David Wellsted
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View article: Home working during the COVID-19 pandemic: The experience of drug and alcohol support workers
Home working during the COVID-19 pandemic: The experience of drug and alcohol support workers Open
Background: Drug and alcohol support workers play a vital role in addressing the growing burden of substance-related harm and mortality. The COVID-19 pandemic led to an abrupt and significant shift towards home working for many in this wor…
View article: Frailty Impact on Kidney Transplantation in Older People
Frailty Impact on Kidney Transplantation in Older People Open
View article: Cost-Effectiveness of α<sub>2</sub> Agonists for Intravenous Sedation in Patients With Critical Illness
Cost-Effectiveness of α<sub>2</sub> Agonists for Intravenous Sedation in Patients With Critical Illness Open
Importance Propofol and the α 2 agonists dexmedetomidine and clonidine are used for sedation in patients with critical illness receiving mechanical ventilation. Evidence about the cost-effectiveness of intravenous (IV) sedation with these …
View article: Effects of transcranial direct current stimulation (tDCS) at different cortical targets on cognition in obsessive-compulsive disorder (OCD): an exploratory analysis
Effects of transcranial direct current stimulation (tDCS) at different cortical targets on cognition in obsessive-compulsive disorder (OCD): an exploratory analysis Open
Transcranial direct current stimulation (tDCS) holds promise as a treatment for obsessive-compulsive disorder (OCD). Patients with OCD show impairment in specific domains of cognitive flexibility and response inhibition. We previously repo…
View article: Development and validation of a measure to assess patient experience of needling of arteriovenous fistulas or grafts for haemodialysis access: the NPREM
Development and validation of a measure to assess patient experience of needling of arteriovenous fistulas or grafts for haemodialysis access: the NPREM Open
Background Needling is a key step in haemodialysis. Research suggests that needling experience is sub-optimal; however, no validated measure exists to inform improvements. We addressed this by developing the Needling Patient Reported Exper…
View article: Depression and anxiety in people with kidney disease: understanding symptom variability, patient experience and preferences for mental health support
Depression and anxiety in people with kidney disease: understanding symptom variability, patient experience and preferences for mental health support Open
Background Depression and anxiety are commonly experienced by people with chronic kidney disease (CKD). This study aimed to evaluate person- and service-level factors associated with depression and anxiety symptoms. We sought to also under…
View article: Haven schools: A pilot evaluation of a school‐based programme to reduce anxiety in young people
Haven schools: A pilot evaluation of a school‐based programme to reduce anxiety in young people Open
Objectives The aim of this study was to conduct a pilot evaluation of a novel six‐week school‐based intervention (‘Haven Schools’) on young people's psychological wellbeing. Methods One hundred and forty‐one students (ages 12–16 years) fro…
View article: Changes in Cardiorespiratory Fitness Following Exercise Training Prescribed Relative to Traditional Intensity Anchors and Physiological Thresholds: A Systematic Review with Meta-analysis of Individual Participant Data
Changes in Cardiorespiratory Fitness Following Exercise Training Prescribed Relative to Traditional Intensity Anchors and Physiological Thresholds: A Systematic Review with Meta-analysis of Individual Participant Data Open
View article: Patients' perspectives on key aspects influencing needling for haemodialysis: A qualitative study
Patients' perspectives on key aspects influencing needling for haemodialysis: A qualitative study Open
Background For many patients, cannulation (‘needling’) is essential for haemodialysis. It is associated with anxiety and fear and contributes to the overall burden of treatment. Limited research exists on patient experience of needling and…
View article: Communicating health risk in chronic kidney disease: a scoping review
Communicating health risk in chronic kidney disease: a scoping review Open
Background Communicating risk is a key component of shared decision-making and is vital for the management of advanced chronic kidney disease (CKD). Despite this, there is little evidence to suggest how best to communicate health risk info…
View article: Using a picture-based book to support epilepsy care in clinical consultations for people with intellectual disabilities
Using a picture-based book to support epilepsy care in clinical consultations for people with intellectual disabilities Open
The Getting on with Epilepsy book can be used in routine clinical practice to support people with intellectual disabilities and epilepsy. There was a balance between exploring patients' narratives and understanding with the need to convey …
View article: #1204 Measuring needling experience: development and validation of the Needling Patient Reported Experience Measure (NPREM)
#1204 Measuring needling experience: development and validation of the Needling Patient Reported Experience Measure (NPREM) Open
Background and Aims Most people on haemodialysis rely on having reliable access to their vascular system, often via surgically created arteriovenous fistula or graft. At the beginning of each dialysis session, needles must be inserted. Whi…
View article: Differential effects of sertraline and cognitive behavioural therapy on behavioural inhibition in patients with obsessive compulsive disorder
Differential effects of sertraline and cognitive behavioural therapy on behavioural inhibition in patients with obsessive compulsive disorder Open
Patients with obsessive compulsive disorder (OCD) randomised to sertraline, manualised cognitive behavioural therapy (CBT), or combination (sertraline + CBT), underwent cognitive assessment. Cognitive testing was conducted at baseline and …
View article: ‘The whole thing is beyond stress’: Family perspectives on the experience of hospitalisation through to discharge for individuals with severe learning disabilities and complex needs
‘The whole thing is beyond stress’: Family perspectives on the experience of hospitalisation through to discharge for individuals with severe learning disabilities and complex needs Open
Background People with severe learning disabilities and complex needs are more likely to experience delayed discharge from hospital; however, there is little research into their experience in hospital and as they move out as part of the Tr…
View article: Definition, assessment and management of frailty for people with intellectual disabilities: A scoping review
Definition, assessment and management of frailty for people with intellectual disabilities: A scoping review Open
Background People with intellectual disabilities may experience frailty earlier than the general population. This scoping review aimed to investigate how frailty is defined, assessed, and managed in adults with an intellectual disability; …
View article: Mapping stakeholders to maximise the impact of research on health inequalities for people with learning disabilities: The development of a framework for the Making Positive Moves study
Mapping stakeholders to maximise the impact of research on health inequalities for people with learning disabilities: The development of a framework for the Making Positive Moves study Open
Background People with learning disabilities experience health and social inequalities, and research that could improve health services may not be implemented in real‐life settings. Building stakeholder networks that can share and implemen…
View article: Impact of very low dose rivaroxaban in addition to dual antiplatelet therapy on endogenous fibrinolysis in acute coronary syndrome: The VaLiDate-R study
Impact of very low dose rivaroxaban in addition to dual antiplatelet therapy on endogenous fibrinolysis in acute coronary syndrome: The VaLiDate-R study Open
Impaired endogenous fibrinolysis is a strong risk factor in ACS. We aimed to assess whether adding very low dose rivaroxaban (VLDR) to DAPT can enhance fibrinolysis. Fibrin and clot lysis were assessed in whole blood. ACS patients with imp…
View article: The identification and management of depression in UK Kidney Care: Results from the Mood Maps Study
The identification and management of depression in UK Kidney Care: Results from the Mood Maps Study Open
Background Depression is common in people with chronic kidney disease, yet little is known about how depression is identified and managed as part of routine kidney care. Objectives The primary objective was to survey all UK adult kidney ce…
View article: Finding the Right Balance: A Framework analysis of staff and service user experiences of moving to remote drug and alcohol support during the COVID-19 pandemic
Finding the Right Balance: A Framework analysis of staff and service user experiences of moving to remote drug and alcohol support during the COVID-19 pandemic Open
Background Dependence on alcohol and other substances contributes significantly to poor health globally. Deaths associated with substance misuse have increased since the COVID-19 pandemic period and providing effective support for recovery…
View article: Referee report. For: Factors associated with the progression of deficit accumulation frailty among adults with an intellectual disability: a systematic review revealing research gaps [version 1; peer review: 4 approved with reservations]
Referee report. For: Factors associated with the progression of deficit accumulation frailty among adults with an intellectual disability: a systematic review revealing research gaps [version 1; peer review: 4 approved with reservations] Open
View article: Impact of the COVID-19 pandemic on services for patients with chronic kidney disease: findings of a national survey of UK kidney centres
Impact of the COVID-19 pandemic on services for patients with chronic kidney disease: findings of a national survey of UK kidney centres Open
View article: A Comparison of the Epidemiological Characteristics Between Influenza and COVID-19 Patients: A Retrospective, Observational Cohort Study
A Comparison of the Epidemiological Characteristics Between Influenza and COVID-19 Patients: A Retrospective, Observational Cohort Study Open
View article: Variability in exercise tolerance and physiological responses to exercise prescribed relative to physiological thresholds and to maximum oxygen uptake
Variability in exercise tolerance and physiological responses to exercise prescribed relative to physiological thresholds and to maximum oxygen uptake Open
The objective of this study was to determine whether the variability in exercise tolerance and physiological responses is lower when exercise is prescribed relative to physiological thresholds (THR) compared to traditional intensity anchor…
View article: Frailty and the psychosocial components of the edmonton frail scale are most associated with patient experience in older kidney transplant candidates – a secondary analysis within the kidney transplantation in older people (KTOP) study
Frailty and the psychosocial components of the edmonton frail scale are most associated with patient experience in older kidney transplant candidates – a secondary analysis within the kidney transplantation in older people (KTOP) study Open
Background Older people with end-stage kidney disease (ESKD) are vulnerable to frailty, which impacts on clinical and experiential outcomes. With kidney transplantation in older people increasing, a better understanding of patient experien…
View article: Approaches to the identification and management of depression in people living with chronic kidney disease: A scoping review of 860 papers
Approaches to the identification and management of depression in people living with chronic kidney disease: A scoping review of 860 papers Open
Background Depression is prevalent across the spectrum of Chronic Kidney Disease and associated with poorer outcomes. There is limited evidence regarding the most effective interventions and care pathways for depression in Chronic Kidney D…
View article: Selective serotonin reuptake inhibitors (SSRIs) may improve behavioral inhibition in patients with obsessive compulsive disorder: a feasibility study
Selective serotonin reuptake inhibitors (SSRIs) may improve behavioral inhibition in patients with obsessive compulsive disorder: a feasibility study Open
View article: Transcranial direct current stimulation in obsessive compulsive symptoms: a personalised approach
Transcranial direct current stimulation in obsessive compulsive symptoms: a personalised approach Open
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View article: Prevalence of frailty and cognitive impairment in older transplant candidates - a preview to the Kidney Transplantation in Older People (KTOP): impact of frailty on outcomes study
Prevalence of frailty and cognitive impairment in older transplant candidates - a preview to the Kidney Transplantation in Older People (KTOP): impact of frailty on outcomes study Open
View article: Repetitive transcranial magnetic stimulation (r-TMS) and selective serotonin reuptake inhibitor-resistance in obsessive-compulsive disorder: A meta-analysis and clinical implications
Repetitive transcranial magnetic stimulation (r-TMS) and selective serotonin reuptake inhibitor-resistance in obsessive-compulsive disorder: A meta-analysis and clinical implications Open
View article: Evaluation of the move to remote delivery of drug and alcohol services during the COVID-19 pandemic: A study protocol
Evaluation of the move to remote delivery of drug and alcohol services during the COVID-19 pandemic: A study protocol Open
Background: Substance misuse is a significant global health concern. In the UK, the prevalence of substance misuse has increased over the past decade and the number of alcohol and drug related deaths are increasing. Individuals with substa…