David H. Wasserman
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View article: α-Parvin Promotes Glucose Uptake and Metabolism in Skeletal Muscle with Minimal Influence on Hepatic Insulin Sensitivity
α-Parvin Promotes Glucose Uptake and Metabolism in Skeletal Muscle with Minimal Influence on Hepatic Insulin Sensitivity Open
Skeletal muscle and liver insulin resistance are early features in the sequelae of type 2 diabetes. Integrins are extracellular matrix receptors expressed on skeletal muscle cells and hepatocytes and have been implicated in modulating obes…
View article: Increased cGMP improves microvascular exercise training adaptations in diet-induced obesity
Increased cGMP improves microvascular exercise training adaptations in diet-induced obesity Open
This study used pharmacological gain-of-function and genetic loss-of-function approaches to test the hypothesis that the eNOS/NO/cGMP axis is central to exercise training adaptations in microcirculatory function and exercise capacity. Chro…
View article: Metastability of stratified magnetohydrostatic equilibria and their relaxation
Metastability of stratified magnetohydrostatic equilibria and their relaxation Open
Motivated by explosive releases of energy in fusion, space and astrophysical plasmas, we consider the nonlinear stability of stratified magnetohydrodynamic equilibria against two-dimensional interchanges of straight magnetic-flux tubes. We…
View article: The Role of Serum Free Fatty Acids in Endothelium‐Dependent Microvascular Function
The Role of Serum Free Fatty Acids in Endothelium‐Dependent Microvascular Function Open
Background Elevated serum free fatty acid (FFA) concentration is associated with insulin resistance and is a hallmark of metabolic syndrome. A pathological feature of insulin resistance is impaired endothelial function. Objective To invest…
View article: Microvascular insulin resistance with enhanced muscle glucose disposal in CD36 deficiency
Microvascular insulin resistance with enhanced muscle glucose disposal in CD36 deficiency Open
Aims/hypothesis Microvascular dysfunction contributes to insulin resistance. CD36, a fatty acid transporter and modulator of insulin signalling, is abundant in microvascular endothelial cells. Humans carrying the minor allele (G) of CD36 c…
View article: Endothelial β1-integrins are necessary for microvascular function and glucose uptake
Endothelial β1-integrins are necessary for microvascular function and glucose uptake Open
The microvasculature is an important site of resistance to muscle glucose uptake. We show that microvasculature integrins determine the exchange of glucose between the circulation and muscle. Specifically, a 30% reduction in the expression…
View article: Increased cGMP improves microvascular exercise training adaptations independent of endothelial nitric oxide synthase
Increased cGMP improves microvascular exercise training adaptations independent of endothelial nitric oxide synthase Open
Impaired microvascular function is a hallmark of pre-diabetes. With development of atherosclerosis this impaired microvascular function can result in diminished capacity for ambulation and is a risk factor for Type 2 Diabetes. Dynamic chan…
View article: Endothelial β1 Integrins are Necessary for Microvascular Function and Glucose Uptake
Endothelial β1 Integrins are Necessary for Microvascular Function and Glucose Uptake Open
Microvascular insulin delivery to myocytes is rate limiting for the onset of insulin-stimulated muscle glucose uptake. The structural integrity of capillaries of the microvasculature is regulated, in part, by a family of transmembrane adhe…
View article: Acute Sympathetic Blockade Improves Insulin‐Mediated Microvascular Blood Flow in the Forearm of Adult Human Subjects With Obesity
Acute Sympathetic Blockade Improves Insulin‐Mediated Microvascular Blood Flow in the Forearm of Adult Human Subjects With Obesity Open
Background Obesity is associated with resistance to the metabolic (glucose uptake) and vascular (nitric‐oxide mediated dilation and microvascular recruitment) actions of insulin. These vascular effects contribute to insulin sensitivity by …
View article: Epoxygenase <i>Cyp2c44 </i>regulates hepatic lipid metabolism and insulin signaling by controlling FATP2 localization and activation of the DAG/PKCδ axis
Epoxygenase <i>Cyp2c44 </i>regulates hepatic lipid metabolism and insulin signaling by controlling FATP2 localization and activation of the DAG/PKCδ axis Open
Cytochrome P450 epoxygenase Cyp2c44, a murine epoxyeicosatrienoic acid (EET) producing enzyme, promotes insulin sensitivity and Cyp2c44(-/-) mice show hepatic insulin resistance. Because insulin resistance leads to hepatic lipid accumulati…
View article: Epoxygenase <i>Cyp2c44</i> Regulates Hepatic Lipid Metabolism and Insulin Signaling by Controlling FATP2 Localization and Activation of the DAG/PKCδ Axis
Epoxygenase <i>Cyp2c44</i> Regulates Hepatic Lipid Metabolism and Insulin Signaling by Controlling FATP2 Localization and Activation of the DAG/PKCδ Axis Open
Cytochrome P450 epoxygenase Cyp2c44, a murine epoxyeicosatrienoic acid (EET)-producing enzyme, promotes insulin sensitivity, and Cyp2c44−/− mice show hepatic insulin resistance. Because insulin resistance leads to hepatic lipid accumulatio…
View article: Epoxygenase <i>Cyp2c44 </i>regulates hepatic lipid metabolism and insulin signaling by controlling FATP2 localization and activation of the DAG/PKCδ axis
Epoxygenase <i>Cyp2c44 </i>regulates hepatic lipid metabolism and insulin signaling by controlling FATP2 localization and activation of the DAG/PKCδ axis Open
Cytochrome P450 epoxygenase Cyp2c44, a murine epoxyeicosatrienoic acid (EET) producing enzyme, promotes insulin sensitivity and Cyp2c44(-/-) mice show hepatic insulin resistance. Because insulin resistance leads to hepatic lipid accumulati…
View article: Epoxygenase <i>Cyp2c44 </i>regulates hepatic lipid metabolism and insulin signaling by controlling FATP2 localization and activation of the DAG/PKCδ axis
Epoxygenase <i>Cyp2c44 </i>regulates hepatic lipid metabolism and insulin signaling by controlling FATP2 localization and activation of the DAG/PKCδ axis Open
Cytochrome P450 epoxygenase Cyp2c44, a murine epoxyeicosatrienoic acid (EET) producing enzyme, promotes insulin sensitivity and Cyp2c44(-/-) mice show hepatic insulin resistance. Because insulin resistance leads to hepatic lipid accumulati…
View article: Pharmacological SERCA activation limits diet-induced steatohepatitis and restores liver metabolic function in mice
Pharmacological SERCA activation limits diet-induced steatohepatitis and restores liver metabolic function in mice Open
Metabolic dysfunction-associated steatotic liver disease is the most common form of liver disease and poses significant health risks to patients who progress to metabolic dysfunction-associated steatohepatitis. Fatty acid overload alters e…
View article: Tubular CPT1A deletion minimally affects aging and chronic kidney injury
Tubular CPT1A deletion minimally affects aging and chronic kidney injury Open
Kidney tubules use fatty acid oxidation (FAO) to support their high energetic requirements. Carnitine palmitoyltransferase 1A (CPT1A) is the rate-limiting enzyme for FAO, and it is necessary to transport long-chain fatty acids into mitocho…
View article: Microvascular insulin resistance associates with enhanced muscle glucose disposal in CD36 deficiency.
Microvascular insulin resistance associates with enhanced muscle glucose disposal in CD36 deficiency. Open
Dysfunction of endothelial insulin delivery to muscle associates with insulin resistance. CD36, a fatty acid transporter and modulator of insulin signaling is abundant in endothelial cells, especially in capillaries. Humans with inherited …
View article: Insulin at the intersection of thermoregulation and glucose homeostasis
Insulin at the intersection of thermoregulation and glucose homeostasis Open
Mammals are protected from changes in environmental temperature by altering energetic processes that modify heat production. Insulin is the dominant stimulus of glucose uptake and metabolism, which are fundamental for thermogenic processes…
View article: Metastability of stratified magnetohydrostatic equilibria and their relaxation
Metastability of stratified magnetohydrostatic equilibria and their relaxation Open
Motivated by explosive releases of energy in fusion, space and astrophysical plasmas, we consider the nonlinear stability of stratified magnetohydrodynamic (MHD) equilibria against two-dimensional interchanges of straight magnetic-flux tub…
View article: Insulin at the Intersection of Thermoregulation and Glucose Homeostasis
Insulin at the Intersection of Thermoregulation and Glucose Homeostasis Open
Mammals are protected from changes in environmental temperature by altering energetic processes that modify heat production. Insulin is the dominant stimulus of glucose uptake and metabolism, which are fundamental for thermogenic processes…
View article: Extracellular Matrix Abnormalities Contribute to Cardiac Insulin Resistance and Associated Dysfunction in Diet-induced Obese Mice
Extracellular Matrix Abnormalities Contribute to Cardiac Insulin Resistance and Associated Dysfunction in Diet-induced Obese Mice Open
Increased deposition of extracellular matrix (ECM) components such as collagens and hyaluronan contributes to the pathogenesis of obesity-associated insulin resistance in muscle, liver, and adipose tissue. Despite the significance of the h…
View article: Exercise training adaptations in liver glycogen and glycerolipids require hepatic AMP-activated protein kinase in mice
Exercise training adaptations in liver glycogen and glycerolipids require hepatic AMP-activated protein kinase in mice Open
This study shows that the energy sensor and transducer, AMP-activated protein kinase (AMPK), is necessary for an exercise training-induced: 1) increase in liver glycogen that is necessary for accelerated glycogenolysis during exercise, 2) …
View article: Exercise training adaptations in liver glycogen and glycerolipids require hepatic AMP-activated protein kinase in mice
Exercise training adaptations in liver glycogen and glycerolipids require hepatic AMP-activated protein kinase in mice Open
Regular exercise elicits adaptations in glucose and lipid metabolism that allow the body to meet energy demands of subsequent exercise bouts more effectively and mitigate metabolic diseases including fatty liver. Energy discharged during t…
View article: Extracellular matrix remodelling in obesity and metabolic disorders
Extracellular matrix remodelling in obesity and metabolic disorders Open
Obesity causes extracellular matrix (ECM) remodelling which can develop into serious pathology and fibrosis, having metabolic effects in insulin-sensitive tissues. The ECM components may be increased in response to overnutrition. This revi…
View article: Home Care in America: The Urgent Challenge of Putting Ethical Care into Practice
Home Care in America: The Urgent Challenge of Putting Ethical Care into Practice Open
Home care is one of the fastest‐growing industries in the United States, providing valuable opportunities for millions of older adults and people with disabilities to live at home rather than in institutional settings. Home care workers as…
View article: Tunable coherent light filter for optical sensing and imaging
Tunable coherent light filter for optical sensing and imaging Open
Systems and methods are provided for filtering coherent infrared light from a thermal background for protection of infrared (IR) imaging arrays and detection systems. A Michelson interferometer is used for coherent light filtering. In an i…