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View article: Long COVID and work in the UK: challenges, support and perspectives
Long COVID and work in the UK: challenges, support and perspectives Open
Aim Long COVID (LC) presents significant challenges for working age individuals, leading to major inequalities in access to work, employment and relevant support. This study investigates the workplace support provided to people with Long C…
View article: Return to work with long COVID: a rapid review of support and challenges
Return to work with long COVID: a rapid review of support and challenges Open
Objectives To explore existing evidence for the provision of support for return to work (RTW) in long COVID (LC) patients and the barriers and facilitators to taking up this support. Design A rapid review reported in accordance with the Pr…
View article: Long COVID and Work in the UK: Challenges, Support and Perspectives
Long COVID and Work in the UK: Challenges, Support and Perspectives Open
Aim Long COVID (LC) presents significant challenges for working age individuals, leading to major inequalities in access to work, employment and relevant support. This study investigates the workplace support provided to people with Long C…
View article: Return to Work with Long COVID: A Rapid Review of Support and Challenges
Return to Work with Long COVID: A Rapid Review of Support and Challenges Open
Objective To explore existing evidence for the provision of support for return to work (RTW) in long COVID (LC) patients, and the barriers and facilitators to taking up this support. Methods A rapid review was reported according to the Pre…
View article: Large <i>Shigella flexneri</i> outbreak linked to a takeaway, South Wales: a case–control study
Large <i>Shigella flexneri</i> outbreak linked to a takeaway, South Wales: a case–control study Open
In February 2023, 52 cases of gastrointestinal illness were reported in customers of Takeaway A, South Wales. Shigella flexneri serotype 2a was the causative organism. An outbreak investigation was conducted to determine the extent and veh…
View article: Efficacy and safety of baricitinib or ravulizumab in adult patients with severe COVID-19 (TACTIC-R): a randomised, parallel-arm, open-label, phase 4 trial
Efficacy and safety of baricitinib or ravulizumab in adult patients with severe COVID-19 (TACTIC-R): a randomised, parallel-arm, open-label, phase 4 trial Open
UK Medical Research Council, UK National Institute for Health Research Cambridge Biomedical Research Centre, Eli Lilly and Company, Alexion Pharmaceuticals, and Addenbrooke's Charitable Trust.
View article: An informatics consult approach for generating clinical evidence for treatment decisions
An informatics consult approach for generating clinical evidence for treatment decisions Open
Background An Informatics Consult has been proposed in which clinicians request novel evidence from large scale health data resources, tailored to the treatment of a specific patient. However, the availability of such consultations is lack…
View article: Temporal development and neutralising potential of antibodies against SARS-CoV-2 in hospitalised COVID-19 patients: An observational cohort study
Temporal development and neutralising potential of antibodies against SARS-CoV-2 in hospitalised COVID-19 patients: An observational cohort study Open
Antibody responses are important in the control of viral respiratory infection in the human host. What is not clear for SARS-CoV-2 is how rapidly this response occurs, or when antibodies with protective capability evolve. Hence, defining t…
View article: An Informatics Consult approach for generating clinical evidence for treatment decisions
An Informatics Consult approach for generating clinical evidence for treatment decisions Open
An Informatics Consult has been proposed in which clinicians request novel evidence from large scale health data resources, tailored to the treatment of a specific patient, with return of results in clinical timescales. However, the availa…
View article: A longitudinal comparison of spike and nucleocapsid SARS-CoV-2 antibody responses in a tertiary hospital’s laboratory workers with validation of DBS specimen analysis
A longitudinal comparison of spike and nucleocapsid SARS-CoV-2 antibody responses in a tertiary hospital’s laboratory workers with validation of DBS specimen analysis Open
There is a requirement for easily accessible, high throughput serological testing as part of the SARS-CoV-2 pandemic response. Whilst of limited diagnostic use in an acute individual setting, its use on a population level is key to informi…
View article: Hepatitis B virus seroepidemiology data for Africa: Modelling intervention strategies based on a systematic review and meta-analysis
Hepatitis B virus seroepidemiology data for Africa: Modelling intervention strategies based on a systematic review and meta-analysis Open
The unique data set collected in this study highlights how regional epidemiology data for HBV can provide insights into patterns of transmission, and it provides an evidence base for future quantitative research into the most effective loc…
View article: HBV seroepidemiology data for Africa provides insights into transmission and prevention
HBV seroepidemiology data for Africa provides insights into transmission and prevention Open
I nternational goals for elimination of hepatitis B virus (HBV) infection set ambitious targets for 2030. In many African populations, HBV prevalence remains high (≥8%) despite the roll-out of infant HBV immunisation from the mid-1990’s on…
View article: Dual prognostic role of 2‐oxoglutarate‐dependent oxygenases in ten cancer types: implications for cell cycle regulation and cell adhesion maintenance
Dual prognostic role of 2‐oxoglutarate‐dependent oxygenases in ten cancer types: implications for cell cycle regulation and cell adhesion maintenance Open
Background Tumor hypoxia is associated with metastasis and resistance to chemotherapy and radiotherapy. Genes involved in oxygen‐sensing are clinically relevant and have significant implications for prognosis. In this study, we examined th…
View article: A novel signature derived from immunoregulatory and hypoxia genes predicts prognosis in liver and five other cancers
A novel signature derived from immunoregulatory and hypoxia genes predicts prognosis in liver and five other cancers Open
Background Despite much progress in cancer research, it’s incidence and mortality continue to rise. A robust biomarker that would predict tumor behavior is highly desirable and could improve patient treatment and prognosis. Methods In a re…
View article: Dual prognostic role for 2-oxoglutarate oxygenases in ten diverse cancer types: Implications for cell cycle regulation and cell adhesion maintenance
Dual prognostic role for 2-oxoglutarate oxygenases in ten diverse cancer types: Implications for cell cycle regulation and cell adhesion maintenance Open
Objectives Tumor hypoxia is associated with metastasis and resistance to chemotherapy and radiotherapy. Genes involved in oxygen-sensing are clinically relevant and have significant implications on prognosis. Methods We identified of two s…
View article: Glucose and glutamine availability regulate HepG2 transcriptional responses to low oxygen
Glucose and glutamine availability regulate HepG2 transcriptional responses to low oxygen Open
Background: Little is known about the impact of nutrients on cellular transcriptional responses, especially in face of environmental stressors such as oxygen deprivation. Hypoxia-inducible factors (HIF) coordinate the expression of genes e…