David W. Williams
YOU?
Author Swipe
View article: Characterization and <i>ex vivo</i> modelling of endodontic infections from the Arabian Gulf region
Characterization and <i>ex vivo</i> modelling of endodontic infections from the Arabian Gulf region Open
Aim The microbiota of endodontic infections in patients from the Arabian Gulf region (AGR) is largely unexplored. While research in different global regions has investigated the microbial composition of such infections, studies using shotg…
View article: Antimicrobial effects of XF drugs against Candida albicans and its biofilms
Antimicrobial effects of XF drugs against Candida albicans and its biofilms Open
Compared with antibiotics for treating bacterial infections, there are a limited number of antifungal agents. This is due to several factors, including the difficulties of identifying suitable antifungals that target the fungal cell withou…
View article: Compositional shifts within the denture-associated bacteriome in pneumonia – an analytical cross-sectional study
Compositional shifts within the denture-associated bacteriome in pneumonia – an analytical cross-sectional study Open
Introduction. Bacterial pneumonia is a common cause of morbidity and mortality in elderly individuals. While the incidence of edentulism is falling, approximately 19 % of the UK population wear a full or partial removable denture. Despite …
View article: Epithelial responses and Candida albicans pathogenicity are enhanced in the presence of oral streptococci
Epithelial responses and Candida albicans pathogenicity are enhanced in the presence of oral streptococci Open
Experimental models that consider host-pathogen interactions are relevant for improving knowledge about oral candidiasis. The aim of this study was to assess the epithelial immune responses, Candida penetration of cell monolayers, and viru…
View article: Phytic Acid Demonstrates Rapid Antibiofilm Activity and Inhibits Biofilm Formation When Used as a Surface Conditioning Agent
Phytic Acid Demonstrates Rapid Antibiofilm Activity and Inhibits Biofilm Formation When Used as a Surface Conditioning Agent Open
Root canal infections are biofilm associated, and despite mechanical and chemical treatment procedures, infection recurrence occurs, and this is likely due to the high tolerance of associated biofilms to antimicrobials. The currently used …
View article: Rapid PCR-lateral flow assay for the onsite detection of Atlantic white shrimp
Rapid PCR-lateral flow assay for the onsite detection of Atlantic white shrimp Open
The Atlantic white shrimp (Litopenaeus setiferus) is of great economic importance to the United States and risk being substituted with imported species due to a shortage in domestic production. To improve the current methods used for the i…
View article: Synthesis, molecular docking and antibacterial activity of an oxadiazole-based lipoteichoic acid inhibitor and its metabolites
Synthesis, molecular docking and antibacterial activity of an oxadiazole-based lipoteichoic acid inhibitor and its metabolites Open
Amongst drug resistant Gram-positive bacteria, Staphylococcus aureus is a pathogen of great concern as it is the leading cause of life-threatening nosocomial and community acquired infections which are often associated with implanted medic…
View article: <i>Geranium</i> leaf-mediated synthesis of silver nanoparticles and their transcriptomic effects on <i>Candida albicans</i>
<i>Geranium</i> leaf-mediated synthesis of silver nanoparticles and their transcriptomic effects on <i>Candida albicans</i> Open
Candida albicans is the most predominant fungal species isolated from medical devices, including catheters, heart valves, and dental prostheses. In recent years, it has been demonstrated to be resistant to many antifungals; therefore, silv…
View article: Antibacterial and Antibiofilm Potency of XF Drugs, Impact of Photodynamic Activation and Synergy With Antibiotics
Antibacterial and Antibiofilm Potency of XF Drugs, Impact of Photodynamic Activation and Synergy With Antibiotics Open
With increasing incidence of antimicrobial resistance, there is an urgent need for novel and effective antibacterials. Destiny Pharma plc have developed a series of porphyrin-based XF drugs, some with dual mechanisms of antibacterial actio…
View article: Norwood modification for hypoplastic left heart and right aortic arch
Norwood modification for hypoplastic left heart and right aortic arch Open
Central MessageRight aortic arch in hypoplastic left heart syndrome poses challenges during the stage 1 Norwood operation requiring a modified approach.Right aortic arch (RAA) in hypoplastic left heart syndrome (HLHS) or variant is extreme…
View article: Preliminary study into the effects of tobacco smoke on Candida albicans
Preliminary study into the effects of tobacco smoke on Candida albicans Open
Background: Denture-stomatitis (DS) is the most common form of oral candidosis with increased prevalence in cigarette smokers (Akram et al. 2018). Interestingly, tobacco condensate (TC) increases Candida albicans adhesion, growth, biofilm-…
View article: Antimicrobial Activity of Phytic Acid: An Emerging Agent in Endodontics
Antimicrobial Activity of Phytic Acid: An Emerging Agent in Endodontics Open
Background Phytic acid (IP6) is a promising and emerging agent, and because of its unique structure and distinctive properties, it lends itself to several applications in dentistry. Recently, IP6 was proposed as a potential chelating agent…
View article: Higher Number of EBI3 Cells in Mucosal Chronic Hyperplastic Candidiasis May Serve to Regulate IL-17-Producing Cells
Higher Number of EBI3 Cells in Mucosal Chronic Hyperplastic Candidiasis May Serve to Regulate IL-17-Producing Cells Open
Previous research into the inflammatory cell infiltrate of chronic hyperplastic candidosis (CHC) determined that the immune response is primarily composed of T cells, the majority of which are T helper (CD4+) cells. This present investigat…
View article: Periscopic technique in Norwood operation is associated with better preservation of early ventricular function
Periscopic technique in Norwood operation is associated with better preservation of early ventricular function Open
The PT for RV to pulmonary artery conduit in Norwood operation results in better preservation of early RV global and regional systolic function. Whether or not this benefit translates to improved clinical outcome still needs to be studied.
View article: Phytic Acid: Properties and Potential Applications in Dentistry
Phytic Acid: Properties and Potential Applications in Dentistry Open
Inositol hexaphosphate (IP6) is the most abundant inositol phosphate in nature and an essential molecule for different biological functions. IP6 has a unique structure granting it distinctive properties; a high negative charge density prov…
View article: Network analysis of nitrate-sensitive oral microbiome reveals interactions with cognitive function and cardiovascular health across dietary interventions
Network analysis of nitrate-sensitive oral microbiome reveals interactions with cognitive function and cardiovascular health across dietary interventions Open
Many oral bacteria reduce inorganic nitrate, a natural part of a vegetable-rich diet, into nitrite that acts as a precursor to nitric oxide, a regulator of vascular tone and neurotransmission. Aging is hallmarked by reduced nitric oxide pr…
View article: Microbial Metabolic Genes Crucial for S. aureus Biofilms: An Insight From Re-analysis of Publicly Available Microarray Datasets
Microbial Metabolic Genes Crucial for S. aureus Biofilms: An Insight From Re-analysis of Publicly Available Microarray Datasets Open
Bacterial biofilms are microbial lifestyles found in all environments. Up to 80% of human infections and 60–70% of hospital-acquired infections have a biofilm origin, with Staphylococcus aureus one of the leading causes of these infections…
View article: Pathogenesis and Virulence of Candida albicans and Candida glabrata
Pathogenesis and Virulence of Candida albicans and Candida glabrata Open
Fungal infections in humans have historically received comparatively less attention than those caused by bacteria and viruses. This may, in part, stem from the relative differences in infection prevalence. However, the more widespread use …
View article: Mediastinal cystic teratoma masquerading as a hydatid cyst
Mediastinal cystic teratoma masquerading as a hydatid cyst Open
A case is presented in which a preoperatively diagnosed hydatid cyst was found to be a mature cystic teratoma on pathological examination. Diagnostic dilemmas surrounding each disease are discussed.
View article: The Effect of Residual Food Stain on Candida Albicans Colonisation of Denture Acrylics
The Effect of Residual Food Stain on Candida Albicans Colonisation of Denture Acrylics Open
Objectives: In the UK, 19% of adults wear dentures. Failure to keep a denture clean can lead to staining from foods, along with subsequent colonisation of the denture and associated mucosa by microorganisms, particularly Candida albicans. …
View article: Metataxonomic sequencing reveals compositional shifts within the denture-associated microbiome in pneumonia
Metataxonomic sequencing reveals compositional shifts within the denture-associated microbiome in pneumonia Open
Background Bacterial pneumonia affects a disproportionate number of the elderly in the UK, with substantial morbidity and mortality. Mounting evidence implicates removable dentures as a potential nidus for respiratory pathogens to form a r…
View article: Methylcellulose Hydrogel with Melissa officinalis Essential Oil as a Potential Treatment for Oral Candidiasis
Methylcellulose Hydrogel with Melissa officinalis Essential Oil as a Potential Treatment for Oral Candidiasis Open
Candida spp. are the most prevalent fungi of the human microbiota and are opportunistic pathogens that can cause oral candidiasis. Management of such infections is limited due to the low number of antifungal drugs available, their relative…
View article: Immunohistochemical Expression Patterns of Inflammatory Cells Involved in Chronic Hyperplastic Candidosis
Immunohistochemical Expression Patterns of Inflammatory Cells Involved in Chronic Hyperplastic Candidosis Open
The profile of the inflammatory cell infiltrate in chronic hyperplastic candidosis (CHC) was determined in oral mucosal biopsies by immunohistochemistry. One tonsillar tissue section was included as an immunohistochemistry control, whilst …