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View article: Hair Transplantation in Primary Cicatricial Alopecias: A Review and Update
Hair Transplantation in Primary Cicatricial Alopecias: A Review and Update Open
Background: Primary cicatricial alopecias (PCA) are inflammatory disorders that cause permanent hair loss through follicular destruction and fibrosis. Hair transplantation (HT) may restore coverage in stable or end-stage PCA cases. This re…
View article: Exploring Cutaneous Lymphoproliferative Disorders in the Wake of COVID-19 Vaccination
Exploring Cutaneous Lymphoproliferative Disorders in the Wake of COVID-19 Vaccination Open
Background Individual reports have described lymphoproliferative disorders (LPDs) and cutaneous lymphomas emerging after administration of the COVID-19 vaccine; however, the relationship between reactions and vaccine types has not yet been…
View article: Patient Satisfaction of General Dermatology Providers: A Quantitative and Qualitative Analysis of 38,008 Online Reviews
Patient Satisfaction of General Dermatology Providers: A Quantitative and Qualitative Analysis of 38,008 Online Reviews Open
Measuring patient satisfaction of general dermatology providers is an important goal because it can lead to improved clinical outcomes. Online reviews are emerging as the newest forum for evaluating physicians in real time and provide a va…
View article: UV biomarker genes for classification and risk stratification of cutaneous actinic keratoses and squamous cell carcinoma subtypes
UV biomarker genes for classification and risk stratification of cutaneous actinic keratoses and squamous cell carcinoma subtypes Open
Currently, there is no sensitive molecular test for identifying transformation‐prone actinic keratoses (AKs) and aggressive squamous cell carcinoma (SCC) subtypes. Biomarker‐based molecular testing represents a promising tool for risk stra…
View article: Genome-wide transcriptome analysis of the STAT6-regulated genes in advanced-stage cutaneous T-cell lymphoma
Genome-wide transcriptome analysis of the STAT6-regulated genes in advanced-stage cutaneous T-cell lymphoma Open
The signal transducer and activator of transcription 6 (STAT6) is a critical up-stream mediator of interleukin-13 (IL-13) and IL-4 signaling and is constitutively activated in malignant lymphocytes from Sezary syndrome (SS) and mycosis fun…
View article: Exome sequencing identifies novel mutation signatures of UV radiation and trichostatin A in primary human keratinocytes
Exome sequencing identifies novel mutation signatures of UV radiation and trichostatin A in primary human keratinocytes Open
Canonical ultraviolet (UV) mutation type and spectra are traditionally defined by direct sequencing-based approaches to map mutations in a limited number of representative DNA elements. To obtain an unbiased view of genome wide UV mutation…
View article: Function and Regulation of IL-36 Signaling in Inflammatory Diseases and Cancer Development
Function and Regulation of IL-36 Signaling in Inflammatory Diseases and Cancer Development Open
The IL-36 subfamily of cytokines belongs to the IL-1 superfamily and consists of three pro-inflammatory agonists IL-36α, IL-36β, IL-36γ, and an IL-36 receptor (IL-36R) antagonist, IL-36Ra. These IL-36 cytokines function through a common re…
View article: An unusual cause of bilateral orbital swelling: Immunoglobulin G4–related orbital disease arising in a patient with ulcerative colitis
An unusual cause of bilateral orbital swelling: Immunoglobulin G4–related orbital disease arising in a patient with ulcerative colitis Open
Immunoglobulin G4–related diseases (IgG4-RD) are a group of immune-mediated disorders characterized by organ infiltration with lymphocytes and IgG4+ plasma cells. IgG4-RD has multiple clinical manifestations, affecting distant organs rangi…
View article: Regeneration of severely damaged lungs using an interventional cross-circulation platform
Regeneration of severely damaged lungs using an interventional cross-circulation platform Open
The number of available donor organs limits lung transplantation, the only lifesaving therapy for the increasing population of patients with end-stage lung disease. A prevalent etiology of injury that renders lungs unacceptable for transpl…
View article: Paraneoplastic cerebellar ataxia in Merkel cell carcinoma of unknown primary
Paraneoplastic cerebellar ataxia in Merkel cell carcinoma of unknown primary Open
Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor that is locally aggressive and frequently associated with metastatic disease. Our literature review found that MCC may be associated with paraneoplastic neurological syndromes (PNS…
View article: Paraneoplastic scleroderma in the setting of CD30+ large cell transformation of mycosis fungoides
Paraneoplastic scleroderma in the setting of CD30+ large cell transformation of mycosis fungoides Open
Cutaneous T-cell lymphoma is a malignant non-Hodgkin T-cell lymphoma, with mycosis fungoides (MF) and Sézary syndrome being the most common subtypes. In patients with MF, transformation to large cell histology is associated with worse prog…
View article: Targeted fibrillar nanocarbon RNAi treatment of acute kidney injury
Targeted fibrillar nanocarbon RNAi treatment of acute kidney injury Open
Fibrillar carbon nanotubes simultaneously deliver two small interfering RNAs, which safely prevent acute kidney injury and prolong survival in mice.