David D. Y. Chen
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View article: Direct Identification and Quantification of Flavonoids and Their Structural Isomers Using Ambient Ionization Tandem Mass Spectrometry
Direct Identification and Quantification of Flavonoids and Their Structural Isomers Using Ambient Ionization Tandem Mass Spectrometry Open
Rationale Flavonoids are phenolic compounds with many health‐benefiting properties. However, differentiating different types of flavonoids and their isomers is challenging due to their highly similar structures of various subtypes and diff…
View article: Development and validation of a nomogram based on LASSO-logistic regression for predicting carotid atherosclerosis in patients with hypertension
Development and validation of a nomogram based on LASSO-logistic regression for predicting carotid atherosclerosis in patients with hypertension Open
Background and objectives Carotid atherosclerosis (CAS) is increasingly prevalent among hypertensive patients. This study aims to develop a predictive nomogram for CAS in hypertensive population. Methods A total of 930 patients with hypert…
View article: EquiOx: A Prospective study of pulse oximeter bias and skin pigmentation in critically-ill adults
EquiOx: A Prospective study of pulse oximeter bias and skin pigmentation in critically-ill adults Open
Rationale Pulse oximeter performance may vary by skin pigmentation, but most data are retrospective with key limitations. Objective To quantify pulse oximeter bias [mean difference between pulse oximeter oxygen saturation (SpO 2 ) and arte…
View article: Methylation in ambient ion source enables direct isomer differentiation of oligosaccharides by tandem mass spectrometry
Methylation in ambient ion source enables direct isomer differentiation of oligosaccharides by tandem mass spectrometry Open
Oligosaccharides are carbohydrate polymers with prebiotic, immunomodulatory, and antimicrobial activities. However, their structural complexity makes it challenging for characterization. In this work, we demonstrated a powerful instant in …
View article: Characterization of the Specific Binding Between Aptamers and Cytochrome <i>c</i> With Pressure‐Assisted Capillary Electrophoresis Frontal Analysis
Characterization of the Specific Binding Between Aptamers and Cytochrome <i>c</i> With Pressure‐Assisted Capillary Electrophoresis Frontal Analysis Open
Cytochrome c (cyt c ) is a heme protein located in the mitochondrial intermembrane space. Because the release of cyt c is a highly specific event in apoptotic signaling, it can serve as an apoptosis‐related marker. To date, three frequentl…
View article: Real-time monitoring of tea volatiles using soft ionization by chemical reaction in transfer with an online sampling interface
Real-time monitoring of tea volatiles using soft ionization by chemical reaction in transfer with an online sampling interface Open
Characterization of tea volatile substances is important for tea quality assessment, flavor evaluation, and manufacturing process control. In this work, an online monitoring system was developed and directly coupled with soft ionization by…
View article: Determination of Critical Micelle Concentration of Ionic and Non‐Ionic Surfactants by Streaming Potential Measurements
Determination of Critical Micelle Concentration of Ionic and Non‐Ionic Surfactants by Streaming Potential Measurements Open
A capillary electrophoresis system capable of measuring streaming potentials was used for the determination of critical micelle concentration (CMC) of anionic, cationic, zwitterionic and non‐ionic surfactants. The CMC values of anionic sur…
View article: Characterization of Taurocholic Acid Binding With Insulin for Potential Oral Formulation Using Different Methods
Characterization of Taurocholic Acid Binding With Insulin for Potential Oral Formulation Using Different Methods Open
In diabetes management, oral formulation of insulin (INS) has the potential to improve safety, convenience, and patient‐centered care compared to subcutaneous injections. However, its bioavailability remains limited, necessitating improved…
View article: Evaluation of Cell-Free DNA Long Fragments in the Triage of FIT+ Patients Enrolled in a Colorectal Cancer Screening Program: An Italian Prospective, Cross-Sectional Study
Evaluation of Cell-Free DNA Long Fragments in the Triage of FIT+ Patients Enrolled in a Colorectal Cancer Screening Program: An Italian Prospective, Cross-Sectional Study Open
Introduction: Colorectal cancer screening programs are effective in reducing incidence and mortality. In Europe, every FIT+ patient is referred to colonoscopy. The available data show that ~75.0% of these patients are negative. It is desir…
View article: Evaluation of Cell-free DNA Long Fragments in the Triage of FIT+ Patients Enrolled in a Colorectal Cancer Screening Program: An Italian Prospective, Cross-Sectional Study
Evaluation of Cell-free DNA Long Fragments in the Triage of FIT+ Patients Enrolled in a Colorectal Cancer Screening Program: An Italian Prospective, Cross-Sectional Study Open
Background: Colorectal Cancer screening programs are effective in reducing incidence and mor-tality. In Europe, every FIT+ patient is referred to colonoscopy. Available data shows that ~75.0% of these patients are negative. It is desirable…
View article: The Impact of potential ‘confounders’ on the diagnostic sensitivity of circulating free DNA in management of FIT+ patients: a pilot study
The Impact of potential ‘confounders’ on the diagnostic sensitivity of circulating free DNA in management of FIT+ patients: a pilot study Open
Cell-free DNA (cfDNA) has long been established as a useful diagnostic and prognostic tool in a variety of clinical settings, ranging from infectious to cardiovascular and neoplastic diseases. However, non-neoplastic diseases can act as co…
View article: Simultaneous quantification of six proteins related to liver injury using nano liquid chromatography–tandem mass spectrometry
Simultaneous quantification of six proteins related to liver injury using nano liquid chromatography–tandem mass spectrometry Open
Rationale In clinical diagnosis of liver injury, which is an important health concern, serum aminotransferase assays have been the go‐to method used worldwide. However, the measurement of serum enzyme activity has limitations, including in…
View article: Numerical modeling and experimental optimization of Taylor dispersion analysis with and without an electric field
Numerical modeling and experimental optimization of Taylor dispersion analysis with and without an electric field Open
Numerical modeling of Taylor dispersion analysis (TDA) was performed using COMSOL Multiphysics to facilitate better and faster optimization of the experimental conditions. Parameters, such as pressure, electric field, diameter, and length …
View article: β‐Cyclodextrin and folic acid host–guest interaction binding parameters determined by Taylor dispersion analysis and affinity capillary electrophoresis
β‐Cyclodextrin and folic acid host–guest interaction binding parameters determined by Taylor dispersion analysis and affinity capillary electrophoresis Open
The thermodynamic properties of molecular recognition in host–guest inclusion complexes can be studied by Taylor dispersion analysis (TDA). Host–guest inclusion complexes have modest size, and it is possible to get convergent results fast,…
View article: Direct carboxylation of cellulose in deep eutectic solvent and its adsorption behavior of methylene blue
Direct carboxylation of cellulose in deep eutectic solvent and its adsorption behavior of methylene blue Open
The surface of cellulose particles was carboxylated (2.44 mmol/g) in a deep eutectic solvent containing carboxylic acid. Based on the carboxyl content, the effects of key factors on cellulose carboxylation was systematically investigated. …
View article: Molecular profiles of naphthenic acid fraction compounds from mine lease wetlands in the Athabasca Oil Sands Region
Molecular profiles of naphthenic acid fraction compounds from mine lease wetlands in the Athabasca Oil Sands Region Open
Naphthenic acid fraction compounds (NAFCs) are a toxicologically relevant component of oil sands process-affected materials (OSPM). For the first time, we report on differences in the concentrations and distribution of NAFCs from wetlands …
View article: Enrichment-Free Identification of Native Definitive (EnFIND) O-glycoproteome of antibodies in autoimmune diseases
Enrichment-Free Identification of Native Definitive (EnFIND) O-glycoproteome of antibodies in autoimmune diseases Open
The detection of O-glycosylation at the proteome level has long been a challenging task and a roadblock for O-linked protein glycosylation research. We report an Enrichment-Free Identification of Native Definitive (EnFIND) O-glycoproteome …
View article: RawTools: Rapid and Dynamic Interrogation of Orbitrap Data Files for Mass Spectrometer System Management
RawTools: Rapid and Dynamic Interrogation of Orbitrap Data Files for Mass Spectrometer System Management Open
Optimizing the quality of proteomics data collected from a mass spectrometer (MS) requires careful selection of acquisition parameters and proper assessment of instrument performance. Software tools capable of extracting a broad set of inf…
View article: Cover Image
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The cover image, by Matthew S. MacLennan et al., is based on the Research Article Characterization of Athabasca Lean Oil Sands and Mixed Surficial Materials: Comparison of Capillary Electrophoresis-Low Resolution Mass Spectrometry and High…
View article: Cover Image
Cover Image Open
The cover image, by Kevin A. Kovalchik et al., is based on the Research Article Characterization of dicarboxylic naphthenic acid fraction compounds utilizing amide derivatization: proof of concept, DOI: 10.1002/rcm.8000.