Dawei Chen
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View article: Four Cytochrome P450 Enzymes Mediate Oxidation Cascades in the Biosynthesis of Cephalotane‐Type Diterpenoids
Four Cytochrome P450 Enzymes Mediate Oxidation Cascades in the Biosynthesis of Cephalotane‐Type Diterpenoids Open
Cephalotane‐type diterpenoids, a class of natural products exclusively found in Cephalotaxus plants, are well known for their attractive structures and potent biological activities. However, their low natural abundance and intricate cage‐l…
View article: Association between Age of Onset of Hypertension and Risk of CKD
Association between Age of Onset of Hypertension and Risk of CKD Open
Key Points This study definitively explores the effect of age at onset of hypertension on the subsequent incidence of CKD. Our study also illuminates subgroup differences within populations characterized by different ages at onset of hyper…
View article: Melatonin as an Alleviator in Decabromodiphenyl Ether-Induced Aberrant Hippocampal Neurogenesis and Synaptogenesis: The Role of Wnt7a
Melatonin as an Alleviator in Decabromodiphenyl Ether-Induced Aberrant Hippocampal Neurogenesis and Synaptogenesis: The Role of Wnt7a Open
Developmental exposure to polybrominated diphenyl ethers (PBDEs), which are commonly used as flame retardants, results in irreversible cognitive impairments. Postnatal hippocampal neurogenesis, which occurs in the subgranular zone (SGZ) of…
View article: Impact of delayed addition of PD-1/PD-L1 inhibitors to chemotherapy on outcomes in patients with extensive-stage small cell lung cancer
Impact of delayed addition of PD-1/PD-L1 inhibitors to chemotherapy on outcomes in patients with extensive-stage small cell lung cancer Open
Background: Immunotherapy combined with chemotherapy is the first-line treatment for extensive-stage small cell lung cancer (ES-SCLC). However, the effect of delayed initiation of immunotherapy on its efficacy remains unclear. Objectives: …
View article: Association of Different Types of Diabetic Autonomic Neuropathy With Left Ventricular Diastolic Dysfunction in Patients With Type 2 Diabetes: A Cross‐Sectional Study
Association of Different Types of Diabetic Autonomic Neuropathy With Left Ventricular Diastolic Dysfunction in Patients With Type 2 Diabetes: A Cross‐Sectional Study Open
Background To investigate the association between different categories of diabetic autonomic neuropathy (DAN) and left ventricular diastolic dysfunction (LVDD) in patients with type 2 diabetes mellitus (T2DM). Methods We conducted a cross‐…
View article: Neutrophil hitchhiking liposomal drugs for starvation therapy in endometriosis
Neutrophil hitchhiking liposomal drugs for starvation therapy in endometriosis Open
Rationale: Endometriosis, characterized by the presence of ectopic endometrial-like tissue, is a common chronic inflammatory disorder in gynecology. However, current treatments, including surgery and hormone therapy, often yield sub…
View article: Transcriptome Analysis Reveals Key Genes Involved in Fatty Acid and Triacylglycerol Accumulation in Developing Sunflower Seeds
Transcriptome Analysis Reveals Key Genes Involved in Fatty Acid and Triacylglycerol Accumulation in Developing Sunflower Seeds Open
Background/Objectives: Sunflower (Helianthus annuus L.) is one of the four major global oilseed crops. Understanding the molecular mechanisms regulating fatty acid synthesis and triacylglycerol (TAG) accumulation is crucial for improving o…
View article: Therapeutic effects and mechanistic insights of YiQiHuangDou decoction on high-fat diet-induced obesity-related Glomerulopathy (ORG) in mice
Therapeutic effects and mechanistic insights of YiQiHuangDou decoction on high-fat diet-induced obesity-related Glomerulopathy (ORG) in mice Open
Yiqiheidou (YQHD) decoction has been traditionally used for treating Obesity-Related Glomerulopathy (ORG), known for its benefits in nourishing kidneys, strengthening Qi, and invigorating the spleen. This study aims to explore the mechanis…
View article: A comparative analysis of nutritional content changes in six Chinese cuisines prepared using industrial versus traditional hand-cooked modes
A comparative analysis of nutritional content changes in six Chinese cuisines prepared using industrial versus traditional hand-cooked modes Open
Objective With the rise of industrialized dishes, the quality differences between industrial and traditional hand-cooked modes are a major concern for the food industry and consumers. This study examined the nutrient content variations in …
View article: Response to Commentary on “Pedal Medial Arterial Calcification in Diabetic Foot Ulcers: A Significant Risk Factor of Amputation and Mortality”
Response to Commentary on “Pedal Medial Arterial Calcification in Diabetic Foot Ulcers: A Significant Risk Factor of Amputation and Mortality” Open
View article: Reserve allocation of high-penetration renewable energy grids considering frequency security
Reserve allocation of high-penetration renewable energy grids considering frequency security Open
As the penetration rate of renewable energy in the power grid continues to rise, the reserve criteria for traditional power grids dominated by synchronous generators (SGs) have difficulty meeting system frequency security requirements. Thi…
View article: Knowledge, Attitudes, and Practices about Hyperuricemia and Gout in Community Health Workers and Patients with Diabetes
Knowledge, Attitudes, and Practices about Hyperuricemia and Gout in Community Health Workers and Patients with Diabetes Open
Hyperuricemia exhibits a high incidence among individuals with diabetes; however, the significance of hyperuricemia and gout is often underestimated. This study aimed to assess the knowledge, attitude, and practice of hyperuricemia and gou…
View article: Post-stroke cognitive impairment: exploring molecular mechanisms and omics biomarkers for early identification and intervention
Post-stroke cognitive impairment: exploring molecular mechanisms and omics biomarkers for early identification and intervention Open
Post-stroke cognitive impairment (PSCI) is a major stroke consequence that has a severe impact on patients’ quality of life and survival rate. For this reason, it is especially crucial to identify and intervene early in high-risk groups du…
View article: Adult ovarian and sellar region mixed germ cell tumor: a case report and literature review
Adult ovarian and sellar region mixed germ cell tumor: a case report and literature review Open
Mixed germ cell tumors (mGCTs) involving both the ovaries and sellar region have been rarely reported; thus, they pose significant challenges in clinical management. Our report of a case of a 26-year-old female with left ovarian mGCTs (dys…
View article: Transcriptomic and physiological analyses of Symphytum officinale L. in response to multiple heavy metal stress
Transcriptomic and physiological analyses of Symphytum officinale L. in response to multiple heavy metal stress Open
Soil heavy metal contamination has become a global environmental issue, which threaten soil quality, food security and human health. Symphytum officinale L. have exhibited high tolerance and restoration capacity to heavy metals (HMs) stres…
View article: Pedal medial arterial calcification in diabetic foot ulcers: A significant risk factor of amputation and mortality
Pedal medial arterial calcification in diabetic foot ulcers: A significant risk factor of amputation and mortality Open
Aims Pedal medial arterial calcification (MAC) is frequently observed in individuals with diabetic foot ulcers (DFUs). However, the impact of pedal MAC on individuals with DFUs remains uncertain. The main aim of this study was to evaluate …
View article: Transcriptomic and physiological analyses of Trichoderma citrinoviride HT-1 assisted phytoremediation of Cd contaminated water by Phragmites australis
Transcriptomic and physiological analyses of Trichoderma citrinoviride HT-1 assisted phytoremediation of Cd contaminated water by Phragmites australis Open
Plant growth promoting microbe assisted phytoremediation is considered a more effective approach to rehabilitation than the single use of plants, but underlying mechanism is still unclear. In this study, we combined transcriptomic and phys…
View article: A broad host phage, CP6, for combating multidrug-resistant Campylobacter prevalent in poultry meat
A broad host phage, CP6, for combating multidrug-resistant Campylobacter prevalent in poultry meat Open
View article: The Mother-Offspring Transfer of Chlorothalonil Through Human Breast Milk: A Pilot Prospective Study
The Mother-Offspring Transfer of Chlorothalonil Through Human Breast Milk: A Pilot Prospective Study Open
View article: The Correlation between Serum Vitamin D Status and the Occurrence of Diabetes Foot Ulcers: A Comprehensive Systematic Review and Meta‐Analysis
The Correlation between Serum Vitamin D Status and the Occurrence of Diabetes Foot Ulcers: A Comprehensive Systematic Review and Meta‐Analysis Open
View article: The Application of Cold-Induced Liquid–Liquid Extraction for the Determination of 4-Methylimidazole in Tea and Associated Risk Assessment for Chinese Tea Consumers
The Application of Cold-Induced Liquid–Liquid Extraction for the Determination of 4-Methylimidazole in Tea and Associated Risk Assessment for Chinese Tea Consumers Open
4-Methylimidazole (4-MEI), as a Maillard reaction product, often occurs in heat-processed food. Due to its widespread occurrence and strong carcinogenicity in food and beverages, 4-MEI has received attention from regulatory organizations a…
View article: Non-Targeted Metabolomics Combined with Chemometrics by UHPLC–Orbitrap–HRMS and Antioxidant Activity of Atractylodes chinensis (DC.) Koidez. from Eight Origins
Non-Targeted Metabolomics Combined with Chemometrics by UHPLC–Orbitrap–HRMS and Antioxidant Activity of Atractylodes chinensis (DC.) Koidez. from Eight Origins Open
Atractylodes chinensis (DC.) Koidez. (AC) is a type of Atractylodis Rhizoma that is widely used in China to treat diarrhea and arthritis, as well as a nutritional supplement. The objective of this study was to investigate and identify the …
View article: Thyroid-Disrupting Effects of Exposure to Fipronil and Its Metabolites from Drinking Water Based on Human Thyroid Follicular Epithelial Nthy-ori 3-1 Cell Lines
Thyroid-Disrupting Effects of Exposure to Fipronil and Its Metabolites from Drinking Water Based on Human Thyroid Follicular Epithelial Nthy-ori 3-1 Cell Lines Open
Fipronil is a broad-spectrum insecticide used for plants and poultry. Owing to its widespread use, fipronil and its metabolites (fipronil sulfone, fipronil desulfinyl, and fipronil sulfide), termed FPM, can be frequently detected in drinki…
View article: Issue Information
Issue Information Open
Aims and Scope: For more than 50 years, clinical pharmacologists, clinical and pharmaceutical researchers, drug development specialists, physicians, nurses, and other medical professionals have relied on The Journal of Clinical Pharmacolog…
View article: Dietary Exposure Risk Assessment of Pyrethroids in Fruits and Vegetables: A National Scale Investigation
Dietary Exposure Risk Assessment of Pyrethroids in Fruits and Vegetables: A National Scale Investigation Open
The pyrethroids (PYRs) were extensively used to increase agriculture outputs. However, the cumulative exposures of PYRs would bring about potential risks through food intake. It is in urgent requirement to explore the cumulative exposures …
View article: A Simulation‐Based Optimization Method for Truck‐Prohibit Ramp Placement along Freeways
A Simulation‐Based Optimization Method for Truck‐Prohibit Ramp Placement along Freeways Open
The increasing number of trucks has a negative impact pertinent to efficiency and safety concerns on the operation of mixed traffic flow along freeways, especially at freeway entrance and exit ramps. To address such issue, this study propo…
View article: [Clinical Characteristics and Prognosis of Diabetic Foot Ulcers Patients of Different Renal Function Statuses].
[Clinical Characteristics and Prognosis of Diabetic Foot Ulcers Patients of Different Renal Function Statuses]. Open
As renal function impairment worsens, patients with DFU present clinical characteristics of greater complexity, higher risks of cardiovascular events, and higher mortality. It is essential to prevent kidney damage and foot ulcers, to pay a…
View article: Prevalence and associated factors of hyperuricemia among Chinese patients with diabetes: a cross-sectional study
Prevalence and associated factors of hyperuricemia among Chinese patients with diabetes: a cross-sectional study Open
Background: As a part of metabolic syndrome, hyperuricemia has a higher incidence in patients with diabetes than in the general population owing to various underlying factors. Objectives: The objective of the present study was to investiga…
View article: Comprehensive Evaluation of Dietary Exposure and Health Risk of Perchlorate for Chinese Adults and Breastfed Infants
Comprehensive Evaluation of Dietary Exposure and Health Risk of Perchlorate for Chinese Adults and Breastfed Infants Open
View article: Suspect and Nontarget Screening of Mycotoxins and Their Modified Forms in Cereals Based on Ultrahigh-Performance Liquid Chromatography-High Resolution Mass Spectrometry
Suspect and Nontarget Screening of Mycotoxins and Their Modified Forms in Cereals Based on Ultrahigh-Performance Liquid Chromatography-High Resolution Mass Spectrometry Open