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View article: Cover Image, Volume 35, Issue 6
Cover Image, Volume 35, Issue 6 Open
View article: Manipulating Engram Histone Acetylation Alters Memory Consolidation
Manipulating Engram Histone Acetylation Alters Memory Consolidation Open
The epigenome provides the brain with a nucleus‐templated form of plasticity that is of fundamental importance for learning and memory. Of the various types of epigenetic modifications, elevations in histone acetylation have been shown to …
View article: Cell-type- and locus-specific epigenetic editing of memory expression
Cell-type- and locus-specific epigenetic editing of memory expression Open
View article: A modular toolbox for the optogenetic deactivation of transcription
A modular toolbox for the optogenetic deactivation of transcription Open
Light-controlled transcriptional activation is a commonly used optogenetic strategy that allows researchers to regulate gene expression with high spatiotemporal precision. The vast majority of existing tools are, however, limited to light-…
View article: Cell type and locus-specific epigenetic editing of memory expression
Cell type and locus-specific epigenetic editing of memory expression Open
Epigenetic modifications parallel multiple memory processes, but evidence that the epigenetic makeup of a single site can guide learnt behaviors has so far been lacking. Here, we developed CRISPR-based epigenetic editing tools to address t…
View article: From cellular to fear memory: An epigenetic toolbox to remember
From cellular to fear memory: An epigenetic toolbox to remember Open
Throughout development, the neuronal epigenome is highly sensitive to external stimuli, yet capable of safeguarding cellular memory for a lifetime. In the adult brain, memories of fearful experiences are rapidly instantiated, yet can last …
View article: A modular toolbox for the optogenetic deactivation of transcription
A modular toolbox for the optogenetic deactivation of transcription Open
Light-controlled transcriptional activation is a commonly used optogenetic strategy that allows researchers to regulate gene expression with high spatiotemporal precision. The vast majority of existing tools are, however, limited to light-…
View article: A network of transcription factors governs the dynamics of NODAL/Activin transcriptional responses
A network of transcription factors governs the dynamics of NODAL/Activin transcriptional responses Open
SMAD2, an effector of the NODAL/Activin signalling pathway, regulates developmental processes by sensing distinct chromatin states and interacting with different transcriptional partners. However, the network of factors that controls SMAD2…
View article: Neurogenetic and Neuroepigenetic Mechanisms in Cognitive Health and Disease
Neurogenetic and Neuroepigenetic Mechanisms in Cognitive Health and Disease Open
Over the last two decades, the explosion of experimental, computational, and high-throughput technologies has led to critical insights into how the brain functions in health and disease. It has become increasingly clear that the vast major…
View article: Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling
Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling Open
NODAL/Activin signaling orchestrates key processes during embryonic development via SMAD2. How SMAD2 activates programs of gene expression that are modulated over time however, is not known. Here we delineate the sequence of events that oc…
View article: Author response: Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling
Author response: Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract NODAL/Activin signaling orche…
View article: Great need for changes in higher education in Greece
Great need for changes in higher education in Greece Open
View article: SMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma
SMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma Open
Rhadomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood. RMS cells resemble fetal myoblasts but are unable to complete myogenic differentiation. In previous work we showed that miR-206, which is low in RMS, when induced i…
View article: SMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma
SMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma Open
Rhadomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood. RMS cells resemble fetal myoblasts but are unable to complete myogenic differentiation. In previous work we showed that miR-206, which is low in RMS, when induced i…
View article: Smyd1 And G6Pd Modulation Are Critical Events For Mir-206-Mediated Differentiation Of Rhabdomyosarcoma
Smyd1 And G6Pd Modulation Are Critical Events For Mir-206-Mediated Differentiation Of Rhabdomyosarcoma Open
Rhadomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood. RMS cells resemble fetal myoblasts but are unable to complete myogenic differentiation. In previous work we showed that miR-206, which is low in RMS, when induced i…
View article: SMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma
SMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma Open
Rhadomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood. RMS cells resemble fetal myoblasts but are unable to complete myogenic differentiation. In previous work we showed that miR-206, which is low in RMS, when induced i…
View article: SMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma
SMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma Open
Rhadomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood. RMS cells resemble fetal myoblasts but are unable to complete myogenic differentiation. In previous work we showed that miR-206, which is low in RMS, when induced i…