Explanipedia

RAIN: machine learning-based identification for HIV-1 bNAbs Open

Mathilde Foglierini, Pauline Nortier, Rachel Schelling, Rahel R. Winiger, Philippe Jacquet , et al. · 2024

Elucidation of Amyloid-Beta’s Gambit in Oligomerization: Truncated Aβ fragments of residues Aβ1-23, Aβ1-24 and Aβ1-25 rapidly seed to form SDS-stable, LMW Aβ oligomers that impair synaptic plasticity Open

Beatriz Gutiérrez‐Gil, Jamie Rose, Davide Demurtas, Gian‐Filippo Mancini, Jessica Sordet‐Dessimoz , et al. · 2022

In Alzheimer’s disease (AD), Amyloid-beta (Aβ) oligomers are considered an appealing therapeutic- and diagnostic target. However, to date, the molecular mechanisms associated with the pathological accumulation or structure of Aβ oligomers …

Cryogenic electron tomography to determine thermodynamic quantities for nanoparticle dispersions Open

Quy K. Ong, Ting Mao, Neda Iranpour Anaraki, Łukasz Richter, Carla Malinverni , et al. · 2021

Nanoparticle dispersions were studied by cryogenic electron tomography, which was found to allow extraction of key thermodynamic quantities.

A highly potent antibody effective against SARS-CoV-2 variants of concern Open

Craig Fenwick, Priscilla Turelli, Laurent Perez, Céline Pellaton, Line Esteves-Leuenberger , et al. · 2021

A Highly Potent Antibody Effective Against SARS-CoV-2 Variants of Concern Open

Craig Fenwick, Priscilla Turelli, Laurent Perez, Céline Pellaton, Line Esteves-Leuenberger , et al. · 2021

Rationally designed Human Cytomegalovirus gB nanoparticle vaccine with improved immunogenicity Open

Michela Perotti, Jessica Marcandalli, Davide Demurtas, Federica Sallusto, Laurent Perez · 2020

Human cytomegalovirus (HCMV) is the primary viral cause of congenital birth defects and causes significant morbidity and mortality in immune-suppressed transplant recipients. Despite considerable efforts in vaccine development, HCMV infect…

Novel features of centriole polarity and cartwheel stacking revealed by cryo‐tomography Open

Sergey Nazarov, Alexandra Bezler, Georgios N. Hatzopoulos, Veronika Nemčíková Villímová, Davide Demurtas , et al. · 2020

Novel features of centriole polarity and cartwheel stacking revealed by cryo-tomography Open

Sergey Nazarov, Alexandra Bezler, Georgios N. Hatzopoulos, Veronika Nemčíková Villímová, Davide Demurtas , et al. · 2020

Summary Centrioles are polarized microtubule-based organelles that seed the formation of cilia, and which assemble from a cartwheel containing stacked ring oligomers of SAS-6 proteins. A cryo-tomography map of centrioles from the termite f…

Native Architecture of the Centriole Proximal Region Reveals Features Underlying Its 9-Fold Radial Symmetry Open

Paul Guichard, Virginie Hachet, Norbert Majubu, Aitana Neves, Davide Demurtas , et al. · 2020

KAP1 is an antiparallel dimer with a functional asymmetry Open

Giulia Fonti, María J. Marcaida, Louise C. Bryan, Sylvain Träger, Alexandra Kalantzi , et al. · 2019

KAP1 (KRAB domain–associated protein 1) plays a fundamental role in regulating gene expression in mammalian cells by recruiting different transcription factors and altering the chromatin state. In doing so, KAP1 acts both as a platform for…

Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients Open

Maria A.S. Broggi, Léa Maillat, Cristina C. Clement, Natacha Bordry, Patricia Corthésy , et al. · 2019

Liquid biopsies allow monitoring of cancer progression and detection of relapse, but reliable biomarkers in melanoma are lacking. Because secreted factors preferentially drain to lymphatic vessels before dilution in the blood, we hypothesi…

KAP1 is an antiparallel dimer with a natively functional asymmetry Open

Giulia Fonti, María J. Marcaida, Louise C. Bryan, Sylvain Traeger, Alexandra Kalantzi , et al. · 2019

KAP1 (KRAB-domain associated protein 1) plays a fundamental role in regulating gene expression in mammalian cells by recruiting different transcription factors and altering the chromatin state. In doing so, KAP1 acts both as a platform for…

Flagellar microtubule doublet assembly in vitro reveals a regulatory role of tubulin C-terminal tails Open

Markéta Schmidt Černohorská, Ilia Zhernov, Emmanuelle Steib, Maeva Le Guennec, R. Achek , et al. · 2019

Assembly of the ciliary microtubule doublet The cilium is a conserved organelle that is crucial for motility as well as for sensing the extracellular environment. Its core structure is characterized by nine microtubule doublets (MTDs). The…

Structure–Property Relationships of Amphiphilic Nanoparticles That Penetrate or Fuse Lipid Membranes Open

Prabhani U. Atukorale, Zekiye P. Güven, Ahmet Bekdemir, Randy P. Carney, Reid C. Van Lehn , et al. · 2018

The development of synthetic nanomaterials that could embed within, penetrate, or induce fusion between membranes without permanent disruption would have great significance for biomedical applications. Here we describe structure-function r…

Nanodesign of new self-assembling core-shell gellan-transfersomes loading baicalin and in vivo evaluation of repair response in skin Open

Maria Manconi, María Letizia Manca, Carla Caddeo, Donatella Valenti, Claudia Cencetti , et al. · 2017

TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity Open

Manoël Prouteau, Ambroise Desfosses, Christian Sieben, Clélia Bourgoint, Nour L. Mozaffari , et al. · 2017

Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity Open

Chiara Cianciaruso, Edward A. Phelps, Miriella Pasquier, Romain Hamelin, Davide Demurtas , et al. · 2016

The target autoantigens in several organ-specific autoimmune diseases, including type 1 diabetes (T1D), are intracellular membrane proteins, whose initial encounter with the immune system is poorly understood. Here we propose a new model f…

Amyloid‐beta oligomerization is associated with the generation of a typical peptide fragment fingerprint Open

Nikita Rudinskiy, Christophe Fuerer, Davide Demurtas, Sebastián Zamorano, Cyntia De Piano , et al. · 2016

Amyloid‐beta (Aβ) peptide oligomerization plays a central role in the pathogenesis of Alzheimer's disease (AD), and Aβ oligomers are collectively considered an appealing therapeutic target for the treatment of AD. However, the molecular me…

Santosomes as natural and efficient carriers for the improvement of phycocyanin reepithelising ability in vitro and in vivo Open

Ines Castangia, María Letizia Manca, Carla Caddeo, Gianluigi Bacchetta, Ramón Pons , et al. · 2016

A Cationic Micelle Complex Improves CD8+ T Cell Responses in Vaccination Against Unmodified Protein Antigen Open

Carrie E. Brubaker, Vasiliki Panagiotou, Davide Demurtas, Daniel K. Bonner, Melody A. Swartz , et al. · 2015

Nanoscale carrier platforms promote immune responses to vaccination by facilitating delivery of vaccine components to immunologically relevant sites. The technique is particularly valuable for subunit vaccination, in which coadministration…

Direct visualization of dispersed lipid bicontinuous cubic phases by cryo-electron tomography Open

Davide Demurtas, Paul Guichard, Isabelle Martiel, Raffaele Mezzenga, C. Hébert , et al. · 2015

Crystalline Oligo(ethylene sulfide) Domains Define Highly Stable Supramolecular Block Copolymer Assemblies Open

Carrie E. Brubaker, Diana Velluto, Davide Demurtas, Edward A. Phelps, Jeffrey A. Hubbell · 2015

With proper control over copolymer design and solvation conditions, self-assembled materials display impressive morphological variety that encompasses nanoscale colloids as well as bulk three-dimensional architectures. Here we take advanta…

Faceted phospholipid vesicles tailored for the delivery of Santolina insularis essential oil to the skin Open

Ines Castangia, María Letizia Manca, Carla Caddeo, Andrea Maxia, Sergio Murgia , et al. · 2015

Molecular screening of cancer-derived exosomes by surface plasmon resonance spectroscopy Open

Luigino Grasso, Romain Wyss, Lorenz Weidenauer, Ashwin Thampi, Davide Demurtas , et al. · 2015

Highly stable ionic liquid-in-water emulsions as a new class of fluorescent sensors for metal ions: the case study of Fe<sup>3+</sup> sensing Open

Alexandre Bettoschi, Andrea Bencini, Debora Berti, Claudia Caltagirone, Luca Conti , et al. · 2015

A stable fluorescent ionic liquid can act as a fluorescent sensor for metal ion recognition.

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