Explanipedia

Successful collection of patient-reported outcomes shows improvement in quality of life, depression, and disease activity among patients with Inflammatory Bowel Disease: A real-world study Open

Cihang Gu, Audrey Bennett, Justin M. Bachmann, David A. Schwartz, Dawn B. Beaulieu , et al. · 2024

Introduction: Patient reported outcomes (PRO) including patient disease activity scores, quality of life, and depressive symptoms are increasingly being used for clinical care in patients with inflammatory bowel disease (IBD). However, lit…

Use of Biosimilars to Infliximab During Pregnancy in Women with Inflammatory Bowel Disease: Results from the Pregnancy in Inflammatory Bowel Disease and Neonatal Outcomes (PIANO) Study Open

Millie D. Long, Sunanda V. Kane, Dawn B. Beaulieu, Bincy Abraham, Xian Zhang , et al. · 2024

Introduction: We aimed to compare pregnancy outcomes of women with inflammatory bowel disease (IBD) utilizing biosimilar vs. originator infliximab (IFX). Methods: In a prospective cohort of pregnant women with IBD, we collected characteris…

Use of Biosimilars to Infliximab During Pregnancy in Women With Inflammatory Bowel Disease: Results From the Pregnancy in Inflammatory Bowel Disease and Neonatal Outcomes Study Open

Millie D. Long, Sunanda V. Kane, Dawn B. Beaulieu, Bincy Abraham, Xian Zhang , et al. · 2024

INTRODUCTION: We aimed to compare pregnancy outcomes of women with inflammatory bowel disease using biosimilar vs originator infliximab (IFX). METHODS: In a prospective cohort of pregnant women with inflammatory bowel disease, we collected…

NON-INVASIVE DETERMINATION OF DISEASE ACTIVITY IN CROHN’S DISEASE BY SERUM LUMINEX PROFILING Open

Gabriella Raffa, Regina N. Tyree, Kate Carson, Margaret M. Allaman, Dawn B. Beaulieu , et al. · 2024

BACKGROUND & AIMS Crohn’s disease (CD) is a chronic inflammatory disease with a complex pathogenesis; treatment and management largely depend on disease activity assessment, which can be challenging and invasive. The aim of this study was …

TELEHEALTH ENHANCES RETENTION OF PATIENTS WITH INFLAMMATORY BOWEL DISEASE WITHIN A TERTIARY CARE INFLAMMATORY BOWEL DISEASE CENTER Open

Jeffrey J. Olson, Dawn B. Beaulieu, Audrey Bennett, Robin Dalal, Baldeep Pabla , et al. · 2024

INTRODUCTION Telehealth care in the ambulatory setting has dramatically increased in the COVID and post-COVID period in medicine. Understanding how this may impact the care of patients (pts) with inflammatory bowel disease (IBD) is importa…

The Comorbidity of Patient-Reported Crohn’s Disease Activity and Depression: The Role of Health Behavior Mediators Open

Lawrence S. Gaines, Michael D. Kappelman, David Schwartz, Sara Horst, Dawn B. Beaulieu , et al. · 2023

Background Longitudinal research reveals a unidirectional relationship between a nonsomatic symptom of depression, a negative view of the self, and later reported Crohn’s disease (CD) activity. We evaluated whether health behaviors mediate…

Maternal and Neonatal Outcomes in Vedolizumab- and Ustekinumab-Exposed Pregnancies: Results From the PIANO Registry Open

Rishika Chugh, Millie D. Long, Yue Jiang, Kimberly N. Weaver, Dawn B. Beaulieu , et al. · 2023

Background: Pregnancy outcomes in patients with inflammatory bowel disease with quiescent disease are similar to those in the general population. Data from the Pregnancy Inflammatory bowel disease And Neonatal Outcomes registry have demons…

A Specialized Epithelial Cell Type Regulating Mucosal Immunity and Driving Human Crohn’s Disease Open

Jia Li, Alan J. Simmons, Sophie Chiron, Marisol Ramirez‐Solano, Naila Tasneem , et al. · 2023

Crohn’s disease (CD) is a complex chronic inflammatory disorder that may affect any part of gastrointestinal tract with extra-intestinal manifestations and associated immune dysregulation. To characterize heterogeneity in CD, we profiled s…

Multicenter Study of Nonadherence to Self-Injectable Biologic Therapy in Patients With Inflammatory Bowel Disease: Risk Factors and Outcomes Open

Lauren George, Erin Causey, Nisha Shah, James C. Slaughter, Jonah Jerabek , et al. · 2023

Tofacitinib Adherence and Outcomes in Refractory Inflammatory Bowel Disease Open

C. Alex Wiles, Nisha Shah, Jake Bell, Baldeep Pabla, Elizabeth Scoville , et al. · 2021

Background Tofacitinib has been approved for moderate-to-severe ulcerative colitis and studied in Crohn’s disease. Understanding medication adherence to oral medications in severe disease is essential. Methods We retrospectively reviewed a…

Vedolizumab Concentrations in Breast Milk: Results from a Prospective, Postmarketing, Milk-Only Lactation Study in Nursing Mothers with Inflammatory Bowel Disease Open

Wan Sun, Blair Fennimore, Dawn B. Beaulieu, Razvan Arsenescu, Adam C. Stein , et al. · 2021

ClinicalTrials.gov, NCT02559713; registered 24 September, 2015.

P509 Vedolizumab levels in breast milk: Results from a prospective, postmarketing, milk-only lactation study in nursing mothers with inflammatory bowel disease Open

Wan Sun, Blair Fennimore, Dawn B. Beaulieu, Razvan Arsenescu, Adam C. Stein , et al. · 2020

Background The safety of inflammatory bowel disease (IBD) medications during lactation is of significant interest and relevance to female patients of childbearing potential. Available data regarding the safety and transfer of biologic agen…

Mo1867 – The Importance of Monitoring the Postpartum Period in Moderate to Severe Crohn’s Disease Open

Audrey Bennett, Alexander Mamunes, Mindy Kim, Ailish Garrett, Caroline Duley , et al. · 2019

Mo1912 – Vedolizumab in Elderly Patients with Inflammatory Bowel Disease is Associated with Improved Disease Outcomes and Low Rates of Serious Infection: A Single Center Real World Experience Open

Baldeep Pabla, Rochelle Wong, Amir Kashani, Elizabeth Scoville, Robin Dalal , et al. · 2019

Histoplasmosis as a Complication of Inflammatory Bowel Disease Therapy: A Case Series Open

Baldeep Pabla, Elizabeth Scoville, Shabnam Sarker, Robin Dalal, Sara Horst , et al. · 2018

Fecal transplantation for treatment of inflammatory bowel disease Open

Aamer Imdad, Maribeth R. Nicholson, Emily E. Tanner‐Smith, Joseph P. Zackular, Óscar G. Gómez-Duarte , et al. · 2018

Background Inflammatory bowel disease (IBD) is a chronic, relapsing disease of the gastrointestinal tract that is thought to be associated with a complex interplay between microbes and the immune system, leading to an abnormal inflammatory…

Use of Biologic Therapy by Pregnant Women With Inflammatory Bowel Disease Does Not Affect Infant Response to Vaccines Open

Dawn B. Beaulieu, Ashwin N. Ananthakrishnan, Christopher Martin, Russell D. Cohen, Sunanda V. Kane , et al. · 2018

BACKGROUND & AIMS: In women with inflammatory bowel diseases (IBDs), exposure to immunomodulator or biologic therapy has not been associated with adverse events during pregnancy or outcomes of newborns. We investigated whether exposure of …

Use of Biologic Therapy by Pregnant Women With Inflammatory Bowel Disease Does Not Affect Infant Response to Vaccines Open

Dawn B. Beaulieu, Ashwin N. Ananthakrishnan, Christopher F. Martin, Russell D. Cohen, Sunanda V. Kane , et al. · 2017

Sarcopenia Is Common in Overweight Patients with Inflammatory Bowel Disease and May Predict Need for Surgery Open

Dawn W. Adams, Shelly Gurwara, Heidi J. Silver, Sara Horst, Dawn B. Beaulieu , et al. · 2017

Almost half of our cohort was sarcopenic. Most of these patients are normal or overweight and would not be identified as malnourished by traditional measures. Sarcopenia was a predictor of surgery in patients with a body mass index ≥ 25. I…

L-Arginine Availability and Metabolism Is Altered in Ulcerative Colitis Open

Lori A. Coburn, Sara Horst, Margaret M. Allaman, Caroline T. Brown, Christopher S. Williams , et al. · 2016

Patients with UC exhibit diminished tissue L-Arg, likely attributable to decreased cellular uptake and increased consumption by NOS2. These findings combined with decreased ARG1 expression indicate a pattern of dysregulated L-Arg availabil…

Vertical Transmission of Histoplasmosis Associated With Anti-Tumor Necrosis Factor Therapy Open

James G. Carlucci, Natasha Halasa, C. Buddy Creech, Daniel E. Dulek, Óscar G. Gómez-Duarte , et al. · 2016

Therapeutics blocking the activity of tumor necrosis factor (anti-TNF) are a risk factor for invasive fungal infections; however, infectious risks to infants born to mothers receiving anti-TNF therapy are not well defined. We report a case…

Association Between Affective-Cognitive Symptoms of Depression and Exacerbation of Crohn’s Disease Open

Lawrence S. Gaines, James C. Slaughter, Sara Horst, David Schwartz, Dawn B. Beaulieu , et al. · 2016

The prevalence of depression is high in patients with Crohn’s Disease (CD). We examined the influence of affective-cognitive symptoms of depression on the risk of exacerbation of CD.

Use of Intravenous Immunoglobulin for Patients with Inflammatory Bowel Disease with Contraindications or Who Are Unresponsive to Conventional Treatments Open

Scott Merkley, Dawn B. Beaulieu, Sara Horst, Caroline Duley, Kim Annis , et al. · 2015

IVIg is safe and effective in the short-term management of patients with IBD when standard therapies are contraindicated.

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