David Whitmore
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View article: Photoperiodic and intrinsic circadian regulation of heart rate in <i>Daphnia pulex</i>
Photoperiodic and intrinsic circadian regulation of heart rate in <i>Daphnia pulex</i> Open
Daphnia species are well-established models for drug testing. These crustaceans possess a unique myogenic heart similar to mammals and a transparent body akin to zebrafish, making them particularly suitable for cardiac studies. Circadian r…
View article: Cardiopulmonary exercise variables and their association with postoperative morbidity and mortality after major oesophagogastric cancer surgery—a multicentre observational study
Cardiopulmonary exercise variables and their association with postoperative morbidity and mortality after major oesophagogastric cancer surgery—a multicentre observational study Open
NCT03637647.
View article: Functional Analyses of Four Cryptochromes From Aquatic Organisms After Heterologous Expression in <i>Drosophila melanogaster</i> Circadian Clock Cells
Functional Analyses of Four Cryptochromes From Aquatic Organisms After Heterologous Expression in <i>Drosophila melanogaster</i> Circadian Clock Cells Open
Cryptochromes (Crys) represent a multi-facetted class of proteins closely associated with circadian clocks. They have been shown to function as photoreceptors but also to fulfill light-independent roles as transcriptional repressors within…
View article: Airfield pavement resiliency assessment against extreme dynamic events by explicit axisymmetric finite element models
Airfield pavement resiliency assessment against extreme dynamic events by explicit axisymmetric finite element models Open
View article: Molecular detection of novel herpesviruses and adenoviruses in two species of Australian freshwater turtles
Molecular detection of novel herpesviruses and adenoviruses in two species of Australian freshwater turtles Open
Cutaneous lesions were observed in a wild population of freshwater turtles during routine disease surveillance at Alligator Creek, Townsville, Australia. Previous attempts to identify the causative agent of these lesions were unsuccessful;…
View article: Blind fish have cells that see light
Blind fish have cells that see light Open
Most animals on earth have evolved under daily light–dark cycles and consequently possess a circadian clock which regulates much of their biology, from cellular processes to behaviour. There are however some animals that have invaded dark …
View article: Draft Genome Sequence of a Novel Adenovirus Recovered from the Metagenome of Agile Wallabies
Draft Genome Sequence of a Novel Adenovirus Recovered from the Metagenome of Agile Wallabies Open
Here, we report the draft genome sequence of a novel agile wallaby adenovirus that was detected in the fecal metagenome of agile wallabies. The genome is 31,512 bp long, with a G+C content of 34.4%. Currently, the pathogenic and zoonotic p…
View article: Development of subfamily-based consensus PCR assays for the detection of human and animal herpesviruses
Development of subfamily-based consensus PCR assays for the detection of human and animal herpesviruses Open
View article: Stats and qPCR data for cell culture from Blind fish have cells that see light
Stats and qPCR data for cell culture from Blind fish have cells that see light Open
Statistics and normalised qPCRdata for cell cultures
View article: Cell culture morphology from Blind fish have cells that see light
Cell culture morphology from Blind fish have cells that see light Open
Photos of morphology of the 4 different cavefish cell cultures
View article: Are the Patterns of Cytomegalovirus Viral Load Seen After Solid Organ Transplantation Affected by Circadian Rhythm?
Are the Patterns of Cytomegalovirus Viral Load Seen After Solid Organ Transplantation Affected by Circadian Rhythm? Open
Background Cytomegalovirus (CMV) is an important opportunistic pathogen after transplantation. Some virological variation in transplant recipients is explained by donor and recipient CMV serostatus, but not all. Circadian variability of he…
View article: Extending the Service Life of Existing Concrete Structures to Last Beyond 100 Years
Extending the Service Life of Existing Concrete Structures to Last Beyond 100 Years Open
New bridges and other concrete structures are being built using the design concepts presented in SHRP2 R19A (Bridges for Service Life Beyond 100 Years: Innovative Systems, Subsystems, and Components) and FIB Bulletin 34 (Model Code for Ser…
View article: Herpesviruses in Reptiles
Herpesviruses in Reptiles Open
Since the 1970s, several species of herpesviruses have been identified and associated with significant diseases in reptiles. Earlier discoveries placed these viruses into different taxonomic groups on the basis of morphological and biologi…
View article: Daily rhythms in heartbeat rate are intrinsic to the zebrafish heart
Daily rhythms in heartbeat rate are intrinsic to the zebrafish heart Open
View article: A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes
A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes Open
Hundreds of human genes are associated with neurological diseases, but translation into tractable biological mechanisms is lagging. Larval zebrafish are an attractive model to investigate genetic contributions to neurological diseases. How…
View article: Author response: A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes
Author response: A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes Open
View article: Zebrafish Circadian Clock Entrainment and the Importance of Broad Spectral Light Sensitivity
Zebrafish Circadian Clock Entrainment and the Importance of Broad Spectral Light Sensitivity Open
One of the key defining features of an endogenous circadian clock is that it can be entrained or set to local time. Though a number of cues can perform this role, light is the predominant environmental signal that acts to entrain circadian…
View article: A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes – Preprint
A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes – Preprint Open
Data and code for preprint Kroll, F. et al. 2020. A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes. https://www.biorxiv.org/content/10.1101/2020.06.04.133462v3 You can also navigate th…
View article: Kroll et al., 2020. A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes
Kroll et al., 2020. A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes Open
Data and code for Kroll, F. et al. 2020. A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes. https://doi.org/10.1101/2020.06.04.133462 You can also navigate through the files at: https:/…
View article: A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes
A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes Open
Hundreds of human genes are associated with neurological diseases, but translation into tractable biological mechanisms is lagging. Larval zebrafish are an attractive model to investigate genetic contributions to neurological diseases. How…
View article: Publisher Correction: Methylation deficiency disrupts biological rhythms from bacteria to humans
Publisher Correction: Methylation deficiency disrupts biological rhythms from bacteria to humans Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Publisher Correction: Methylation deficiency disrupts biological rhythms from bacteria to humans
Publisher Correction: Methylation deficiency disrupts biological rhythms from bacteria to humans Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Are megaprojects ready for the Fourth Industrial Revolution?
Are megaprojects ready for the Fourth Industrial Revolution? Open
Complex projects and megaprojects are increasingly shaped by new enabling technologies and new demands from businesses, including how people are treated when working on these endeavours. This is often referred to as the Fourth Industrial R…
View article: Methylation deficiency disrupts biological rhythms from bacteria to humans
Methylation deficiency disrupts biological rhythms from bacteria to humans Open
The methyl cycle is a universal metabolic pathway providing methyl groups for the methylation of nuclei acids and proteins, regulating all aspects of cellular physiology. We have previously shown that methyl cycle inhibition in mammals str…
View article: The methyl cycle is a conserved regulator of biological clocks
The methyl cycle is a conserved regulator of biological clocks Open
The methyl cycle is a universally conserved metabolic pathway operating in prokaryotes and eukaryotes. In this pathway, the amino acid methionine is used to synthesize S-adenosylmethionine, the methyl donor co-substrate in the methylation …
View article: Circadian Clocks in Fish—What Have We Learned so far?
Circadian Clocks in Fish—What Have We Learned so far? Open
Zebrafish represent the one alternative vertebrate, genetic model system to mice that can be easily manipulated in a laboratory setting. With the teleost Medaka (Oryzias latipes), which now has a significant following, and over 30,000 othe…
View article: 1566. Is Primary CMV Infection Post-transplant Influenced by Circadian Rhythms?
1566. Is Primary CMV Infection Post-transplant Influenced by Circadian Rhythms? Open
BACKGROUND: Cytomegalovirus (CMV) infection causes significant morbidity after transplant. Patients can be stratified by donor and recipient CMV serostatus, but the infection phenotype remains variable. We hypothesized that some of this va…
View article: Development of the Astyanax mexicanus circadian clock and non-visual light responses
Development of the Astyanax mexicanus circadian clock and non-visual light responses Open
Most animals and plants live on the planet exposed to periods of rhythmic light and dark. As such, they have evolved endogenous circadian clocks to regulate their physiology rhythmically, and non-visual light detection mechanisms to set th…
View article: Circadian Clock Synchronization of the Cell Cycle in Zebrafish Occurs through a Gating Mechanism Rather Than a Period-phase Locking Process
Circadian Clock Synchronization of the Cell Cycle in Zebrafish Occurs through a Gating Mechanism Rather Than a Period-phase Locking Process Open
Studies from a number of model systems have shown that the circadian clock controls expression of key cell cycle checkpoints, thus providing permissive or inhibitory windows in which specific cell cycle events can occur. However, a major q…
View article: Impregnation Technique Provides Corrosion Protection to Grouted Post-Tensioning Tendons
Impregnation Technique Provides Corrosion Protection to Grouted Post-Tensioning Tendons Open
Thousands of bridge structures rely on grouted post-tensioning (PT) tendons. Problems with grouting techniques and grout materials have resulted in bridges with grout voids, chloride contaminated grout and soft grout. These problems have p…