David Warwick
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View article: Contrast‐Enhanced Ultrasound (CEUS) Reveals Perfusion of Human Bone in Acute Fracture Healing: A Pilot Study
Contrast‐Enhanced Ultrasound (CEUS) Reveals Perfusion of Human Bone in Acute Fracture Healing: A Pilot Study Open
Bone fractures are common injuries with reported non‐union rates of up to 9%. Current treatments for non‐union include surgery with complication rates of up to 17% and significant costs. Microbubbles are used clinically in ultrasonography …
View article: Collagenase Injection versus Limited Fasciectomy for Dupuytren’s Contracture
Collagenase Injection versus Limited Fasciectomy for Dupuytren’s Contracture Open
Collagenase injection was not noninferior to limited fasciectomy with respect to the score on the PEM at 1 year after treatment. (Funded by the National Institute for Health and Care Research Health Technology Assessment Programme; DISC IS…
View article: The ‘Universal Approach’ for Dupuytrenʼs disease: A safe and reproducible sequence for planning fasciectomy incisions
The ‘Universal Approach’ for Dupuytrenʼs disease: A safe and reproducible sequence for planning fasciectomy incisions Open
Dupuytren's disease continues to present many challenges for the surgeon. A variety of surgical approaches and their variations have been described in the literature, further complicated by the degree of skin shortage and/or the need for l…
View article: OpenHands: An Open-Source Statistical Shape Model of the Finger Bones
OpenHands: An Open-Source Statistical Shape Model of the Finger Bones Open
This paper presents statistical shape models of the four fingers of the hand, with an emphasis on anatomic analysis of the proximal and distal interphalangeal joints. A multi-body statistical shape modelling pipeline was implemented on an …
View article: Collagenase injection versus limited fasciectomy surgery to treat Dupuytren’s contracture in adult patients in the UK: DISC, a non-inferiority RCT and economic evaluation
Collagenase injection versus limited fasciectomy surgery to treat Dupuytren’s contracture in adult patients in the UK: DISC, a non-inferiority RCT and economic evaluation Open
Background Dupuytren’s contracture is caused by nodules and cords which pull the fingers towards the palm of the hand. Treatments include limited fasciectomy surgery, collagenase injection and needle fasciotomy. There is limited evidence c…
View article: Investigation of the short-term in vivo performance of metal-on-carbon fibre reinforced poly ether ether ketone Motec wrists: an explant analysis
Investigation of the short-term in vivo performance of metal-on-carbon fibre reinforced poly ether ether ketone Motec wrists: an explant analysis Open
Total wrist arthroplasty (TWA) aims to restore pain-free motion to diseased joints. One such TWA, the Motec, has demonstrated good results with acceptable complication rates. It has recently been suggested that the metal-on-carbon fibre re…
View article: Examining the benefit of graduated compression stockings in the prevention of hospital-associated venous thromboembolism in low-risk surgical patients: a multicentre cluster randomised controlled trial (PETS trial)
Examining the benefit of graduated compression stockings in the prevention of hospital-associated venous thromboembolism in low-risk surgical patients: a multicentre cluster randomised controlled trial (PETS trial) Open
Introduction Hospital-acquired thrombosis (HAT) is defined as any venous thromboembolism (VTE)-related event during a hospital admission or occurring up to 90 days post discharge, and is associated with significant morbidity, mortality and…
View article: Can learnings from the COVID-19 pandemic improve trial conduct post-pandemic? A case study of strategies used by the DISC trial
Can learnings from the COVID-19 pandemic improve trial conduct post-pandemic? A case study of strategies used by the DISC trial Open
Background RCTs often face issues such as slow recruitment, poor intervention adherence and high attrition, however the 2020/2021 COVID-19 pandemic intensified these challenges. Strategies employed by the DISC trial to overcome pandemic-re…
View article: Dupuytren’s interventions surgery versus collagenase (DISC) trial: study protocol for a pragmatic, two-arm parallel-group, non-inferiority randomised controlled trial
Dupuytren’s interventions surgery versus collagenase (DISC) trial: study protocol for a pragmatic, two-arm parallel-group, non-inferiority randomised controlled trial Open
Background Dupuytren’s contracture is a fibro-proliferative disease of the hands affecting over 2 million UK adults, particularly the white, male population. Surgery is the traditional treatment; however, recent studies have indicated that…
View article: Dupuytren’s disease: using needles more across the world
Dupuytren’s disease: using needles more across the world Open
In this article we take an international perspective on the use of needles, either percutaneous needle fasciotomy (PNF) or Clostridial Collagenase Histiolyticum (CCH), in treating Dupuytren’s Disease (DD). Worldwide, PNF is now used more f…
View article: How to Lead in Federal Government
How to Lead in Federal Government Open
In todays workplace, especially in the midst of todays challenging times, we must understand the values of resilience, communication, decision-making, team-building, and diversity. These core competencies contribute to the success of being…
View article: Sickness absence after carpal tunnel release: a multicentre prospective cohort study
Sickness absence after carpal tunnel release: a multicentre prospective cohort study Open
Objectives To describe when patients return to different types of work after elective carpal tunnel release (CTR) surgery and identify the factors associated with the duration of sickness absence. Design Multicentre prospective observation…
View article: Compression stockings in addition to low-molecular-weight heparin to prevent venous thromboembolism in surgical inpatients requiring pharmacoprophylaxis: the GAPS non-inferiority RCT
Compression stockings in addition to low-molecular-weight heparin to prevent venous thromboembolism in surgical inpatients requiring pharmacoprophylaxis: the GAPS non-inferiority RCT Open
Background Patients admitted to hospital for surgery are at an increased risk of venous thromboembolism. Pharmaco-thromboprophylaxis and mechanical prophylaxis (usually graduated compression stockings or intermittent pneumatic compression)…
View article: Identifying collagen VI as a target of fibrotic diseases regulated by CREBBP/EP300
Identifying collagen VI as a target of fibrotic diseases regulated by CREBBP/EP300 Open
Significance Fibrosis remains a major unmet medical need as therapeutic targets discovered in animal models have failed to translate. A major challenge for identifying novel targets is the limited availability of early-stage human disease …
View article: Graduated compression stockings as adjuvant to pharmaco-thromboprophylaxis in elective surgical patients (GAPS study): randomised controlled trial
Graduated compression stockings as adjuvant to pharmaco-thromboprophylaxis in elective surgical patients (GAPS study): randomised controlled trial Open
Objectives To investigate whether the use of graduated compression stockings (GCS) offers any adjuvant benefit when pharmaco-thromboprophylaxis is used for venous thromboembolism prophylaxis in patients undergoing elective surgery. Design …
View article: Sickness absence after carpal tunnel release: a systematic review of the literature
Sickness absence after carpal tunnel release: a systematic review of the literature Open
Objectives The aim of this systematic review was to provide an overview of time to return to work (RTW) after carpal tunnel release (CTR), including return to different occupations and working patterns. Methods A systematic search from inc…
View article: How Do Anthocyanins Affect Peripheral Blood Flow: A Systematic Review
How Do Anthocyanins Affect Peripheral Blood Flow: A Systematic Review Open
Foods rich in polyphenols, a type of antioxidant, have many health benefits. The largest and most important subgroup of polyphenols are flavonoids, of which anthocyanins are one. In vitro studies have shown that anthocyanin induced vasorel…
View article: Venous thromboembolism after total knee replacement or total hip replacement: what can be learnt from root-cause analysis?
Venous thromboembolism after total knee replacement or total hip replacement: what can be learnt from root-cause analysis? Open
INTRODUCTION Because of the high risk of venous thromboembolism (VTE) in total hip replacement (THR) and total knee replacement (TKR), guidelines are used widely to enhance effective (yet safe) prophylaxis. If patients develop VTEs despite…
View article: <i>Collagenase Clostridium histolyticum</i><i>:</i>emerging practice patterns and treatment advances
<i>Collagenase Clostridium histolyticum</i><i>:</i>emerging practice patterns and treatment advances Open
CCH has an evolving role as one of the tools available for treating Dupuytren's disease.