David W. Woolston
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View article: Spatial proteomics and transcriptomics characterization of tissue and multiple cancer types including decalcified marrow
Spatial proteomics and transcriptomics characterization of tissue and multiple cancer types including decalcified marrow Open
Background Recent technologies enabling the study of spatial biology include multiple high-dimensional spatial imaging methods that have rapidly emerged with different capabilities evaluating tissues at different resolutions for different …
View article: Genomic Proximity Mapping (GPM): Evaluation of a Next Generation Cytogenomic Assay for Improved Risk Stratification in Acute Myeloid Leukemia
Genomic Proximity Mapping (GPM): Evaluation of a Next Generation Cytogenomic Assay for Improved Risk Stratification in Acute Myeloid Leukemia Open
Cytogenetics encompasses a suite of diagnostics assays that provides critical diagnostic and prognostic information that can help guide care for acute myeloid leukemias (AML) patients. Routine cytogenetic workup for AML includes karyotypin…
View article: <i>Erratum</i> to: Ultra-deep mutational landscape in chronic lymphocytic leukemia uncovers dynamics of resistance to targeted therapies
<i>Erratum</i> to: Ultra-deep mutational landscape in chronic lymphocytic leukemia uncovers dynamics of resistance to targeted therapies Open
1 in the sentence reproduced below, "ibrutinib" should be replaced with "acalabrutinib": Incorrect sentence: "Sample R002-A was collected after 3 months of combination therapy with ibrutinib and venetoclax."Correct sentence: "Sample R002-A…
View article: qPCR assay for detection of Woodchuck Hepatitis Virus Post-Transcriptional Regulatory Elements from CAR-T and TCR-T cells in fresh and formalin-fixed tissue
qPCR assay for detection of Woodchuck Hepatitis Virus Post-Transcriptional Regulatory Elements from CAR-T and TCR-T cells in fresh and formalin-fixed tissue Open
As adoptive cellular therapies become more commonplace in cancer care, there is a growing need to monitor site-specific localization of engineered cells—such as chimeric antigen receptor T (CAR-T) cells and T-cell receptor T (TCR-T) cells—…
View article: Evaluation of Acute Myeloid Leukemia Genomes using Genomic Proximity Mapping
Evaluation of Acute Myeloid Leukemia Genomes using Genomic Proximity Mapping Open
Background Cytogenetic analysis encompasses a suite of standard-of-care diagnostic testing methods that is routinely applied in cases of acute myeloid leukemia (AML) to assess chromosomal changes that are clinically relevant for risk class…
View article: Ultra-deep mutational landscape in chronic lymphocytic leukemia uncovers dynamics of resistance to targeted therapies
Ultra-deep mutational landscape in chronic lymphocytic leukemia uncovers dynamics of resistance to targeted therapies Open
BTK inhibitors, Bcl-2 inhibitors, and other targeted therapies have significantly improved outcomes for patients with chronic lymphocytic leukemia (CLL). With increased survivorship, monitoring disease and deciphering potential mechanisms …
View article: 93 PCR assay to identify woodchuck hepatitis virus posttranscriptional regulatory element in CAR-T and TCR-T cells for fresh and formalin-fixed samples
93 PCR assay to identify woodchuck hepatitis virus posttranscriptional regulatory element in CAR-T and TCR-T cells for fresh and formalin-fixed samples Open
Background Chimeric antigen receptor T-cell (CART) and engineered T-cell receptor cytotoxic T cell (TCRT) therapy are adoptive cellular therapies developed by modifying T-cells to target surface antigens of cancer cells in CART, and both c…
View article: AKR1C3 expression in T acute lymphoblastic leukemia/lymphoma for clinical use as a biomarker
AKR1C3 expression in T acute lymphoblastic leukemia/lymphoma for clinical use as a biomarker Open
To investigate aldo–keto reductase 1C3 (AKR1C3) expression in T and B acute lymphoblastic leukemia/lymphoma (ALL) patients. Three commercial antibodies were evaluated for AKR1C3 immunohistochemistry (IHC) staining performance: Polyclonal T…
View article: AKR1C3 Expression in T and B Acute Lymphoblastic Leukemia/Lymphoma for Clinical Use as a Biomarker
AKR1C3 Expression in T and B Acute Lymphoblastic Leukemia/Lymphoma for Clinical Use as a Biomarker Open
Objectives: To investigate aldo–keto reductase 1C3 (AKR1C3) expression in T and B acute lymphoblastic leukemia/lymphoma (ALL) patients. Methods: Three commercial antibodies were evaluated for AKR1C3 immunohistochemistry (IHC) staining perf…
View article: Mutational profiling in acute lymphoblastic leukemia by RNA sequencing and chromosomal genomic array testing
Mutational profiling in acute lymphoblastic leukemia by RNA sequencing and chromosomal genomic array testing Open
Background Comprehensive molecular and cytogenetic profiling of acute lymphoblastic leukemia (ALL) is important and critical to the current standard of care for patients with B‐acute lymphoblastic leukemia (B‐ALL). Here we propose a rapid …
View article: 642 Retrospective review of pulmonary pathology associated with chimeric antigen receptor T cell therapy
642 Retrospective review of pulmonary pathology associated with chimeric antigen receptor T cell therapy Open
Background Chimeric antigen receptor (CAR) T-cell therapy is an immunotherapy which uses genetically modified T cells engineered to express CARs to recognize and kill cells that harbor specific antigens. CAR T-cell products designed to tar…
View article: 643 Autopsy review of chimeric-antigen receptor T cell therapy: a single institution experience
643 Autopsy review of chimeric-antigen receptor T cell therapy: a single institution experience Open
Background Our institution has treated over 300 patients with chimeric antigen receptor (CAR) T-cell immunotherapy (CAR T-cell therapy) since 2013. Phase I and II trials were primarily based on heavily treated patients with B cell acute ly…
View article: Impact of clinical, cytogenetic, and molecular profiles on long-term survival after transplantation in patients with chronic myelomonocytic leukemia
Impact of clinical, cytogenetic, and molecular profiles on long-term survival after transplantation in patients with chronic myelomonocytic leukemia Open
Chronic myelomonocytic leukemia (CMML) is a heterogeneous group of clonal hematopoietic malignancies with variable clinical and molecular features. We analyzed long-term results of allogeneic hematopoietic cell transplantation in patients …