Dawit Tesfaye
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View article: Evaluating Machine Translation Datasets for Low-Web Data Languages: A Gendered Lens
Evaluating Machine Translation Datasets for Low-Web Data Languages: A Gendered Lens Open
As low-resourced languages are increasingly incorporated into NLP research, there is an emphasis on collecting large-scale datasets. But in prioritizing quantity over quality, we risk 1) building language technologies that perform poorly f…
View article: Efficient genome editing of bovine in vitro derived zygotes via Cas9 RNP-electroporation using extended-stored bovine ovaries
Efficient genome editing of bovine in vitro derived zygotes via Cas9 RNP-electroporation using extended-stored bovine ovaries Open
Bovine embryos serve as a relevant model for human preimplantation development and are increasingly used in genome editing research. Although CRISPR-Cas9 electroporation in zygotes offers a promising approach, challenges with respect to ed…
View article: Functional COPA is indispensable for early embryo development beyond major genome activation in bovines
Functional COPA is indispensable for early embryo development beyond major genome activation in bovines Open
Embryonic genome activation is divided into a minor and a major wave of transition to endogenous transcription. In bovines, minor genome activation begins early in the 2-cell stage and is completed by the 8-cell stage when major genome act…
View article: Seasonal environmental fluctuations alter the transcriptome dynamics of oocytes and granulosa cells in beef cows
Seasonal environmental fluctuations alter the transcriptome dynamics of oocytes and granulosa cells in beef cows Open
Background Examining the mechanistic cellular responses to heat stress could aid in addressing the increasing prevalence of decreased fertility due to elevated ambient temperatures. Here, we aimed to study the differential responses of ooc…
View article: Seasonal influence on miRNA expression dynamics of extracellular vesicles in equine follicular fluid
Seasonal influence on miRNA expression dynamics of extracellular vesicles in equine follicular fluid Open
View article: L-Carnitine sustainably affects bioenergetic profile of bovine blastocysts and transcriptome profile of elongation-stage embryos
L-Carnitine sustainably affects bioenergetic profile of bovine blastocysts and transcriptome profile of elongation-stage embryos Open
In brief In the present study the sustainable effect of L-carnitine during the culture period on the post-transfer development was investigated. Taken together, we uncovered direct effects of L-carnitine on the bioenergetic profile of day …
View article: Synthesis, structural characterisations, electrochemical behavior and antibacterial activities of a chromium(III) resorcinolate complex
Synthesis, structural characterisations, electrochemical behavior and antibacterial activities of a chromium(III) resorcinolate complex Open
The integration and implementation of transition metal complexes as working electrode for surface modifications has become an area of research interest now a days. Based on this, a novel anionic complex having a formula of Na3[Cr(HR)4Cl2] …
View article: MicroRNA Nano-Shuttles: Engineering Extracellular Vesicles as a Cutting-Edge Biotechnology Platform for Clinical Use in Therapeutics
MicroRNA Nano-Shuttles: Engineering Extracellular Vesicles as a Cutting-Edge Biotechnology Platform for Clinical Use in Therapeutics Open
Extracellular vesicles (EVs) are nano-sized, membranous transporters of various active biomolecules with inflicting phenotypic capabilities, that are naturally secreted by almost all cells with a promising vantage point as a potential lead…
View article: Mapping the follicle-specific regulation of extracellular vesicle-mediated microRNA transport in the southern white rhinoceros (<i>Ceratotherium simum simum</i>)
Mapping the follicle-specific regulation of extracellular vesicle-mediated microRNA transport in the southern white rhinoceros (<i>Ceratotherium simum simum</i>) Open
Efforts to implement effective assisted reproductive technologies (ARTs) for the conservation of the northern white rhinoceros (NWR; Ceratotherium simum cottoni) to prevent its forthcoming extinction, could be supported by research conduct…
View article: Sexual dimorphic miRNA-mediated response of bovine elongated embryos to the maternal microenvironment
Sexual dimorphic miRNA-mediated response of bovine elongated embryos to the maternal microenvironment Open
A skewed male-to-female ratio in cattle is believed to be due to the biased embryo losses during pregnancy. The changes in biochemical secretion such as miRNAs by the embryo due to altered maternal environment could cause a sex biased sele…
View article: Endometrial DNA methylation signatures during the time of breeding in relation to the pregnancy outcome in postpartum dairy cows fed a control diet or supplemented with rumen-protected methionine
Endometrial DNA methylation signatures during the time of breeding in relation to the pregnancy outcome in postpartum dairy cows fed a control diet or supplemented with rumen-protected methionine Open
Post calving metabolic stress reduces the fertility of high producing dairy cows possibly by altering the expression of genes in the maternal environment via epigenetic modifications. Therefore, this study was conducted to identify endomet…
View article: The mitochondrial respiration signature of the bovine blastocyst reflects both environmental conditions of development as well as embryo quality
The mitochondrial respiration signature of the bovine blastocyst reflects both environmental conditions of development as well as embryo quality Open
View article: 60 Molecular Characterization of Boar Semen in Relation to Sperm Quality
60 Molecular Characterization of Boar Semen in Relation to Sperm Quality Open
Artificial insemination (AI) with fresh semen is the primary breeding tool in the swine industry. However, the heterogenous semen doses create challenges in boar studs due to the lack of consistent assessment criteria. Seminal plasma (SP) …
View article: Bovine oviductal organoids: a multi-omics approach to capture the cellular and extracellular molecular response of the oviduct to heat stress
Bovine oviductal organoids: a multi-omics approach to capture the cellular and extracellular molecular response of the oviduct to heat stress Open
View article: Mitochondrial bioenergetic profiles of warmed bovine blastocysts are typically altered after cryopreservation by slow freezing and vitrification
Mitochondrial bioenergetic profiles of warmed bovine blastocysts are typically altered after cryopreservation by slow freezing and vitrification Open
The widespread use of cryopreserved in vitro produced (IVP) bovine embryos is limited due to their low post-warming viability compared to their ex vivo derived counterparts. Therefore, the present study aimed to analyse in detail the conse…
View article: Incidence of Acute Kidney Injury and its predictors among neonates admitted at neonatal intensive care unit, university of Gondar, Debretabor and Tibebe Ghion Amhara Region Comprehensive Specialized Hospitals, Northwest Ethiopia, 2023
Incidence of Acute Kidney Injury and its predictors among neonates admitted at neonatal intensive care unit, university of Gondar, Debretabor and Tibebe Ghion Amhara Region Comprehensive Specialized Hospitals, Northwest Ethiopia, 2023 Open
Background: Although acute kidney injury is a major cause of neonatal morbidity and mortality worldwide, it is a serious problem in low and middle-income countries, particularly in sub-Saharan Africa such as Ethiopia. Moreover, there are f…
View article: Extracellular vesicle-microRNAs mediated response of bovine ovaries to seasonal environmental changes
Extracellular vesicle-microRNAs mediated response of bovine ovaries to seasonal environmental changes Open
View article: Assessment and Documentation of Indigenous and Introduced Soil and Water Conservation Measures in Some Parts of Southern Ethiopia
Assessment and Documentation of Indigenous and Introduced Soil and Water Conservation Measures in Some Parts of Southern Ethiopia Open
In Ethiopia, soil and water conservation (SWC) activities were initiated after the famines of 1973 and 1985. Subsequently, various conservation measures were implemented by the government and non-governmental organizations to improve susta…
View article: Granulosa cell-derived extracellular vesicles mitigate the detrimental impact of thermal stress on bovine oocytes and embryos
Granulosa cell-derived extracellular vesicles mitigate the detrimental impact of thermal stress on bovine oocytes and embryos Open
Climate change-induced global warming results in rises in body temperatures above normal physiological levels (hyperthermia) with negative impacts on reproductive function in dairy and beef animals. Extracellular vesicles (EVs), commonly d…
View article: Incidence and predictors of mortality among neonates admitted with perinatal asphyxia at west Oromia region referral hospitals, Ethiopia, 2022
Incidence and predictors of mortality among neonates admitted with perinatal asphyxia at west Oromia region referral hospitals, Ethiopia, 2022 Open
Background Perinatal asphyxia is one of the preventable and treatable causes of neonatal mortality. However it is the fifth largest cause of under-five mortality. There are both long-term and short-term neurodevelopmental consequences of p…
View article: Dynamics of extracellular vesicle-coupled microRNAs in equine follicular fluid associated with follicle selection and ovulation
Dynamics of extracellular vesicle-coupled microRNAs in equine follicular fluid associated with follicle selection and ovulation Open
Innumerable similarities in reproductive cyclicity and hormonal alterations highlight the considerable utility of the mare to study aspects of follicular dynamics and reproductive function in view of the largely constricted, human research…
View article: Machine‐learning methods applied to integrated transcriptomic data from bovine blastocysts and elongating conceptuses to identify genes predictive of embryonic competence
Machine‐learning methods applied to integrated transcriptomic data from bovine blastocysts and elongating conceptuses to identify genes predictive of embryonic competence Open
Early pregnancy loss markedly impacts reproductive efficiency in cattle. The objectives were to model a biologically relevant gene signature predicting embryonic competence for survival after integrating transcriptomic data from blastocyst…
View article: Characterization of Extracellular Vesicle-Coupled miRNA Profiles in Seminal Plasma of Boars with Divergent Semen Quality Status
Characterization of Extracellular Vesicle-Coupled miRNA Profiles in Seminal Plasma of Boars with Divergent Semen Quality Status Open
Sperm heterogeneity creates challenges for successful artificial insemination. Seminal plasma (SP) surrounding sperm is an excellent source for detecting reliable non-invasive biomarkers of sperm quality. Here, we isolated microRNAs (miRNA…
View article: Extracellular vesicle-microRNAs mediated response of bovine ovaries to environmental heat stress
Extracellular vesicle-microRNAs mediated response of bovine ovaries to environmental heat stress Open
Background Elevated ambient temperature during the summer season is a main cause of stress in dairy and beef cows, leading to impaired reproductive function and fertility. Follicular fluid extracellular vesicles (FF-EVs) play an important …
View article: Author Correction: The cell cycle stage of bovine zygotes electroporated with CRISPR/Cas9-RNP affects frequency of Loss-of-heterozygosity editing events
Author Correction: The cell cycle stage of bovine zygotes electroporated with CRISPR/Cas9-RNP affects frequency of Loss-of-heterozygosity editing events Open
View article: PSIII-17 Transcriptome Response of Granulosa Cells to Seasonal Heat Stress in Beef Cows
PSIII-17 Transcriptome Response of Granulosa Cells to Seasonal Heat Stress in Beef Cows Open
Investigation of cellular responses to thermal heat stress can lead to identifying novel targets of intervention to tackle the increasing fertility decline due to climate change-associated seasonal heat stress. We aimed to study the respon…
View article: The cell cycle stage of bovine zygotes electroporated with CRISPR/Cas9-RNP affects frequency of Loss-of-heterozygosity editing events
The cell cycle stage of bovine zygotes electroporated with CRISPR/Cas9-RNP affects frequency of Loss-of-heterozygosity editing events Open
View article: Sulforaphane Enhanced Proliferation of Porcine Satellite Cells via Epigenetic Augmentation of SMAD7
Sulforaphane Enhanced Proliferation of Porcine Satellite Cells via Epigenetic Augmentation of SMAD7 Open
Satellite cells take an indispensable place in skeletal muscle regeneration, maintenance, and growth. However, only limited works have investigated effects of dietary compounds on the proliferation of porcine satellite cells (PSCs) and rel…
View article: 259 The Role of Extracellular Vesicles in Mitigating the Effect of Heat Stress
259 The Role of Extracellular Vesicles in Mitigating the Effect of Heat Stress Open
Environmental heat stress negatively affects the fertility of dairy cows by disrupting reproductive processes spanning from follicular development to maternal recognition of pregnancy. Investigation of cellular level responses to stress wo…
View article: PSX-A-19 Late-Breaking: Potential application of granulosa cell derived extracellular vesicles to mitigate the effects of heat stress in bovine oocytes
PSX-A-19 Late-Breaking: Potential application of granulosa cell derived extracellular vesicles to mitigate the effects of heat stress in bovine oocytes Open
Environmental heat stress negatively affects reproductive efficiency by disrupting follicular development, ultimately compromising gamete competency in cattle. Recently, outlined through the bystander effect, granulosa cell derived extrace…