2025-03-31
Integrating Subacute Ruminal Acidosis, Lipopolysaccharide, and Trained Immunity: A Comprehensive Review
2025-03-31 • Guobin Hou, Jingjun Wang, Shuai Liu, Duo Gao, Yiming Xu, Yimin Zhuang, Wang-chao Dong, Yi Yue, Jinni Bai, Shangru Li, Jiaying Ma, Mengmeng Li, Dawe...
Subacute ruminal acidosis (SARA) has emerged as a prevalent digestive disorder that significantly affects the overall health of ruminants, with notable links to various inflammatory diseases. Throughout the progression of SARA, elevated lipopolysaccharide (LPS) levels in the rumen play a crucial role in initiating the innate immune response. In this review, we evaluate the recent insights into the pathways associated with SARA-induced inflammatory responses, with a specific focus on LPS. It is important to recogni…