David Waller
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View article: Objective Assessment of Ergonomics and Performance of Thoracic Surgeons During Real-Life Anatomical Robotic Pulmonary Resections
Objective Assessment of Ergonomics and Performance of Thoracic Surgeons During Real-Life Anatomical Robotic Pulmonary Resections Open
Objectives Motion tracking tools have been used in the analysis of surgeons’ technical expertise and posture in simulated endoscopic surgery. But its use in humans in real-life robotic surgery is limited. We analysed the effect of surgeons…
View article: Incidental finding of lung adenocarcinoma following routine bullectomy and pleurodesis on a young patient: a case report
Incidental finding of lung adenocarcinoma following routine bullectomy and pleurodesis on a young patient: a case report Open
Lesson Spontaneous pneumothorax is a rare complication of lung cancer. In this report, we present a case of a patient with recurrent pneumothorax undergoing routine bullectomy and pleurodesis and lung adenocarcinoma is diagnosed incidental…
View article: Why the MARS2 Trial Does Not Mean the End of All Mesothelioma Surgery
Why the MARS2 Trial Does Not Mean the End of All Mesothelioma Surgery Open
Background/Objectives: The published report of the MARS2 trial suggested that the addition of extended pleurectomy/decortication to chemotherapy for pleural mesothelioma was harmful. Thus, the report goes on, all disease should be consider…
View article: Malignant Pleural Mesothelioma: A 2025 Update
Malignant Pleural Mesothelioma: A 2025 Update Open
The incidence of pleural mesothelioma (PM) is slightly increasing, with 2417 new cases/year worldwide [...]
View article: Joint ERS/EACTS/ESTS clinical practice guidelines on adults with spontaneous pneumothorax
Joint ERS/EACTS/ESTS clinical practice guidelines on adults with spontaneous pneumothorax Open
OBJECTIVES The optimal management for spontaneous pneumothorax (SP) remains contentious, with various proposed approaches. This joint clinical practice guideline from the ERS, EACTS and ESTS societies provides evidence-based recommendation…
View article: Bronchoscopic Lung Volume Reduction as the Treatment of Choice versus Robotic-Assisted Lung Volume Reduction Surgery in Similar Patients with Emphysema – An Initial Experience of the Benefits and Complications
Bronchoscopic Lung Volume Reduction as the Treatment of Choice versus Robotic-Assisted Lung Volume Reduction Surgery in Similar Patients with Emphysema – An Initial Experience of the Benefits and Complications Open
Endobronchial LVR does use less hospital resources than RATS LVRS in comparable groups if the recovery is uncomplicated. However, this advantage is lost if one includes the resources needed for the treatment of complications and revisional…
View article: Joint ERS/EACTS/ESTS clinical practice guidelines on adults with spontaneous pneumothorax
Joint ERS/EACTS/ESTS clinical practice guidelines on adults with spontaneous pneumothorax Open
Background The optimal management for spontaneous pneumothorax (SP) remains contentious, with various proposed approaches. This joint clinical practice guideline from the ERS, EACTS and ESTS societies provides evidence-based recommendation…
View article: Validation of Inflammatory Prognostic Biomarkers in Pleural Mesothelioma
Validation of Inflammatory Prognostic Biomarkers in Pleural Mesothelioma Open
Evoked from asbestos-induced inflammation, pleural mesothelioma represents a fatal diagnosis. Therapy ranges from nihilism to aggressive multimodality regimens. However, it is still unclear who ultimately benefits from which treatment. We …
View article: A rare case of ‘ring-sling complex’ in a symptomatic adult patient: A left pulmonary artery sling with complete tracheal rings
A rare case of ‘ring-sling complex’ in a symptomatic adult patient: A left pulmonary artery sling with complete tracheal rings Open
Pulmonary artery sling (PAS) is a rare congenital condition, in which the left pulmonary artery (LPA) originates from the right pulmonary artery instead of the main pulmonary artery. It courses between the oesophagus and the trachea, formi…
View article: Perioperative discordance in mesothelioma cell type after pleurectomy/decortication—a possible detrimental effect of neoadjuvant chemotherapy due to epithelial to mesenchymal transition?
Perioperative discordance in mesothelioma cell type after pleurectomy/decortication—a possible detrimental effect of neoadjuvant chemotherapy due to epithelial to mesenchymal transition? Open
OBJECTIVES The goal was to evaluate the accuracy of preoperative histological assessment and the factors affecting the accuracy and the subsequent effect on postoperative survival after surgical treatment for malignant pleural mesothelioma…
View article: Lung volume reduction surgery<i>versus</i>endobronchial valves: a randomised controlled trial
Lung volume reduction surgery<i>versus</i>endobronchial valves: a randomised controlled trial Open
Background Lung volume reduction surgery (LVRS) and bronchoscopic lung volume reduction (BLVR) with endobronchial valves can improve outcomes in appropriately selected patients with emphysema. However, no direct comparison data exist to in…
View article: The Effects of Preserving the Diaphragm on Early and Late Outcome of Lung-Sparing Radical Surgery for Malignant Pleural Mesothelioma
The Effects of Preserving the Diaphragm on Early and Late Outcome of Lung-Sparing Radical Surgery for Malignant Pleural Mesothelioma Open
Background: The accepted aim of radical surgery for malignant pleural mesothelioma (MPM) is the achievement of macroscopic complete resection (MCR) whilst reducing perioperative morbidity by preserving normal tissue. Whilst preservation of…
View article: Additional file 6 of Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma
Additional file 6 of Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma Open
Additional file 6: Table S5. Significantly mutated gene analysis in MPM.
View article: Additional file 5 of Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma
Additional file 5 of Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma Open
Additional file 5: Table S4. Somatic structural rearrangements detected in the 58 MPM samples.
View article: “All things must pass” - Cutaneous migration of an endobronchial valve
“All things must pass” - Cutaneous migration of an endobronchial valve Open
Summary The Zephyr (PulmonX Inc., Redwood, CA) endobronchial valve (EBV), predominantly designed for lung volume reduction in emphysema, can also be used to close a spontaneous or post-operative prolonged air leak (PAL). We describe a prev…
View article: Additional file 4 of Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma
Additional file 4 of Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma Open
Additional file 4: Table S3. Somatic coding mutations detected in the 58 MPM.
View article: Additional file 3 of Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma
Additional file 3 of Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma Open
Additional file 3: Table S2. Summary of read depth and the number of somatic mutations identified in MPM samples from whole genome sequencing.
View article: Additional file 1 of Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma
Additional file 1 of Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma Open
Additional file 1: Table S1. Clinical characteristics of the MPM samples that underwent whole genome sequencing
View article: S75 Redo bronchoscopy after endobronchial lung volume reduction – indications and implications
S75 Redo bronchoscopy after endobronchial lung volume reduction – indications and implications Open
Background Endobronchial lung volume reduction (EBLVR) is an effective treatment in patients with severe emphysema. It is perceived as a low-risk, low-morbidity procedure but there is the potential for longer term complications requiring r…
View article: Maintaining safe lung cancer surgery during the COVID-19 pandemic in a global city
Maintaining safe lung cancer surgery during the COVID-19 pandemic in a global city Open
Background: SARS-CoV-2 has challenged health service provision worldwide. This work evaluates safe surgical pathways and standard operating procedures implemented in the high volume, global city of London during the first wave of SARS-CoV-…