Explanipedia

A High‐Throughput AngioPlate Platform with Integrated AngioTEER for Modeling and Monitoring Renal Proximal Tubule Injury Open

Shravanthi Rajasekar, Aranyak Chakravarty, Kimia Asadi Jozani, Binh Quang Truong, Michael Hendrickson , et al. · 2025

Renal tubular injury is the leading cause of acute and chronic kidney diseases. This condition occurs when renal proximal tubular epithelial cells sustain damage from exposure to nephrotoxins, infections, or ischemia leading to tubular int…

Immune‐Infiltrated Cancer Spheroid Model with Vascular Recirculation Reveals Temporally Dependent and Tissue‐Specific Macrophage Recruitment Open

Feng Zhang, Kimia Asadi Jozani, Aranyak Chakravarty, Dawn Lin, Andrew Hollinger , et al. · 2025

Immune cell infiltration in tumors has been reported to influence tumor progression and clinical outcomes. Considerable efforts have been made to understand interactions between tumors and the immune system. However, current models are eit…

TAFM-Net: A Novel Approach to Skin Lesion Segmentation Using Transformer Attention and Focal Modulation Open

Tariq Khan, Dawn Lin, Shahzaib Iqbal, Erik Meijering · 2024

Incorporating modern computer vision techniques into clinical protocols shows promise in improving skin lesion segmentation. The U-Net architecture has been a key model in this area, iteratively improved to address challenges arising from …

A<i>multi-track</i>landscape of haematopoiesis informed by cellular barcoding and agent-based modelling Open

Dawn Lin, Stephen Zhang, Jaring Schreuder, Jessica Tran, Tobias Sargeant , et al. · 2024

In classic ‘ball-and-stick’ models of haematopoiesis the implicit assumption is that all cells within each defined stem or progenitor cell population are equivalent in their fate. Instead, more recent models suggest a haematopoietic stem a…

New insight into the causes, consequences, and correction of hematopoietic stem cell aging Open

Els Mansell, Dawn Lin, Stephen J. Loughran, Michael D. Milsom, Jennifer J. Trowbridge · 2023

Aging of hematopoietic stem cells (HSCs) is characterized by lineage bias, increased clonal expansion, and functional decrease. At the molecular level, aged HSCs typically display metabolic dysregulation, upregulation of inflammatory pathw…

Clonal multi-omics reveals Bcor as a negative regulator of emergency dendritic cell development Open

Luyi Tian, Sara Tomei, Jaring Schreuder, Tom Weber, Daniela Amann‐Zalcenstein , et al. · 2021

Macrophage Immunomodulation Through New Polymers that Recapitulate Functional Effects of Itaconate as a Power House of Innate Immunity Open

Locke Davenport Huyer, Serena Mandla, Yufeng Wang, S. Campbell, Bess Yee , et al. · 2020

Itaconate (ITA) is an emerging powerhouse of innate immunity with therapeutic potential that is limited in its ability to be administered in a soluble form. A library of polyester materials that incorporate ITA into polymer backbones resul…

Single-cell lineage tracing approaches in hematology research: technical considerations Open

Joana Carrelha, Dawn Lin, Alejo Rodriguez-Fraticelli, Tiago C. Luís, Adam C. Wilkinson , et al. · 2020

The clonal and molecular aetiology of emergency dendritic cell development Open

Dawn Lin, Luyi Tian, Sara Tomei, Daniela Amann‐Zalcenstein, Tracey M. Baldwin , et al. · 2020

Summary Extrinsic regulation of single haematopoietic stem and progenitor cell (HSPC) fate is crucial for immune cell development. Here, we examine the aetiology of Flt3 ligand (Flt3L)-mediated emergency development of type 1 conventional …

PIK3CA alterations in metastatic breast cancer (mBC) Open

Joan Albanell, David Casadevall, E.S. Sokol, Lee A. Albacker, J.A. Elvin , et al. · 2019

CLONAL ETIOLOGY OF EMERGENCY DENDRITIC CELL DEVELOPMENT Open

Dawn Lin, Philip D. Hodgkin, Shalin H. Naik, Luyi Tian · 2019

Publisher Correction: Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer Open

Delphine Mérino, Tom Weber, Antonin Serrano, François Vaillant, K. Liu , et al. · 2019

Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer Open

Delphine Mérino, Tom Weber, Antonin Serrano, François Vaillant, K. Liu , et al. · 2019

Primary triple negative breast cancers (TNBC) are prone to dissemination but sub-clonal relationships between tumors and resulting metastases are poorly understood. Here we use cellular barcoding of two treatment-naïve TNBC patient-derived…

Longitudinal single cell fate of hematopoiesis <i>in vivo</i> using cellular barcoding and DiSNE movie visualization Open

Jerry Gao, Dawn Lin, Edmund J. Crampin, Shalin H. Naik · 2018

Identifying the progeny of many single progenitor cells simultaneously can be achieved by tagging progenitors with unique heritable DNA barcodes, and allows inferences of lineage relationships, including longitudinally. While this approach…

DiSNE Movie Visualization and Assessment of Clonal Kinetics Reveal Multiple Trajectories of Dendritic Cell Development Open

Dawn Lin, Andrey Kan, Jerry Gao, Edmund J. Crampin, Philip D. Hodgkin , et al. · 2018

A thorough understanding of cellular development is incumbent on assessing the complexities of fate and kinetics of individual clones within a population. Here, we develop a system for robust periodical assessment of lineage outputs of tho…

Code and data: Assessment of clonal kinetics reveals multiple trajectories of dendritic cell development Open

Dawn Lin · 2018

SF1 contains processed barcode data and the matlab codes used to analyze the data presented in the paper. SF2 contains the matlab codes to build the PieMaker software, which allows the generation of Di-SNE movie visualization presented in …

Assessment of clonal kinetics reveals multiple trajectories of dendritic cell development Open

Dawn Lin, Andrey Kan, Jerry Gao, Edmund J. Crampin, Philip D. Hodgkin , et al. · 2017

SUMMARY A thorough understanding of cellular development is incumbent on assessing the complexities of fate and kinetics of individual clones within a population. Here, we develop a system for robust periodical assessment of lineage output…

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