hepatitis and a History of Prior Liver Decompensation Open
INTRODUCTION: In the published studies of early liver transplantation (LT) for alcohol-associated hepatitis (AH), patients with a prior liver decompensation are excluded. The appropriateness of this criteria is unknown. Methods: Among 6 Am…
View article: Viral hepatitis: A narrative review of hepatitis A–E
Viral hepatitis: A narrative review of hepatitis A–E Open